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ProhibitedBinding ruleINOriginal is EnglishOfficial-source import checked

-Methylenediphenyl diisocyanate; diphenylmethane- -diisocyanate -Methylenediphenyl 4,4′ 4,4′ [1], 2,2′ ′ diisocyanate; diphenylmethane-2,2 -diisocyanate [2], o-(p-Isocyanatobenzyl)phenyl isocyanate diphenylmethane- -diisocyanate [3], Methylenediphenyl diisocyanate [4] (CAS No. 101-68-8 [1], ] 2,4′

-Methylenediphenyl diisocyanate; diphenylmethane- -diisocyanate -Methylenediphenyl 4,4′ 4,4′ [1], 2,2′ ′ diisocyanate; diphenylmethane-2,2 -diisocyanate [2], o-(p-Isocyanatobenzyl)phenyl isocyanate diphenylmethane- -diisocyanate [3], Methylenediphenyl dii

IS 4707 Part 2:2025 Annex A lists this ingredient as one that must not form part of a cosmetic product in India.

All India recordsOpen ingredient profileCompare all marketsOpen official source

Regulatory decision and full conditions

Status
Prohibited
Legal role
Binding rule
Regulatory summary
IS 4707 Part 2:2025 Annex A lists this ingredient as one that must not form part of a cosmetic product in India.
Conditions and restrictions
Must not form part of the composition of cosmetic products. Apply the general trace and safety notes published after Annex A.

Substance identity

Official source name
-Methylenediphenyl diisocyanate; diphenylmethane- -diisocyanate -Methylenediphenyl 4,4′ 4,4′ [1], 2,2′ ′ diisocyanate; diphenylmethane-2,2 -diisocyanate [2], o-(p-Isocyanatobenzyl)phenyl isocyanate diphenylmethane- -diisocyanate [3], Methylenediphenyl diisocyanate [4] (CAS No. 101-68-8 [1], ] 2,4′
CAS
101-68-8
EC
202-966-0
Identity mapping
cas_number
Linked ingredient
METHYLENE DIPHENYL DIISOCYANATE
Search this identity across the siteCAS 101-68-8EC 202-966-0

Linked CosIng identity data

Names and aliases

METHYLENE DIPHENYL DIISOCYANATE

CosIng description: 4,4'-Diisocyanatodiphenylmethane,4,4'-Diphenylmethane diisocyanate,MDI,1,1'-Methylenebis(4-isocyanaotbenzene)

EU inventory restriction note: II/1533

Recorded cosmetic function: NOT REPORTED

Function pages:NOT REPORTED

View the complete ingredient profile

Cross-market snapshot for this identity

Exact linked records currently present in this site. An absent market means no imported exact match, not permission to use the substance.

5 market datasets
PubChem 2D chemical structure for CAS 101-68-8
CAS 101-68-8PubChem CID 7570

Verified chemistry for CAS 101-68-8

Diphenylmethane diisocyanate

IUPAC name
1-isocyanato-4-[(4-isocyanatophenyl)methyl]benzene
Molecular formula
C15H10N2O2
Molecular weight
250.25 g/mol
Exact mass
250.074227566 Da
Monoisotopic mass
250.074227566 Da
XLogP3
5.4
Topological polar surface area
58.9 Ų
Molecular complexity
332.0
Formal charge
0
Hydrogen-bond donors
0
Hydrogen-bond acceptors
4
Rotatable bonds
4
Heavy atoms
19
Covalent units
1

Names and synonyms reported to PubChem

4,4'-Diphenylmethane diisocyanateBis(4-isocyanatophenyl)methane4,4'-Methylenebis(phenyl isocyanate)IsonateDesmodur 44p,p'-Diphenylmethane diisocyanate1,1'-Methylenebis(4-isocyanatobenzene)Methylbisphenyl isocyanate
16 more reported names
4,4'-Methylenediphenyl diisocyanate4,4'-DiisocyanatodiphenylmethaneMethylene bisphenyl isocyanatediphenylmethane-4,4'-diisocyanateCaradate 30Nacconate 300Isonate 125MBis(p-isocyanatophenyl)methaneDiphenylmethyl diisocyanateIsonate 125 MFRubinate 44Bis(1,4-isocyanatophenyl)methaneMethylenebis(4-phenyl isocyanate)Hylene M50Diphenylmethan-4,4'-diisocyanatMethylenebis(4-isocyanatobenzene)
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D pharmacophore features
4
3D rings
2
3D hydrophobes
0
3D acceptor features
2
3D donor features
0
3D anionic centres
0
3D cationic centres
0
3D conformers
10
Effective 3D rotors
4.0
Machine-readable structure identifiers
SMILES
C1=CC(=CC=C1CC2=CC=C(C=C2)N=C=O)N=C=O
InChI
InChI=1S/C15H10N2O2/c18-10-16-14-5-1-12(2-6-14)9-13-3-7-15(8-4-13)17-11-19/h1-8H,9H2
InChIKey
UPMLOUAZCHDJJD-UHFFFAOYSA-N

Evidence from additional scientific databases

EMBL-EBI ChEBI
Exact identifier matchCHEBI:53218

diphenylmethane-4,4'-diisocyanate

A diisocyanate consisting of diphenylmethane with two isocyanate groups at the 4- and 4'-positions.

Formula
C15H10N2O2
Average mass
250.257 g/mol
Monoisotopic mass
250.07423 Da
Formal charge
0
  • diisocyanate — is a (CHEBI:53213)
  • hapten — has role (CHEBI:59174)
  • allergen — has role (CHEBI:50904)
  • diphenylmethane — has parent hydride (CHEBI:38884)
  • hapten — has role (CHEBI:59174)
  • allergen — has role (CHEBI:50904)
  • diisocyanate — is a (CHEBI:53213)
Additional curated names
1,1'-methylenebis(4-isocyanatobenzene)1,1'-Methylenebis(4-isocyanatobenzene)4-4'-Diisocyanate de diphenylmethane4,4'-Diisocyanatodiphenylmethane4,4'-Diphenylmethane diisocyanate4,4'-Methylenebis(phenyl isocyanate)4,4'-methylene diphenyl diisocyanate4,4'-Methylenediphenyl diisocyanate4,4'-Methylenediphenylene diisocyanate4,4'-Methylenediphenylene isocyanate4,4'-Methylenedi(phenyl isocyanate)4,4'-Methylenediphenyl isocyanate4,4'-Methylenedi-p-phenylene diisocyanateBis(1,4-isocyanatophenyl)methaneBis(4-isocyanatophenyl)methaneBis(para-isocyanatophenyl)methaneBis(p-isocyanatophenyl)methaneDiphenylmethan-4,4'-diisocyanatDiphenylmethane-4,4'-diisocyanateDiphenyl methane diisocyanateDiphenylmethane diisocyanateDiphenylmethyl diisocyanateMDIMDRMethylbisphenyl isocyanateMethylenebis(4-isocyanatobenzene)Methylenebis(4-phenylene isocyanate)Methylenebis(4-phenyl isocyanate)Methylenebis(para-phenylene isocyanate)Methylenebis(para-phenyl isocyanate)Methylenebisphenyl diisocyanateMethylene bisphenyl isocyanateMethylenebis(p-phenylene isocyanate)Methylenebis(p-phenyl isocyanate)Methylenedi-para-phenylene diisocyanateMethylene diphenyl diisocyanateMethylenedi-p-phenylene diisocyanateMethylene di-p-phenylene isocyanatepara,para'-Diphenylmethane diisocyanatepara,para'-Methylenebis(phenyl isocyanate)
Cross-references from this source

Mapped by: Exact CAS cross-reference in the ChEBI compound record. Source updated: 2016-03-21. Retrieved: 2026-08-31. Open source record

NIH PubChem PUG-View
Exact identifier match7570

Attributed physical-property, hazard, environmental and use annotations.

  • First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.; SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas.; INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknow Source: CAMEO Chemicals
  • First Aid: (General first aid procedures); Eye: Irrigate immediately - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.; Skin: Soap wash immediately - If this chemical contacts the skin, immediately wash the contaminated skin with soap and water. If this chemical penetrates the clothing, immediately remove the clothing, wash the skin with soap and water, and get medical attention promptly.; Breathing: Respiratory support; Swallow: Medical attention immediately - If this chemical has been swallowed, get medical attention immediately. Source: The National Institute for Occupational Safety and Health (NIOSH)
  • Signal: Danger Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • GHS Hazard Statements: H315: Causes skin irritation [Warning Skin corrosion/irritation]; H317: May cause an allergic skin reaction [Warning Sensitization, Skin]; H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H332: Harmful if inhaled [Warning Acute toxicity, inhalation]; H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled [Danger Sensitization, respiratory]; H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]; H351: Suspected of causing cancer [Warning Carcinogenicity]; H373 **: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Precautionary Statement Codes: P203, P233, P260, P261, P264, P264+P265, P271, P272, P280, P284, P302+P352, P304+P340, P305+P351+P338, P317, P318, P319, P321, P332+P317, P333+P317, P337+P317, P342+P316, P362+P364, P403, P403+P233, P405, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Signal: Danger Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]; H317 (100%): May cause an allergic skin reaction [Warning Sensitization, Skin]; H319 (99.9%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H332 (90.1%): Harmful if inhaled [Warning Acute toxicity, inhalation]; H334 (100%): May cause allergy or asthma symptoms or breathing difficulties if inhaled [Danger Sensitization, respiratory]; H335 (96%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]; H351 (99%): Suspected of causing cancer [Warning Carcinogenicity]; H373 (88.9%): May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P203, P233, P260, P261, P264, P264+P265, P271, P272, P280, P284, P302+P352, P304+P340, P305+P351+P338, P317, P318, P319, P321, P332+P317, P333+P317, P337+P317, P342+P316, P362+P364, P403, P403+P233, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 1939 reports by companies from 54 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Note: This chemical does not meet GHS hazard criteria for 2.6% (37 of 1404) of reports. Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H315 (97.4%): Causes skin irritation [Warning Skin corrosion/irritation]; H317 (97.4%): May cause an allergic skin reaction [Warning Sensitization, Skin]; H319 (97.4%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H330 (31.4%): Fatal if inhaled [Danger Acute toxicity, inhalation]; H332 (66%): Harmful if inhaled [Warning Acute toxicity, inhalation]; H334 (97.4%): May cause allergy or asthma symptoms or breathing difficulties if inhaled [Danger Sensitization, respiratory]; H335 (92%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]; H351 (94.3%): Suspected of causing cancer [Warning Carcinogenicity]; H373 (95.4%): May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P203, P233, P260, P261, P264, P264+P265, P271, P272, P280, P284, P302+P352, P304+P340, P305+P351+P338, P316, P317, P318, P319, P320, P321, P332+P317, P333+P317, P337+P317, P342+P316, P362+P364, P403, P403+P233, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 1404 reports by companies from 40 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Reported as not meeting GHS hazard criteria per 37 of 1404 reports by companies.; There are 39 notifications provided by 1367 of 1404 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Signal: Danger Source: NITE-CMC
  • Health Effects: Exposure to high levels of cyanide for a short time harms the brain and heart and can even cause coma, seizures, apnea, cardiac arrest and death. Chronic inhalation of cyanide causes breathing difficulties, chest pain, vomiting, blood changes, headaches, and enlargement of the thyroid gland. Skin contact with cyanide salts can irritate and produce sores. (L96, L97) Source: Toxin and Toxin Target Database (T3DB)
  • Toxicity Summary: IDENTIFICATION AND USE: This chemical exists as a colorless or light yellow fused solid. 4,4'-Methylenediphenyl diisocyanate (MDI) is miscible in water, and soluble in acetone, benzene, kerosene, and nitrobenzene. The product is used to make rigid and semi-rigid polyurethane foams. Pure MDI is distilled from the reaction mixture and is used for reaction injection molding, thermoplastic elastomers, and adhesives. HUMAN EXPOSURE AND TOXICITY: MDI is irritating to skin, eyes, and respiratory passages. Nose and throat irritation has also been observed. A few cases of alveolitis have been reported in workers exposed to MDI vapors. Contact allergy and allergic contact eczema have been reported in workers exposed to MDI. Cases of asthmatic breathing have been observed in workers. Lung fibrosis is also been observed in workers exposed to MDI. Children living in proximity of an accidental MDI release had signs of sore throat, dizziness, nausea and breathing difficulties MDI is an allergic sensitizer. Workers in occupational settings have the potential for inhalation or skin contact with particles of MDI. There is inadequate evidence for the carcinogenicity of MDI in humans. ANIMAL STUDIES: Source: Hazardous Substances Data Bank (HSDB)
  • Toxicity Summary: Cyanide is an inhibitor of cytochrome c oxidase in the fourth complex of the electron transport chain (found in the membrane of the mitochondria of eukaryotic cells). It complexes with the ferric iron atom in this enzyme. The binding of cyanide to this cytochrome prevents transport of electrons from cytochrome c oxidase to oxygen. As a result, the electron transport chain is disrupted and the cell can no longer aerobically produce ATP for energy. Tissues that mainly depend on aerobic respiration, such as the central nervous system and the heart, are particularly affected. Cyanide is also known produce some of its toxic effects by binding to catalase, glutathione peroxidase, methemoglobin, hydroxocobalamin, phosphatase, tyrosinase, ascorbic acid oxidase, xanthine oxidase, succinic dehydrogenase, and Cu/Zn superoxide dismutase. Cyanide binds to the ferric ion of methemoglobin to form inactive cyanmethemoglobin. (L97) Source: Toxin and Toxin Target Database (T3DB)
  • Environmental Bioconcentration: 4,4'-Methylenediphenyl diisocyanate hydrolyzes rapidly in aqueous solution(1-3); therefore, bioconcentration will not be an important environmental fate process(SRC). Exposure of carp to 0.00001% concentrations of 4,4'-methylenediphenyl diisocyanate for an eight week period resulted in no bioaccumulations(4). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: When monomeric 4,4'-methylenediphenyl diisocyanate is handled as a liquid (melting point 38 °C), it will solidify on contact with soil(1). 4,4'-Methylenediphenyl diisocyanate reacts readily with water(1-5). If released to soil, agglomerations of 4,4'-methylenediphenyl diisocyanate react with water to form a hard crust of inert, water-insoluble material comprised of polyureas(1); the polyurea crusts can entrap monomeric 4,4'-methylenediphenyl diisocyanate and prevent further contact with water, thereby increasing the persistence time(1). 4,4'-Methylenediphenyl diisocyanate is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 5.0X10-6 mm Hg(6). Biodegradation data in soil were not available(SRC, 2012). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: AQUATIC FATE: 4,4'-Methylenediphenyl diisocyanate was added to a model marine system and a model river to simulate spill situations(1,2); 4,4'-methylenediphenyl diisocyanate concentrations fell to a maximum of 5% of initial value within one day(1,2). Spills or agglomerations of 4,4'-methylenediphenyl diisocyanate react with water to form a hard crust of inert, water-insoluble material comprised of polyureas(1); the polyurea crusts can entrap monomeric 4,4'-methylenediphenyl diisocyanate and prevent further contact with water, thereby increasing the persistence time(1). Small aquatic releases of 4,4'-methylenediphenyl diisocyanate will hydrolyze rapidly in water with an estimated half-life of a few minutes to a few hours(3-5). Biodegradation data in water were not available(SRC, 2012). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 4,4'-methylenediphenyl diisocyanate, which has a vapor pressure of 5.0X10-6 mm Hg at 25 °C(2), is expected to exist in both the vapor and particulate phases in the ambient atmosphere(SRC). Vapor-phase 4,4'-methylenediphenyl diisocyanate is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 11 hours(SRC), calculated from its rate constant of 1.2X10-11 cu cm/molecule-sec at 25 °C(SRC) determined using a structure estimation method(3). Reaction with atmospheric water vapor(4) may increase the atmospheric degradation rate several fold(SRC). Particulate-phase 4,4'-methylenediphenyl diisocyanate will be removed from the atmosphere by wet and dry deposition(SRC). 4,4'-Methylenediphenyl diisocyanate does not contain chromophores that absorb at wavelengths >290 nm(5), and therefore is not expected to be susceptible to direct photolysis by sunlight(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Industry Uses: Monomers; Polymerization promoter; Binder; Intermediate; Pigment Source: EPA Chemical Data Reporting (CDR)
  • Industry Uses: Other; Binder; Polymerization promoter; Monomers; Sealant (barrier); Not Known or Reasonably Ascertainable; Elasticizer; Surface modifier; Adhesion/cohesion promoter; Hardener; Intermediate Source: EPA Chemical Data Reporting (CDR)
  • Uses: The commercial form of MDI is primarily used to produce polyurethane foams. Source: EPA Hazardous Air Pollutants
  • Sources/Uses: Pattern of use in 1974: coatings (28%); elastomers (22%); thermoplastic resins (22%); spandex fibers (19%); millable gums (9%); [HSDB] Occupational asthma reported in foundry; [Malo] Allergic contact dermatitis in shoemakers and other workers using glues; [Marks] Used in spray-on truck bed liners; [Reference #2] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Industrial Processes with risk of exposure: Molding and Core Making [Category: Foundry]; Metal Preparation and Pouring [Category: Foundry]; Textiles (Fiber & Fabric Manufacturing) [Category: Industry]; Painting (Pigments, Binders, and Biocides) [Category: Paint]; Working with Glues and Adhesives [Category: Other]; Plastic Composites Manufacturing [Category: Industry] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Activities with risk of exposure: Preparing and mounting animal skins (taxidermy) [Category: Hobbies] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Sources/Uses: Used in the furniture, car, shoe, carpet, refrigerators and freezers, textile, coatings, and construction industries; [IUCLID] Used primarily in the manufacture of rigid polyurethane foams; Other uses include coatings, adhesives, sealants, elastomers, paints, footwear, (semi) flexible and thermoplastic polyurethane foams, polyurethane fibers, and to make particle board and foundry mould cores; [CPS&Q: RARs - Final Report] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Industrial Processes with risk of exposure: Molding and Core Making [Category: Foundry]; Textiles (Fiber & Fabric Manufacturing) [Category: Industry]; Painting (Pigments, Binders, and Biocides) [Category: Paint]; Working with Glues and Adhesives [Category: Other]; Plastic Composites Manufacturing [Category: Industry] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Uses: Typically, a mixture of MDI and its dimer and trimer is formed (polymeric MDI). This product is used primarily to make rigid and semi-rigid polyurethane foams. Pure MDI is distilled from the reaction mixture and is mainly used for reaction injection-molding, thermoplastic elastomers and adhesives. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Preparation of polyurethane resin and spandex fibers; bonding rubber to rayon and nylon. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: MDI is used in two-component polyurethane coating systems which are used for aircraft, tank trucks and truck trailers due to durability and toughness. It is also used to produce polyurethane lacquer coatings applied to certain automobile body components and, to small extent, to patent leather. Other uses ... are in production of thermoplastic polyurethane resins, millable gums and spandex fibers. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: TDI and MDI are used in surface coatings (e.g. for chutes used in mining and agriculture), in the shoe industry for shoe soles, in the automobile industry for shock absorbers, and in a wide variety of other industries. MDI occurs in foundries in binders for casting forms, and in orthopedic surgery in casts for broken bones. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Methylene diphenyl diisocyanate is used in the manufacture of polyurethane and as an an industrial strength adhesive. (L576) Source: Toxin and Toxin Target Database (T3DB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
EMBL-EBI ChEBIExact match2026-08-31
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Official source and provenance

Registered source
India BIS IS 4707 cosmetic ingredient standards
Source reference
IS 4707 (Part 2):2025 Annex A, entry 1536
Source record ID
annex-a:1536
Source version
IS 4707 (Part 2):2025, fifth revision
Source language
English
Translation status
Original is English
Effective date
2025-08-09
Source updated
2025-08-09
Snapshot checked
2026-08-31 15:30 UTC
Validation method
206 text layers; Annex A 1-1614 and Annex B 1-313 with seven lettered source rows
SHA-256
905dd0326361c53da8a354b948331946951ac3ae27d60d8e2474efb051239603

Registered dataset notes

Dataset coverage
Complete current Part 2:2025 Annex A prohibited and Annex B restricted rows; Parts 1, 3 and 4 remain linked official checks
Authority note
Indian Standards referenced by the cosmetics regulatory framework; use the controlled current editions
Inspect the exact official sourceRegulator guidance

How this record fits the market dataset

1931
current India records
1614
records marked Prohibited
1931
records from this source version
1836
market records with CAS identity

Status distribution

Prohibited: 1614Restricted: 317

Condition text is present on 1931 of 1931 current records. An empty condition field is interpreted according to the record type above; it is never converted into an unrestricted-use claim.

India market context

Complete current Part 2 dataset plus official workflow for Parts 1, 3 and 4

Coverage version: Cosmetics Rules 2020 plus current BIS IS 4707 parts (1:2020, 2:2025, 3:2025, 4:2022)

All 1,614 prohibited Annex A rows and 317 numbered/lettered restricted Annex B rows from IS 4707 Part 2:2025; official checks remain for colourants, preservatives and UV filters in Parts 1, 3 and 4.

Verification checklist

  1. Confirm product class and current Cosmetics Rules/gazette amendments.
  2. Check all applicable parts of IS 4707 by exact identity.
  3. Apply Schedule S/other finished-product standards where relevant.
  4. Verify licence/import registration, labelling and testing requirements.

Official market sources

Verification workflow and record completeness

Before using this result in a compliance decision

  1. Confirm that “-Methylenediphenyl diisocyanate; diphenylmethane- -diisocyanate -Methylenediphenyl 4,4′ 4,4′ [1], 2,2′ ′ diisocyanate; diphenylmethane-2,2 -diisocyanate [2], o-(p-Isocyanatobenzyl)phenyl isocyanate diphenylmethane- -diisocyanate [3], Methylenediphenyl diisocyanate [4] (CAS No. 101-68-8 [1], ] 2,4′” and every CAS/EC identifier refer to the material in your supplier specification.
  2. Confirm product class and current Cosmetics Rules/gazette amendments.
  3. Check all applicable parts of IS 4707 by exact identity.
  4. Apply Schedule S/other finished-product standards where relevant.
  5. Verify licence/import registration, labelling and testing requirements.
  6. Document the source version and recheck the regulator before manufacture, notification or market placement.

Fields available in this record

  • Official substance nameAvailable
  • CASAvailable
  • ECAvailable
  • Separate condition textAvailable
  • Effective dateAvailable
  • Snapshot hash and methodAvailable

Questions this page answers

This official record identifies the substance as prohibited for cosmetic use in the stated market scope. Do not rely on a formulation containing this identity until the cited source, effective date and exact substance match have been verified.

A prohibition entry may contain no separate condition text because the regulatory outcome is the prohibition itself. The standards are separate controlled publications; absence from a locally indexed excerpt is not permission.

The record cites IS 4707 (Part 2):2025 Annex A, entry 1536, source version IS 4707 (Part 2):2025, fifth revision. Open the official source.

No. CAS helps resolve identity, but jurisdictions can classify the same substance differently and can apply different product scopes, limits, warnings and transition dates.

Stable citation

-Methylenediphenyl diisocyanate; diphenylmethane- -diisocyanate -Methylenediphenyl 4,4′ 4,4′ [1], 2,2′ ′ diisocyanate; diphenylmethane-2,2 -diisocyanate [2], o-(p-Isocyanatobenzyl)phenyl isocyanate diphenylmethane- -diisocyanate [3], Methylenediphenyl diisocyanate [4] (CAS No. 101-68-8 [1], ] 2,4′. IS 4707 (Part 2):2025 Annex A, entry 1536. India. Source version IS 4707 (Part 2):2025, fifth revision. CosIng Checker regulatory record: https://cosingchecker.com/regulations/in/records/16130/

Cite the regulator as the legal authority. This page is a structured evidence index and verification aid, not a substitute for the official text or professional legal assessment.

Interpretation and limits for India

This official record identifies the substance as prohibited for cosmetic use in the stated market scope.

Do not rely on a formulation containing this identity until the cited source, effective date and exact substance match have been verified.

How to interpret the legal role

The cited row forms part of a binding rule or legally incorporated list for this market.

Evidence on this page

  • Recorded outcome: Prohibited
  • Legal role: Binding rule
  • Source version: IS 4707 (Part 2):2025, fifth revision
  • Effective date: 2025-08-09

What it does not prove

The standards are separate controlled publications; absence from a locally indexed excerpt is not permission.

Further authoritative substance research

These sources can add identity, safety, exposure or hazard context. A link is not evidence that the database contains this exact substance, and none of these sources overrides the market decision above.

Cosmetic Ingredient Review safety assessments

Expert Panel conclusions, assessed ingredient groups, use conditions, dates and report documents

Independent expert review considered by FDA; not a government approval or binding market rule

Research this identity at the source

FDA Global Substance Registration System

UNII identifiers, preferred names, substance types, codes and public substance relationships

Identity registry only; UNII availability does not imply FDA review or approval

Research this identity at the source

ILO/WHO International Chemical Safety Cards

Hazards, symptoms, first aid, storage, incompatibilities and physical properties for covered chemicals

International occupational chemical-safety reference; not cosmetic-use approval

Research this identity at the source

Japan NITE-CHRIP

Chemical identity, Japanese and foreign legal lists, GHS hazards and exposure-related information

Chemical-management evidence; cosmetic status remains governed by the applicable MHLW standard and market rules

Research this identity at the source

NIOSH Pocket Guide to Chemical Hazards

REL, PEL, IDLH, properties, exposure routes, symptoms, target organs, first aid and measurement methods for covered workplace chemicals

US occupational-health guidance and limits; not a cosmetic ingredient decision

Research this identity at the source

OECD eChemPortal

Gateway to authority-owned physical-property, fate, ecotoxicity, toxicity, exposure and GHS records

Discovery gateway; each linked authority remains responsible for its data

Research this identity at the source

US EPA CompTox CTX APIs

API key required for import

DTXSID identity, experimental and predicted properties, toxicity, bioactivity, exposure and environmental data

Scientific and computational evidence; predictions must remain labelled and do not determine cosmetic legality

Research this identity at the source