CosIng Checker
CosIng Checker
EU cosmetic ingredients, restrictions and safety
Login
ProhibitedBinding ruleINOriginal is EnglishOfficial-source import checked

Tetraethyl pyrophosphate; TEPP (ISO) (CAS No. 107-49-3)

IS 4707 Part 2:2025 Annex A lists this ingredient as one that must not form part of a cosmetic product in India.

All India recordsCompare all marketsOpen official source

Regulatory decision and full conditions

Status
Prohibited
Legal role
Binding rule
Regulatory summary
IS 4707 Part 2:2025 Annex A lists this ingredient as one that must not form part of a cosmetic product in India.
Conditions and restrictions
Must not form part of the composition of cosmetic products. Apply the general trace and safety notes published after Annex A.

Substance identity

Official source name
Tetraethyl pyrophosphate; TEPP (ISO) (CAS No. 107-49-3)
CAS
107-49-3
EC
Not supplied in this source row
Identity mapping
standalone:official_bis_record
Search this identity across the siteCAS 107-49-3

Cross-market snapshot for this identity

Exact linked records currently present in this site. An absent market means no imported exact match, not permission to use the substance.

10 market datasets
PubChem 2D chemical structure for CAS 107-49-3
CAS 107-49-3PubChem CID 7873

Verified chemistry for CAS 107-49-3

Tetraethyl Pyrophosphate

TEPP is an organic diphosphate. — ChEBI

IUPAC name
diethoxyphosphoryl diethyl phosphate
Molecular formula
C8H20O7P2
Molecular weight
290.19 g/mol
Exact mass
290.06842697 Da
Monoisotopic mass
290.06842697 Da
XLogP3
0.4
Topological polar surface area
80.3 Ų
Molecular complexity
246.0
Formal charge
0
Hydrogen-bond donors
0
Hydrogen-bond acceptors
7
Rotatable bonds
10
Heavy atoms
17
Covalent units
1

Names and synonyms reported to PubChem

TEPPTetraethyl diphosphateVapotoneBladanTetronMortopalTetrastigmineHepthexamite
16 more reported names
FosvexGrisolKillaxLirohexNifostNifosKilmite 40HexamiteKillexLethalaire G-52Tetron-100Nifos TDiphosphoric acid, tetraethyl esterEthyl pyrophosphate, tetra-Rcra waste number P111Ethyl pyrophosphate (Et4P2O7)
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D pharmacophore features
2
3D rings
0
3D hydrophobes
0
3D acceptor features
2
3D donor features
0
3D anionic centres
0
3D cationic centres
0
3D conformers
10
Effective 3D rotors
10.0
Machine-readable structure identifiers
SMILES
CCOP(=O)(OCC)OP(=O)(OCC)OCC
InChI
InChI=1S/C8H20O7P2/c1-5-11-16(9,12-6-2)15-17(10,13-7-3)14-8-4/h5-8H2,1-4H3
InChIKey
IDCBOTIENDVCBQ-UHFFFAOYSA-N

Evidence from additional scientific databases

EMBL-EBI ChEBI
Exact identifier matchCHEBI:82149

TEPP

Formula
C8H20O7P2
Average mass
290.189 g/mol
Monoisotopic mass
290.06843 Da
Formal charge
0
  • organic diphosphate — is a (CHEBI:62889)
  • organic diphosphate — is a (CHEBI:62889)
Additional curated names
ethyl pyrophosphateEthyl pyrophosphateNSC-14707Tetraethyl pyrophosphate
Cross-references from this source
  • CAS: 107-49-3 — KEGG COMPOUND
  • MANUAL_X_REF: 1272 — PPDB
  • MANUAL_X_REF: C19017 — KEGG COMPOUND

Mapped by: Exact CAS cross-reference in the ChEBI compound record. Retrieved: 2026-08-31. Open source record

NIH PubChem PUG-View
Exact identifier match7873

Attributed physical-property, hazard, environmental and use annotations.

  • First Aid: Warning: Effects may be delayed up to 12 hours. Caution is advised.; Note: TEPP is a cholinesterase inhibitor.; Signs and Symptoms of TEPP Exposure: Acute exposure to TEPP may produce the following signs and symptoms: sweating, pinpoint pupils, blurred vision, headache, dizziness, profound weakness, muscle spasms, seizures, and coma. Mental confusion and psychosis may occur. Excessive salivation, nausea, vomiting, anorexia, diarrhea, and abdominal pain may also occur. The heart rate may decrease following oral exposure or increase following dermal exposure. Chest pain may be noted. Hypotension (low blood pressure) may be observed, although hypertension (high blood pressure) is not uncommon. Respiratory symptoms include dyspnea (shortness of breath), pulmonary edema, respiratory depression, and respiratory paralysis.; Emergency Life-Support Procedures: Acute exposure to TEPP may require decontamination and life support for the victims. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheet Source: CAMEO Chemicals
  • First Aid: (General first aid procedures); Eye: Irrigate immediately - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.; Skin: Water flush immediately - If this chemical contacts the skin, immediately flush the contaminated skin with water. If this chemical penetrates the clothing, immediately remove the clothing and flush the skin with water. Get medical attention promptly.; Breathing: Respiratory support; Swallow: Medical attention immediately - If this chemical has been swallowed, get medical attention immediately. Source: The National Institute for Occupational Safety and Health (NIOSH)
  • Signal: Danger Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • GHS Hazard Statements: H300: Fatal if swallowed [Danger Acute toxicity, oral]; H310: Fatal in contact with skin [Danger Acute toxicity, dermal]; H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Precautionary Statement Codes: P262, P264, P270, P273, P280, P301+P316, P302+P352, P316, P321, P330, P361+P364, P391, P405, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Signal: Danger Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H300 (100%): Fatal if swallowed [Danger Acute toxicity, oral]; H310 (100%): Fatal in contact with skin [Danger Acute toxicity, dermal]; H400 (100%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P262, P264, P270, P273, P280, P301+P316, P302+P352, P316, P321, P330, P361+P364, P391, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 42 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Signal: Danger Source: NITE-CMC
  • GHS Hazard Statements: H300: Fatal if swallowed [Danger Acute toxicity, oral]; H310: Fatal in contact with skin [Danger Acute toxicity, dermal]; H315: Causes skin irritation [Warning Skin corrosion/irritation]; H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H330: Fatal if inhaled [Danger Acute toxicity, inhalation]; H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]; H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure] Source: NITE-CMC
  • Precautionary Statement Codes: P260, P262, P264, P264+P265, P270, P271, P280, P284, P301+P316, P302+P352, P304+P340, P305+P351+P338, P308+P316, P316, P319, P320, P321, P330, P332+P317, P337+P317, P361+P364, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • GHS Hazard Statements: H300: Fatal if swallowed [Danger Acute toxicity, oral]; H310: Fatal in contact with skin [Danger Acute toxicity, dermal]; H315: Causes skin irritation [Warning Skin corrosion/irritation]; H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H330: Fatal if inhaled [Danger Acute toxicity, inhalation]; H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]; H373: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure] Source: NITE-CMC
  • Signal: Danger Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
  • Environmental Bioconcentration: An estimated BCF of 3.2 was calculated for tetraethyl pyrophosphate(SRC), using an estimated log Kow of 0.45(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC), provided the compound is not altered physically or chemically once released into the environment. Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 2.2(SRC), determined from a water solubility of 1.00X10+6 mg/L(2) and a regression-derived equation(3), indicates that tetraethyl pyrophosphate is expected to have very high mobility in soil(SRC). Volatilization of tetraethyl pyrophosphate from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 2.2X10-10 atm-cu m/mole(SRC) derived from its vapor pressure, 2.60X10-4 mm Hg at 25 °C(2), and water solubility(2). Tetraethyl pyrophosphate is not expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(2). Biodegradation data for this substance were not located in the literature. Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 2.2(SRC), determined from a water solubility of 1.00X10+6 mg/L(2) and a regression-derived equation(3), indicates that tetraethyl pyrophosphate is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon an estimated Henry's Law constant of 2.2X10-10 atm-cu m/mole(SRC), derived from its vapor pressure, 2.60X10-4 mm Hg at 25 °C(2), and water solubility(2). Using this Henry's Law constant and an estimation method(3). According to a classification scheme(4), an estimated BCF of 3.2(SRC), from an estimated log Kow(5) and a regression-derived equation(6), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Biodegradation data for this substance were not located in the literature. Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), tetraethyl pyrophosphate, which has a vapor pressure of 2.60X10-4 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase tetraethyl pyrophosphate is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 5.0 hours(SRC), calculated from its rate constant of 7.7X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: Aquatic or Terrestrial Fate: ... Rapidly hydrolyzed in the presence of moisture. Source: Hazardous Substances Data Bank (HSDB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
EMBL-EBI ChEBIExact match2026-08-31
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Official source and provenance

Registered source
India BIS IS 4707 cosmetic ingredient standards
Source reference
IS 4707 (Part 2):2025 Annex A, entry 274
Source record ID
annex-a:274
Source version
IS 4707 (Part 2):2025, fifth revision
Source language
English
Translation status
Original is English
Effective date
2025-08-09
Source updated
2025-08-09
Snapshot checked
2026-08-31 15:30 UTC
Validation method
206 text layers; Annex A 1-1614 and Annex B 1-313 with seven lettered source rows
SHA-256
905dd0326361c53da8a354b948331946951ac3ae27d60d8e2474efb051239603

Registered dataset notes

Dataset coverage
Complete current Part 2:2025 Annex A prohibited and Annex B restricted rows; Parts 1, 3 and 4 remain linked official checks
Authority note
Indian Standards referenced by the cosmetics regulatory framework; use the controlled current editions
Inspect the exact official sourceRegulator guidance

How this record fits the market dataset

1931
current India records
1614
records marked Prohibited
1931
records from this source version
1836
market records with CAS identity

Status distribution

Prohibited: 1614Restricted: 317

Condition text is present on 1931 of 1931 current records. An empty condition field is interpreted according to the record type above; it is never converted into an unrestricted-use claim.

India market context

Complete current Part 2 dataset plus official workflow for Parts 1, 3 and 4

Coverage version: Cosmetics Rules 2020 plus current BIS IS 4707 parts (1:2020, 2:2025, 3:2025, 4:2022)

All 1,614 prohibited Annex A rows and 317 numbered/lettered restricted Annex B rows from IS 4707 Part 2:2025; official checks remain for colourants, preservatives and UV filters in Parts 1, 3 and 4.

Verification checklist

  1. Confirm product class and current Cosmetics Rules/gazette amendments.
  2. Check all applicable parts of IS 4707 by exact identity.
  3. Apply Schedule S/other finished-product standards where relevant.
  4. Verify licence/import registration, labelling and testing requirements.

Official market sources

Verification workflow and record completeness

Before using this result in a compliance decision

  1. Confirm that “Tetraethyl pyrophosphate; TEPP (ISO) (CAS No. 107-49-3)” and every CAS/EC identifier refer to the material in your supplier specification.
  2. Confirm product class and current Cosmetics Rules/gazette amendments.
  3. Check all applicable parts of IS 4707 by exact identity.
  4. Apply Schedule S/other finished-product standards where relevant.
  5. Verify licence/import registration, labelling and testing requirements.
  6. Document the source version and recheck the regulator before manufacture, notification or market placement.

Fields available in this record

  • Official substance nameAvailable
  • CASAvailable
  • ECNot supplied
  • Separate condition textAvailable
  • Effective dateAvailable
  • Snapshot hash and methodAvailable

Questions this page answers

This official record identifies the substance as prohibited for cosmetic use in the stated market scope. Do not rely on a formulation containing this identity until the cited source, effective date and exact substance match have been verified.

A prohibition entry may contain no separate condition text because the regulatory outcome is the prohibition itself. The standards are separate controlled publications; absence from a locally indexed excerpt is not permission.

The record cites IS 4707 (Part 2):2025 Annex A, entry 274, source version IS 4707 (Part 2):2025, fifth revision. Open the official source.

No. CAS helps resolve identity, but jurisdictions can classify the same substance differently and can apply different product scopes, limits, warnings and transition dates.

Stable citation

Tetraethyl pyrophosphate; TEPP (ISO) (CAS No. 107-49-3). IS 4707 (Part 2):2025 Annex A, entry 274. India. Source version IS 4707 (Part 2):2025, fifth revision. CosIng Checker regulatory record: https://cosingchecker.com/regulations/in/records/14868/

Cite the regulator as the legal authority. This page is a structured evidence index and verification aid, not a substitute for the official text or professional legal assessment.

Interpretation and limits for India

This official record identifies the substance as prohibited for cosmetic use in the stated market scope.

Do not rely on a formulation containing this identity until the cited source, effective date and exact substance match have been verified.

How to interpret the legal role

The cited row forms part of a binding rule or legally incorporated list for this market.

Evidence on this page

  • Recorded outcome: Prohibited
  • Legal role: Binding rule
  • Source version: IS 4707 (Part 2):2025, fifth revision
  • Effective date: 2025-08-09

What it does not prove

The standards are separate controlled publications; absence from a locally indexed excerpt is not permission.

Further authoritative substance research

These sources can add identity, safety, exposure or hazard context. A link is not evidence that the database contains this exact substance, and none of these sources overrides the market decision above.

Cosmetic Ingredient Review safety assessments

Expert Panel conclusions, assessed ingredient groups, use conditions, dates and report documents

Independent expert review considered by FDA; not a government approval or binding market rule

Research this identity at the source

FDA Global Substance Registration System

UNII identifiers, preferred names, substance types, codes and public substance relationships

Identity registry only; UNII availability does not imply FDA review or approval

Research this identity at the source

ILO/WHO International Chemical Safety Cards

Hazards, symptoms, first aid, storage, incompatibilities and physical properties for covered chemicals

International occupational chemical-safety reference; not cosmetic-use approval

Research this identity at the source

Japan NITE-CHRIP

Chemical identity, Japanese and foreign legal lists, GHS hazards and exposure-related information

Chemical-management evidence; cosmetic status remains governed by the applicable MHLW standard and market rules

Research this identity at the source

NIOSH Pocket Guide to Chemical Hazards

REL, PEL, IDLH, properties, exposure routes, symptoms, target organs, first aid and measurement methods for covered workplace chemicals

US occupational-health guidance and limits; not a cosmetic ingredient decision

Research this identity at the source

OECD eChemPortal

Gateway to authority-owned physical-property, fate, ecotoxicity, toxicity, exposure and GHS records

Discovery gateway; each linked authority remains responsible for its data

Research this identity at the source

US EPA CompTox CTX APIs

API key required for import

DTXSID identity, experimental and predicted properties, toxicity, bioactivity, exposure and environmental data

Scientific and computational evidence; predictions must remain labelled and do not determine cosmetic legality

Research this identity at the source