Hexyl cinnamal
The consolidated GB Cosmetics Regulation lists this record in Annex III.
Regulatory decision and full conditions
- Status
- Restricted
- Legal role
- Binding rule
- Regulatory summary
- The consolidated GB Cosmetics Regulation lists this record in Annex III.
- Conditions and restrictions
- The presence of the substance must be indicated in the list of ingredients referred to in Article 19(1)(g) when its concentration exceeds: 0,001% in leave-on products 0,01% in rinse-off products
Substance identity
- Official source name
- Hexyl cinnamal
- CAS
- 101-86-0
- EC
- 202-983-3
- Identity mapping
- cas_number
- Linked ingredient
- HEXYL CINNAMAL
Linked CosIng identity data
Names and aliases
CosIng description: 2-Phenylmethyleneoctanal; alpha-Hexylcinnamaldehyde; 2-Benzylideneoctanal; alpha-n-hexyl-beta-phenylacrolein
EU inventory restriction note: III/87
Recorded cosmetic function: PERFUMING
Function pages:PERFUMING
View the complete ingredient profileCross-market snapshot for this identity
Exact linked records currently present in this site. An absent market means no imported exact match, not permission to use the substance.
European Union
1 linked record · 1 with specific conditions
Open supporting recordGreat Britain
Current record1 linked record · 1 with specific conditions
Open supporting recordNew Zealand
1 linked record · 1 with specific conditions
Open supporting recordIndia
1 linked record · 1 with specific conditions
Open supporting recordSaudi Arabia
1 linked record
Open supporting recordVerified chemistry for CAS 101-86-0
alpha-Hexylcinnamaldehyde
Alpha-hexylcinnamaldehyde is a member of the class of cinnamaldehydes carrying a hexyl substituent at the alpha-position. It is functionally related to an (E)-cinnamaldehyde. — ChEBI
- IUPAC name
- (2E)-2-benzylideneoctanal
- Molecular formula
- C15H20O
- Molecular weight
- 216.32 g/mol
- Exact mass
- 216.151415257 Da
- Monoisotopic mass
- 216.151415257 Da
- XLogP3
- 4.8
- Topological polar surface area
- 17.1 Ų
- Molecular complexity
- 211.0
- Formal charge
- 0
- Hydrogen-bond donors
- 0
- Hydrogen-bond acceptors
- 1
- Rotatable bonds
- 7
- Heavy atoms
- 16
- Covalent units
- 1
Names and synonyms reported to PubChem
16 more reported names
External database identifiers
- ChEBI:CHEBI:55365
- ChEMBL:CHEMBL1449245
- EPA DTXSID:DTXSID401020801
- PubMed:31734321
- PubMed:26244607
- PubMed:22381623
- PubMed:21920952
Advanced structure statistics
- Defined atom stereocentres
- 0
- Undefined atom stereocentres
- 0
- Defined bond stereocentres
- 1
- Undefined bond stereocentres
- 0
- 3D pharmacophore features
- 5
- 3D rings
- 1
- 3D hydrophobes
- 3
- 3D acceptor features
- 1
- 3D donor features
- 0
- 3D anionic centres
- 0
- 3D cationic centres
- 0
- 3D conformers
- 10
- Effective 3D rotors
- 7.0
Machine-readable structure identifiers
- SMILES
CCCCCC/C(=C\C1=CC=CC=C1)/C=O- InChI
InChI=1S/C15H20O/c1-2-3-4-6-11-15(13-16)12-14-9-7-5-8-10-14/h5,7-10,12-13H,2-4,6,11H2,1H3/b15-12+- InChIKey
GUUHFMWKWLOQMM-NTCAYCPXSA-N
Evidence from additional scientific databases
EMBL-EBI ChEBI
α-hexylcinnamaldehyde
A member of the class of cinnamaldehydes carrying a hexyl substituent at the α-position.
- Formula
- C15H20O
- Average mass
- 216.324 g/mol
- Monoisotopic mass
- 216.15142 Da
- Formal charge
- 0
- cinnamaldehydes — is a (CHEBI:23245)
- (E)-cinnamaldehyde — has functional parent (CHEBI:16731)
- cinnamaldehydes — is a (CHEBI:23245)
Additional curated names
Cross-references from this source
- CAS: 101-86-0 — ChemIDplus
- CAS: 101-86-0 — NIST Chemistry WebBook
- REGISTRY_NUMBER: 2502968 — Reaxys
- MANUAL_X_REF: HMDB0031736 — HMDB
- MANUAL_X_REF: US5792467 — Patent
Mapped by: Exact CAS cross-reference in the ChEBI compound record. Source updated: 2015-10-23. Retrieved: 2026-08-31. Open source record
NIH PubChem PUG-View
Attributed physical-property, hazard, environmental and use annotations.
- Boiling Point: 174-175 °C (15 mm Hg) Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Density: 0.950-0.961 Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Melting Point: 4 °C Source: Human Metabolome Database (HMDB)
- Physical Description: Other Solid; CBI; Liquid; Dry Powder; Liquid Source: EPA Chemical Data Reporting (CDR)
- Physical Description: Liquid Source: Human Metabolome Database (HMDB)
- Physical Description: Pale yellow liquid, jasmine like odour Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Refractive Index: 1.547-1.553 Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Solubility: insoluble in water; miscible in oils Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Solubility: miscible (in ethanol) Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Note: This chemical does not meet GHS hazard criteria for < 0.1% (2 of 2496) of reports. Source: European Chemicals Agency (ECHA)
- Signal: Warning Source: European Chemicals Agency (ECHA)
- GHS Hazard Statements: H317 (99.6%): May cause an allergic skin reaction [Warning Sensitization, Skin]; H400 (65.1%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H411 (62.4%): Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
- Precautionary Statement Codes: P261, P272, P273, P280, P302+P352, P321, P333+P317, P362+P364, P391, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
- ECHA C&L Notifications Summary: Aggregated GHS information provided per 2496 reports by companies from 37 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Reported as not meeting GHS hazard criteria per 2 of 2496 reports by companies.; There are 36 notifications provided by 2494 of 2496 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
- GHS Hazard Statements: H317 (100%): May cause an allergic skin reaction [Warning Sensitization, Skin]; H400 (100%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H411 (99.4%): Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
- ECHA C&L Notifications Summary: Aggregated GHS information provided per 168 reports by companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
- Signal: Warning Source: NITE-CMC
- GHS Hazard Statements: H315: Causes skin irritation [Warning Skin corrosion/irritation]; H317: May cause an allergic skin reaction [Warning Sensitization, Skin] Source: NITE-CMC
- Precautionary Statement Codes: P261, P264, P272, P280, P302+P352, P321, P332+P317, P333+P317, P362+P364, and P501 (click each P-code to see the statement) Source: NITE-CMC
- Signal: Warning Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
- GHS Hazard Statements: H315: Causes skin irritation [Warning Skin corrosion/irritation]; H317: May cause an allergic skin reaction [Warning Sensitization, Skin] Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
- Consumer Uses: Fragrance Source: EPA Chemical Data Reporting (CDR)
- Industry Uses: Fragrance; Flavoring and nutrient Source: EPA Chemical Data Reporting (CDR)
Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record
Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.
Additional source coverage and match status
| Source | Result | Checked |
|---|---|---|
| EMBL-EBI ChEBI | Exact match | 2026-08-31 |
| NIH PubChem PUG-View | Exact match | 2026-08-31 |
A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.
Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Official source and provenance
- Registered source
- Great Britain Cosmetics Regulation — consolidated Annexes II–VI and amendments
- Source reference
- GB Cosmetics Regulation, Annex III, entry 87
- Source record ID
III-87- Source version
- 2026-08-15
- Source language
- English
- Translation status
- Original is English
- Effective date
- 2026-08-15
- Source updated
- 2026-08-19
- Snapshot checked
- 2026-08-30 04:51 UTC
- Validation method
- legislation.gov.uk XML table parse; {'II': 1758, 'III': 326, 'IV': 154, 'V': 57, 'VI': 34}
- SHA-256
e3a386d950f54c6e7a7f9e784d1bd46e52de725137e89d5630709824475215d8
Registered dataset notes
- Dataset coverage
- Complete consolidated GB Annexes II–VI, with later amendments versioned separately
- Authority note
- Binding GB schedules and versioned amendments to retained Regulation 1223/2009; applies to England, Wales and Scotland, not Northern Ireland
- Source licence
- Open Government Licence v3.0 / Crown copyright
- Attribution
- Contains public sector information licensed under the Open Government Licence v3.0.
How this record fits the market dataset
Status distribution
Condition text is present on 517 of 2329 current records. An empty condition field is interpreted according to the record type above; it is never converted into an unrestricted-use claim.
Great Britain market context
Complete consolidated annex dataset
Coverage version: GB retained Regulation 1223/2009 schedules, effective 15 August 2026
Current consolidated Annexes II–VI for England, Scotland and Wales.
Verification checklist
- Confirm INCI/CAS/EC identity.
- Review every current GB Annex II–VI match.
- Check commencement dates and later statutory instruments.
- Verify SCPN, responsible-person, safety-report and labelling duties.
Official market sources
- Great Britain Cosmetics Regulation — consolidated Annexes II–VI and amendmentsBinding GB schedules and versioned amendments to retained Regulation 1223/2009; applies to England, Wales and Scotland, not Northern Ireland
Verification workflow and record completeness
Before using this result in a compliance decision
- Confirm that “Hexyl cinnamal” and every CAS/EC identifier refer to the material in your supplier specification.
- Confirm INCI/CAS/EC identity.
- Review every current GB Annex II–VI match.
- Check commencement dates and later statutory instruments.
- Verify SCPN, responsible-person, safety-report and labelling duties.
- Document the source version and recheck the regulator before manufacture, notification or market placement.
Fields available in this record
- Official substance nameAvailable
- CASAvailable
- ECAvailable
- Separate condition textAvailable
- Effective dateAvailable
- Snapshot hash and methodAvailable
Questions this page answers
Stable citation
Hexyl cinnamal. GB Cosmetics Regulation, Annex III, entry 87. Great Britain. Source version 2026-08-15. CosIng Checker regulatory record: https://cosingchecker.com/regulations/gb/records/6205/
Cite the regulator as the legal authority. This page is a structured evidence index and verification aid, not a substitute for the official text or professional legal assessment.
Interpretation and limits for Great Britain
This substance is not unrestricted: cosmetic use is subject to the conditions in the cited official record.
Check product type, body area, concentration, purity and warning requirements before deciding whether a formulation is compliant.
How to interpret the legal role
The cited row forms part of a binding rule or legally incorporated list for this market.
Evidence on this page
- Recorded outcome: Restricted
- Legal role: Binding rule
- Source version: 2026-08-15
- Effective date: 2026-08-15
What it does not prove
No annex match is not approval and does not cover Northern Ireland, which follows the applicable EU framework.
Further authoritative substance research
These sources can add identity, safety, exposure or hazard context. A link is not evidence that the database contains this exact substance, and none of these sources overrides the market decision above.
Cosmetic Ingredient Review safety assessments
Expert Panel conclusions, assessed ingredient groups, use conditions, dates and report documents
Independent expert review considered by FDA; not a government approval or binding market rule
Research this identity at the sourceFDA Global Substance Registration System
UNII identifiers, preferred names, substance types, codes and public substance relationships
Identity registry only; UNII availability does not imply FDA review or approval
Research this identity at the sourceILO/WHO International Chemical Safety Cards
Hazards, symptoms, first aid, storage, incompatibilities and physical properties for covered chemicals
International occupational chemical-safety reference; not cosmetic-use approval
Research this identity at the sourceJapan NITE-CHRIP
Chemical identity, Japanese and foreign legal lists, GHS hazards and exposure-related information
Chemical-management evidence; cosmetic status remains governed by the applicable MHLW standard and market rules
Research this identity at the sourceNIOSH Pocket Guide to Chemical Hazards
REL, PEL, IDLH, properties, exposure routes, symptoms, target organs, first aid and measurement methods for covered workplace chemicals
US occupational-health guidance and limits; not a cosmetic ingredient decision
Research this identity at the sourceOECD eChemPortal
Gateway to authority-owned physical-property, fate, ecotoxicity, toxicity, exposure and GHS records
Discovery gateway; each linked authority remains responsible for its data
Research this identity at the sourceUS EPA CompTox CTX APIs
API key required for importDTXSID identity, experimental and predicted properties, toxicity, bioactivity, exposure and environmental data
Scientific and computational evidence; predictions must remain labelled and do not determine cosmetic legality
Research this identity at the source