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ProhibitedBinding ruleGBOriginal is EnglishOfficial-source import checked

Trimethyl borate

The consolidated GB Cosmetics Regulation lists this record in Annex II.

All Great Britain recordsCompare all marketsOpen official source

Regulatory decision and full conditions

Status
Prohibited
Legal role
Binding rule
Regulatory summary
The consolidated GB Cosmetics Regulation lists this record in Annex II.
Conditions and restrictions
A prohibition entry may contain no separate condition text because the regulatory outcome is the prohibition itself. Open the cited source and apply the market-wide requirements below.

Substance identity

Official source name
Trimethyl borate
CAS
121-43-7
EC
204-468-9
Identity mapping
standalone:official_gb_annex
Search this identity across the siteCAS 121-43-7EC 204-468-9

Cross-market snapshot for this identity

Exact linked records currently present in this site. An absent market means no imported exact match, not permission to use the substance.

2 market datasets
PubChem 2D chemical structure for CAS 121-43-7
CAS 121-43-7PubChem CID 8470

Verified chemistry for CAS 121-43-7

Trimethyl borate

Trimethyl borate is a member of the class of borate esters obtained by the formal condensation of three equivalents of methanol with boric acid. — ChEBI

IUPAC name
trimethyl borate
Molecular formula
C3H9BO3
Molecular weight
103.92 g/mol
Exact mass
104.0644743 Da
Monoisotopic mass
104.0644743 Da
Topological polar surface area
27.7 Ų
Molecular complexity
31.0
Formal charge
0
Hydrogen-bond donors
0
Hydrogen-bond acceptors
3
Rotatable bonds
3
Heavy atoms
7
Covalent units
1

Names and synonyms reported to PubChem

TrimethoxyboraneMethyl boratetrimethylborateTrimethoxyboronBoric acid trimethyl esterBorester OBoric acid, trimethyl esterTrimethoxyborine
16 more reported names
Boric acid (H3BO3), trimethyl esterTrimethylester kyseliny boriteNSC-77782U64J6F5NCHEBI:38913RefChem:191751204-468-9934-685-0B(OMe)3B(OCH3)3NSC 777(MeO)3B3349-42-6Trimethyl borate-11BHSDB 5589EINECS 204-468-9
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D conformers
0
Machine-readable structure identifiers
SMILES
B(OC)(OC)OC
InChI
InChI=1S/C3H9BO3/c1-5-4(6-2)7-3/h1-3H3
InChIKey
WRECIMRULFAWHA-UHFFFAOYSA-N

Evidence from additional scientific databases

NIH PubChem PUG-View
Exact identifier match8470

Attributed physical-property, hazard, environmental and use annotations.

  • First Aid: Excerpt from ERG Guide 129 [Flammable Liquids (Water-Miscible / Noxious)]:; Refer to the "General First Aid" section. Specific First Aid: Wash skin with soap and water. In case of burns, immediately cool affected skin for as long as possible with cold water. Do not remove clothing if adhering to skin. (ERG, 2024) Source: CAMEO Chemicals
  • ERG2024, Guide 129 (Trimethyl borate): General First Aid:; · Call 911 or emergency medical service.; · Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.; · Move victim to fresh air if it can be done safely.; · Administer oxygen if breathing is difficult.; · If victim is not breathing:; -- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.; -- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).; -- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.; · Remove and isolate contaminated clothing and shoes.; · For minor skin contact, avoid spreading material on unaffected skin.; · In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.; · For severe burns, immediate medical attention is required.; · Effects of exposure (inhalation, ingestion, Source: Emergency Response Guidebook (ERG)
  • Signal: Danger Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • GHS Hazard Statements: H226: Flammable liquid and vapor [Warning Flammable liquids]; H312: Harmful in contact with skin [Warning Acute toxicity, dermal]; H360FD: May damage fertility; May damage the unborn child [Danger Reproductive toxicity] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Precautionary Statement Codes: P203, P210, P233, P240, P241, P242, P243, P280, P302+P352, P303+P361+P353, P317, P318, P321, P362+P364, P370+P378, P403+P235, P405, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Signal: Danger Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H225 (40.5%): Highly Flammable liquid and vapor [Danger Flammable liquids]; H226 (59.5%): Flammable liquid and vapor [Warning Flammable liquids]; H301 (14.9%): Toxic if swallowed [Danger Acute toxicity, oral]; H311 (14.6%): Toxic in contact with skin [Danger Acute toxicity, dermal]; H312 (85.4%): Harmful in contact with skin [Warning Acute toxicity, dermal]; H319 (30.3%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H331 (14.6%): Toxic if inhaled [Danger Acute toxicity, inhalation]; H360 (11%): May damage fertility or the unborn child [Danger Reproductive toxicity]; H360FD (19.3%): May damage fertility; May damage the unborn child [Danger Reproductive toxicity]; H370 (19.8%): Causes damage to organs [Danger Specific target organ toxicity, single exposure] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P203, P210, P233, P240, P241, P242, P243, P260, P261, P262, P264, P264+P265, P270, P271, P280, P301+P316, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P308+P316, P316, P317, P318, P321, P330, P337+P317, P361+P364, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 383 reports by companies from 15 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H225 (100%): Highly Flammable liquid and vapor [Danger Flammable liquids]; H312 (97.4%): Harmful in contact with skin [Warning Acute toxicity, dermal]; H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P210, P233, P240, P241, P242, P243, P264+P265, P280, P302+P352, P303+P361+P353, P305+P351+P338, P317, P321, P337+P317, P362+P364, P370+P378, P403+P235, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 39 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H225 (100%): Highly Flammable liquid and vapor [Danger Flammable liquids]; H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]; H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H360 (100%): May damage fertility or the unborn child [Danger Reproductive toxicity]; H370 (100%): Causes damage to organs [Danger Specific target organ toxicity, single exposure] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P203, P210, P233, P240, P241, P242, P243, P260, P264, P264+P265, P270, P280, P301+P317, P303+P361+P353, P305+P351+P338, P308+P316, P318, P321, P330, P337+P317, P370+P378, P403+P235, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • NFPA Health Rating: 1 - Materials that, under emergency conditions, can cause significant irritation. Source: Hazardous Substances Data Bank (HSDB)
  • NFPA Fire Rating: 3 - Liquids and solids that can be ignited under almost all ambient temperature conditions. Materials produce hazardous atmospheres with air under almost all ambient temperatures or, though unaffected by ambient temperatures, are readily ignited under almost all conditions. Source: Hazardous Substances Data Bank (HSDB)
  • NFPA Instability Rating: 1 - Materials that in themselves are normally stable but that can become unstable at elevated temperatures and pressures. Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Bioconcentration: Trimethyl borate is rapidly hydrolyzed to boric acid and methanol in the presence of water(1,2). Hydrolysis would be expected to be the dominate fate process for trimethyl borate in the environment(SRC). Bioconcentration is not considered an important environmental fate for trimethyl borate(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: Trimethyl borate is rapidly hydrolyzed to boric acid and methanol in the presence of water(1,2). Hydrolysis would be expected to be the dominate fate process for trimethyl borate in the environment(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: AQUATIC FATE: Trimethyl borate is rapidly hydrolyzed to boric acid and methanol in the presence of water(1,2). Hydrolysis would be expected to be the dominate fate process for trimethyl borate in the environment(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), trimethyl borate, which has a vapor pressure of 136 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Trimethyl borate is rapidly hydrolyzed to boric acid and methanol in the presence of water(3,4). Hydrolysis would be expected to be the dominate fate process for trimethyl borate in the environment(SRC). Source: Hazardous Substances Data Bank (HSDB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Official source and provenance

Registered source
Great Britain Cosmetics Regulation — consolidated Annexes II–VI and amendments
Source reference
GB Cosmetics Regulation, Annex II, entry 1760
Source record ID
II-1760
Source version
2026-08-15
Source language
English
Translation status
Original is English
Effective date
2026-08-15
Source updated
2026-08-19
Snapshot checked
2026-08-30 04:51 UTC
Validation method
legislation.gov.uk XML table parse; {'II': 1758, 'III': 326, 'IV': 154, 'V': 57, 'VI': 34}
SHA-256
e3a386d950f54c6e7a7f9e784d1bd46e52de725137e89d5630709824475215d8

Registered dataset notes

Dataset coverage
Complete consolidated GB Annexes II–VI, with later amendments versioned separately
Authority note
Binding GB schedules and versioned amendments to retained Regulation 1223/2009; applies to England, Wales and Scotland, not Northern Ireland
Source licence
Open Government Licence v3.0 / Crown copyright
Attribution
Contains public sector information licensed under the Open Government Licence v3.0.
Inspect the exact official sourceRegulator guidance

How this record fits the market dataset

2329
current Great Britain records
1758
records marked Prohibited
2329
records from this source version
2015
market records with CAS identity

Status distribution

Permitted list with conditions: 245Prohibited: 1758Restricted: 326

Condition text is present on 517 of 2329 current records. An empty condition field is interpreted according to the record type above; it is never converted into an unrestricted-use claim.

Great Britain market context

Complete consolidated annex dataset

Coverage version: GB retained Regulation 1223/2009 schedules, effective 15 August 2026

Current consolidated Annexes II–VI for England, Scotland and Wales.

Verification checklist

  1. Confirm INCI/CAS/EC identity.
  2. Review every current GB Annex II–VI match.
  3. Check commencement dates and later statutory instruments.
  4. Verify SCPN, responsible-person, safety-report and labelling duties.

Official market sources

Verification workflow and record completeness

Before using this result in a compliance decision

  1. Confirm that “Trimethyl borate” and every CAS/EC identifier refer to the material in your supplier specification.
  2. Confirm INCI/CAS/EC identity.
  3. Review every current GB Annex II–VI match.
  4. Check commencement dates and later statutory instruments.
  5. Verify SCPN, responsible-person, safety-report and labelling duties.
  6. Document the source version and recheck the regulator before manufacture, notification or market placement.

Fields available in this record

  • Official substance nameAvailable
  • CASAvailable
  • ECAvailable
  • Separate condition textNot present in source row
  • Effective dateAvailable
  • Snapshot hash and methodAvailable

Questions this page answers

This official record identifies the substance as prohibited for cosmetic use in the stated market scope. Do not rely on a formulation containing this identity until the cited source, effective date and exact substance match have been verified.

A prohibition entry may contain no separate condition text because the regulatory outcome is the prohibition itself. No annex match is not approval and does not cover Northern Ireland, which follows the applicable EU framework.

The record cites GB Cosmetics Regulation, Annex II, entry 1760, source version 2026-08-15. Open the official source.

No. CAS helps resolve identity, but jurisdictions can classify the same substance differently and can apply different product scopes, limits, warnings and transition dates.

Stable citation

Trimethyl borate. GB Cosmetics Regulation, Annex II, entry 1760. Great Britain. Source version 2026-08-15. CosIng Checker regulatory record: https://cosingchecker.com/regulations/gb/records/6115/

Cite the regulator as the legal authority. This page is a structured evidence index and verification aid, not a substitute for the official text or professional legal assessment.

Interpretation and limits for Great Britain

This official record identifies the substance as prohibited for cosmetic use in the stated market scope.

Do not rely on a formulation containing this identity until the cited source, effective date and exact substance match have been verified.

How to interpret the legal role

The cited row forms part of a binding rule or legally incorporated list for this market.

Evidence on this page

  • Recorded outcome: Prohibited
  • Legal role: Binding rule
  • Source version: 2026-08-15
  • Effective date: 2026-08-15

What it does not prove

No annex match is not approval and does not cover Northern Ireland, which follows the applicable EU framework.

Further authoritative substance research

These sources can add identity, safety, exposure or hazard context. A link is not evidence that the database contains this exact substance, and none of these sources overrides the market decision above.

Cosmetic Ingredient Review safety assessments

Expert Panel conclusions, assessed ingredient groups, use conditions, dates and report documents

Independent expert review considered by FDA; not a government approval or binding market rule

Research this identity at the source

FDA Global Substance Registration System

UNII identifiers, preferred names, substance types, codes and public substance relationships

Identity registry only; UNII availability does not imply FDA review or approval

Research this identity at the source

ILO/WHO International Chemical Safety Cards

Hazards, symptoms, first aid, storage, incompatibilities and physical properties for covered chemicals

International occupational chemical-safety reference; not cosmetic-use approval

Research this identity at the source

Japan NITE-CHRIP

Chemical identity, Japanese and foreign legal lists, GHS hazards and exposure-related information

Chemical-management evidence; cosmetic status remains governed by the applicable MHLW standard and market rules

Research this identity at the source

NIOSH Pocket Guide to Chemical Hazards

REL, PEL, IDLH, properties, exposure routes, symptoms, target organs, first aid and measurement methods for covered workplace chemicals

US occupational-health guidance and limits; not a cosmetic ingredient decision

Research this identity at the source

OECD eChemPortal

Gateway to authority-owned physical-property, fate, ecotoxicity, toxicity, exposure and GHS records

Discovery gateway; each linked authority remains responsible for its data

Research this identity at the source

US EPA CompTox CTX APIs

API key required for import

DTXSID identity, experimental and predicted properties, toxicity, bioactivity, exposure and environmental data

Scientific and computational evidence; predictions must remain labelled and do not determine cosmetic legality

Research this identity at the source