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ProhibitedBinding ruleGBOriginal is EnglishOfficial-source import checked

1,3,5-triazine-2,4,6-triamine; melamine

The consolidated GB Cosmetics Regulation lists this record in Annex II.

All Great Britain recordsOpen ingredient profileCompare all marketsOpen official source

Regulatory decision and full conditions

Status
Prohibited
Legal role
Binding rule
Regulatory summary
The consolidated GB Cosmetics Regulation lists this record in Annex II.
Conditions and restrictions
A prohibition entry may contain no separate condition text because the regulatory outcome is the prohibition itself. Open the cited source and apply the market-wide requirements below.

Substance identity

Official source name
1,3,5-triazine-2,4,6-triamine; melamine
CAS
108-78-1
EC
203-615-4
Identity mapping
cas_number
Linked ingredient
MELAMINE
Search this identity across the siteCAS 108-78-1EC 203-615-4

Linked CosIng identity data

Names and aliases

MELAMINE

CosIng description: Cyanuric triamide,triaminotriazine,1,3,5-triazine-2,4,6-triamine

Recorded cosmetic function: NOT REPORTED

Function pages:NOT REPORTED

View the complete ingredient profile

Cross-market snapshot for this identity

Exact linked records currently present in this site. An absent market means no imported exact match, not permission to use the substance.

3 market datasets
PubChem 2D chemical structure for CAS 108-78-1
CAS 108-78-1PubChem CID 7955

Verified chemistry for CAS 108-78-1

Melamine

IUPAC name
1,3,5-triazine-2,4,6-triamine
Molecular formula
C3H6N6
Molecular weight
126.12 g/mol
Exact mass
126.06539422 Da
Monoisotopic mass
126.06539422 Da
XLogP3
-1.4
Topological polar surface area
117.0 Ų
Molecular complexity
63.0
Formal charge
0
Hydrogen-bond donors
3
Hydrogen-bond acceptors
6
Rotatable bonds
0
Heavy atoms
9
Covalent units
1

Names and synonyms reported to PubChem

CyanuramideCyanurotriamideCyanurotriamineIsomelamineTheoharnCyanuric triamides-TriazinetriamineTeoharn
16 more reported names
TriaminotriazineHicophor PR2,4,6-Triamino-1,3,5-triazineAeroPluragardYukamelamine2,4,6-Triamino-s-triazineCymelVirset 656-4Spinflam ML 94MPluragard C 1332,4,6-TriaminotriazineMark ZS 27ADK Stab ZS 27DG 002 (amine)NCI-C50715
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D pharmacophore features
7
3D rings
1
3D hydrophobes
0
3D acceptor features
0
3D donor features
3
3D anionic centres
0
3D cationic centres
3
3D conformers
1
Effective 3D rotors
0.0
Machine-readable structure identifiers
SMILES
C1(=NC(=NC(=N1)N)N)N
InChI
InChI=1S/C3H6N6/c4-1-7-2(5)9-3(6)8-1/h(H6,4,5,6,7,8,9)
InChIKey
JDSHMPZPIAZGSV-UHFFFAOYSA-N

Evidence from additional scientific databases

NIH PubChem PUG-View
Exact identifier match7955

Attributed physical-property, hazard, environmental and use annotations.

  • First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.; SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.; INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Ap Source: CAMEO Chemicals
  • Signal: Warning Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • GHS Hazard Statements: H351: Suspected of causing cancer [Warning Carcinogenicity]; H373: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Precautionary Statement Codes: P203, P260, P280, P318, P319, P405, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Note: This chemical does not meet GHS hazard criteria for 67.5% (624 of 924) of all reports. Source: European Chemicals Agency (ECHA)
  • Signal: Warning Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H351 (18.2%): Suspected of causing cancer [Warning Carcinogenicity]; H361 (18.7%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]; H361f (17.1%): Suspected of damaging fertility [Warning Reproductive toxicity]; H373 (18.5%): May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P203, P260, P280, P318, P319, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 924 reports by companies from 31 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Reported as not meeting GHS hazard criteria per 624 of 924 reports by companies.; There are 28 notifications provided by 300 of 924 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Signal: Warning Source: NITE-CMC
  • GHS Hazard Statements: H227: Combustible liquid [Warning Flammable liquids]; H315: Causes skin irritation [Warning Skin corrosion/irritation]; H317: May cause an allergic skin reaction [Warning Sensitization, Skin]; H336: May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects] Source: NITE-CMC
  • Precautionary Statement Codes: P210, P261, P264, P271, P272, P280, P302+P352, P304+P340, P319, P321, P332+P317, P333+P317, P362+P364, P370+P378, P403, P403+P233, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • Health Effects: Studies ranging from skin irritation to carcinogenicity are available. Melamine is not genotoxic but it causes carcinomas of the urinary bladder at high doses. Melamine is not irritating to skin and eye, not sensitising and not teratogenic. (L1777) Source: Toxin and Toxin Target Database (T3DB)
  • Toxicity Summary: IDENTIFICATION: Melamine is a monoclinic prismatic substance that is slightly soluble in water and ethanol. It is insoluble in diethyl ether. Melamine forms synthetic resins with formaldehyde. It is used in the manufacture of melamine resins, laminates, surface coating resins, plastic molding compounds, textile resins, bonding resins, gypsum melamine resin mixtures, orthopedic casts, rubber additives and paper products. HUMAN EXPOSURE: Occupational exposure to melamine may occur during its production and use in manufacture of synthetic resins with formaldehyde. ANIMAL STUDIES: Melamine was tested for its carcinogenicity by oral diet in mice and rats and for initiating activity by skin application in mice. No neoplasm related to treatment was observed after oral administration in mice. Male rats fed diets containing melamine developed transitional cell tumors in the urinary bladder, with one exception; all tumor bearing animals had bladder stones probably containing melamine. The incidence of urinary bladder hyperplasia associated with toxicity in male mice treated with melamine in the diet was observed. Groups of 20 male Fisher 344 rats, six weeks old were fed diets containing mela Source: Hazardous Substances Data Bank (HSDB)
  • Toxicity Summary: Melamine causes carcinomas of the urinary bladder at high doses (in male rats). Formation of bladder stones occurred and these calculi are necessary for the induction of tumours. Carcinomas are induced by continuous irritation of the bladder epithelium by the calculi, so that melamine acts only indirectly as a non-genotoxic carcinogen. (L1777) Source: Toxin and Toxin Target Database (T3DB)
  • Environmental Bioconcentration: An estimated BCF of 3 was calculated in fish for melamine(SRC), using a log Kow of -1.37(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 5(SRC), determined from a log Kow of -1.37(2) and a regression-derived equation(3), indicates that melamine is expected to have very high mobility in soil(SRC). Volatilization of melamine from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 1.8X10-14 atm-cu m/mole(SRC), derived from its vapor pressure, 3.59X10-10 mm Hg(4), and water solubility, 3.23 mg/L(5). Melamine is not expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(4). No biodegradation using a standard 5-day BOD test(6) suggests that biodegradation may not be an important environmental fate process in soil(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 5(SRC), determined from a log Kow of -1.37(2) and a regression-derived equation(3), indicates that melamine is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon an estimated Henry's Law constant of 1.84X10-14 atm-cu m/mole(SRC), derived from its vapor pressure, 3.59X10-10 mm Hg(4), and water solubility, 3.23X10+3 mg/L(5). According to a classification scheme(6), an estimated BCF of 3(SRC), from its log Kow(2) and a regression-derived equation(7), suggests the potential for bioconcentration in aquatic organisms is(SRC). No biodegradation using a standard 5-day BOD test was observed(8), suggesting that biodegradation may not be an important environmental fate process in water(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), melamine, which has a vapor pressure of 3.59X10-10 mm Hg at 20 °C(2), is expected to exist solely in the particulate phase in the ambient atmosphere. Particulate-phase melamine may be removed from the air by wet or dry deposition(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Consumer Uses: Filler; Not Known or Reasonably Ascertainable; Sealant (barrier); Flame retardant; Surface modifier; Hardener; Pigment; Adhesion/cohesion promoter; Other; Binder Source: EPA Chemical Data Reporting (CDR)
  • Industry Uses: Flame retardant; Sealant (barrier); Stabilizing agent; Filler; Not Known or Reasonably Ascertainable; Hardener; Pigment; Adhesion/cohesion promoter; Intermediate; Other; Processing aids not otherwise specified; Surfactant (surface active agent) Source: EPA Chemical Data Reporting (CDR)
  • Sources/Uses: Used as a co-monomer with formaldehyde to make high pressure laminate resins, molding compounds and surface coating resins, textile and paper treating resins, adhesive resins for gluing lumber, plywood, and flooring; Also used as a flame retardant additive for polypropylene and polyethylene, a leather tanning agent, a rust remover, a metal surface cleaner, an etching agent in the semiconductor industry, and a reagent in numerous fluorination processes; [HSDB] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Industrial Processes with risk of exposure: Metal Degreasing [Category: Clean]; Semiconductor Manufacturing [Category: Industry]; Pulp and Paper Processing [Category: Industry]; Textiles (Fiber & Fabric Manufacturing) [Category: Industry]; Painting (Pigments, Binders, and Biocides) [Category: Paint]; Working with Glues and Adhesives [Category: Other]; Plastic Composites Manufacturing [Category: Industry]; Leather Tanning and Processing [Category: Industry] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Uses: Melamine, melamine cyanurate, other melamine salts and guanidine compounds are currently the most used group of nitrogen-containing flame retardants. Melamine is used as a flame retardant additive for polypropylene and polyethylene. Melamine cyanurate is employed commercially as a flame retardant for polyamides and terephthalates (PET/PBT) and is being developed for use in epoxy and polyurethane resins. Melamine phosphate is also used as a flame retardant for terephthalates (PET/PBT) and is currently being developed for use in epoxy and polyurethane flame retardant formulations. Also in the development stages for use as flame-retardant additives are melamine salts and melamine formaldehyde for their application in thermoset resins. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Melamine resins, organic syntheses, leather tanning. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: TO MAKE HIGH PRESSURE LAMINATE RESINS, MOLDING COMPOUNDS & SURFACE COATING RESINS, TEXTILE & PAPER TREATING RESINS, ADHESIVE RESINS FOR GLUING LUMBER, PLYWOOD, & FLOORING Source: Hazardous Substances Data Bank (HSDB)
  • Uses: COMONOMER WITH FORMALDEHYDE FOR AMINO RESIN PRODN Source: Hazardous Substances Data Bank (HSDB)
  • Uses: For more Uses (Complete) data for MELAMINE (6 total), please visit the HSDB record page. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Plastics -> Typical concentration range in plastic materials -> 25% Source: NORMAN Suspect List Exchange
  • Uses: Melamine has many industrial uses, including the production of laminates, glues, adhesives, moulding compounds, coatings and flame retardants. It is also used in some fertilizers and in the production of melamine resins, typically by reaction with formaldehyde. Melamine is a metabolite of the pesticide cyromazine in plants, goats, hens and rats. (L1775) (L1778) Source: Toxin and Toxin Target Database (T3DB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Official source and provenance

Registered source
Great Britain Cosmetics Regulation — consolidated Annexes II–VI and amendments
Source reference
GB Cosmetics Regulation, Annex II, entry 1730
Source record ID
II-1730
Source version
2026-08-15
Source language
English
Translation status
Original is English
Effective date
2026-08-15
Source updated
2026-08-19
Snapshot checked
2026-08-30 04:51 UTC
Validation method
legislation.gov.uk XML table parse; {'II': 1758, 'III': 326, 'IV': 154, 'V': 57, 'VI': 34}
SHA-256
e3a386d950f54c6e7a7f9e784d1bd46e52de725137e89d5630709824475215d8

Registered dataset notes

Dataset coverage
Complete consolidated GB Annexes II–VI, with later amendments versioned separately
Authority note
Binding GB schedules and versioned amendments to retained Regulation 1223/2009; applies to England, Wales and Scotland, not Northern Ireland
Source licence
Open Government Licence v3.0 / Crown copyright
Attribution
Contains public sector information licensed under the Open Government Licence v3.0.
Inspect the exact official sourceRegulator guidance

How this record fits the market dataset

2329
current Great Britain records
1758
records marked Prohibited
2329
records from this source version
2015
market records with CAS identity

Status distribution

Permitted list with conditions: 245Prohibited: 1758Restricted: 326

Condition text is present on 517 of 2329 current records. An empty condition field is interpreted according to the record type above; it is never converted into an unrestricted-use claim.

Great Britain market context

Complete consolidated annex dataset

Coverage version: GB retained Regulation 1223/2009 schedules, effective 15 August 2026

Current consolidated Annexes II–VI for England, Scotland and Wales.

Verification checklist

  1. Confirm INCI/CAS/EC identity.
  2. Review every current GB Annex II–VI match.
  3. Check commencement dates and later statutory instruments.
  4. Verify SCPN, responsible-person, safety-report and labelling duties.

Official market sources

Verification workflow and record completeness

Before using this result in a compliance decision

  1. Confirm that “1,3,5-triazine-2,4,6-triamine; melamine” and every CAS/EC identifier refer to the material in your supplier specification.
  2. Confirm INCI/CAS/EC identity.
  3. Review every current GB Annex II–VI match.
  4. Check commencement dates and later statutory instruments.
  5. Verify SCPN, responsible-person, safety-report and labelling duties.
  6. Document the source version and recheck the regulator before manufacture, notification or market placement.

Fields available in this record

  • Official substance nameAvailable
  • CASAvailable
  • ECAvailable
  • Separate condition textNot present in source row
  • Effective dateAvailable
  • Snapshot hash and methodAvailable

Questions this page answers

This official record identifies the substance as prohibited for cosmetic use in the stated market scope. Do not rely on a formulation containing this identity until the cited source, effective date and exact substance match have been verified.

A prohibition entry may contain no separate condition text because the regulatory outcome is the prohibition itself. No annex match is not approval and does not cover Northern Ireland, which follows the applicable EU framework.

The record cites GB Cosmetics Regulation, Annex II, entry 1730, source version 2026-08-15. Open the official source.

No. CAS helps resolve identity, but jurisdictions can classify the same substance differently and can apply different product scopes, limits, warnings and transition dates.

Stable citation

1,3,5-triazine-2,4,6-triamine; melamine. GB Cosmetics Regulation, Annex II, entry 1730. Great Britain. Source version 2026-08-15. CosIng Checker regulatory record: https://cosingchecker.com/regulations/gb/records/6085/

Cite the regulator as the legal authority. This page is a structured evidence index and verification aid, not a substitute for the official text or professional legal assessment.

Interpretation and limits for Great Britain

This official record identifies the substance as prohibited for cosmetic use in the stated market scope.

Do not rely on a formulation containing this identity until the cited source, effective date and exact substance match have been verified.

How to interpret the legal role

The cited row forms part of a binding rule or legally incorporated list for this market.

Evidence on this page

  • Recorded outcome: Prohibited
  • Legal role: Binding rule
  • Source version: 2026-08-15
  • Effective date: 2026-08-15

What it does not prove

No annex match is not approval and does not cover Northern Ireland, which follows the applicable EU framework.

Further authoritative substance research

These sources can add identity, safety, exposure or hazard context. A link is not evidence that the database contains this exact substance, and none of these sources overrides the market decision above.

Cosmetic Ingredient Review safety assessments

Expert Panel conclusions, assessed ingredient groups, use conditions, dates and report documents

Independent expert review considered by FDA; not a government approval or binding market rule

Research this identity at the source

FDA Global Substance Registration System

UNII identifiers, preferred names, substance types, codes and public substance relationships

Identity registry only; UNII availability does not imply FDA review or approval

Research this identity at the source

ILO/WHO International Chemical Safety Cards

Hazards, symptoms, first aid, storage, incompatibilities and physical properties for covered chemicals

International occupational chemical-safety reference; not cosmetic-use approval

Research this identity at the source

Japan NITE-CHRIP

Chemical identity, Japanese and foreign legal lists, GHS hazards and exposure-related information

Chemical-management evidence; cosmetic status remains governed by the applicable MHLW standard and market rules

Research this identity at the source

NIOSH Pocket Guide to Chemical Hazards

REL, PEL, IDLH, properties, exposure routes, symptoms, target organs, first aid and measurement methods for covered workplace chemicals

US occupational-health guidance and limits; not a cosmetic ingredient decision

Research this identity at the source

OECD eChemPortal

Gateway to authority-owned physical-property, fate, ecotoxicity, toxicity, exposure and GHS records

Discovery gateway; each linked authority remains responsible for its data

Research this identity at the source

US EPA CompTox CTX APIs

API key required for import

DTXSID identity, experimental and predicted properties, toxicity, bioactivity, exposure and environmental data

Scientific and computational evidence; predictions must remain labelled and do not determine cosmetic legality

Research this identity at the source