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ProhibitedBinding ruleGBOriginal is EnglishOfficial-source import checked

Chlorpropham (ISO); isopropyl 3-chlorocarbanilate

The consolidated GB Cosmetics Regulation lists this record in Annex II.

All Great Britain recordsCompare all marketsOpen official source

Regulatory decision and full conditions

Status
Prohibited
Legal role
Binding rule
Regulatory summary
The consolidated GB Cosmetics Regulation lists this record in Annex II.
Conditions and restrictions
A prohibition entry may contain no separate condition text because the regulatory outcome is the prohibition itself. Open the cited source and apply the market-wide requirements below.

Substance identity

Official source name
Chlorpropham (ISO); isopropyl 3-chlorocarbanilate
CAS
101-21-3
EC
202-925-7
Identity mapping
standalone:official_gb_annex
Search this identity across the siteCAS 101-21-3EC 202-925-7

Cross-market snapshot for this identity

Exact linked records currently present in this site. An absent market means no imported exact match, not permission to use the substance.

6 market datasets
PubChem 2D chemical structure for CAS 101-21-3
CAS 101-21-3PubChem CID 2728

Verified chemistry for CAS 101-21-3

Chlorpropham

IUPAC name
propan-2-yl N-(3-chlorophenyl)carbamate
Molecular formula
C10H12ClNO2
Molecular weight
213.66 g/mol
Exact mass
213.0556563 Da
Monoisotopic mass
213.0556563 Da
XLogP3
3.5
Topological polar surface area
38.3 Ų
Molecular complexity
197.0
Formal charge
0
Hydrogen-bond donors
1
Hydrogen-bond acceptors
2
Rotatable bonds
3
Heavy atoms
14
Covalent units
1

Names and synonyms reported to PubChem

CHLOROPROPHAMChloro-IPCCIPCisopropyl (3-chlorophenyl)carbamatePreventolElbanilMetoxonNexoval
16 more reported names
Isopropyl N-(3-chlorophenyl)carbamateChlorprophameTaterpexTriherbicide CIPCMirvalePreventol 56PreweedLiro CIPCKeim-stopStopgerme-SSprout NipChlorIPCIsopropyl m-chlorocarbanilateSpud-NicSpud-NieChloro-IFK
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D pharmacophore features
4
3D rings
1
3D hydrophobes
1
3D acceptor features
1
3D donor features
1
3D anionic centres
0
3D cationic centres
0
3D conformers
10
Effective 3D rotors
4.0
Machine-readable structure identifiers
SMILES
CC(C)OC(=O)NC1=CC(=CC=C1)Cl
InChI
InChI=1S/C10H12ClNO2/c1-7(2)14-10(13)12-9-5-3-4-8(11)6-9/h3-7H,1-2H3,(H,12,13)
InChIKey
CWJSHJJYOPWUGX-UHFFFAOYSA-N

Evidence from additional scientific databases

EMBL-EBI ChEBI
Exact identifier matchCHEBI:34630

chlorpropham

A carbamate ester that is the isopropyl ester of 3-chlorophenylcarbamic acid.

Formula
C10H12ClNO2
Average mass
213.664 g/mol
Monoisotopic mass
213.05566 Da
Formal charge
0
  • benzenes — is a (CHEBI:22712)
  • carbamate ester — is a (CHEBI:23003)
  • monochlorobenzenes — is a (CHEBI:83403)
  • herbicide — has role (CHEBI:24527)
  • plant growth retardant — has role (CHEBI:35219)
  • herbicide — has role (CHEBI:24527)
  • plant growth retardant — has role (CHEBI:35219)
  • benzenes — is a (CHEBI:22712)
  • carbamate ester — is a (CHEBI:23003)
  • monochlorobenzenes — is a (CHEBI:83403)
Additional curated names
propan-2-yl (3-chlorophenyl)carbamate1-Methylethyl (3-chlorophenyl)carbamate3-Chlorocarbanilic acid, isopropyl ester(3-Chlorophenyl)carbamic acid, 1-methylethyl esterChloroprophamChlorprophameIsopropyl 3-chlorocarbanilateisopropyl (3-chlorophenyl)carbamateIsopropyl 3-chlorophenylcarbamateIsopropyl m-chlorocarbanilateIsopropyl-m-chlorocarbanilateIsopropyl meta-chlorocarbanilateIsopropyl N-(3-chlorophenyl)carbamateIsopropyl-N-(3-chlorophenyl)carbamateIsopropyl-N-3-chlorophenyl carbamateIsopropyl-N-(3-chlorphenyl)-carbamatIsopropyl N-(m-chlorophenyl)carbamateIsopropyl-N-m-chlorophenyl-carbamatem-Chlorocarbanilic acid isopropyl esterm-Chlorocarbanilic acid, isopropyl esterN-(3-Chlorophenyl)carbamic acid, isopropyl esterN-(3-Chlorophenyl)isopropyl carbamateN-3-ChlorophenylisopropylcarbamateO-Isopropyl N-(3-chlorophenyl)carbamate
Cross-references from this source
  • CAS: 101-21-3 — ChemIDplus
  • CAS: 101-21-3 — KEGG COMPOUND
  • CAS: 101-21-3 — NIST Chemistry WebBook
  • MANUAL_X_REF: 153 — PPDB
  • MANUAL_X_REF: C14506 — KEGG COMPOUND
  • MANUAL_X_REF: Chlorpropham — Wikipedia
  • REGISTRY_NUMBER: 2211397 — Reaxys

Mapped by: Exact CAS cross-reference in the ChEBI compound record. Source updated: 2014-10-24. Retrieved: 2026-08-31. Open source record

NIH PubChem PUG-View
Exact identifier match2728

Attributed physical-property, hazard, environmental and use annotations.

  • First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.; SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.; INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) shou Source: CAMEO Chemicals
  • Signal: Warning Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • GHS Hazard Statements: H351: Suspected of causing cancer [Warning Carcinogenicity]; H373 **: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]; H411: Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Precautionary Statement Codes: P203, P260, P273, P280, P318, P319, P391, P405, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Note: This chemical does not meet GHS hazard criteria for 1.4% (1 of 71) of reports. Source: European Chemicals Agency (ECHA)
  • Signal: Warning Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H351 (98.6%): Suspected of causing cancer [Warning Carcinogenicity]; H373 (98.6%): May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]; H411 (98.6%): Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P203, P260, P273, P280, P318, P319, P391, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 71 reports by companies from 10 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Reported as not meeting GHS hazard criteria per 1 of 71 reports by companies.; There are 9 notifications provided by 70 of 71 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Signal: Danger Source: NITE-CMC
  • GHS Hazard Statements: H320: Causes eye irritation [Warning Serious eye damage/eye irritation]; H332: Harmful if inhaled [Warning Acute toxicity, inhalation]; H351: Suspected of causing cancer [Warning Carcinogenicity]; H361: Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]; H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]; H371: May cause damage to organs [Warning Specific target organ toxicity, single exposure]; H373: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]; H401: Toxic to aquatic life [Hazardous to the aquatic environment, acute hazard]; H411: Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: NITE-CMC
  • Precautionary Statement Codes: P203, P260, P261, P264, P264+P265, P270, P271, P273, P280, P304+P340, P305+P351+P338, P308+P316, P317, P318, P319, P321, P337+P317, P391, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • Signal: Warning Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
  • Health Effects: Acute exposure to cholinesterase inhibitors can cause a cholinergic crisis characterized by severe nausea/vomiting, salivation, sweating, bradycardia, hypotension, collapse, and convulsions. Increasing muscle weakness is a possibility and may result in death if respiratory muscles are involved. Accumulation of ACh at motor nerves causes overstimulation of nicotinic expression at the neuromuscular junction. When this occurs symptoms such as muscle weakness, fatigue, muscle cramps, fasciculation, and paralysis can be seen. When there is an accumulation of ACh at autonomic ganglia this causes overstimulation of nicotinic expression in the sympathetic system. Symptoms associated with this are hypertension, and hypoglycemia. Overstimulation of nicotinic acetylcholine receptors in the central nervous system, due to accumulation of ACh, results in anxiety, headache, convulsions, ataxia, depression of respiration and circulation, tremor, general weakness, and potentially coma. When there is expression of muscarinic overstimulation due to excess acetylcholine at muscarinic acetylcholine receptors symptoms of visual disturbances, tightness in chest, wheezing due to bronchoconstriction, incre Source: Toxin and Toxin Target Database (T3DB)
  • Toxicity Summary: Chlorpropham is a cholinesterase or acetylcholinesterase (AChE) inhibitor. Carbamates form unstable complexes with chlolinesterases by carbamoylation of the active sites of the enzymes. This inhibition is reversible. A cholinesterase inhibitor suppresses the action of acetylcholine esterase. Because of its essential function, chemicals that interfere with the action of acetylcholine esterase are potent neurotoxins, causing excessive salivation and eye-watering in low doses. Headache, salivation, nausea, vomiting, abdominal pain and diarrhea are often prominent at higher levels of exposure. Acetylcholine esterase breaks down the neurotransmitter acetylcholine, which is released at nerve and muscle junctions, in order to allow the muscle or organ to relax. The result of acetylcholine esterase inhibition is that acetylcholine builds up and continues to act so that any nerve impulses are continually transmitted and muscle contractions do not stop. Source: Toxin and Toxin Target Database (T3DB)
  • Environmental Bioconcentration: An estimated BCF of 100 was calculated for chlorpropham(SRC), using a log Kow of 3.51(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is moderate(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), Koc values ranging from 245 to 816(2-5), indicates that chlorpropham is expected to have moderate to low mobility in soil(SRC). Volatilization of chlorpropham from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 5.7X10-7 atm-cu m/mole(SRC),derived from its vapor pressure 1.8X10-4 mm Hg(6) and, water solubility, 89 mg/L(6). Chlorpropham is not expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure of 1.8X10-4 mm Hg(6). The leaching of chlorpropham from three types of soil was low and more than 90% of chlorpropham was found in the upper inch of the soil after 4 cm of rain(7). Depending on the nature of soil and climatic conditions, the field half-lives of chlorpropham in soil range from less than 30 days to 65 days(8) with an average half-life of 30 days(9). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), Koc values ranging from 245 to 816(2-5), indicate that chlorpropham is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(6) based upon an estimated Henry's Law constant of 5.7X10-7 atm-cu m/mole(SRC), derived from its vapor pressure, 1.8X10-4 mm Hg(7), and water solubility, 89 mg/L(7). According to a classification scheme(8), an estimated BCF of 100(SRC), from its log Kow of 3.51(9) and a regression-derived equation(10), suggests the potential for bioconcentration in aquatic organisms is moderate(SRC). Chlorpropham was found to not hydrolyze in aqueous buffer solution at pH 4, 7, and 9(11). Based on a mean rate constant of 2.6X10-14 L/organism-hr and a bacterial concn of 5X10+8 organisms/L in water, the half-life of chlorpropham has been estimated to be 2208 days(12). Therefore, biodegradation of chlorpropham should not be important in clear bodies of water(SRC). However, biodegradation may become important if the bacterial population in water is several orders of magnitude higher than 10+8 organisms(13). The estimated minimum half-life for the direct sunlight photolysis of Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), chlorpropham, which has a vapor pressure of 1.8X10-4 mm Hg at 20 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase chlorpropham is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 9.7 hours (SRC), calculated from its rate constant of 4.0X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Chlorpropham does not absorb light with wavelengths >290 nm(4), and is therefore not expected to be susceptible to direct photolysis by sunlight. Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: MOIST SOIL TREATED WITH CHLORPROPHAM TO GIVE CONCN OF 100 PPM AI WAS INCUBATED IN POLYETHYLENE BAGS @ 23 °C FOR 30 WK. CO2 EVOLUTION WAS DETERMINED WEEKLY. CHLORPROPHAM WAS DEGRADED RAPIDLY IN FIRST 6WK & 5% OF ORIGINAL AMT COULD BE DETECTED 30 WK LATER. Source: Hazardous Substances Data Bank (HSDB)
  • Sources/Uses: Used as a herbicide to control many annual grassy and broadleaf weeds in alfalfa, lima and snap beans, blueberries, cane berries, cranberries, carrots, ladino clover, garlic, seed grass, peas, onions, spinach, sugar beets, tomatoes, safflower, soybeans, gladioli, and woody nursery stock; Also used to inhibit potato sprouting and for systemic sucker control in tobacco; [HSDB] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Uses: For chloropropham (USEPA/OPP Pesticide Code: 018301) ACTIVE products with label matches. /SRP: Registered for use in the U.S. but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses./ Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Chlorpropham acts as highly selective preemergence and early postemergence herbicide; it effectively controls many annual grassy and broadleaf weeds; application during late fall and winter for control of some perennial weeds. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: For control of weeds in alfalfa, lima and snap beans, blueberries, cane berries, cranberries, carrots, ladino clover, garlic, seed grass, peas, onions, spinach, sugar beets, tomatoes, safflower, soybeans, gladioli, woody nursery stock. Also for inhibiting potato sprouting and systemic sucker control in tobacco. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Chlorpropham is widely used as an insecticide or pesticide in homes, gardens and agricultural applications. It is a synthetic compound. Source: Toxin and Toxin Target Database (T3DB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
EMBL-EBI ChEBIExact match2026-08-31
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Official source and provenance

Registered source
Great Britain Cosmetics Regulation — consolidated Annexes II–VI and amendments
Source reference
GB Cosmetics Regulation, Annex II, entry 1406
Source record ID
II-1406
Source version
2026-08-15
Source language
English
Translation status
Original is English
Effective date
2026-08-15
Source updated
2026-08-19
Snapshot checked
2026-08-30 04:51 UTC
Validation method
legislation.gov.uk XML table parse; {'II': 1758, 'III': 326, 'IV': 154, 'V': 57, 'VI': 34}
SHA-256
e3a386d950f54c6e7a7f9e784d1bd46e52de725137e89d5630709824475215d8

Registered dataset notes

Dataset coverage
Complete consolidated GB Annexes II–VI, with later amendments versioned separately
Authority note
Binding GB schedules and versioned amendments to retained Regulation 1223/2009; applies to England, Wales and Scotland, not Northern Ireland
Source licence
Open Government Licence v3.0 / Crown copyright
Attribution
Contains public sector information licensed under the Open Government Licence v3.0.
Inspect the exact official sourceRegulator guidance

How this record fits the market dataset

2329
current Great Britain records
1758
records marked Prohibited
2329
records from this source version
2015
market records with CAS identity

Status distribution

Permitted list with conditions: 245Prohibited: 1758Restricted: 326

Condition text is present on 517 of 2329 current records. An empty condition field is interpreted according to the record type above; it is never converted into an unrestricted-use claim.

Great Britain market context

Complete consolidated annex dataset

Coverage version: GB retained Regulation 1223/2009 schedules, effective 15 August 2026

Current consolidated Annexes II–VI for England, Scotland and Wales.

Verification checklist

  1. Confirm INCI/CAS/EC identity.
  2. Review every current GB Annex II–VI match.
  3. Check commencement dates and later statutory instruments.
  4. Verify SCPN, responsible-person, safety-report and labelling duties.

Official market sources

Verification workflow and record completeness

Before using this result in a compliance decision

  1. Confirm that “Chlorpropham (ISO); isopropyl 3-chlorocarbanilate” and every CAS/EC identifier refer to the material in your supplier specification.
  2. Confirm INCI/CAS/EC identity.
  3. Review every current GB Annex II–VI match.
  4. Check commencement dates and later statutory instruments.
  5. Verify SCPN, responsible-person, safety-report and labelling duties.
  6. Document the source version and recheck the regulator before manufacture, notification or market placement.

Fields available in this record

  • Official substance nameAvailable
  • CASAvailable
  • ECAvailable
  • Separate condition textNot present in source row
  • Effective dateAvailable
  • Snapshot hash and methodAvailable

Questions this page answers

This official record identifies the substance as prohibited for cosmetic use in the stated market scope. Do not rely on a formulation containing this identity until the cited source, effective date and exact substance match have been verified.

A prohibition entry may contain no separate condition text because the regulatory outcome is the prohibition itself. No annex match is not approval and does not cover Northern Ireland, which follows the applicable EU framework.

The record cites GB Cosmetics Regulation, Annex II, entry 1406, source version 2026-08-15. Open the official source.

No. CAS helps resolve identity, but jurisdictions can classify the same substance differently and can apply different product scopes, limits, warnings and transition dates.

Stable citation

Chlorpropham (ISO); isopropyl 3-chlorocarbanilate. GB Cosmetics Regulation, Annex II, entry 1406. Great Britain. Source version 2026-08-15. CosIng Checker regulatory record: https://cosingchecker.com/regulations/gb/records/5761/

Cite the regulator as the legal authority. This page is a structured evidence index and verification aid, not a substitute for the official text or professional legal assessment.

Interpretation and limits for Great Britain

This official record identifies the substance as prohibited for cosmetic use in the stated market scope.

Do not rely on a formulation containing this identity until the cited source, effective date and exact substance match have been verified.

How to interpret the legal role

The cited row forms part of a binding rule or legally incorporated list for this market.

Evidence on this page

  • Recorded outcome: Prohibited
  • Legal role: Binding rule
  • Source version: 2026-08-15
  • Effective date: 2026-08-15

What it does not prove

No annex match is not approval and does not cover Northern Ireland, which follows the applicable EU framework.

Further authoritative substance research

These sources can add identity, safety, exposure or hazard context. A link is not evidence that the database contains this exact substance, and none of these sources overrides the market decision above.

Cosmetic Ingredient Review safety assessments

Expert Panel conclusions, assessed ingredient groups, use conditions, dates and report documents

Independent expert review considered by FDA; not a government approval or binding market rule

Research this identity at the source

FDA Global Substance Registration System

UNII identifiers, preferred names, substance types, codes and public substance relationships

Identity registry only; UNII availability does not imply FDA review or approval

Research this identity at the source

ILO/WHO International Chemical Safety Cards

Hazards, symptoms, first aid, storage, incompatibilities and physical properties for covered chemicals

International occupational chemical-safety reference; not cosmetic-use approval

Research this identity at the source

Japan NITE-CHRIP

Chemical identity, Japanese and foreign legal lists, GHS hazards and exposure-related information

Chemical-management evidence; cosmetic status remains governed by the applicable MHLW standard and market rules

Research this identity at the source

NIOSH Pocket Guide to Chemical Hazards

REL, PEL, IDLH, properties, exposure routes, symptoms, target organs, first aid and measurement methods for covered workplace chemicals

US occupational-health guidance and limits; not a cosmetic ingredient decision

Research this identity at the source

OECD eChemPortal

Gateway to authority-owned physical-property, fate, ecotoxicity, toxicity, exposure and GHS records

Discovery gateway; each linked authority remains responsible for its data

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US EPA CompTox CTX APIs

API key required for import

DTXSID identity, experimental and predicted properties, toxicity, bioactivity, exposure and environmental data

Scientific and computational evidence; predictions must remain labelled and do not determine cosmetic legality

Research this identity at the source