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Tributyl phosphate

The consolidated GB Cosmetics Regulation lists this record in Annex II.

All Great Britain recordsCompare all marketsOpen official source

Regulatory decision and full conditions

Status
Prohibited
Legal role
Binding rule
Regulatory summary
The consolidated GB Cosmetics Regulation lists this record in Annex II.
Conditions and restrictions
A prohibition entry may contain no separate condition text because the regulatory outcome is the prohibition itself. Open the cited source and apply the market-wide requirements below.

Substance identity

Official source name
Tributyl phosphate
CAS
126-73-8
EC
204-800-2
Identity mapping
standalone:official_gb_annex
Search this identity across the siteCAS 126-73-8EC 204-800-2

Cross-market snapshot for this identity

Exact linked records currently present in this site. An absent market means no imported exact match, not permission to use the substance.

8 market datasets
PubChem 2D chemical structure for CAS 126-73-8
CAS 126-73-8PubChem CID 31357

Verified chemistry for CAS 126-73-8

Tributyl Phosphate

IUPAC name
tributyl phosphate
Molecular formula
C12H27O4P
Molecular weight
266.31 g/mol
Exact mass
266.16469634 Da
Monoisotopic mass
266.16469634 Da
XLogP3
2.9
Topological polar surface area
44.8 Ų
Molecular complexity
175.0
Formal charge
0
Hydrogen-bond donors
0
Hydrogen-bond acceptors
4
Rotatable bonds
12
Heavy atoms
17
Covalent units
1

Names and synonyms reported to PubChem

Tri-n-butyl phosphateTributylphosphatePhosphoric acid tributyl esterTributylphosphatCelluphos 4tbpaDisflamoll TBTributilfosfato
16 more reported names
TributylfosfaatTributoxyphosphine oxidePhosphoric acid, tributyl esterTributyle (phosphate de)Butyl phosphate, tri-TributylfosfatTri-N-butylphosphateButyl phosphate, ((BuO)3PO)MCS 249595UAS8YAF5Tributyl ester of phosphoric acidNSC-8484CHEBI:35019NSC8484tri-(n-butyl)-phosphateRefChem:190910
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D pharmacophore features
4
3D rings
0
3D hydrophobes
3
3D acceptor features
1
3D donor features
0
3D anionic centres
0
3D cationic centres
0
3D conformers
10
Effective 3D rotors
12.0
Machine-readable structure identifiers
SMILES
CCCCOP(=O)(OCCCC)OCCCC
InChI
InChI=1S/C12H27O4P/c1-4-7-10-14-17(13,15-11-8-5-2)16-12-9-6-3/h4-12H2,1-3H3
InChIKey
STCOOQWBFONSKY-UHFFFAOYSA-N

Evidence from additional scientific databases

NIH PubChem PUG-View
Exact identifier match31357

Attributed physical-property, hazard, environmental and use annotations.

  • First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.; SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas.; INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknow Source: CAMEO Chemicals
  • First Aid: (General first aid procedures); Eye: Irrigate immediately - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.; Skin: Soap wash promptly - If this chemical contacts the skin, promptly wash the contaminated skin with soap and water. If this chemical penetrates the clothing, promptly remove the clothing and wash the skin with soap and water. Get medical attention promptly.; Breathing: Respiratory support; Swallow: Medical attention immediately - If this chemical has been swallowed, get medical attention immediately. Source: The National Institute for Occupational Safety and Health (NIOSH)
  • Signal: Warning Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • GHS Hazard Statements: H302: Harmful if swallowed [Warning Acute toxicity, oral]; H315: Causes skin irritation [Warning Skin corrosion/irritation]; H351: Suspected of causing cancer [Warning Carcinogenicity] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Precautionary Statement Codes: P203, P264, P270, P280, P301+P317, P302+P352, P318, P321, P330, P332+P317, P362+P364, P405, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Signal: Warning Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]; H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]; H351 (> 99.9%): Suspected of causing cancer [Warning Carcinogenicity]; H412 (19.6%): Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P203, P264, P270, P273, P280, P301+P317, P302+P352, P318, P321, P330, P332+P317, P362+P364, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 1091 reports by companies from 13 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Signal: Danger Source: NITE-CMC
  • GHS Hazard Statements: H302: Harmful if swallowed [Warning Acute toxicity, oral]; H315: Causes skin irritation [Warning Skin corrosion/irritation]; H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]; H332: Harmful if inhaled [Warning Acute toxicity, inhalation]; H351: Suspected of causing cancer [Warning Carcinogenicity]; H371: May cause damage to organs [Warning Specific target organ toxicity, single exposure]; H373: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]; H401: Toxic to aquatic life [Hazardous to the aquatic environment, acute hazard]; H411: Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: NITE-CMC
  • Precautionary Statement Codes: P203, P260, P261, P264, P264+P265, P270, P271, P273, P280, P301+P317, P302+P352, P304+P340, P305+P354+P338, P308+P316, P317, P318, P319, P321, P330, P332+P317, P362+P364, P391, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • GHS Hazard Statements: H401: Toxic to aquatic life [Hazardous to the aquatic environment, acute hazard]; H411: Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: NITE-CMC
  • Precautionary Statement Codes: P273, P391, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • NFPA Health Rating: 3 - Materials that, under emergency conditions, can cause serious or permanent injury. Source: Hazardous Substances Data Bank (HSDB)
  • NFPA Fire Rating: 1 - Materials that must be preheated before ignition can occur. Materials require considerable preheating, under all ambient temperature conditions, before ignition and combustion can occur. Source: Hazardous Substances Data Bank (HSDB)
  • NFPA Instability Rating: 0 - Materials that in themselves are normally stable, even under fire conditions. Source: Hazardous Substances Data Bank (HSDB)
  • Toxicity Summary: IDENTIFICATION AND USE: Tributyl phosphate is a colorless to pale-yellow odorless liquid. It is used as a plasticizer for cellulose esters, lacquers, plastics, and vinyl resins. Used in fire-resistant aircraft hydraulic fluids. Other uses include heat-exchange medium, solvent extraction of metal ions from solution of reactor products, solvent for nitrocellulose, cellulose acetate, pigment grinding assistant, antifoaming agent, dielectric. HUMAN EXPOSURE AND TOXICITY: Breathing vapors of tributyl phosphate causes irritation of mucous membranes and if inhalation is prolonged there can be general poisoning with paralysis. In contact with skin tributyl phosphate can cause irritation. Tributyl phosphate may cause irritation of the eyes, nose, and throat. It may also cause nausea and headache. In a series of 42 patients with furniture related dermatitis, a positive patch test reaction was seen in 1 patient. In vitro it acts as androgen receptor, and glucocorticoid receptor antagonist. ANIMAL STUDIES: Tributyl phosphate was not acutely toxic by dermal exposure in the rabbit and in the guinea pig. Application to either intact or abraded skin of rabbits and guinea pigs produced irritation w Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Bioconcentration: BCFs of 7.1-20 and 5.5-10 were reported in carp (Cyprinus carpio) which were exposed to tributyl phosphate at 6 and 60 ppb, respectively, over a 6-week period(1). The BCF of tributyl phosphate (exposure concentration of 3-4 ug/L) in killifish (Oryzias latipes) was found to be 30-35 and in goldfish (Carassius auratus) was found to be 6-11(2). According to a classification scheme(3), these BCFs suggest bioconcentration in aquatic organisms is low to moderate(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 2400(SRC), determined from a structure estimation method(2), indicates that tributyl phosphate is expected to have slight mobility in soil(SRC). Volatilization of tributyl phosphate from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry's Law constant of 1.4X10-6 atm-cu m/mole(SRC), based upon its vapor pressure, 1.13X10-3 mm Hg(3), and water solubility, 280 mg/L(4). However, adsorption to soil is expected to attenuate volatilization(SRC). Tributyl phosphate is not expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(3). Biodegradation of 56-96% in activated sludge inoculum(4) and a 3% of theoretical BOD using activated sludge in the Japanese MITI test(5) suggest that biodegradation may be an important environmental fate process in soil(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 2400(SRC), determined from a structure estimation method(2), indicates that tributyl phosphate is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon an estimated Henry's Law constant of 1.4X10-6 atm-cu m/mole(SRC), derived from its vapor pressure, 1.13X10-3 mm Hg(4), and water solubility, 280 mg/L(5). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 40 and 300 days, respectively(SRC). Tributyl phosphate is not expected to undergo hydrolysis in the environment(SRC) due to estimated hydrolysis half-lives of 9.9 to 11.5 years at pH 9 to 5(2). According to a classification scheme(6), BCFs of 5.5-20 in carp(7), 30-35 in killifish and 6-11 in goldfish(8), suggest bioconcentration in aquatic organisms is low to moderate(SRC). Aqueous biodegradation test results for tributyl phosphate varied from negligible biodegradation(9-11) to 30-100% biodegradation(5,11). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), tributyl phosphate, which has a vapor pressure of 1.13X10-3 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase tributyl phosphate is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 4.4 hours(SRC), calculated from its rate constant of 7.9X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Tributyl phosphate does not contain chromophores that absorb at wavelengths >290 nm(4) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Industry Uses: Lubricating agent; Hydraulic fluids; Plasticizer; Flame retardant; Not Known or Reasonably Ascertainable; Defoamer Source: EPA Chemical Data Reporting (CDR)
  • Sources/Uses: Mainly used as a flame retardant in aircraft hydraulic fluid, which can contain 25 to 75% TBP; Also used as a solvent (rare earth extraction and nuclear fuel cycle), plasticizer, carrier for fluorescent dyes, and antifoam agent (cement casings for oil wells); [ACGIH] Used as an antifoaming agent (concrete, textile, and paper industries); [HSDB] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Industrial Processes with risk of exposure: Petroleum Production and Refining [Category: Industry]; Pulp and Paper Processing [Category: Industry]; Textiles (Fiber & Fabric Manufacturing) [Category: Industry]; Metal Extraction and Refining [Category: Industry] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Uses: Plasticizer for cellulose esters, lacquers, plastics, and vinyl resins. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: ... Used in fire-resistant aircraft hydraulic fluids. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Heat-exchange medium, solvent extraction of metal ions from solution of reactor products, solvent for nitrocellulose, cellulose acetate, plasticizer, pigment grinding assistant, antifoam agent, dielectric. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Extraction chromatography, in which the organic extractant is adsorbed on the surfaces of a fine, porous powder placed in a column, offers another excellent method for separating the actinide elements from each other. Useful cation extracting agents include ... n-tributyl phosphate. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: For more Uses (Complete) data for TRIBUTYL PHOSPHATE (10 total), please visit the HSDB record page. Source: Hazardous Substances Data Bank (HSDB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Official source and provenance

Registered source
Great Britain Cosmetics Regulation — consolidated Annexes II–VI and amendments
Source reference
GB Cosmetics Regulation, Annex II, entry 1166
Source record ID
II-1166
Source version
2026-08-15
Source language
English
Translation status
Original is English
Effective date
2026-08-15
Source updated
2026-08-19
Snapshot checked
2026-08-30 04:51 UTC
Validation method
legislation.gov.uk XML table parse; {'II': 1758, 'III': 326, 'IV': 154, 'V': 57, 'VI': 34}
SHA-256
e3a386d950f54c6e7a7f9e784d1bd46e52de725137e89d5630709824475215d8

Registered dataset notes

Dataset coverage
Complete consolidated GB Annexes II–VI, with later amendments versioned separately
Authority note
Binding GB schedules and versioned amendments to retained Regulation 1223/2009; applies to England, Wales and Scotland, not Northern Ireland
Source licence
Open Government Licence v3.0 / Crown copyright
Attribution
Contains public sector information licensed under the Open Government Licence v3.0.
Inspect the exact official sourceRegulator guidance

How this record fits the market dataset

2329
current Great Britain records
1758
records marked Prohibited
2329
records from this source version
2015
market records with CAS identity

Status distribution

Permitted list with conditions: 245Prohibited: 1758Restricted: 326

Condition text is present on 517 of 2329 current records. An empty condition field is interpreted according to the record type above; it is never converted into an unrestricted-use claim.

Great Britain market context

Complete consolidated annex dataset

Coverage version: GB retained Regulation 1223/2009 schedules, effective 15 August 2026

Current consolidated Annexes II–VI for England, Scotland and Wales.

Verification checklist

  1. Confirm INCI/CAS/EC identity.
  2. Review every current GB Annex II–VI match.
  3. Check commencement dates and later statutory instruments.
  4. Verify SCPN, responsible-person, safety-report and labelling duties.

Official market sources

Verification workflow and record completeness

Before using this result in a compliance decision

  1. Confirm that “Tributyl phosphate” and every CAS/EC identifier refer to the material in your supplier specification.
  2. Confirm INCI/CAS/EC identity.
  3. Review every current GB Annex II–VI match.
  4. Check commencement dates and later statutory instruments.
  5. Verify SCPN, responsible-person, safety-report and labelling duties.
  6. Document the source version and recheck the regulator before manufacture, notification or market placement.

Fields available in this record

  • Official substance nameAvailable
  • CASAvailable
  • ECAvailable
  • Separate condition textNot present in source row
  • Effective dateAvailable
  • Snapshot hash and methodAvailable

Questions this page answers

This official record identifies the substance as prohibited for cosmetic use in the stated market scope. Do not rely on a formulation containing this identity until the cited source, effective date and exact substance match have been verified.

A prohibition entry may contain no separate condition text because the regulatory outcome is the prohibition itself. No annex match is not approval and does not cover Northern Ireland, which follows the applicable EU framework.

The record cites GB Cosmetics Regulation, Annex II, entry 1166, source version 2026-08-15. Open the official source.

No. CAS helps resolve identity, but jurisdictions can classify the same substance differently and can apply different product scopes, limits, warnings and transition dates.

Stable citation

Tributyl phosphate. GB Cosmetics Regulation, Annex II, entry 1166. Great Britain. Source version 2026-08-15. CosIng Checker regulatory record: https://cosingchecker.com/regulations/gb/records/5521/

Cite the regulator as the legal authority. This page is a structured evidence index and verification aid, not a substitute for the official text or professional legal assessment.

Interpretation and limits for Great Britain

This official record identifies the substance as prohibited for cosmetic use in the stated market scope.

Do not rely on a formulation containing this identity until the cited source, effective date and exact substance match have been verified.

How to interpret the legal role

The cited row forms part of a binding rule or legally incorporated list for this market.

Evidence on this page

  • Recorded outcome: Prohibited
  • Legal role: Binding rule
  • Source version: 2026-08-15
  • Effective date: 2026-08-15

What it does not prove

No annex match is not approval and does not cover Northern Ireland, which follows the applicable EU framework.

Further authoritative substance research

These sources can add identity, safety, exposure or hazard context. A link is not evidence that the database contains this exact substance, and none of these sources overrides the market decision above.

Cosmetic Ingredient Review safety assessments

Expert Panel conclusions, assessed ingredient groups, use conditions, dates and report documents

Independent expert review considered by FDA; not a government approval or binding market rule

Research this identity at the source

FDA Global Substance Registration System

UNII identifiers, preferred names, substance types, codes and public substance relationships

Identity registry only; UNII availability does not imply FDA review or approval

Research this identity at the source

ILO/WHO International Chemical Safety Cards

Hazards, symptoms, first aid, storage, incompatibilities and physical properties for covered chemicals

International occupational chemical-safety reference; not cosmetic-use approval

Research this identity at the source

Japan NITE-CHRIP

Chemical identity, Japanese and foreign legal lists, GHS hazards and exposure-related information

Chemical-management evidence; cosmetic status remains governed by the applicable MHLW standard and market rules

Research this identity at the source

NIOSH Pocket Guide to Chemical Hazards

REL, PEL, IDLH, properties, exposure routes, symptoms, target organs, first aid and measurement methods for covered workplace chemicals

US occupational-health guidance and limits; not a cosmetic ingredient decision

Research this identity at the source

OECD eChemPortal

Gateway to authority-owned physical-property, fate, ecotoxicity, toxicity, exposure and GHS records

Discovery gateway; each linked authority remains responsible for its data

Research this identity at the source

US EPA CompTox CTX APIs

API key required for import

DTXSID identity, experimental and predicted properties, toxicity, bioactivity, exposure and environmental data

Scientific and computational evidence; predictions must remain labelled and do not determine cosmetic legality

Research this identity at the source