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CAS 1 record

CAS 126-73-8

CAS 126-73-8 matches 1 EU annex record across Annex II–VI of Regulation 1223/2009.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 126-73-8
CAS 126-73-8PubChem CID 31357

Tributyl Phosphate

Tributyl phosphate is a trialkyl phosphate that is the tributyl ester of phosphoric acid. — ChEBI

IUPAC name
tributyl phosphate
Molecular formula
C12H27O4P
Molecular weight
266.31 g/mol
Exact mass
266.16469634 Da
XLogP3
2.9
Topological polar surface area
44.8 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
4
Covalent units
1
Defined stereocentres
0

Also known as

Tri-n-butyl phosphateTributylphosphatePhosphoric acid tributyl esterTributylphosphatCelluphos 4tbpaDisflamoll TBTributilfosfato
16 more reported names
TributylfosfaatTributoxyphosphine oxidePhosphoric acid, tributyl esterTributyle (phosphate de)Butyl phosphate, tri-TributylfosfatTri-N-butylphosphateButyl phosphate, ((BuO)3PO)MCS 249595UAS8YAF5Tributyl ester of phosphoric acidNSC-8484CHEBI:35019NSC8484tri-(n-butyl)-phosphateRefChem:190910
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Evidence from additional scientific databases

NIH PubChem PUG-View
Exact identifier match31357

Attributed physical-property, hazard, environmental and use annotations.

  • First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.; SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas.; INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknow Source: CAMEO Chemicals
  • First Aid: (General first aid procedures); Eye: Irrigate immediately - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.; Skin: Soap wash promptly - If this chemical contacts the skin, promptly wash the contaminated skin with soap and water. If this chemical penetrates the clothing, promptly remove the clothing and wash the skin with soap and water. Get medical attention promptly.; Breathing: Respiratory support; Swallow: Medical attention immediately - If this chemical has been swallowed, get medical attention immediately. Source: The National Institute for Occupational Safety and Health (NIOSH)
  • Signal: Warning Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • GHS Hazard Statements: H302: Harmful if swallowed [Warning Acute toxicity, oral]; H315: Causes skin irritation [Warning Skin corrosion/irritation]; H351: Suspected of causing cancer [Warning Carcinogenicity] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Precautionary Statement Codes: P203, P264, P270, P280, P301+P317, P302+P352, P318, P321, P330, P332+P317, P362+P364, P405, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Signal: Warning Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]; H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]; H351 (> 99.9%): Suspected of causing cancer [Warning Carcinogenicity]; H412 (19.6%): Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P203, P264, P270, P273, P280, P301+P317, P302+P352, P318, P321, P330, P332+P317, P362+P364, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 1091 reports by companies from 13 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Signal: Danger Source: NITE-CMC
  • GHS Hazard Statements: H302: Harmful if swallowed [Warning Acute toxicity, oral]; H315: Causes skin irritation [Warning Skin corrosion/irritation]; H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]; H332: Harmful if inhaled [Warning Acute toxicity, inhalation]; H351: Suspected of causing cancer [Warning Carcinogenicity]; H371: May cause damage to organs [Warning Specific target organ toxicity, single exposure]; H373: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]; H401: Toxic to aquatic life [Hazardous to the aquatic environment, acute hazard]; H411: Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: NITE-CMC
  • Precautionary Statement Codes: P203, P260, P261, P264, P264+P265, P270, P271, P273, P280, P301+P317, P302+P352, P304+P340, P305+P354+P338, P308+P316, P317, P318, P319, P321, P330, P332+P317, P362+P364, P391, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • GHS Hazard Statements: H401: Toxic to aquatic life [Hazardous to the aquatic environment, acute hazard]; H411: Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: NITE-CMC
  • Precautionary Statement Codes: P273, P391, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • NFPA Health Rating: 3 - Materials that, under emergency conditions, can cause serious or permanent injury. Source: Hazardous Substances Data Bank (HSDB)
  • NFPA Fire Rating: 1 - Materials that must be preheated before ignition can occur. Materials require considerable preheating, under all ambient temperature conditions, before ignition and combustion can occur. Source: Hazardous Substances Data Bank (HSDB)
  • NFPA Instability Rating: 0 - Materials that in themselves are normally stable, even under fire conditions. Source: Hazardous Substances Data Bank (HSDB)
  • Toxicity Summary: IDENTIFICATION AND USE: Tributyl phosphate is a colorless to pale-yellow odorless liquid. It is used as a plasticizer for cellulose esters, lacquers, plastics, and vinyl resins. Used in fire-resistant aircraft hydraulic fluids. Other uses include heat-exchange medium, solvent extraction of metal ions from solution of reactor products, solvent for nitrocellulose, cellulose acetate, pigment grinding assistant, antifoaming agent, dielectric. HUMAN EXPOSURE AND TOXICITY: Breathing vapors of tributyl phosphate causes irritation of mucous membranes and if inhalation is prolonged there can be general poisoning with paralysis. In contact with skin tributyl phosphate can cause irritation. Tributyl phosphate may cause irritation of the eyes, nose, and throat. It may also cause nausea and headache. In a series of 42 patients with furniture related dermatitis, a positive patch test reaction was seen in 1 patient. In vitro it acts as androgen receptor, and glucocorticoid receptor antagonist. ANIMAL STUDIES: Tributyl phosphate was not acutely toxic by dermal exposure in the rabbit and in the guinea pig. Application to either intact or abraded skin of rabbits and guinea pigs produced irritation w Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Bioconcentration: BCFs of 7.1-20 and 5.5-10 were reported in carp (Cyprinus carpio) which were exposed to tributyl phosphate at 6 and 60 ppb, respectively, over a 6-week period(1). The BCF of tributyl phosphate (exposure concentration of 3-4 ug/L) in killifish (Oryzias latipes) was found to be 30-35 and in goldfish (Carassius auratus) was found to be 6-11(2). According to a classification scheme(3), these BCFs suggest bioconcentration in aquatic organisms is low to moderate(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 2400(SRC), determined from a structure estimation method(2), indicates that tributyl phosphate is expected to have slight mobility in soil(SRC). Volatilization of tributyl phosphate from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry's Law constant of 1.4X10-6 atm-cu m/mole(SRC), based upon its vapor pressure, 1.13X10-3 mm Hg(3), and water solubility, 280 mg/L(4). However, adsorption to soil is expected to attenuate volatilization(SRC). Tributyl phosphate is not expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(3). Biodegradation of 56-96% in activated sludge inoculum(4) and a 3% of theoretical BOD using activated sludge in the Japanese MITI test(5) suggest that biodegradation may be an important environmental fate process in soil(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 2400(SRC), determined from a structure estimation method(2), indicates that tributyl phosphate is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon an estimated Henry's Law constant of 1.4X10-6 atm-cu m/mole(SRC), derived from its vapor pressure, 1.13X10-3 mm Hg(4), and water solubility, 280 mg/L(5). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 40 and 300 days, respectively(SRC). Tributyl phosphate is not expected to undergo hydrolysis in the environment(SRC) due to estimated hydrolysis half-lives of 9.9 to 11.5 years at pH 9 to 5(2). According to a classification scheme(6), BCFs of 5.5-20 in carp(7), 30-35 in killifish and 6-11 in goldfish(8), suggest bioconcentration in aquatic organisms is low to moderate(SRC). Aqueous biodegradation test results for tributyl phosphate varied from negligible biodegradation(9-11) to 30-100% biodegradation(5,11). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), tributyl phosphate, which has a vapor pressure of 1.13X10-3 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase tributyl phosphate is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 4.4 hours(SRC), calculated from its rate constant of 7.9X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Tributyl phosphate does not contain chromophores that absorb at wavelengths >290 nm(4) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Industry Uses: Lubricating agent; Hydraulic fluids; Plasticizer; Flame retardant; Not Known or Reasonably Ascertainable; Defoamer Source: EPA Chemical Data Reporting (CDR)
  • Sources/Uses: Mainly used as a flame retardant in aircraft hydraulic fluid, which can contain 25 to 75% TBP; Also used as a solvent (rare earth extraction and nuclear fuel cycle), plasticizer, carrier for fluorescent dyes, and antifoam agent (cement casings for oil wells); [ACGIH] Used as an antifoaming agent (concrete, textile, and paper industries); [HSDB] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Industrial Processes with risk of exposure: Petroleum Production and Refining [Category: Industry]; Pulp and Paper Processing [Category: Industry]; Textiles (Fiber & Fabric Manufacturing) [Category: Industry]; Metal Extraction and Refining [Category: Industry] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Uses: Plasticizer for cellulose esters, lacquers, plastics, and vinyl resins. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: ... Used in fire-resistant aircraft hydraulic fluids. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Heat-exchange medium, solvent extraction of metal ions from solution of reactor products, solvent for nitrocellulose, cellulose acetate, plasticizer, pigment grinding assistant, antifoam agent, dielectric. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Extraction chromatography, in which the organic extractant is adsorbed on the surfaces of a fine, porous powder placed in a column, offers another excellent method for separating the actinide elements from each other. Useful cation extracting agents include ... n-tributyl phosphate. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: For more Uses (Complete) data for TRIBUTYL PHOSPHATE (10 total), please visit the HSDB record page. Source: Hazardous Substances Data Bank (HSDB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Records for CAS 126-73-8

1 total

How CAS 126-73-8 is used on this site

CAS 126-73-8 is the Chemical Abstracts Service identifier used to pin this page to a specific substance. In the current dataset, 1 EU annex record shares this identifier, which helps you cross-check whether the same substance appears under one regulatory context or several.

Use this page when a supplier specification, SDS or raw-material dossier gives you CAS 126-73-8 and you need to see every linked Annex II–VI record in one place. The entry cards above are the quickest route to concentration limits, warnings, annex placement and product-type conditions.

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A substance identified by CAS 126-73-8 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts. For example, a substance might be restricted under Annex III with specific conditions, and the same CAS might also appear in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

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