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8-羟基喹啉及其硫酸盐（化妆品限用组 分中的8-羟基喹啉硫酸盐除外） — Hydroxy-8-quinoline （CAS No. 148-24-3） and its sulfate （CAS No. 134-31-6）, except for the uses of the sulphate provided in restricted substances in cosmetics products

Hydroxy-8-quinoline （CAS No. 148-24-3） and its sulfate （CAS No. 134-31-6）, except for the uses of the sulphate provided in restricted substances in cosmetics products

The NMPA binding 2021 catalogue prohibits this raw material in cosmetic formulas in China.

All China recordsOpen ingredient profileCompare all marketsOpen official source

Regulatory decision and full conditions

Status
Prohibited
Legal role
Binding rule
Regulatory summary
The NMPA binding 2021 catalogue prohibits this raw material in cosmetic formulas in China.
Conditions and restrictions
Prohibited in cosmetic product formulas. Verify the cited Chinese source identity and any later NMPA amendment before use.

Substance identity

Official source name
8-羟基喹啉及其硫酸盐（化妆品限用组 分中的8-羟基喹啉硫酸盐除外） — Hydroxy-8-quinoline （CAS No. 148-24-3） and its sulfate （CAS No. 134-31-6）, except for the uses of the sulphate provided in restricted substances in cosmetics products
CAS
148-24-3; 134-31-6
EC
205-711-1
Identity mapping
cas_number
Linked ingredient
OXYQUINOLINE
Search this identity across the siteCAS 148-24-3CAS 134-31-6EC 205-711-1

Linked CosIng identity data

Names and aliases

OXYQUINOLINEoxyquinoline

CosIng description: 8-Hydroxyquinoline; 1-Azanaphthalene-8-ol; Quinolin-8-ol; 8-Quinolinol; Phenopyridine

EU inventory restriction note: II/395

Recorded cosmetic function: ANTIMICROBIAL, CHELATING

Function pages:ANTIMICROBIAL, CHELATING

View the complete ingredient profile

Cross-market snapshot for this identity

Exact linked records currently present in this site. An absent market means no imported exact match, not permission to use the substance.

10 market datasets
PubChem 2D chemical structure for CAS 134-31-6
CAS 134-31-6PubChem CID 517000

Verified chemistry for CAS 134-31-6

Hydroxyquinoline sulfate

IUPAC name
bis(quinolin-8-ol);sulfuric acid
Molecular formula
C18H16N2O6S
Molecular weight
388.4 g/mol
Exact mass
388.07290741 Da
Monoisotopic mass
388.07290741 Da
Topological polar surface area
149.0 Ų
Molecular complexity
219.0
Formal charge
0
Hydrogen-bond donors
4
Hydrogen-bond acceptors
8
Rotatable bonds
0
Heavy atoms
27
Covalent units
3

Names and synonyms reported to PubChem

8-Hydroxyquinoline sulfateOxyquinoline sulfateOxine sulfateoxyquinoline sulphate8-Quinolinol sulfate (2:1) (salt)61VUG75Y3PCRIPTONOLSulfate, Oxyquinoline
16 more reported names
RefChem:5484218 Hydroxyquinoline SulfateSulfate, 8-Hydroxyquinoline205-137-1AlbisalCryptonolHappyOctofenQuinosol ExtraSolvochin-ExtraSunoxol8-Quinolinol sulfate8-Hydroxy-chinolin-sulfatOxyquinoline sulfate [USAN]Oxychinolinsulfat8-HYDROXYQUINOLINE HEMISULFATE
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D conformers
0
Machine-readable structure identifiers
SMILES
C1=CC2=C(C(=C1)O)N=CC=C2.C1=CC2=C(C(=C1)O)N=CC=C2.OS(=O)(=O)O
InChI
InChI=1S/2C9H7NO.H2O4S/c2*11-8-5-1-3-7-4-2-6-10-9(7)8;1-5(2,3)4/h2*1-6,11H;(H2,1,2,3,4)
InChIKey
YYVFXSYQSOZCOQ-UHFFFAOYSA-N

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 148-24-3
CAS 148-24-3PubChem CID 1923

Verified chemistry for CAS 148-24-3

8-Hydroxyquinoline

Quinolin-8-ol is a monohydroxyquinoline that is quinoline substituted by a hydroxy group at position 8. Its fungicidal properties are used for the control of grey mould on vines and tomatoes. It has a role as an antibacterial agent, an iron chelator, an antiseptic drug and an antifungal agrochemical. It derives from a hydride of a quinoline. — ChEBI

IUPAC name
quinolin-8-ol
Molecular formula
C9H7NO
Molecular weight
145.16 g/mol
Exact mass
145.052763847 Da
Monoisotopic mass
145.052763847 Da
XLogP3
2.0
Topological polar surface area
33.1 Ų
Molecular complexity
138.0
Formal charge
0
Hydrogen-bond donors
1
Hydrogen-bond acceptors
2
Rotatable bonds
0
Heavy atoms
11
Covalent units
1

Names and synonyms reported to PubChem

8-quinolinolOxyquinolineOxineQuinophenolOxychinolinPhenopyridine8-QuinolBioquin
16 more reported names
TumexOxinOxybenzopyridineHydroxybenzopyridine8-Oxyquinoline1-Azanaphthalene-8-ol8-Hydroxychinolin8-Chinolinol8-Hydroxy-chinolinFennosan H 30Fennosano-OxychinolinUsaf ek-794OxyquinolQuinoline, 8-hydroxy-NCI-C55298
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D pharmacophore features
4
3D rings
2
3D hydrophobes
0
3D acceptor features
1
3D donor features
1
3D anionic centres
0
3D cationic centres
0
3D conformers
1
Effective 3D rotors
0.0
Machine-readable structure identifiers
SMILES
C1=CC2=C(C(=C1)O)N=CC=C2
InChI
InChI=1S/C9H7NO/c11-8-5-1-3-7-4-2-6-10-9(7)8/h1-6,11H
InChIKey
MCJGNVYPOGVAJF-UHFFFAOYSA-N

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Official source and provenance

Registered source
China NMPA banned raw-material catalogues (2021)
Source reference
NMPA 2021 Catalogue of Raw Materials Banned for Cosmetics, entry 834
Source record ID
chemical-834
Source version
NMPA Announcement No. 74 of 2021, effective 2021-05-26
Source language
Chinese with source English/Latin identity
Translation status
Official English translation · English translation
Effective date
2021-05-26
Source updated
2021-05-26
Snapshot checked
2026-08-31 14:13 UTC
Validation method
pdfplumber tables; exact 1,284 + 109 row counts and contiguous source numbering
SHA-256
8848aa3e0c7ac5e74f56fc27927336c4fc2e5bc80137da087c2ca9ba2d2c075e

Registered dataset notes

Dataset coverage
All 1,284 banned raw materials and 109 banned plant/animal raw materials effective from 26 May 2021
Authority note
Binding NMPA catalogues replacing Tables 1 and 2 of the 2015 Technical Specification
Inspect the exact official sourceRegulator guidance

How this record fits the market dataset

1393
current China records
1393
records marked Prohibited
1393
records from this source version
1249
market records with CAS identity

Status distribution

Prohibited: 1393

Condition text is present on 1393 of 1393 current records. An empty condition field is interpreted according to the record type above; it is never converted into an unrestricted-use claim.

China market context

Complete prohibited catalogues plus official-source workflow

Coverage version: NMPA 2021 banned catalogues plus dynamic IECIC List I/List II system current since 2025

All 1,284 banned raw materials and 109 banned plant/animal raw materials, plus the official workflow for the dynamic existing-ingredient inventory, other technical restrictions and new ingredients.

Verification checklist

  1. Search the current NMPA IECIC List I and List II by Chinese name and identity.
  2. Check prohibited/restricted and positive lists in the current Safety and Technical Standards.
  3. Review technical purpose, use history and any monitoring period.
  4. Confirm Chinese labelling, safety assessment and filing/registration duties.

Official market sources

Verification workflow and record completeness

Before using this result in a compliance decision

  1. Confirm that “8-羟基喹啉及其硫酸盐（化妆品限用组 分中的8-羟基喹啉硫酸盐除外） — Hydroxy-8-quinoline （CAS No. 148-24-3） and its sulfate （CAS No. 134-31-6）, except for the uses of the sulphate provided in restricted substances in cosmetics products” and every CAS/EC identifier refer to the material in your supplier specification.
  2. Search the current NMPA IECIC List I and List II by Chinese name and identity.
  3. Check prohibited/restricted and positive lists in the current Safety and Technical Standards.
  4. Review technical purpose, use history and any monitoring period.
  5. Confirm Chinese labelling, safety assessment and filing/registration duties.
  6. Document the source version and recheck the regulator before manufacture, notification or market placement.

Fields available in this record

  • Official substance nameAvailable
  • CASAvailable
  • ECAvailable
  • Separate condition textAvailable
  • Effective dateAvailable
  • Snapshot hash and methodAvailable

Questions this page answers

This official record identifies the substance as prohibited for cosmetic use in the stated market scope. Do not rely on a formulation containing this identity until the cited source, effective date and exact substance match have been verified.

A prohibition entry may contain no separate condition text because the regulatory outcome is the prohibition itself. IECIC listing is not blanket approval; absence may require the new cosmetic ingredient route, and restrictions are checked separately.

The record cites NMPA 2021 Catalogue of Raw Materials Banned for Cosmetics, entry 834, source version NMPA Announcement No. 74 of 2021, effective 2021-05-26. Open the official source.

No. CAS helps resolve identity, but jurisdictions can classify the same substance differently and can apply different product scopes, limits, warnings and transition dates.

Stable citation

8-羟基喹啉及其硫酸盐（化妆品限用组 分中的8-羟基喹啉硫酸盐除外） — Hydroxy-8-quinoline （CAS No. 148-24-3） and its sulfate （CAS No. 134-31-6）, except for the uses of the sulphate provided in restricted substances in cosmetics products. NMPA 2021 Catalogue of Raw Materials Banned for Cosmetics, entry 834. China. Source version NMPA Announcement No. 74 of 2021, effective 2021-05-26. CosIng Checker regulatory record: https://cosingchecker.com/regulations/cn/records/12523/

Cite the regulator as the legal authority. This page is a structured evidence index and verification aid, not a substitute for the official text or professional legal assessment.

Interpretation and limits for China

This official record identifies the substance as prohibited for cosmetic use in the stated market scope.

Do not rely on a formulation containing this identity until the cited source, effective date and exact substance match have been verified.

How to interpret the legal role

The cited row forms part of a binding rule or legally incorporated list for this market.

Evidence on this page

  • Recorded outcome: Prohibited
  • Legal role: Binding rule
  • Source version: NMPA Announcement No. 74 of 2021, effective 2021-05-26
  • Effective date: 2021-05-26

What it does not prove

IECIC listing is not blanket approval; absence may require the new cosmetic ingredient route, and restrictions are checked separately.

Further authoritative substance research

These sources can add identity, safety, exposure or hazard context. A link is not evidence that the database contains this exact substance, and none of these sources overrides the market decision above.

Cosmetic Ingredient Review safety assessments

Expert Panel conclusions, assessed ingredient groups, use conditions, dates and report documents

Independent expert review considered by FDA; not a government approval or binding market rule

Research this identity at the source

FDA Global Substance Registration System

UNII identifiers, preferred names, substance types, codes and public substance relationships

Identity registry only; UNII availability does not imply FDA review or approval

Research this identity at the source

ILO/WHO International Chemical Safety Cards

Hazards, symptoms, first aid, storage, incompatibilities and physical properties for covered chemicals

International occupational chemical-safety reference; not cosmetic-use approval

Research this identity at the source

Japan NITE-CHRIP

Chemical identity, Japanese and foreign legal lists, GHS hazards and exposure-related information

Chemical-management evidence; cosmetic status remains governed by the applicable MHLW standard and market rules

Research this identity at the source

NIOSH Pocket Guide to Chemical Hazards

REL, PEL, IDLH, properties, exposure routes, symptoms, target organs, first aid and measurement methods for covered workplace chemicals

US occupational-health guidance and limits; not a cosmetic ingredient decision

Research this identity at the source

OECD eChemPortal

Gateway to authority-owned physical-property, fate, ecotoxicity, toxicity, exposure and GHS records

Discovery gateway; each linked authority remains responsible for its data

Research this identity at the source

US EPA CompTox CTX APIs

API key required for import

DTXSID identity, experimental and predicted properties, toxicity, bioactivity, exposure and environmental data

Scientific and computational evidence; predictions must remain labelled and do not determine cosmetic legality

Research this identity at the source