Skip to main content
CosIng Checker
CosIng Checker
EU cosmetic ingredients, restrictions and safety
Login
Annex II Entry 395 CMR31/07/2020

Hydroxy-8-quinoline and its sulphate bis(8-hydroxyquinolinium) sulphate, except for the uses of the sulphate provided for in entry 51 of Annex III

Hydroxy-8-quinoline and its sulphate bis(8-hydroxyquinolinium) sulphate, except for the uses of the sulphate provided for in entry 51 of Annex III is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

Search similar Back to annex Compare
Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 395
CMR

Chemical identity and properties

PubChem 2D chemical structure for CAS 134-31-6
CAS 134-31-6PubChem CID 517000

Hydroxyquinoline sulfate

8-hydroxyquinoline sulfate is a pale yellow to yellow crystalline powder with a slight saffron odor. Burning taste. (NTP, 1992) — CAMEO Chemicals

IUPAC name
bis(quinolin-8-ol);sulfuric acid
Molecular formula
C18H16N2O6S
Molecular weight
388.4 g/mol
Exact mass
388.07290741 Da
Topological polar surface area
149.0 Ų
Hydrogen-bond donors
4
Hydrogen-bond acceptors
8
Covalent units
3
Defined stereocentres
0

Also known as

8-Hydroxyquinoline sulfateOxyquinoline sulfateOxine sulfateoxyquinoline sulphate8-Quinolinol sulfate (2:1) (salt)61VUG75Y3PCRIPTONOLSulfate, Oxyquinoline
16 more reported names
RefChem:5484218 Hydroxyquinoline SulfateSulfate, 8-Hydroxyquinoline205-137-1AlbisalCryptonolHappyOctofenQuinosol ExtraSolvochin-ExtraSunoxol8-Quinolinol sulfate8-Hydroxy-chinolin-sulfatOxyquinoline sulfate [USAN]Oxychinolinsulfat8-HYDROXYQUINOLINE HEMISULFATE
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 148-24-3
CAS 148-24-3PubChem CID 1923

8-Hydroxyquinoline

Quinolin-8-ol is a monohydroxyquinoline that is quinoline substituted by a hydroxy group at position 8. Its fungicidal properties are used for the control of grey mould on vines and tomatoes. It has a role as an antibacterial agent, an iron chelator, an antiseptic drug and an antifungal agrochemical. It derives from a hydride of a quinoline. — ChEBI

IUPAC name
quinolin-8-ol
Molecular formula
C9H7NO
Molecular weight
145.16 g/mol
Exact mass
145.052763847 Da
XLogP3
2.0
Topological polar surface area
33.1 Ų
Hydrogen-bond donors
1
Hydrogen-bond acceptors
2
Covalent units
1
Defined stereocentres
0

Also known as

8-quinolinolOxyquinolineOxineQuinophenolOxychinolinPhenopyridine8-QuinolBioquin
16 more reported names
TumexOxinOxybenzopyridineHydroxybenzopyridine8-Oxyquinoline1-Azanaphthalene-8-ol8-Hydroxychinolin8-Chinolinol8-Hydroxy-chinolinFennosan H 30Fennosano-OxychinolinUsaf ek-794OxyquinolQuinoline, 8-hydroxy-NCI-C55298
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

Hydroxy-8-quinoline and its sulphate bis(8-hydroxyquinolinium) sulphate, except for the uses of the sulphate provided for in entry 51 of Annex III

Chemical / IUPAC name

1-Azanaphthalene-8-ol;

Regulatory information

Regulation

(EU) 2019/1966

See every entry this act set

Identified ingredients

CMR

CategoryCarcinogenicMutagenicReprotoxic
Cat. 1B——✓

Key data

CAS
148-24-3 [1]; 134-31-6 [2]
EC
205-711-1 [1]; 205-137-1 [2]
Annex
II
Entry number
395

Inventory links for Hydroxy-8-quinoline and its sulphate bis(8-hydroxyquinolinium) sulphate, except for the uses of the sulphate provided for in entry 51 of Annex III

Inventory Restriction reference
Ref 35773

OXYQUINOLINE

CAS: 148-24-3
EC: 205-711-1

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

Annex II 393
Nearby record in the same annex

Acetonitrile

CAS: 75-05-8
EC: 200-835-2
Annex II 399
Nearby record in the same annex

Lidocaine (INN)

CAS: 137-58-6
EC: 205-302-8
Annex II 400
Nearby record in the same annex

1,2-Epoxybutane

CAS: 106-88-7
EC: 203-438-2

What Annex II means for Hydroxy-8-quinoline and its sulphate bis(8-hydroxyquinolinium) sulphate, except for the uses of the sulphate provided for in entry 51 of Annex III

Hydroxy-8-quinoline and its sulphate bis(8-hydroxyquinolinium) sulphate, except for the uses of the sulphate provided for in entry 51 of Annex III is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

This record is linked to 2 CosIng inventory ingredients for name and identifier cross-reference. The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).
  • This substance has CMR classification. Review the CMR table above and verify current Annex II/III status before use.

Frequently asked questions

Yes. Hydroxy-8-quinoline and its sulphate bis(8-hydroxyquinolinium) sulphate, except for the uses of the sulphate provided for in entry 51 of Annex III is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 148-24-3 [1]; 134-31-6 [2] is the unique numerical identifier assigned to Hydroxy-8-quinoline and its sulphate bis(8-hydroxyquinolinium) sulphate, except for the uses of the sulphate provided for in entry 51 of Annex III by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Hydroxy-8-quinoline and its sulphate bis(8-hydroxyquinolinium) sulphate, except for the uses of the sulphate provided for in entry 51 of Annex III has a CMR (carcinogenic, mutagenic or reprotoxic) classification under EU CLP Regulation. Under Article 15 of EU Cosmetics Regulation 1223/2009, CMR substances of category 1A or 1B are prohibited in cosmetics unless specifically permitted. Category 2 CMR substances may be used only if assessed safe by the SCCS. Always verify current annex status and any applicable derogations before use.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
Open INCI Checker

Source note for Annex II record Hydroxy-8-quinoline and its sulphate bis(8-hydroxyquinolinium) sulphate, except for the uses of the sulphate provided for in entry 51 of Annex III

This page summarizes one Annex II record for Hydroxy-8-quinoline and its sulphate bis(8-hydroxyquinolinium) sulphate, except for the uses of the sulphate provided for in entry 51 of Annex III from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for Hydroxy-8-quinoline and its sulphate bis(8-hydroxyquinolinium) sulphate, except for the uses of the sulphate provided for in entry 51 of Annex III, but confirm any final regulatory decision against the current official annex wording and source files.

View sourcesView updates

Tools & next steps

Check your formula

Paste a full INCI list to detect Hydroxy-8-quinoline and its sulphate bis(8-hydroxyquinolinium) sulphate, except for the uses of the sulphate provided for in entry 51 of Annex III and other flagged EU annex records in one pass.

INCI Checker

Compare entries

Compare Hydroxy-8-quinoline and its sulphate bis(8-hydroxyquinolinium) sulphate, except for the uses of the sulphate provided for in entry 51 of Annex III side by side with another annex record to review differences in restrictions, concentrations and annex placement.

Compare

Browse the annex

See all records in Annex II and compare regulatory conditions across substances in this annex.

Open Annex II