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Methoxyisopropyl acetate

Canada Hotlist: Methoxyisopropyl acetate

Health Canada lists this ingredient as restricted; the listed conditions and warnings apply.

All Canada recordsOpen ingredient profileCompare all marketsOpen official source

Regulatory decision and full conditions

Status
Restricted
Legal role
Official guidance
Regulatory summary
Health Canada lists this ingredient as restricted; the listed conditions and warnings apply.
Conditions and restrictions
Synonyms or related compounds: Propylene glycol monomethyl ether acetate. · Maximum concentration: 0.5% total of 2-methoxypropanol (1589-47-5) and/or 2-methoxypropyl-1-acetate (70657-70-4)

Substance identity

Official source name
Methoxyisopropyl acetate
CAS
108-65-6; 84540-57-8
EC
203-603-9
Identity mapping
cas_number
Linked ingredient
METHOXYISOPROPYL ACETATE
Search this identity across the siteCAS 108-65-6CAS 84540-57-8EC 203-603-9

Linked CosIng identity data

Names and aliases

METHOXYISOPROPYL ACETATE

CosIng description: 2-methoxy-1-methylethyl acetate

Recorded cosmetic function: SOLVENT

Function pages:SOLVENT

View the complete ingredient profile

Cross-market snapshot for this identity

Exact linked records currently present in this site. An absent market means no imported exact match, not permission to use the substance.

1 market dataset
PubChem 2D chemical structure for CAS 108-65-6
CAS 108-65-6PubChem CID 7946

Verified chemistry for CAS 108-65-6

Propylene glycol methyl ether acetate

IUPAC name
1-methoxypropan-2-yl acetate
Molecular formula
C6H12O3
Molecular weight
132.16 g/mol
Exact mass
132.078644241 Da
Monoisotopic mass
132.078644241 Da
XLogP3
0.4
Topological polar surface area
35.5 Ų
Molecular complexity
90.0
Formal charge
0
Hydrogen-bond donors
0
Hydrogen-bond acceptors
3
Rotatable bonds
4
Heavy atoms
9
Covalent units
1

Names and synonyms reported to PubChem

PGMEA cpdRefChem:4334931-Methoxy-2-propyl acetatePropylene glycol monomethyl ether acetate2-Acetoxy-1-methoxypropane1-Methoxy-2-acetoxypropaneMETHOXYISOPROPYL ACETATE2-Methoxy-1-methylethyl acetate
16 more reported names
2-Propanol, 1-methoxy-, acetate1-METHOXY-2-PROPANOL ACETATEPropyleneglycol monomethyl ether acetateNSC 2207Acetic acid, 2-methoxy-1-methylethyl ester2-Propanol, 1-methoxy-, 2-acetatePropylene glycol 1-methyl ether 2-acetateNSC-2207PROPYLENEGLYCOLMETHYLETHERACETATEPA7O2U6S2QPropylene Glycol 1-Monomethyl Ether 2-Acetate1,2-Propanediol monomethyl ether acetatePropylene glycol monomethyl ether acetate (PMA)Dowanol (R) PMA glycol ether acetateEINECS 203-603-9UNII-PA7O2U6S2Q
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
1
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D pharmacophore features
2
3D rings
0
3D hydrophobes
0
3D acceptor features
2
3D donor features
0
3D anionic centres
0
3D cationic centres
0
3D conformers
10
Effective 3D rotors
4.0
Machine-readable structure identifiers
SMILES
CC(COC)OC(=O)C
InChI
InChI=1S/C6H12O3/c1-5(4-8-3)9-6(2)7/h5H,4H2,1-3H3
InChIKey
LLHKCFNBLRBOGN-UHFFFAOYSA-N

Evidence from additional scientific databases

NIH PubChem PUG-View
Exact identifier match7946

Attributed physical-property, hazard, environmental and use annotations.

  • First Aid: Call for medical aid.; EYES: Wash with water for 15 min.; call a physician.; SKIN: Remove contaminated clothing and wash skin with soap and water.; INGESTION: Induce vomiting after drinking two glasses of water. (USCG, 1999) Source: CAMEO Chemicals
  • Signal: Warning Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • GHS Hazard Statements: H226: Flammable liquid and vapor [Warning Flammable liquids] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Precautionary Statement Codes: P210, P233, P240, P241, P242, P243, P280, P303+P361+P353, P370+P378, P403+P235, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Note: This chemical does not meet GHS hazard criteria for < 0.1% (1 of 3028) of reports. Source: European Chemicals Agency (ECHA)
  • Signal: Warning Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H226 (> 99.9%): Flammable liquid and vapor [Warning Flammable liquids]; H336 (15.6%): May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P210, P233, P240, P241, P242, P243, P261, P271, P280, P303+P361+P353, P304+P340, P319, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 3028 reports by companies from 38 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Reported as not meeting GHS hazard criteria per 1 of 3028 reports by companies.; There are 37 notifications provided by 3027 of 3028 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Signal: Warning Source: NITE-CMC
  • GHS Hazard Statements: H320: Causes eye irritation [Warning Serious eye damage/eye irritation]; H336: May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects] Source: NITE-CMC
  • Precautionary Statement Codes: P261, P264+P265, P271, P304+P340, P305+P351+P338, P319, P337+P317, P403+P233, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • GHS Hazard Statements: H226: Flammable liquid and vapor [Warning Flammable liquids]; H320: Causes eye irritation [Warning Serious eye damage/eye irritation]; H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]; H336: May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects] Source: NITE-CMC
  • NFPA Health Rating: 1 - Materials that, under emergency conditions, can cause significant irritation. Source: Hazardous Substances Data Bank (HSDB)
  • NFPA Fire Rating: 2 - Materials that must be moderately heated or exposed to relatively high ambient temperatures before ignition can occur. Materials would not under normal conditions form hazardous atmospheres with air, but under high ambient temperatures or under moderate heating could release vapor in sufficient quantities to produce hazardous atmospheres with air. Source: Hazardous Substances Data Bank (HSDB)
  • NFPA Instability Rating: 0 - Materials that in themselves are normally stable, even under fire conditions. Source: Hazardous Substances Data Bank (HSDB)
  • Cosmetic Ingredient Review Finding(s): Safe in the present practices of use and concentration. Ingredient, concentration, and use information are available in documents discoverable at https://cir-reports.cir-safety.org Source: Cosmetic Ingredient Review (CIR)
  • Toxicity Summary: IDENTIFICATION AND USE: 1-Methoxy-2-propyl acetate is used as a solvent in cosmetic formulations, as well as in surface coatings, inks, and cleaners. HUMAN STUDIES: The substance defats the skin, which may cause dryness or cracking. It is irritating to the eyes and respiratory tract. Exposure at high levels could cause depression of the central nervous system. ANIMAL STUDIES: Watery eyes, anorexia, rapid shallow breathing, and excess salivation were observed in rats given a single dose of 4000, 6300, or 10,000 mg/kg 1-methoxy-2-propyl acetate. 1-Methoxy-2-propyl acetate was not a skin irritant in rabbits. 10% 1-methoxy-2-propyl acetate in water was not a sensitizer in a guinea pig maximization test. Some slight changes were observed in the appearance of renal tissues in rats exposed to 3000 ppm 1-methoxy-2-propyl acetate. Slight to moderate degeneration of the olfactory epithelium in the nasal cavities was seen in rats and in mice. 1-Methoxy-2-propyl acetate had no adverse effect on reproductive parameters in rat developmental studies. 1-Methoxy-2-propyl acetate did not induce mutations or toxicity in Salmonella typhimurium strains TA98, TA100, TA1535, or TA1537 or in Escherichia c Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Bioconcentration: An estimated BCF of 3 was calculated in fish for 1-methoxy-2-propyl acetate(SRC), using a log Kow of 0.56(1) and a regression-derived equation(1). According to a classification scheme(2), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), a measured log Koc of 0.362, corresponding to a Koc of 2.3(2) indicates that 1-methoxy-2-propyl acetate is expected to have very high mobility in soil(SRC). Volatilization of 1-methoxy-2-propyl acetate from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry's Law constant of 3.4X10-6 atm-cu m/mole(SRC), based upon its vapor pressure, 3.92 mm Hg(3), and water solubility, 1.98X10+5 mg/L(2). 1-Methoxy-2-propyl acetate is expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(2). 50% Biodegradation in less than one day using sandy and sandy loam soils(4) suggests that biodegradation is an important environmental fate process in soil(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), a measured log Koc of 0.362, corresponding to a Koc of 2.3(2) indicates that 1-methoxy-2-propyl acetate is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon an estimated Henry's Law constant of 3.4X10-6 atm-cu m/mole(SRC), derived from its vapor pressure, 3.92 mm Hg(4), and water solubility, 1.2X10+5 mg/L(2). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 12 and 93 days, respectively(SRC). According to a classification scheme(5), an estimated BCF of 3(SRC), from its log Kow of 0.56(2) and a regression-derived equation(6), suggests the potential for bioconcentration in aquatic organisms is low(SRC). 100% Biodegadation in the Zahn-Wellens test(7) indicates that biodegradation is an important environmental fate process in water(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 1-methoxy-2-propyl acetate, which has a vapor pressure of 3.92 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase 1-methoxy-2-propyl acetate is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 32 hrs(SRC), calculated from its rate constant of 1.2X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). d(1); this corresponds to half-lives of 2.4 yrs and 88 days at pH values of 7 and 8, respectively(1). Using an atmospheric simulation chamber, no photolysis of 1-methoxy-2-propyl acetate was observed(4); therefore, the compound is not expected to be susceptible to direct photolysis by sunlight(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Consumer Uses: Cleaning agent; Not Known or Reasonably Ascertainable; Filler; Hardener; Pigment; Defoamer; Polymerization promoter; Dispersing agent; Solvent; Insulators; Binder; Monomers; Semiconductor and photovoltaic agent; Tanning agents not otherwise specified Source: EPA Chemical Data Reporting (CDR)
  • Industry Uses: Not Known or Reasonably Ascertainable; Diluent; Cleaning agent; Hardener; Pigment; Drier; Adhesion/cohesion promoter; Intermediate; Other; Binder; Polymerization promoter; Solvent; Dispersing agent; Plating agent; Chemical reaction regulator; UV stabilizer; Processing aids not otherwise specified; Semiconductor and photovoltaic agent; Monomers; Tanning agents not otherwise specified Source: EPA Chemical Data Reporting (CDR)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Official source and provenance

Registered source
Health Canada Cosmetic Ingredient Hotlist
Source reference
Hotlist restricted entry 54
Source record ID
restricted:54
Source version
Health Canada Hotlist 2025-08-13
Source language
English
Translation status
Original is English
Source updated
2025-08-13
Snapshot checked
2026-08-30 04:07 UTC
Validation method
strict HTML tables t1=490 and t2=90
SHA-256
8b52ff573d08373ee90121f6a701b3607e4a3d6fc748a7d56171eb53510af91a

Registered dataset notes

Dataset coverage
Administrative prohibitions, restrictions, conditions and warning requirements
Authority note
Official Health Canada compliance indicator; not a complete safety clearance
Inspect the exact official sourceRegulator guidance

How this record fits the market dataset

580
current Canada records
90
records marked Restricted
580
records from this source version
516
market records with CAS identity

Status distribution

Prohibited: 490Restricted: 90

Condition text is present on 172 of 580 current records. An empty condition field is interpreted according to the record type above; it is never converted into an unrestricted-use claim.

Canada market context

Complete Hotlist snapshot

Coverage version: Health Canada Cosmetic Ingredient Hotlist, 13 August 2025

All prohibited and restricted Hotlist entries, including conditions and warning requirements published in the official list.

Verification checklist

  1. Search English/French names and CAS identifiers.
  2. Apply every restriction, concentration and label warning.
  3. Check Food and Drugs Act/Cosmetic Regulations requirements.
  4. Recheck the current Hotlist before notification or sale.

Official market sources

Verification workflow and record completeness

Before using this result in a compliance decision

  1. Confirm that “Methoxyisopropyl acetate” and every CAS/EC identifier refer to the material in your supplier specification.
  2. Search English/French names and CAS identifiers.
  3. Apply every restriction, concentration and label warning.
  4. Check Food and Drugs Act/Cosmetic Regulations requirements.
  5. Recheck the current Hotlist before notification or sale.
  6. Document the source version and recheck the regulator before manufacture, notification or market placement.

Fields available in this record

  • Official substance nameAvailable
  • CASAvailable
  • ECAvailable
  • Separate condition textAvailable
  • Effective dateNot supplied
  • Snapshot hash and methodAvailable

Questions this page answers

This substance is not unrestricted: cosmetic use is subject to the conditions in the cited official record. Check product type, body area, concentration, purity and warning requirements before deciding whether a formulation is compliant.

If this row does not reproduce conditions, open the cited official detail because omission does not mean unrestricted use. The Hotlist is an administrative compliance tool, not an exhaustive safety approval list.

The record cites Hotlist restricted entry 54, source version Health Canada Hotlist 2025-08-13. Open the official source.

No. CAS helps resolve identity, but jurisdictions can classify the same substance differently and can apply different product scopes, limits, warnings and transition dates.

Stable citation

Methoxyisopropyl acetate. Hotlist restricted entry 54. Canada. Source version Health Canada Hotlist 2025-08-13. CosIng Checker regulatory record: https://cosingchecker.com/regulations/ca/records/544/

Cite the regulator as the legal authority. This page is a structured evidence index and verification aid, not a substitute for the official text or professional legal assessment.

Interpretation and limits for Canada

This substance is not unrestricted: cosmetic use is subject to the conditions in the cited official record.

Check product type, body area, concentration, purity and warning requirements before deciding whether a formulation is compliant.

How to interpret the legal role

The authority uses this source as compliance guidance; the underlying legislation remains controlling.

Evidence on this page

  • Recorded outcome: Restricted
  • Legal role: Official guidance
  • Source version: Health Canada Hotlist 2025-08-13

What it does not prove

The Hotlist is an administrative compliance tool, not an exhaustive safety approval list.

Further authoritative substance research

These sources can add identity, safety, exposure or hazard context. A link is not evidence that the database contains this exact substance, and none of these sources overrides the market decision above.

Cosmetic Ingredient Review safety assessments

Expert Panel conclusions, assessed ingredient groups, use conditions, dates and report documents

Independent expert review considered by FDA; not a government approval or binding market rule

Research this identity at the source

FDA Global Substance Registration System

UNII identifiers, preferred names, substance types, codes and public substance relationships

Identity registry only; UNII availability does not imply FDA review or approval

Research this identity at the source

ILO/WHO International Chemical Safety Cards

Hazards, symptoms, first aid, storage, incompatibilities and physical properties for covered chemicals

International occupational chemical-safety reference; not cosmetic-use approval

Research this identity at the source

Japan NITE-CHRIP

Chemical identity, Japanese and foreign legal lists, GHS hazards and exposure-related information

Chemical-management evidence; cosmetic status remains governed by the applicable MHLW standard and market rules

Research this identity at the source

NIOSH Pocket Guide to Chemical Hazards

REL, PEL, IDLH, properties, exposure routes, symptoms, target organs, first aid and measurement methods for covered workplace chemicals

US occupational-health guidance and limits; not a cosmetic ingredient decision

Research this identity at the source

OECD eChemPortal

Gateway to authority-owned physical-property, fate, ecotoxicity, toxicity, exposure and GHS records

Discovery gateway; each linked authority remains responsible for its data

Research this identity at the source

US EPA CompTox CTX APIs

API key required for import

DTXSID identity, experimental and predicted properties, toxicity, bioactivity, exposure and environmental data

Scientific and computational evidence; predictions must remain labelled and do not determine cosmetic legality

Research this identity at the source