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Fluoride containing substances

Canada Hotlist: Fluoride containing substances

Health Canada lists this ingredient as restricted; the listed conditions and warnings apply.

All Canada recordsOpen ingredient profileCompare all marketsOpen official source

Regulatory decision and full conditions

Status
Restricted
Legal role
Official guidance
Regulatory summary
Health Canada lists this ingredient as restricted; the listed conditions and warnings apply.
Conditions and restrictions
Synonyms or related compounds: Sodium fluoride; Calcium fluoride; Stannous fluoride; Sodium monofluorophosphate | a) Not permitted in oral products. | b) other products

Substance identity

Official source name
Fluoride containing substances
CAS
16984-48-8; 1333-83-1; 7681-49-4; 7789-75-5; 7783-47-3; 10163-15-2
EC
Not supplied in this source row
Identity mapping
Exact CAS: 7681-49-4
Linked ingredient
SODIUM FLUORIDE
Search this identity across the siteCAS 16984-48-8CAS 1333-83-1CAS 7681-49-4CAS 7789-75-5CAS 7783-47-3CAS 10163-15-2

Linked CosIng identity data

Names and aliases

SODIUM FLUORIDEsodium fluoridenatrii fluoridum

CosIng description: Sodium fluoride

EU inventory restriction note: III/31

Recorded cosmetic function: ANTIPLAQUE, ORAL CARE

Function pages:ANTIPLAQUE, ORAL CARE

View the complete ingredient profile

Cross-market snapshot for this identity

Exact linked records currently present in this site. An absent market means no imported exact match, not permission to use the substance.

7 market datasets
PubChem 2D chemical structure for CAS 10163-15-2
CAS 10163-15-2PubChem CID 24266

Verified chemistry for CAS 10163-15-2

Sodium Monofluorophosphate

IUPAC name
disodium;fluoro-dioxido-oxo-lambda5-phosphane
Molecular formula
FNa2O3P
Molecular weight
143.950 g/mol
Exact mass
143.93644758 Da
Monoisotopic mass
143.93644758 Da
Topological polar surface area
63.2 Ų
Molecular complexity
49.0
Formal charge
0
Hydrogen-bond donors
0
Hydrogen-bond acceptors
4
Rotatable bonds
0
Heavy atoms
7
Covalent units
3

Names and synonyms reported to PubChem

Phosphorofluoridic acid, disodium saltExtra-Strength AimC810JCZ56QNSC-248bridentsmilecareRegularRembrandt
16 more reported names
SaliveaBarbieOrazenPriyalSparkleFreshMyntSmilepurple toothSmartMouthAGToothpasteCloveden ToothDeCureFinefra SilverGlancure ToothHello WhiteningKroger CompanyNatures Promise
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D conformers
0
Machine-readable structure identifiers
SMILES
[O-]P(=O)([O-])F.[Na+].[Na+]
InChI
InChI=1S/FH2O3P.2Na/c1-5(2,3)4;;/h(H2,2,3,4);;/q;2*+1/p-2
InChIKey
BFDWBSRJQZPEEB-UHFFFAOYSA-L

Evidence from additional scientific databases

EMBL-EBI ChEBI
Exact identifier matchCHEBI:86431

sodium fluorophosphate

Sodium fluorophosphate, commonly abbreviated MFP, is an inorganic compound with the chemical formula Na2PO3F. Typical for a salt, MFP is odourless, colourless, and water-soluble. This salt is an ingredient in toothpastes.

Formula
FO3P.2Na
Average mass
143.949 g/mol
Monoisotopic mass
143.93645 Da
Formal charge
0
  • inorganic sodium salt — is a (CHEBI:38702)
  • inorganic phosphate — is a (CHEBI:24838)
  • antibacterial agent — has role (CHEBI:33282)
  • antibacterial agent — has role (CHEBI:33282)
  • inorganic sodium salt — is a (CHEBI:38702)
  • inorganic phosphate — is a (CHEBI:24838)
Additional curated names
disodium phosphorofluoridatedisodium fluorophosphatedisodium monofluorophosphateNSC-248Phosphorofluoridic acid, disodium saltSodium fluorophosphatesodium monofluorophosphateSodium phosphorofluoridate
Cross-references from this source

Mapped by: Exact CAS cross-reference in the ChEBI compound record. Source updated: 2015-07-24. Retrieved: 2026-08-31. Open source record

NIH PubChem PUG-View
Exact identifier match24266

Attributed physical-property, hazard, environmental and use annotations.

  • Note: This chemical does not meet GHS hazard criteria for 1.4% (1 of 72) of reports. Source: European Chemicals Agency (ECHA)
  • Signal: Warning Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H302 (91.7%): Harmful if swallowed [Warning Acute toxicity, oral]; H315 (11.1%): Causes skin irritation [Warning Skin corrosion/irritation] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P264, P270, P280, P301+P317, P302+P352, P321, P330, P332+P317, P362+P364, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 72 reports by companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Reported as not meeting GHS hazard criteria per 1 of 72 reports by companies.; There are 4 notifications provided by 71 of 72 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]; H312 (100%): Harmful in contact with skin [Warning Acute toxicity, dermal]; H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]; H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H332 (100%): Harmful if inhaled [Warning Acute toxicity, inhalation]; H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 8 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
EMBL-EBI ChEBIExact match2026-08-31
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 1333-83-1
CAS 1333-83-1PubChem CID 219061

Verified chemistry for CAS 1333-83-1

Sodium hydrogen difluoride

IUPAC name
sodium;fluoride;hydrofluoride
Molecular formula
F2HNa
Molecular weight
61.9946 g/mol
Exact mass
61.99440064 Da
Monoisotopic mass
61.99440064 Da
Topological polar surface area
0.0 Ų
Molecular complexity
2.0
Formal charge
0
Hydrogen-bond donors
1
Hydrogen-bond acceptors
2
Rotatable bonds
0
Heavy atoms
3
Covalent units
3

Names and synonyms reported to PubChem

Sodium bifluorideSodium acid fluorideSodium hydrogen fluorideSodium hydrogendifluorideCaswell No. 747AFluoruro acido de sodioHSDB 5820Fluorure acide de soodium
16 more reported names
Fluoruro acido de sodio [Spanish]Fluorure acide de soodium [French]EINECS 215-608-3Sodium fluoride (NaF), mixt. contgUN2439Sodium fluoride-hydrofluoric acid mixtEPA Pesticide Chemical Code 0752013W2KK83V5GHydrofluoric acid, mixt. with sodium fluorideSODIUM BIFLUORIDE [MI]EC 215-608-3Hydrofluoric acid, mixt. with sodium fluoride (NaF)SODIUM HYDROGEN DIFLUORIDE [HSDB]Fluoruro acido de sodio (Spanish)SODIUM DIFLUORIDESODIUM BIFLUORIDE, (SOLID)
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D conformers
0
Machine-readable structure identifiers
SMILES
F.[F-].[Na+]
InChI
InChI=1S/2FH.Na/h2*1H;/q;;+1/p-1
InChIKey
BFXAWOHHDUIALU-UHFFFAOYSA-M

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 16984-48-8
CAS 16984-48-8PubChem CID 28179

Verified chemistry for CAS 16984-48-8

Fluoride Ion

IUPAC name
fluoride
Molecular formula
F-
Formula without charge
F
Molecular weight
18.99840316 g/mol
Exact mass
18.998403162 Da
Monoisotopic mass
18.998403162 Da
XLogP3
0.6
Topological polar surface area
0.0 Ų
Molecular complexity
0.0
Formal charge
-1
Hydrogen-bond donors
0
Hydrogen-bond acceptors
1
Rotatable bonds
0
Heavy atoms
1
Covalent units
1

Names and synonyms reported to PubChem

Fluoride ion(1-)PerfluorideFluorine ionFluoride(1-)Fluoride ion(F-)Fluorine ion(1-)Drinking water, fluoride treatedF-
16 more reported names
UNII-Q80VPU408OQ80VPU408OFLURORIDE-IONFLUORINE ION(F1-)CHEBI:17051F(-)Fluorine-RefChem:5836Topex Neutral pH Fluoride GelTopex Neutral pH Fluoride GelMintTopex Neutral pH Fluoride GelStrawberryFLUORIDE STANDARDCHEMBL1362Fluoride dustFluoridesFluoride as dust
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D conformers
0
Machine-readable structure identifiers
SMILES
[F-]
InChI
InChI=1S/FH/h1H/p-1
InChIKey
KRHYYFGTRYWZRS-UHFFFAOYSA-M

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 7681-49-4
CAS 7681-49-4PubChem CID 5235

Verified chemistry for CAS 7681-49-4

Sodium Fluoride

IUPAC name
sodium fluoride
Molecular formula
FNa
Molecular weight
41.9881724 g/mol
Exact mass
41.98817244 Da
Monoisotopic mass
41.98817244 Da
Topological polar surface area
0.0 Ų
Molecular complexity
2.0
Formal charge
0
Hydrogen-bond donors
0
Hydrogen-bond acceptors
1
Rotatable bonds
0
Heavy atoms
2
Covalent units
2

Names and synonyms reported to PubChem

Sodium fluoride (NaF)Fluoride, sodiumFlorocidPerganteneZymafluorPediaflorOssinSodium flouride
16 more reported names
FluonatrilFluoridentSodium monofluorideVilliaumiteAntibulitFloridineFluoradayFluorolFlursolKaridiumKoreberonLiquiflurOssalinXaridiumFluraLuride
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D conformers
0
Machine-readable structure identifiers
SMILES
[F-].[Na+]
InChI
InChI=1S/FH.Na/h1H;/q;+1/p-1
InChIKey
PUZPDOWCWNUUKD-UHFFFAOYSA-M

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 7783-47-3
CAS 7783-47-3PubChem CID 24550

Verified chemistry for CAS 7783-47-3

Stop

IUPAC name
difluorotin
Molecular formula
F2Sn
Molecular weight
156.71 g/mol
Exact mass
157.899009 Da
Monoisotopic mass
157.899009 Da
Topological polar surface area
0.0 Ų
Molecular complexity
2.0
Formal charge
0
Hydrogen-bond donors
0
Hydrogen-bond acceptors
2
Rotatable bonds
0
Heavy atoms
3
Covalent units
1

Names and synonyms reported to PubChem

STANNOUS FLUORIDETin difluorideTin bifluorideTin Fluoride (SnF2)EasygelStancareStanideCrest
16 more reported names
Iradicar SnF2Iradicav SnF2King's Gel-TinCap-Tin MouthrinseStop Home TreatmentIradicar Stannous FluorideStannous fluoride (SnF2)Stannous fluoride (USP)Stannous fluoride [USP]BurkhartEvernamelFluoridexGingimedOmnigelStangardWhitening
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D conformers
0
Machine-readable structure identifiers
SMILES
F[Sn]F
InChI
InChI=1S/2FH.Sn/h2*1H;/q;;+2/p-2
InChIKey
ANOBYBYXJXCGBS-UHFFFAOYSA-L

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 7789-75-5
CAS 7789-75-5PubChem CID 84512

Verified chemistry for CAS 7789-75-5

Calcium Fluoride

Calcium difluoride is an inorganic calcium salt and a calcium salt. — ChEBI

IUPAC name
calcium difluoride
Molecular formula
CaF2
Molecular weight
78.07 g/mol
Exact mass
77.9593972 Da
Monoisotopic mass
77.9593972 Da
Topological polar surface area
0.0 Ų
Molecular complexity
0.0
Formal charge
0
Hydrogen-bond donors
0
Hydrogen-bond acceptors
2
Rotatable bonds
0
Heavy atoms
3
Covalent units
3

Names and synonyms reported to PubChem

FluorsparCHEBI:35437Calc FluorFluoride, CalciumCalc Fluor 6XCalc Fluor 12XCalc Fluor 30XAmethyst 8104
16 more reported names
Calc Fluor 200XFluorite 8118CALCAREA FLOURCALCAREA FLUORRefChem:5634TONICPET 1Calcarea Fluorica 8001CALCAREA FLUORICA 6X232-188-7Bestmade Natural Products Calc FluorJacksons Cell Salts CALC FLUOR 6XJacksons Cell Salts CALC FLUOR 6X 1D-121Calcarea FluoricaCalcium fluoratumCalcium fluoride (CaF2)
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D conformers
0
Machine-readable structure identifiers
SMILES
[F-].[F-].[Ca+2]
InChI
InChI=1S/Ca.2FH/h;2*1H/q+2;;/p-2
InChIKey
WUKWITHWXAAZEY-UHFFFAOYSA-L

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Official source and provenance

Registered source
Health Canada Cosmetic Ingredient Hotlist
Source reference
Hotlist restricted entry 39
Source record ID
restricted:39
Source version
Health Canada Hotlist 2025-08-13
Source language
English
Translation status
Original is English
Source updated
2025-08-13
Snapshot checked
2026-08-30 04:07 UTC
Validation method
strict HTML tables t1=490 and t2=90
SHA-256
8b52ff573d08373ee90121f6a701b3607e4a3d6fc748a7d56171eb53510af91a

Registered dataset notes

Dataset coverage
Administrative prohibitions, restrictions, conditions and warning requirements
Authority note
Official Health Canada compliance indicator; not a complete safety clearance
Inspect the exact official sourceRegulator guidance

How this record fits the market dataset

580
current Canada records
90
records marked Restricted
580
records from this source version
516
market records with CAS identity

Status distribution

Prohibited: 490Restricted: 90

Condition text is present on 172 of 580 current records. An empty condition field is interpreted according to the record type above; it is never converted into an unrestricted-use claim.

Canada market context

Complete Hotlist snapshot

Coverage version: Health Canada Cosmetic Ingredient Hotlist, 13 August 2025

All prohibited and restricted Hotlist entries, including conditions and warning requirements published in the official list.

Verification checklist

  1. Search English/French names and CAS identifiers.
  2. Apply every restriction, concentration and label warning.
  3. Check Food and Drugs Act/Cosmetic Regulations requirements.
  4. Recheck the current Hotlist before notification or sale.

Official market sources

Verification workflow and record completeness

Before using this result in a compliance decision

  1. Confirm that “Fluoride containing substances” and every CAS/EC identifier refer to the material in your supplier specification.
  2. Search English/French names and CAS identifiers.
  3. Apply every restriction, concentration and label warning.
  4. Check Food and Drugs Act/Cosmetic Regulations requirements.
  5. Recheck the current Hotlist before notification or sale.
  6. Document the source version and recheck the regulator before manufacture, notification or market placement.

Fields available in this record

  • Official substance nameAvailable
  • CASAvailable
  • ECNot supplied
  • Separate condition textAvailable
  • Effective dateNot supplied
  • Snapshot hash and methodAvailable

Questions this page answers

This substance is not unrestricted: cosmetic use is subject to the conditions in the cited official record. Check product type, body area, concentration, purity and warning requirements before deciding whether a formulation is compliant.

If this row does not reproduce conditions, open the cited official detail because omission does not mean unrestricted use. The Hotlist is an administrative compliance tool, not an exhaustive safety approval list.

The record cites Hotlist restricted entry 39, source version Health Canada Hotlist 2025-08-13. Open the official source.

No. CAS helps resolve identity, but jurisdictions can classify the same substance differently and can apply different product scopes, limits, warnings and transition dates.

Stable citation

Fluoride containing substances. Hotlist restricted entry 39. Canada. Source version Health Canada Hotlist 2025-08-13. CosIng Checker regulatory record: https://cosingchecker.com/regulations/ca/records/529/

Cite the regulator as the legal authority. This page is a structured evidence index and verification aid, not a substitute for the official text or professional legal assessment.

Interpretation and limits for Canada

This substance is not unrestricted: cosmetic use is subject to the conditions in the cited official record.

Check product type, body area, concentration, purity and warning requirements before deciding whether a formulation is compliant.

How to interpret the legal role

The authority uses this source as compliance guidance; the underlying legislation remains controlling.

Evidence on this page

  • Recorded outcome: Restricted
  • Legal role: Official guidance
  • Source version: Health Canada Hotlist 2025-08-13

What it does not prove

The Hotlist is an administrative compliance tool, not an exhaustive safety approval list.

Further authoritative substance research

These sources can add identity, safety, exposure or hazard context. A link is not evidence that the database contains this exact substance, and none of these sources overrides the market decision above.

Cosmetic Ingredient Review safety assessments

Expert Panel conclusions, assessed ingredient groups, use conditions, dates and report documents

Independent expert review considered by FDA; not a government approval or binding market rule

Research this identity at the source

FDA Global Substance Registration System

UNII identifiers, preferred names, substance types, codes and public substance relationships

Identity registry only; UNII availability does not imply FDA review or approval

Research this identity at the source

ILO/WHO International Chemical Safety Cards

Hazards, symptoms, first aid, storage, incompatibilities and physical properties for covered chemicals

International occupational chemical-safety reference; not cosmetic-use approval

Research this identity at the source

Japan NITE-CHRIP

Chemical identity, Japanese and foreign legal lists, GHS hazards and exposure-related information

Chemical-management evidence; cosmetic status remains governed by the applicable MHLW standard and market rules

Research this identity at the source

NIOSH Pocket Guide to Chemical Hazards

REL, PEL, IDLH, properties, exposure routes, symptoms, target organs, first aid and measurement methods for covered workplace chemicals

US occupational-health guidance and limits; not a cosmetic ingredient decision

Research this identity at the source

OECD eChemPortal

Gateway to authority-owned physical-property, fate, ecotoxicity, toxicity, exposure and GHS records

Discovery gateway; each linked authority remains responsible for its data

Research this identity at the source

US EPA CompTox CTX APIs

API key required for import

DTXSID identity, experimental and predicted properties, toxicity, bioactivity, exposure and environmental data

Scientific and computational evidence; predictions must remain labelled and do not determine cosmetic legality

Research this identity at the source