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ProhibitedOfficial guidanceCAOriginal is EnglishOfficial-source import checked

Sulfonamides and their salts obtained by substitution of one or more H-atoms of the -NH2 groups

Canada Hotlist: Sulfonamides and their salts obtained by substitution of one or more H-atoms of the -NH2 groups

Health Canada lists this ingredient as prohibited for use in cosmetic products.

All Canada recordsCompare all marketsOpen official source

Regulatory decision and full conditions

Status
Prohibited
Legal role
Official guidance
Regulatory summary
Health Canada lists this ingredient as prohibited for use in cosmetic products.
Conditions and restrictions
A prohibition entry may contain no separate condition text because the regulatory outcome is the prohibition itself. Open the cited source and apply the market-wide requirements below.

Substance identity

Official source name
Sulfonamides and their salts obtained by substitution of one or more H-atoms of the -NH2 groups
CAS
63-74-1; 10103-15-8; 6101-31-1; 723-46-6
EC
Not supplied in this source row
Identity mapping
standalone:cas_number
Search this identity across the siteCAS 63-74-1CAS 10103-15-8CAS 6101-31-1CAS 723-46-6

Cross-market snapshot for this identity

Exact linked records currently present in this site. An absent market means no imported exact match, not permission to use the substance.

4 market datasets
PubChem 2D chemical structure for CAS 10103-15-8
CAS 10103-15-8PubChem CID 12226950

Verified chemistry for CAS 10103-15-8

Sulfanilamide Sodium

IUPAC name
sodium (4-aminophenyl)sulfonylazanide
Molecular formula
C6H7N2NaO2S
Molecular weight
194.19 g/mol
Exact mass
194.01259293 Da
Monoisotopic mass
194.01259293 Da
Topological polar surface area
69.5 Ų
Molecular complexity
216.0
Formal charge
0
Hydrogen-bond donors
2
Hydrogen-bond acceptors
4
Rotatable bonds
1
Heavy atoms
12
Covalent units
2

Names and synonyms reported to PubChem

Sodium sulfanilamideSulfanilamide, monosodium salt4ZB6W6B524RefChem:186525Sulfanilamide Sodium SaltBenzenesulfonamide, 4-amino-, monosodium saltsodium;(4-aminophenyl)sulfonylazanideSodium ((4-aminophenyl)sulfonyl)amide
5 more reported names
Sulfanilamid natriumUNII-4ZB6W6B524Sulfadimethoxine Impurity 23SULFANILAMIDE MONOSODIUMSodium (4-aminobenzene-1-sulfonyl)azanide
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D conformers
0
Machine-readable structure identifiers
SMILES
C1=CC(=CC=C1N)S(=O)(=O)[NH-].[Na+]
InChI
InChI=1S/C6H7N2O2S.Na/c7-5-1-3-6(4-2-5)11(8,9)10;/h1-4H,7H2,(H-,8,9,10);/q-1;+1
InChIKey
CGRKCGWEOIQFRD-UHFFFAOYSA-N

Evidence from additional scientific databases

NIH PubChem PUG-View
Exact identifier match12226950

Attributed physical-property, hazard, environmental and use annotations.

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
EMBL-EBI ChEBINo exact record2026-08-31
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 6101-31-1
CAS 6101-31-1PubChem CID 80197

Verified chemistry for CAS 6101-31-1

Sulfanilamide Hydrochloride

IUPAC name
4-aminobenzenesulfonamide;hydrochloride
Molecular formula
C6H9ClN2O2S
Molecular weight
208.67 g/mol
Exact mass
208.0073264 Da
Monoisotopic mass
208.0073264 Da
Topological polar surface area
94.6 Ų
Molecular complexity
211.0
Formal charge
0
Hydrogen-bond donors
3
Hydrogen-bond acceptors
4
Rotatable bonds
1
Heavy atoms
12
Covalent units
2

Names and synonyms reported to PubChem

Sulfanilamide monohydrochlorideR2MR7LN8WPRefChem:9323694-aminobenzenesulfonamide hydrochloride4-AMINOBENZENESULPHONAMIDE HCL4-aminobenzenesulphonamide hydrochloride4-aminobenzene-1-sulfonamide hydrochlorideSulfanilamide HCl
9 more reported names
Sulfanilamide, monohydrochloridePABIAMIDUNII-R2MR7LN8WPBenzenesulfonamide, 4-amino-, monohydrochlorideXZMIAZCXISFPEJ-UHFFFAOYSA-NAS-60080CS-04541454-Aminobenzene-1-sulfonamide--hydrogen chloride (1/1)BENZENESULFONAMIDE, 4-AMINO-, HYDROCHLORIDE (1:1)
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D conformers
0
Machine-readable structure identifiers
SMILES
C1=CC(=CC=C1N)S(=O)(=O)N.Cl
InChI
InChI=1S/C6H8N2O2S.ClH/c7-5-1-3-6(4-2-5)11(8,9)10;/h1-4H,7H2,(H2,8,9,10);1H
InChIKey
XZMIAZCXISFPEJ-UHFFFAOYSA-N

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 63-74-1
CAS 63-74-1PubChem CID 5333

Verified chemistry for CAS 63-74-1

Sulfanilamide

IUPAC name
4-aminobenzenesulfonamide
Molecular formula
C6H8N2O2S
Molecular weight
172.21 g/mol
Exact mass
172.03064868 Da
Monoisotopic mass
172.03064868 Da
XLogP3
-0.6
Topological polar surface area
94.6 Ų
Molecular complexity
211.0
Formal charge
0
Hydrogen-bond donors
2
Hydrogen-bond acceptors
4
Rotatable bonds
1
Heavy atoms
11
Covalent units
1

Names and synonyms reported to PubChem

SulphanilamideSulfaminep-AminobenzenesulfonamideSulfonamideSulphonamideProntylinSulfonylamideBacteramid
16 more reported names
Prontosil AlbumProntosil IEstreptocidap-AminobenzenesulfamideStreptasolStreptocidp-Sulfamoylaniline4-SulfamoylanilineSulfonamide PBenzenesulfonamide, 4-amino-4-Aminobenzene-1-SulfonamideAntistreptAstreptineCollomideColsulanydeCopticide
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D pharmacophore features
6
3D rings
1
3D hydrophobes
0
3D acceptor features
2
3D donor features
2
3D anionic centres
0
3D cationic centres
1
3D conformers
1
Effective 3D rotors
1.0
Machine-readable structure identifiers
SMILES
C1=CC(=CC=C1N)S(=O)(=O)N
InChI
InChI=1S/C6H8N2O2S/c7-5-1-3-6(4-2-5)11(8,9)10/h1-4H,7H2,(H2,8,9,10)
InChIKey
FDDDEECHVMSUSB-UHFFFAOYSA-N

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 723-46-6
CAS 723-46-6PubChem CID 5329

Verified chemistry for CAS 723-46-6

Sulfamethoxazole

IUPAC name
4-amino-N-(5-methyl-1,2-oxazol-3-yl)benzenesulfonamide
Molecular formula
C10H11N3O3S
Molecular weight
253.28 g/mol
Exact mass
253.05211239 Da
Monoisotopic mass
253.05211239 Da
XLogP3
0.9
Topological polar surface area
107.0 Ų
Molecular complexity
346.0
Formal charge
0
Hydrogen-bond donors
2
Hydrogen-bond acceptors
6
Rotatable bonds
3
Heavy atoms
17
Covalent units
1

Names and synonyms reported to PubChem

GantanolSulphamethoxazoleSulfisomezoleSulfamethoxazol4-Amino-N-(5-methyl-3-isoxazolyl)benzenesulfonamideRadonilSinomin4-amino-N-(5-methylisoxazol-3-yl)benzenesulfonamide
16 more reported names
SulfamethylisoxazoleSulfamethalazoleAzo-gantanolUrobakSulfamethoxizoleGantanol-DSRo 4-2130SulfametoxazolGamazole3-Sulfanilamido-5-methylisoxazoleSulfamethoxazolumBenzenesulfonamide, 4-amino-N-(5-methyl-3-isoxazolyl)-5-Methyl-3-sulfanilamidoisoxazoleMS 533-(p-Aminophenylsulfonamido)-5-methylisoxazole3-(para-Aminophenylsulphonamido)-5-methylisoxazole
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D pharmacophore features
8
3D rings
2
3D hydrophobes
0
3D acceptor features
3
3D donor features
2
3D anionic centres
0
3D cationic centres
1
3D conformers
10
Effective 3D rotors
3.0
Machine-readable structure identifiers
SMILES
CC1=CC(=NO1)NS(=O)(=O)C2=CC=C(C=C2)N
InChI
InChI=1S/C10H11N3O3S/c1-7-6-10(12-16-7)13-17(14,15)9-4-2-8(11)3-5-9/h2-6H,11H2,1H3,(H,12,13)
InChIKey
JLKIGFTWXXRPMT-UHFFFAOYSA-N

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Official source and provenance

Registered source
Health Canada Cosmetic Ingredient Hotlist
Source reference
Hotlist prohibited entry 430
Source record ID
prohibited:430
Source version
Health Canada Hotlist 2025-08-13
Source language
English
Translation status
Original is English
Source updated
2025-08-13
Snapshot checked
2026-08-30 04:07 UTC
Validation method
strict HTML tables t1=490 and t2=90
SHA-256
8b52ff573d08373ee90121f6a701b3607e4a3d6fc748a7d56171eb53510af91a

Registered dataset notes

Dataset coverage
Administrative prohibitions, restrictions, conditions and warning requirements
Authority note
Official Health Canada compliance indicator; not a complete safety clearance
Inspect the exact official sourceRegulator guidance

How this record fits the market dataset

580
current Canada records
490
records marked Prohibited
580
records from this source version
516
market records with CAS identity

Status distribution

Prohibited: 490Restricted: 90

Condition text is present on 172 of 580 current records. An empty condition field is interpreted according to the record type above; it is never converted into an unrestricted-use claim.

Canada market context

Complete Hotlist snapshot

Coverage version: Health Canada Cosmetic Ingredient Hotlist, 13 August 2025

All prohibited and restricted Hotlist entries, including conditions and warning requirements published in the official list.

Verification checklist

  1. Search English/French names and CAS identifiers.
  2. Apply every restriction, concentration and label warning.
  3. Check Food and Drugs Act/Cosmetic Regulations requirements.
  4. Recheck the current Hotlist before notification or sale.

Official market sources

Verification workflow and record completeness

Before using this result in a compliance decision

  1. Confirm that “Sulfonamides and their salts obtained by substitution of one or more H-atoms of the -NH2 groups” and every CAS/EC identifier refer to the material in your supplier specification.
  2. Search English/French names and CAS identifiers.
  3. Apply every restriction, concentration and label warning.
  4. Check Food and Drugs Act/Cosmetic Regulations requirements.
  5. Recheck the current Hotlist before notification or sale.
  6. Document the source version and recheck the regulator before manufacture, notification or market placement.

Fields available in this record

  • Official substance nameAvailable
  • CASAvailable
  • ECNot supplied
  • Separate condition textNot present in source row
  • Effective dateNot supplied
  • Snapshot hash and methodAvailable

Questions this page answers

This official record identifies the substance as prohibited for cosmetic use in the stated market scope. Do not rely on a formulation containing this identity until the cited source, effective date and exact substance match have been verified.

A prohibition entry may contain no separate condition text because the regulatory outcome is the prohibition itself. The Hotlist is an administrative compliance tool, not an exhaustive safety approval list.

The record cites Hotlist prohibited entry 430, source version Health Canada Hotlist 2025-08-13. Open the official source.

No. CAS helps resolve identity, but jurisdictions can classify the same substance differently and can apply different product scopes, limits, warnings and transition dates.

Stable citation

Sulfonamides and their salts obtained by substitution of one or more H-atoms of the -NH2 groups. Hotlist prohibited entry 430. Canada. Source version Health Canada Hotlist 2025-08-13. CosIng Checker regulatory record: https://cosingchecker.com/regulations/ca/records/430/

Cite the regulator as the legal authority. This page is a structured evidence index and verification aid, not a substitute for the official text or professional legal assessment.

Interpretation and limits for Canada

This official record identifies the substance as prohibited for cosmetic use in the stated market scope.

Do not rely on a formulation containing this identity until the cited source, effective date and exact substance match have been verified.

How to interpret the legal role

The authority uses this source as compliance guidance; the underlying legislation remains controlling.

Evidence on this page

  • Recorded outcome: Prohibited
  • Legal role: Official guidance
  • Source version: Health Canada Hotlist 2025-08-13

What it does not prove

The Hotlist is an administrative compliance tool, not an exhaustive safety approval list.

Further authoritative substance research

These sources can add identity, safety, exposure or hazard context. A link is not evidence that the database contains this exact substance, and none of these sources overrides the market decision above.

Cosmetic Ingredient Review safety assessments

Expert Panel conclusions, assessed ingredient groups, use conditions, dates and report documents

Independent expert review considered by FDA; not a government approval or binding market rule

Research this identity at the source

FDA Global Substance Registration System

UNII identifiers, preferred names, substance types, codes and public substance relationships

Identity registry only; UNII availability does not imply FDA review or approval

Research this identity at the source

ILO/WHO International Chemical Safety Cards

Hazards, symptoms, first aid, storage, incompatibilities and physical properties for covered chemicals

International occupational chemical-safety reference; not cosmetic-use approval

Research this identity at the source

Japan NITE-CHRIP

Chemical identity, Japanese and foreign legal lists, GHS hazards and exposure-related information

Chemical-management evidence; cosmetic status remains governed by the applicable MHLW standard and market rules

Research this identity at the source

NIOSH Pocket Guide to Chemical Hazards

REL, PEL, IDLH, properties, exposure routes, symptoms, target organs, first aid and measurement methods for covered workplace chemicals

US occupational-health guidance and limits; not a cosmetic ingredient decision

Research this identity at the source

OECD eChemPortal

Gateway to authority-owned physical-property, fate, ecotoxicity, toxicity, exposure and GHS records

Discovery gateway; each linked authority remains responsible for its data

Research this identity at the source

US EPA CompTox CTX APIs

API key required for import

DTXSID identity, experimental and predicted properties, toxicity, bioactivity, exposure and environmental data

Scientific and computational evidence; predictions must remain labelled and do not determine cosmetic legality

Research this identity at the source