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Decamethylenebis (trimethylammonium) salts

Canada Hotlist: Decamethylenebis (trimethylammonium) salts

Health Canada lists this ingredient as prohibited for use in cosmetic products.

All Canada recordsCompare all marketsOpen official source

Regulatory decision and full conditions

Status
Prohibited
Legal role
Official guidance
Regulatory summary
Health Canada lists this ingredient as prohibited for use in cosmetic products.
Conditions and restrictions
Synonyms or related compounds: Decamethonium bromide; Decamethonium dichloride; Decamethonium iodide

Substance identity

Official source name
Decamethylenebis (trimethylammonium) salts
CAS
541-22-0; 3198-38-7; 1420-40-2
EC
Not supplied in this source row
Identity mapping
standalone:cas_number
Search this identity across the siteCAS 541-22-0CAS 3198-38-7CAS 1420-40-2

Cross-market snapshot for this identity

Exact linked records currently present in this site. An absent market means no imported exact match, not permission to use the substance.

9 market datasets
PubChem 2D chemical structure for CAS 1420-40-2
CAS 1420-40-2PubChem CID 74014

Verified chemistry for CAS 1420-40-2

Decamethonium iodide

IUPAC name
trimethyl-[10-(trimethylazaniumyl)decyl]azanium diiodide
Molecular formula
C16H38I2N2
Molecular weight
512.30 g/mol
Exact mass
512.11244 Da
Monoisotopic mass
512.11244 Da
Topological polar surface area
0.0 Ų
Molecular complexity
164.0
Formal charge
0
Hydrogen-bond donors
0
Hydrogen-bond acceptors
2
Rotatable bonds
11
Heavy atoms
20
Covalent units
3

Names and synonyms reported to PubChem

Decamethonium diiodideTX886PAQ89RefChem:131173215-816-4EulixineEulissin AN1,N1,N1,N10,N10,N10-Hexamethyldecane-1,10-diaminium iodideDecamethylenebis(trimethylammonium iodide)
16 more reported names
trimethyl-[10-(trimethylazaniumyl)decyl]azanium;diiodideDecane-1,10-bis(trimethylammonium Iodide)DECAMETHONIUM IODIDE [MART.]ProcuranCS-01858691,10-Decanediaminium, N1,N1,N1,N10,N10,N10-hexamethyl-, iodide (1:2)Decamethionium iodideDecamethonium iodatumDekamethoniumjodidDekamethoniumjodid [Czech]EINECS 215-816-4trimethyl[10-(trimethylamino)decyl]amine, iodide, iodideUNII-TX886PAQ891,10-Decanediaminium, N,N,N,N',N',N'-hexamethyl-, diiodideDecamethonium iodide [INN:BAN]Dekamethylen-bis-trimethylamoniumjodid [Czech]
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D conformers
0
Machine-readable structure identifiers
SMILES
C[N+](C)(C)CCCCCCCCCC[N+](C)(C)C.[I-].[I-]
InChI
InChI=1S/C16H38N2.2HI/c1-17(2,3)15-13-11-9-7-8-10-12-14-16-18(4,5)6;;/h7-16H2,1-6H3;2*1H/q+2;;/p-2
InChIKey
ARMLJSXXXFXSLQ-UHFFFAOYSA-L

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 3198-38-7
CAS 3198-38-7PubChem CID 165087

Verified chemistry for CAS 3198-38-7

Decamethonium chloride

IUPAC name
trimethyl-[10-(trimethylazaniumyl)decyl]azanium dichloride
Molecular formula
C16H38Cl2N2
Molecular weight
329.4 g/mol
Exact mass
328.2412046 Da
Monoisotopic mass
328.2412046 Da
Topological polar surface area
0.0 Ų
Molecular complexity
164.0
Formal charge
0
Hydrogen-bond donors
0
Hydrogen-bond acceptors
2
Rotatable bonds
11
Heavy atoms
20
Covalent units
3

Names and synonyms reported to PubChem

Decamethonium dichloride62I07N48KGAmmonium, decamethylenebis(trimethyl-, dichloride1,10-Decanediaminium, N,N,N,N',N',N'-hexamethyl-, dichlorideRefChem:919731trimethyl-[10-(trimethylazaniumyl)decyl]azanium;dichlorideN1,N1,N1,N10,N10,N10-Hexamethyldecane-1,10-diaminium chloride1,10-DECANEDIAMINIUM, N1,N1,N1,N10,N10,N10-HEXAMETHYL-, CHLORIDE (1:2)
7 more reported names
Decamethylenebis(trimethylammonium chloride)UNII-62I07N48KG1,10-Decanediaminium, N,N,N,N',N',N'-hexamethyl-, dichloride (9CI)EBC-139031trimethyl[10-(trimethylazaniumyl)decyl]azanium dichlorideN~1~,N~1~,N~1~,N~10~,N~10~,N~10~-Hexamethyldecane-1,10-bis(aminium) dichlorideN~1~,N~1~,N~1~,N~10~,N~10~,N~10~-Hexamethyldecane-1,10-bis(aminium)ato dichlorido
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D conformers
0
Machine-readable structure identifiers
SMILES
C[N+](C)(C)CCCCCCCCCC[N+](C)(C)C.[Cl-].[Cl-]
InChI
InChI=1S/C16H38N2.2ClH/c1-17(2,3)15-13-11-9-7-8-10-12-14-16-18(4,5)6;;/h7-16H2,1-6H3;2*1H/q+2;;/p-2
InChIKey
KMVDECFGXJKYHV-UHFFFAOYSA-L

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 541-22-0
CAS 541-22-0PubChem CID 10921

Verified chemistry for CAS 541-22-0

Decamethonium dibromide

IUPAC name
trimethyl-[10-(trimethylazaniumyl)decyl]azanium dibromide
Molecular formula
C16H38Br2N2
Molecular weight
418.3 g/mol
Exact mass
418.13812 Da
Monoisotopic mass
416.14017 Da
Topological polar surface area
0.0 Ų
Molecular complexity
164.0
Formal charge
0
Hydrogen-bond donors
0
Hydrogen-bond acceptors
2
Rotatable bonds
11
Heavy atoms
20
Covalent units
3

Names and synonyms reported to PubChem

Decamethylenebis(trimethylammonium bromide)Decamethylene bis(trimethylammonium bromide)Decamethylene-1,10-bistrimethylammonium dibromideAmmonium, decamethylenebis(trimethyl-, dibromideRefChem:54940DECAMETHONIUM BROMIDESyncurineDecamethonium (Bromide)
16 more reported names
DecacuranBromuro de decametonioDecamethonium bromideBromure de decamethonium1,10-Decanediaminium, N,N,N,N',N',N'-hexamethyl-, dibromideDecamethylene bis(trimethylammonium) dibromide55C6RK944KNSC-23004Dekamethoniumbromidtrimethyl[10-(trimethylazaniumyl)decyl]azanium dibromideCHEMBL1134Dekamethoniumbromid [Czech]Decametonio bromuroDecametonio bromuro [DCIT]Decamethonium bromide [INN]Decamethonii bromidum
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D conformers
0
Machine-readable structure identifiers
SMILES
C[N+](C)(C)CCCCCCCCCC[N+](C)(C)C.[Br-].[Br-]
InChI
InChI=1S/C16H38N2.2BrH/c1-17(2,3)15-13-11-9-7-8-10-12-14-16-18(4,5)6;;/h7-16H2,1-6H3;2*1H/q+2;;/p-2
InChIKey
HLXQFVXURMXRPU-UHFFFAOYSA-L

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Official source and provenance

Registered source
Health Canada Cosmetic Ingredient Hotlist
Source reference
Hotlist prohibited entry 187
Source record ID
prohibited:187
Source version
Health Canada Hotlist 2025-08-13
Source language
English
Translation status
Original is English
Source updated
2025-08-13
Snapshot checked
2026-08-30 04:07 UTC
Validation method
strict HTML tables t1=490 and t2=90
SHA-256
8b52ff573d08373ee90121f6a701b3607e4a3d6fc748a7d56171eb53510af91a

Registered dataset notes

Dataset coverage
Administrative prohibitions, restrictions, conditions and warning requirements
Authority note
Official Health Canada compliance indicator; not a complete safety clearance
Inspect the exact official sourceRegulator guidance

How this record fits the market dataset

580
current Canada records
490
records marked Prohibited
580
records from this source version
516
market records with CAS identity

Status distribution

Prohibited: 490Restricted: 90

Condition text is present on 172 of 580 current records. An empty condition field is interpreted according to the record type above; it is never converted into an unrestricted-use claim.

Canada market context

Complete Hotlist snapshot

Coverage version: Health Canada Cosmetic Ingredient Hotlist, 13 August 2025

All prohibited and restricted Hotlist entries, including conditions and warning requirements published in the official list.

Verification checklist

  1. Search English/French names and CAS identifiers.
  2. Apply every restriction, concentration and label warning.
  3. Check Food and Drugs Act/Cosmetic Regulations requirements.
  4. Recheck the current Hotlist before notification or sale.

Official market sources

Verification workflow and record completeness

Before using this result in a compliance decision

  1. Confirm that “Decamethylenebis (trimethylammonium) salts” and every CAS/EC identifier refer to the material in your supplier specification.
  2. Search English/French names and CAS identifiers.
  3. Apply every restriction, concentration and label warning.
  4. Check Food and Drugs Act/Cosmetic Regulations requirements.
  5. Recheck the current Hotlist before notification or sale.
  6. Document the source version and recheck the regulator before manufacture, notification or market placement.

Fields available in this record

  • Official substance nameAvailable
  • CASAvailable
  • ECNot supplied
  • Separate condition textAvailable
  • Effective dateNot supplied
  • Snapshot hash and methodAvailable

Questions this page answers

This official record identifies the substance as prohibited for cosmetic use in the stated market scope. Do not rely on a formulation containing this identity until the cited source, effective date and exact substance match have been verified.

A prohibition entry may contain no separate condition text because the regulatory outcome is the prohibition itself. The Hotlist is an administrative compliance tool, not an exhaustive safety approval list.

The record cites Hotlist prohibited entry 187, source version Health Canada Hotlist 2025-08-13. Open the official source.

No. CAS helps resolve identity, but jurisdictions can classify the same substance differently and can apply different product scopes, limits, warnings and transition dates.

Stable citation

Decamethylenebis (trimethylammonium) salts. Hotlist prohibited entry 187. Canada. Source version Health Canada Hotlist 2025-08-13. CosIng Checker regulatory record: https://cosingchecker.com/regulations/ca/records/187/

Cite the regulator as the legal authority. This page is a structured evidence index and verification aid, not a substitute for the official text or professional legal assessment.

Interpretation and limits for Canada

This official record identifies the substance as prohibited for cosmetic use in the stated market scope.

Do not rely on a formulation containing this identity until the cited source, effective date and exact substance match have been verified.

How to interpret the legal role

The authority uses this source as compliance guidance; the underlying legislation remains controlling.

Evidence on this page

  • Recorded outcome: Prohibited
  • Legal role: Official guidance
  • Source version: Health Canada Hotlist 2025-08-13

What it does not prove

The Hotlist is an administrative compliance tool, not an exhaustive safety approval list.

Further authoritative substance research

These sources can add identity, safety, exposure or hazard context. A link is not evidence that the database contains this exact substance, and none of these sources overrides the market decision above.

Cosmetic Ingredient Review safety assessments

Expert Panel conclusions, assessed ingredient groups, use conditions, dates and report documents

Independent expert review considered by FDA; not a government approval or binding market rule

Research this identity at the source

FDA Global Substance Registration System

UNII identifiers, preferred names, substance types, codes and public substance relationships

Identity registry only; UNII availability does not imply FDA review or approval

Research this identity at the source

ILO/WHO International Chemical Safety Cards

Hazards, symptoms, first aid, storage, incompatibilities and physical properties for covered chemicals

International occupational chemical-safety reference; not cosmetic-use approval

Research this identity at the source

Japan NITE-CHRIP

Chemical identity, Japanese and foreign legal lists, GHS hazards and exposure-related information

Chemical-management evidence; cosmetic status remains governed by the applicable MHLW standard and market rules

Research this identity at the source

NIOSH Pocket Guide to Chemical Hazards

REL, PEL, IDLH, properties, exposure routes, symptoms, target organs, first aid and measurement methods for covered workplace chemicals

US occupational-health guidance and limits; not a cosmetic ingredient decision

Research this identity at the source

OECD eChemPortal

Gateway to authority-owned physical-property, fate, ecotoxicity, toxicity, exposure and GHS records

Discovery gateway; each linked authority remains responsible for its data

Research this identity at the source

US EPA CompTox CTX APIs

API key required for import

DTXSID identity, experimental and predicted properties, toxicity, bioactivity, exposure and environmental data

Scientific and computational evidence; predictions must remain labelled and do not determine cosmetic legality

Research this identity at the source