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ProhibitedBinding ruleBROfficial English translationOfficial-source import checked

4,4’-Metilenodianilina

ANVISA lists this substance among materials that may not be used in personal-hygiene products, cosmetics or perfumes in Brazil.

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Regulatory decision and full conditions

Status
Prohibited
Legal role
Binding rule
Regulatory summary
ANVISA lists this substance among materials that may not be used in personal-hygiene products, cosmetics or perfumes in Brazil.
Conditions and restrictions
4,4’-Metilenodianilina

Substance identity

Official source name
4,4’-Metilenodianilina
CAS
101-77-9
EC
202-974-4
Identity mapping
standalone:official_anvisa_record
Search this identity across the siteCAS 101-77-9EC 202-974-4

Cross-market snapshot for this identity

Exact linked records currently present in this site. An absent market means no imported exact match, not permission to use the substance.

9 market datasets
PubChem 2D chemical structure for CAS 101-77-9
CAS 101-77-9PubChem CID 7577

Verified chemistry for CAS 101-77-9

4,4-Diaminodiphenylmethane

IUPAC name
4-[(4-aminophenyl)methyl]aniline
Molecular formula
C13H14N2
Molecular weight
198.26 g/mol
Exact mass
198.115698455 Da
Monoisotopic mass
198.115698455 Da
XLogP3
1.6
Topological polar surface area
52.0 Ų
Molecular complexity
157.0
Formal charge
0
Hydrogen-bond donors
2
Hydrogen-bond acceptors
2
Rotatable bonds
2
Heavy atoms
15
Covalent units
1

Names and synonyms reported to PubChem

4,4'-Methylenedianiline4,4'-DIAMINODIPHENYLMETHANEDadpmMethylenedianilineBis(4-aminophenyl)methaneDianilinemethaneDianilinomethanep,p'-Methylenedianiline
16 more reported names
Epicure DDMEpikure DDMCurithane4-(4-Aminobenzyl)anilineBenzenamine, 4,4'-methylenebis-Jeffamine AP-20p,p'-DiaminodiphenylmethaneSumicure M4,4'-DiphenylmethanediamineAncamine TLBis(p-aminophenyl)methaneDi(4-aminophenyl)methaneMethylenebis(aniline)Bis-p-aminofenylmethan4,4'-Methylene dianilineDi-(4-aminophenyl)methane
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D pharmacophore features
6
3D rings
2
3D hydrophobes
0
3D acceptor features
0
3D donor features
2
3D anionic centres
0
3D cationic centres
2
3D conformers
3
Effective 3D rotors
2.0
Machine-readable structure identifiers
SMILES
C1=CC(=CC=C1CC2=CC=C(C=C2)N)N
InChI
InChI=1S/C13H14N2/c14-12-5-1-10(2-6-12)9-11-3-7-13(15)8-4-11/h1-8H,9,14-15H2
InChIKey
YBRVSVVVWCFQMG-UHFFFAOYSA-N

Evidence from additional scientific databases

EMBL-EBI ChEBI
Exact identifier matchCHEBI:32506

4,4'-diaminodiphenylmethane

An aromatic amine that is diphenylmethane substituted at the 4-position of each benzene ring by an amino group.

Formula
C13H14N2
Average mass
198.269 g/mol
Monoisotopic mass
198.11570 Da
Formal charge
0
  • aromatic amine — is a (CHEBI:33860)
  • allergen — has role (CHEBI:50904)
  • carcinogenic agent — has role (CHEBI:50903)
  • diphenylmethane — has parent hydride (CHEBI:38884)
  • allergen — has role (CHEBI:50904)
  • carcinogenic agent — has role (CHEBI:50903)
  • aromatic amine — is a (CHEBI:33860)
Additional curated names
4,4'-methylenedianiline4-(4-aminobenzyl)aniline4,4'-Diaminodiphenylmethane4,4'-Diphenylmethanediamine4,4'-Methylenebis(benzeneamine)Bis(4-aminophenyl)methanebis-p-aminophenylmethaneBis(p-aminophenyl)methaneDADPMDAPMDDMdi-(4-aminophenyl)methaneDianilinomethanedi-(p-aminophenyl)methanep,p'-Diaminodiphenylmethanep,p'-Methylenedianilinealpha-(p-aminophenyl)-p-toluidine
Cross-references from this source

Mapped by: Exact CAS cross-reference in the ChEBI compound record. Source updated: 2019-03-07. Retrieved: 2026-08-31. Open source record

NIH PubChem PUG-View
Exact identifier match7577

Attributed physical-property, hazard, environmental and use annotations.

  • First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.; SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas.; INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknow Source: CAMEO Chemicals
  • ERG2024, Guide 153 (4,4'-Diaminodiphenylmethane): General First Aid:; · Call 911 or emergency medical service.; · Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.; · Move victim to fresh air if it can be done safely.; · Administer oxygen if breathing is difficult.; · If victim is not breathing:; -- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.; -- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).; -- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.; · Remove and isolate contaminated clothing and shoes.; · For minor skin contact, avoid spreading material on unaffected skin.; · In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.; · For severe burns, immediate medical attention is required.; · Effects of exposure (inhalation, ingestion, Source: Emergency Response Guidebook (ERG)
  • First Aid: (General first aid procedures); Eye: Irrigate immediately - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.; Skin: Soap wash immediately - If this chemical contacts the skin, immediately wash the contaminated skin with soap and water. If this chemical penetrates the clothing, immediately remove the clothing, wash the skin with soap and water, and get medical attention promptly.; Breathing: Respiratory support; Swallow: Medical attention immediately - If this chemical has been swallowed, get medical attention immediately. Source: The National Institute for Occupational Safety and Health (NIOSH)
  • Signal: Danger Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • GHS Hazard Statements: H317: May cause an allergic skin reaction [Warning Sensitization, Skin]; H341: Suspected of causing genetic defects [Warning Germ cell mutagenicity]; H350: May cause cancer [Danger Carcinogenicity]; H370 **: Causes damage to organs [Danger Specific target organ toxicity, single exposure]; H373 **: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]; H411: Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Precautionary Statement Codes: P203, P260, P261, P264, P270, P272, P273, P280, P302+P352, P308+P316, P318, P319, P321, P333+P317, P362+P364, P391, P405, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Signal: Danger Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H301 (14.5%): Toxic if swallowed [Danger Acute toxicity, oral]; H317 (100%): May cause an allergic skin reaction [Warning Sensitization, Skin]; H341 (100%): Suspected of causing genetic defects [Warning Germ cell mutagenicity]; H350 (100%): May cause cancer [Danger Carcinogenicity]; H370 (100%): Causes damage to organs [Danger Specific target organ toxicity, single exposure]; H373 (99.8%): May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]; H400 (28.5%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H411 (97.1%): Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P203, P260, P261, P264, P270, P272, P273, P280, P301+P316, P302+P352, P308+P316, P318, P319, P321, P330, P333+P317, P362+P364, P391, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 629 reports by companies from 19 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H317 (100%): May cause an allergic skin reaction [Warning Sensitization, Skin]; H341 (100%): Suspected of causing genetic defects [Warning Germ cell mutagenicity]; H350 (100%): May cause cancer [Danger Carcinogenicity]; H370 (100%): Causes damage to organs [Danger Specific target organ toxicity, single exposure]; H373 (100%): May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]; H411 (100%): Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P203, P260, P261, P264, P270, P272, P273, P280, P302+P352, P308+P316, P318, P319, P321, P333+P317, P362+P364, P391, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 39 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Signal: Danger Source: NITE-CMC
  • GHS Hazard Statements: H302: Harmful if swallowed [Warning Acute toxicity, oral]; H311: Toxic in contact with skin [Danger Acute toxicity, dermal]; H317: May cause an allergic skin reaction [Warning Sensitization, Skin]; H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H341: Suspected of causing genetic defects [Warning Germ cell mutagenicity]; H350: May cause cancer [Danger Carcinogenicity]; H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]; H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]; H373: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]; H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: NITE-CMC
  • NFPA Health Rating: 3 - Materials that, under emergency conditions, can cause serious or permanent injury. Source: Hazardous Substances Data Bank (HSDB)
  • NFPA Fire Rating: 1 - Materials that must be preheated before ignition can occur. Materials require considerable preheating, under all ambient temperature conditions, before ignition and combustion can occur. Source: Hazardous Substances Data Bank (HSDB)
  • NFPA Instability Rating: 0 - Materials that in themselves are normally stable, even under fire conditions. Source: Hazardous Substances Data Bank (HSDB)
  • Toxicity Summary: After 4,4'-Methylenedianiline enters to our body, it is transported in the blood or stored in tissues. The N-N-acetylation of the compound leads to the formation of some toxic derivatives. The liver and thyroid are the targets of 4,4'-methylenedianiline in animals. Source: Toxin and Toxin Target Database (T3DB)
  • Environmental Bioconcentration: BCF values ranging from 3.0 to 14 were measured for 4,4'-diaminodiphenylmethane (200 ug/L) in carp (4.5% lipid content) after a 6 week period(1). According to a classification scheme(2), these BCF values suggest the bioconcentration in aquatic organisms is low(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), Koc values ranging from 3825 to 5681(2), indicate that 4,4'-diaminodiphenylmethane is expected to have slight to no mobility in soil(SRC). Volatilization of 4,4'-diaminodiphenylmethane from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 5.30X10-11 atm-cu m/mole(SRC), based upon its vapor pressure, 2.03X10-7 mm Hg(3), and water solubility, 1.00E+3(4). 4,4'-Diaminodiphenylmethane is not expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(3). A 0% of theoretical BOD using activated sludge in the Japanese MITI test(5) suggests that biodegradation will not be an important environmental fate process in soil(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), measured Koc values ranging from 3825 to 5681(2), indicate that 4,4'-diaminodiphenylmethane is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon an estimated Henry's Law constant of 5.30X10-11 atm-cu m/mole(SRC), derived from its vapor pressure, 2.03X10-7 mm Hg(4), and water solubility, 1.00E+3(5). According to a classification scheme(6), BCF values of 3.0 to 14(7) suggest the bioconcentration in aquatic organisms is low(SRC). 4,4'-Diaminodiphenylmethane, present at 100 mg/L, reached 0% of its theoretical BOD in 4 weeks using an activated sludge inoculum at 30 mg/L in the Japanese MITI test(7), suggesting that biodegradation will not be an important fate process in the aquatic environment(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 4,4'-diaminodiphenylmethane, which has a vapor pressure of 2.03X10-7 mm Hg at 25 °C(2), will exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase 4,4'-diaminodiphenylmethane is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 12.8 hours(SRC), calculated from its rate constant of 3.00X10-11 cu cm/molecule-sec at 25 °C(3). Particulate-phase 4,4'-diaminodiphenylmethane may be removed from the air by wet or dry deposition(SRC). 4,4'-Diaminodiphenylmethane contains chromophores that absorb at wavelengths >290 nm(4) and therefore may be susceptible to direct photolysis by sunlight(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Uses: MDA is primarily used to produce 4,4-'methylenedianiline diisocyanate and other polymeric isocyanates which are used to manufacture polyurethane foams. MDA is also used as a curing agent for epoxy resins and urethane elastomers, as a corrosion preventative for iron, as an antioxidant for lubricating oils, as a rubber processing chemical, as an intermediate in the manufacture of elastomeric fibers (e.g., Spandex), and in the preparation of azo dyes. Source: EPA Hazardous Air Pollutants
  • Sources/Uses: Used as a chemical intermediate, lab analytic agent, and monomer for polyamide and polymide resins; [HSDB] Used primarily in the manufacture of rubber and plastics; used as an epoxy resin hardener in the following applications: glues, paints, inks, polyvinylchloride products, dental bonding agents, and microelectronic encapsulations; [Marks, p. 269] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Restricted Notes: Carcinogen--See 29 CFR 1910.1050 Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Industrial Processes with risk of exposure: Plastic Composites Manufacturing [Category: Industry] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Uses: As chemical intermediate in prodn of isocyanates and polyisocyanates for prepn of polyurethane foams, Spandex fibers; as curing agent for epoxy resins and urethane elastomers; in production of polyamides; in the determination of tungsten and sulfates; in prepn of azo dyes; as corrosion inhibitor. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Determination of tungsten and sulfates, polymer and dye intermediate, corrosion inhibitor, epoxy-resin hardening agent, isocyanate resins, polyamides. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: The isocyanates developed from 4,4'-methylenedianiline are also incorporated into semiflexible polyurethane foams for automobile safety cushioning. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: 4,4'-Methylenediphenyl diisocyanate produced from the highly purified 4,4'-methylene dianiline isomer is used for the manufacture of elastomers such as spandex fibres. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: For more Uses (Complete) data for 4,4'-DIAMINODIPHENYLMETHANE (6 total), please visit the HSDB record page. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Substance listed with specific concentration in tattoo ink and/or permanent make up according to EU Commission Regulation 2020/2081. The concentration limit (by weight) is 0.0005%. Source: NORMAN Suspect List Exchange

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
EMBL-EBI ChEBIExact match2026-08-31
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Official source and provenance

Registered source
Brazil ANVISA consolidated prohibited substances — RDC 529/2021 through RDC 1.030/2026
Source reference
RDC 529/2021 consolidated annex, entry 705 (through RDC 1.030/2026)
Source record ID
annex:705
Source version
RDC 529/2021 consolidated through RDC 1.030/2026
Source language
Portuguese with official English identity where published
Translation status
Official English translation · English translation
Effective date
2026-06-15
Source updated
2026-06-15
Snapshot checked
2026-08-31 15:26 UTC
Validation method
pdfplumber government baseline + 4 RDC 1.030 exclusions + 15 additions; 1,387 substantive rows
SHA-256
a212e85540a186a842664fbdd4f351af0b1b4baeeb0c4765b9b52c6ce91c1e84

Registered dataset notes

Dataset coverage
All 1,387 substantive current prohibited rows after applying RDC 1.030/2026 additions, amendments and exclusions to RDC 529/2021
Authority note
Binding consolidated prohibited list for personal-hygiene products, cosmetics and perfumes
Inspect the exact official sourceRegulator guidance

How this record fits the market dataset

1387
current Brazil records
1387
records marked Prohibited
1387
records from this source version
1335
market records with CAS identity

Status distribution

Prohibited: 1387

Condition text is present on 1387 of 1387 current records. An empty condition field is interpreted according to the record type above; it is never converted into an unrestricted-use claim.

Brazil market context

Complete prohibited dataset plus current restricted-list workflow

Coverage version: ANVISA RDC 1.029/2026 and RDC 1.030/2026, published 15 June 2026

All 1,387 substantive current prohibited rows in RDC 529/2021 consolidated through RDC 1.030/2026, plus the current RDC 1.029 restricted-list and identity workflow.

Verification checklist

  1. Resolve Portuguese, INCI and CAS identity with the ANVISA crosswalk.
  2. Check the consolidated prohibited list including RDC 1.030/2026 changes.
  3. Apply RDC 1.029/2026 restrictions and the still-effective complementary rules.
  4. Verify Mercosur incorporation, regularisation, labelling and transition periods.

Official market sources

Verification workflow and record completeness

Before using this result in a compliance decision

  1. Confirm that “4,4’-Metilenodianilina” and every CAS/EC identifier refer to the material in your supplier specification.
  2. Resolve Portuguese, INCI and CAS identity with the ANVISA crosswalk.
  3. Check the consolidated prohibited list including RDC 1.030/2026 changes.
  4. Apply RDC 1.029/2026 restrictions and the still-effective complementary rules.
  5. Verify Mercosur incorporation, regularisation, labelling and transition periods.
  6. Document the source version and recheck the regulator before manufacture, notification or market placement.

Fields available in this record

  • Official substance nameAvailable
  • CASAvailable
  • ECAvailable
  • Separate condition textAvailable
  • Effective dateAvailable
  • Snapshot hash and methodAvailable

Questions this page answers

This official record identifies the substance as prohibited for cosmetic use in the stated market scope. Do not rely on a formulation containing this identity until the cited source, effective date and exact substance match have been verified.

A prohibition entry may contain no separate condition text because the regulatory outcome is the prohibition itself. RDC 1.030/2026 amends rather than replaces the prohibited baseline, and the second restricted-list revision was still under consultation in July 2026.

The record cites RDC 529/2021 consolidated annex, entry 705 (through RDC 1.030/2026), source version RDC 529/2021 consolidated through RDC 1.030/2026. Open the official source.

No. CAS helps resolve identity, but jurisdictions can classify the same substance differently and can apply different product scopes, limits, warnings and transition dates.

Stable citation

4,4’-Metilenodianilina. RDC 529/2021 consolidated annex, entry 705 (through RDC 1.030/2026). Brazil. Source version RDC 529/2021 consolidated through RDC 1.030/2026. CosIng Checker regulatory record: https://cosingchecker.com/regulations/br/records/13905/

Cite the regulator as the legal authority. This page is a structured evidence index and verification aid, not a substitute for the official text or professional legal assessment.

Interpretation and limits for Brazil

This official record identifies the substance as prohibited for cosmetic use in the stated market scope.

Do not rely on a formulation containing this identity until the cited source, effective date and exact substance match have been verified.

How to interpret the legal role

The cited row forms part of a binding rule or legally incorporated list for this market.

Evidence on this page

  • Recorded outcome: Prohibited
  • Legal role: Binding rule
  • Source version: RDC 529/2021 consolidated through RDC 1.030/2026
  • Effective date: 2026-06-15

What it does not prove

RDC 1.030/2026 amends rather than replaces the prohibited baseline, and the second restricted-list revision was still under consultation in July 2026.

Further authoritative substance research

These sources can add identity, safety, exposure or hazard context. A link is not evidence that the database contains this exact substance, and none of these sources overrides the market decision above.

Cosmetic Ingredient Review safety assessments

Expert Panel conclusions, assessed ingredient groups, use conditions, dates and report documents

Independent expert review considered by FDA; not a government approval or binding market rule

Research this identity at the source

FDA Global Substance Registration System

UNII identifiers, preferred names, substance types, codes and public substance relationships

Identity registry only; UNII availability does not imply FDA review or approval

Research this identity at the source

ILO/WHO International Chemical Safety Cards

Hazards, symptoms, first aid, storage, incompatibilities and physical properties for covered chemicals

International occupational chemical-safety reference; not cosmetic-use approval

Research this identity at the source

Japan NITE-CHRIP

Chemical identity, Japanese and foreign legal lists, GHS hazards and exposure-related information

Chemical-management evidence; cosmetic status remains governed by the applicable MHLW standard and market rules

Research this identity at the source

NIOSH Pocket Guide to Chemical Hazards

REL, PEL, IDLH, properties, exposure routes, symptoms, target organs, first aid and measurement methods for covered workplace chemicals

US occupational-health guidance and limits; not a cosmetic ingredient decision

Research this identity at the source

OECD eChemPortal

Gateway to authority-owned physical-property, fate, ecotoxicity, toxicity, exposure and GHS records

Discovery gateway; each linked authority remains responsible for its data

Research this identity at the source

US EPA CompTox CTX APIs

API key required for import

DTXSID identity, experimental and predicted properties, toxicity, bioactivity, exposure and environmental data

Scientific and computational evidence; predictions must remain labelled and do not determine cosmetic legality

Research this identity at the source