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ProhibitedBinding ruleBROfficial English translationOfficial-source import checked

Furocumarinas (por exemplo trioxisalano* , 8 - metoxipsoraleno, 5 - metoxipsoraleno), exceto para os conteúdos normais em essências

ANVISA lists this substance among materials that may not be used in personal-hygiene products, cosmetics or perfumes in Brazil.

All Brazil recordsCompare all marketsOpen official source

Regulatory decision and full conditions

Status
Prohibited
Legal role
Binding rule
Regulatory summary
ANVISA lists this substance among materials that may not be used in personal-hygiene products, cosmetics or perfumes in Brazil.
Conditions and restrictions
Furocumarinas (por exemplo trioxisalano* , 8 - metoxipsoraleno, 5 - metoxipsoraleno), exceto para os conteúdos normais em essências

Substance identity

Official source name
Furocumarinas (por exemplo trioxisalano* , 8 - metoxipsoraleno, 5 - metoxipsoraleno), exceto para os conteúdos normais em essências
CAS
66-97-7; 298-81-7; 484-20-8; 3902-71-4
EC
200-639-7; 206-066-9; 207-604-5; 223-459-0
Identity mapping
standalone:official_anvisa_record
Search this identity across the siteCAS 66-97-7CAS 298-81-7CAS 484-20-8CAS 3902-71-4EC 200-639-7EC 206-066-9EC 207-604-5EC 223-459-0

Cross-market snapshot for this identity

Exact linked records currently present in this site. An absent market means no imported exact match, not permission to use the substance.

10 market datasets
PubChem 2D chemical structure for CAS 298-81-7
CAS 298-81-7PubChem CID 4114

Verified chemistry for CAS 298-81-7

8-Methoxypsoralen

IUPAC name
9-methoxyfuro[3,2-g]chromen-7-one
Molecular formula
C12H8O4
Molecular weight
216.19 g/mol
Exact mass
216.04225873 Da
Monoisotopic mass
216.04225873 Da
XLogP3
1.9
Topological polar surface area
48.7 Ų
Molecular complexity
325.0
Formal charge
0
Hydrogen-bond donors
0
Hydrogen-bond acceptors
4
Rotatable bonds
1
Heavy atoms
16
Covalent units
1

Names and synonyms reported to PubChem

methoxsalenXANTHOTOXIN8-MOPOxsoralen9-Methoxy-7H-furo[3,2-g]chromen-7-oneMeladinineOxypsoralenMeloxine
16 more reported names
PuvalenXanthotoxineAmmoidinMeladininMeladoxenAmmodinUvadex8-MethoxypsoraleneGeroxalenNew-MeladininZanthotoxinPuvametPsoralon-MOP9-MethoxypsoralenOxsoralen Ultra8-Methoxyfuranocoumarin
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D pharmacophore features
6
3D rings
3
3D hydrophobes
0
3D acceptor features
3
3D donor features
0
3D anionic centres
0
3D cationic centres
0
3D conformers
1
Effective 3D rotors
1.0
Machine-readable structure identifiers
SMILES
COC1=C2C(=CC3=C1OC=C3)C=CC(=O)O2
InChI
InChI=1S/C12H8O4/c1-14-12-10-8(4-5-15-10)6-7-2-3-9(13)16-11(7)12/h2-6H,1H3
InChIKey
QXKHYNVANLEOEG-UHFFFAOYSA-N

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 3902-71-4
CAS 3902-71-4PubChem CID 5585

Verified chemistry for CAS 3902-71-4

Trimethylpsoralen

IUPAC name
2,5,9-trimethylfuro[3,2-g]chromen-7-one
Molecular formula
C14H12O3
Molecular weight
228.24 g/mol
Exact mass
228.078644241 Da
Monoisotopic mass
228.078644241 Da
XLogP3
3.0
Topological polar surface area
39.4 Ų
Molecular complexity
374.0
Formal charge
0
Hydrogen-bond donors
0
Hydrogen-bond acceptors
3
Rotatable bonds
0
Heavy atoms
17
Covalent units
1

Names and synonyms reported to PubChem

trioxsalenTrioxysalen4,5',8-TrimethylpsoralenTrioxisalenoTrioxysalene2',4,8-TrimethylpsoralenTrioxysalenumTmp (psoralen)
16 more reported names
NSC 710477H-Furo[3,2-g][1]benzopyran-7-one, 2,5,9-trimethyl-Y6UY8OV51T2,5,9-Trimethyl-7H-furo(3,2-g)(1)benzopyran-7-one7H-Furo(3,2-g)(1)benzopyran-7-one, 2,5,9-trimethyl-2,5,9-Trimethyl-7H-furo[3,2-g][1]benzopyran-7-oneCHEBI:283296-hydroxy-beta,2,7-trimethyl-5-benzofuranacrylic acid, delta-lactoneTrioxisalenum2,5,9-trimethylfuro(3,2-g)chromen-7-one4,7,9-trimethyl-2H-furo(3,2-g)chromen-2-one4,7,9-trimethyl-2H-furo[3,2-g]chromen-2-onetrioxisaleneRefChem:581762,5,9-Trimethyl-7H-furo(3,2-g)benzopyran-7-oneD05AD01
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D pharmacophore features
5
3D rings
3
3D hydrophobes
0
3D acceptor features
2
3D donor features
0
3D anionic centres
0
3D cationic centres
0
3D conformers
1
Effective 3D rotors
0.0
Machine-readable structure identifiers
SMILES
CC1=CC(=O)OC2=C1C=C3C=C(OC3=C2C)C
InChI
InChI=1S/C14H12O3/c1-7-4-12(15)17-14-9(3)13-10(6-11(7)14)5-8(2)16-13/h4-6H,1-3H3
InChIKey
FMHHVULEAZTJMA-UHFFFAOYSA-N

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 484-20-8
CAS 484-20-8PubChem CID 2355

Verified chemistry for CAS 484-20-8

Bergapten

5-methoxypsoralen is a 5-methoxyfurocoumarin that is psoralen substituted by a methoxy group at position 5. It has a role as a hepatoprotective agent and a plant metabolite. It is a member of psoralens, an organic heterotricyclic compound and a 5-methoxyfurocoumarin. It is functionally related to a psoralen. — ChEBI

IUPAC name
4-methoxyfuro[3,2-g]chromen-7-one
Molecular formula
C12H8O4
Molecular weight
216.19 g/mol
Exact mass
216.04225873 Da
Monoisotopic mass
216.04225873 Da
XLogP3
2.3
Topological polar surface area
48.7 Ų
Molecular complexity
325.0
Formal charge
0
Hydrogen-bond donors
0
Hydrogen-bond acceptors
4
Rotatable bonds
1
Heavy atoms
16
Covalent units
1

Names and synonyms reported to PubChem

5-MethoxypsoralenbergapteneHeraclinMajudinBERGAPTAN5-MopPsoradermO-Methylbergaptol
16 more reported names
5-Methoxy psoralen5-Methoxy-6,7-furanocoumarin5-MethoxyfuranocoumarinGeralen4-Methoxy-7H-furo(3,2-g)(1)benzopyran-7-one7H-Furo[3,2-g][1]benzopyran-7-one, 4-methoxy-5 methoxypsoralen4-methoxy-7H-furo[3,2-g][1]benzopyran-7-oneNSC-954376-Hydroxy-4-methoxy-5-benzofuranacrylic acid, gamma-lactone4FVK84C92X7H-Furo(3,2-g)(1)benzopyran-7-one, 4-methoxy-CHEBI:182935-methoxy-2H-furo[3,2-g]chromen-2-one5 Methoxy Psoralen5-methoxy-2H-furo(3,2-g)chromen-2-one
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D pharmacophore features
6
3D rings
3
3D hydrophobes
0
3D acceptor features
3
3D donor features
0
3D anionic centres
0
3D cationic centres
0
3D conformers
1
Effective 3D rotors
1.0
Machine-readable structure identifiers
SMILES
COC1=C2C=CC(=O)OC2=CC3=C1C=CO3
InChI
InChI=1S/C12H8O4/c1-14-12-7-2-3-11(13)16-10(7)6-9-8(12)4-5-15-9/h2-6H,1H3
InChIKey
BGEBZHIAGXMEMV-UHFFFAOYSA-N

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 66-97-7
CAS 66-97-7PubChem CID 6199

Verified chemistry for CAS 66-97-7

Psoralen

IUPAC name
furo[3,2-g]chromen-7-one
Molecular formula
C11H6O3
Molecular weight
186.16 g/mol
Exact mass
186.031694049 Da
Monoisotopic mass
186.031694049 Da
XLogP3
2.3
Topological polar surface area
39.4 Ų
Molecular complexity
284.0
Formal charge
0
Hydrogen-bond donors
0
Hydrogen-bond acceptors
3
Rotatable bonds
0
Heavy atoms
14
Covalent units
1

Names and synonyms reported to PubChem

Ficusin7H-Furo[3,2-g]chromen-7-oneFurocoumarinPsoralene7H-Furo[3,2-g][1]benzopyran-7-onePsorline-P6,7-FuranocoumarinFuro(2',3',7,6)coumarin
16 more reported names
Furo(3,2-g)-coumarinFuro(4',5',6,7)coumarin7H-Furo(3,2-g)(1)benzopyran-7-oneFuro[4',5':6,7]coumarinManadermFuro[2',3':7,6]coumarinKTZ7ZCN2EX6-Hydroxy-5-benzofuranacrylic acid beta-lactoneNSC-4045625-Benzofuranacrylic acid, 6-hydroxy-, delta-lactone6-hydroxy-5-benzofuranacrylic acid delta-lactoneCHEBI:276162H-furo[3,2-g]chromen-2-one2-Propenoic acid, 3-(6-hydroxy-5-benzofuranyl)-, delta-lactone6-hydroxy-5-benzofuranacrylic acid gamma-lactone3-(6-hydroxy-5-benzofuranyl)-2-propenoic acid delta-lactone
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D pharmacophore features
5
3D rings
3
3D hydrophobes
0
3D acceptor features
2
3D donor features
0
3D anionic centres
0
3D cationic centres
0
3D conformers
1
Effective 3D rotors
0.0
Machine-readable structure identifiers
SMILES
C1=CC(=O)OC2=CC3=C(C=CO3)C=C21
InChI
InChI=1S/C11H6O3/c12-11-2-1-7-5-8-3-4-13-9(8)6-10(7)14-11/h1-6H
InChIKey
ZCCUUQDIBDJBTK-UHFFFAOYSA-N

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Official source and provenance

Registered source
Brazil ANVISA consolidated prohibited substances — RDC 529/2021 through RDC 1.030/2026
Source reference
RDC 529/2021 consolidated annex, entry 358 (through RDC 1.030/2026)
Source record ID
annex:358
Source version
RDC 529/2021 consolidated through RDC 1.030/2026
Source language
Portuguese with official English identity where published
Translation status
Official English translation · English translation
Effective date
2026-06-15
Source updated
2026-06-15
Snapshot checked
2026-08-31 15:26 UTC
Validation method
pdfplumber government baseline + 4 RDC 1.030 exclusions + 15 additions; 1,387 substantive rows
SHA-256
a212e85540a186a842664fbdd4f351af0b1b4baeeb0c4765b9b52c6ce91c1e84

Registered dataset notes

Dataset coverage
All 1,387 substantive current prohibited rows after applying RDC 1.030/2026 additions, amendments and exclusions to RDC 529/2021
Authority note
Binding consolidated prohibited list for personal-hygiene products, cosmetics and perfumes
Inspect the exact official sourceRegulator guidance

How this record fits the market dataset

1387
current Brazil records
1387
records marked Prohibited
1387
records from this source version
1335
market records with CAS identity

Status distribution

Prohibited: 1387

Condition text is present on 1387 of 1387 current records. An empty condition field is interpreted according to the record type above; it is never converted into an unrestricted-use claim.

Brazil market context

Complete prohibited dataset plus current restricted-list workflow

Coverage version: ANVISA RDC 1.029/2026 and RDC 1.030/2026, published 15 June 2026

All 1,387 substantive current prohibited rows in RDC 529/2021 consolidated through RDC 1.030/2026, plus the current RDC 1.029 restricted-list and identity workflow.

Verification checklist

  1. Resolve Portuguese, INCI and CAS identity with the ANVISA crosswalk.
  2. Check the consolidated prohibited list including RDC 1.030/2026 changes.
  3. Apply RDC 1.029/2026 restrictions and the still-effective complementary rules.
  4. Verify Mercosur incorporation, regularisation, labelling and transition periods.

Official market sources

Verification workflow and record completeness

Before using this result in a compliance decision

  1. Confirm that “Furocumarinas (por exemplo trioxisalano* , 8 - metoxipsoraleno, 5 - metoxipsoraleno), exceto para os conteúdos normais em essências” and every CAS/EC identifier refer to the material in your supplier specification.
  2. Resolve Portuguese, INCI and CAS identity with the ANVISA crosswalk.
  3. Check the consolidated prohibited list including RDC 1.030/2026 changes.
  4. Apply RDC 1.029/2026 restrictions and the still-effective complementary rules.
  5. Verify Mercosur incorporation, regularisation, labelling and transition periods.
  6. Document the source version and recheck the regulator before manufacture, notification or market placement.

Fields available in this record

  • Official substance nameAvailable
  • CASAvailable
  • ECAvailable
  • Separate condition textAvailable
  • Effective dateAvailable
  • Snapshot hash and methodAvailable

Questions this page answers

This official record identifies the substance as prohibited for cosmetic use in the stated market scope. Do not rely on a formulation containing this identity until the cited source, effective date and exact substance match have been verified.

A prohibition entry may contain no separate condition text because the regulatory outcome is the prohibition itself. RDC 1.030/2026 amends rather than replaces the prohibited baseline, and the second restricted-list revision was still under consultation in July 2026.

The record cites RDC 529/2021 consolidated annex, entry 358 (through RDC 1.030/2026), source version RDC 529/2021 consolidated through RDC 1.030/2026. Open the official source.

No. CAS helps resolve identity, but jurisdictions can classify the same substance differently and can apply different product scopes, limits, warnings and transition dates.

Stable citation

Furocumarinas (por exemplo trioxisalano* , 8 - metoxipsoraleno, 5 - metoxipsoraleno), exceto para os conteúdos normais em essências. RDC 529/2021 consolidated annex, entry 358 (through RDC 1.030/2026). Brazil. Source version RDC 529/2021 consolidated through RDC 1.030/2026. CosIng Checker regulatory record: https://cosingchecker.com/regulations/br/records/13564/

Cite the regulator as the legal authority. This page is a structured evidence index and verification aid, not a substitute for the official text or professional legal assessment.

Interpretation and limits for Brazil

This official record identifies the substance as prohibited for cosmetic use in the stated market scope.

Do not rely on a formulation containing this identity until the cited source, effective date and exact substance match have been verified.

How to interpret the legal role

The cited row forms part of a binding rule or legally incorporated list for this market.

Evidence on this page

  • Recorded outcome: Prohibited
  • Legal role: Binding rule
  • Source version: RDC 529/2021 consolidated through RDC 1.030/2026
  • Effective date: 2026-06-15

What it does not prove

RDC 1.030/2026 amends rather than replaces the prohibited baseline, and the second restricted-list revision was still under consultation in July 2026.

Further authoritative substance research

These sources can add identity, safety, exposure or hazard context. A link is not evidence that the database contains this exact substance, and none of these sources overrides the market decision above.

Cosmetic Ingredient Review safety assessments

Expert Panel conclusions, assessed ingredient groups, use conditions, dates and report documents

Independent expert review considered by FDA; not a government approval or binding market rule

Research this identity at the source

FDA Global Substance Registration System

UNII identifiers, preferred names, substance types, codes and public substance relationships

Identity registry only; UNII availability does not imply FDA review or approval

Research this identity at the source

ILO/WHO International Chemical Safety Cards

Hazards, symptoms, first aid, storage, incompatibilities and physical properties for covered chemicals

International occupational chemical-safety reference; not cosmetic-use approval

Research this identity at the source

Japan NITE-CHRIP

Chemical identity, Japanese and foreign legal lists, GHS hazards and exposure-related information

Chemical-management evidence; cosmetic status remains governed by the applicable MHLW standard and market rules

Research this identity at the source

NIOSH Pocket Guide to Chemical Hazards

REL, PEL, IDLH, properties, exposure routes, symptoms, target organs, first aid and measurement methods for covered workplace chemicals

US occupational-health guidance and limits; not a cosmetic ingredient decision

Research this identity at the source

OECD eChemPortal

Gateway to authority-owned physical-property, fate, ecotoxicity, toxicity, exposure and GHS records

Discovery gateway; each linked authority remains responsible for its data

Research this identity at the source

US EPA CompTox CTX APIs

API key required for import

DTXSID identity, experimental and predicted properties, toxicity, bioactivity, exposure and environmental data

Scientific and computational evidence; predictions must remain labelled and do not determine cosmetic legality

Research this identity at the source