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Annex II Entry 358 02/12/2016

Furocoumarines (e.g. trioxysalen (INN), 8-methoxypsoralen, 5-methoxypsoralen) except for normal content in natural essences used. In sun protection and in bronzing products, furocoumarines shall be below 1 mg/kg

Furocoumarines (e.g. trioxysalen (INN), 8-methoxypsoralen, 5-methoxypsoralen) except for normal content in natural essences used. In sun protection and in bronzing products, furocoumarines shall be below 1 mg/kg is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 358

Chemical identity and properties

PubChem 2D chemical structure for CAS 298-81-7
CAS 298-81-7PubChem CID 4114

8-Methoxypsoralen

Methoxsalen is a member of the class of psoralens that is 7H-furo[3,2-g]chromen-7-one in which the 9 position is substituted by a methoxy group. It is a constituent of the fruits of Ammi majus. Like other psoralens, trioxsalen causes photosensitization of the skin. It is administered topically or orally in conjunction with UV-A for phototherapy treatment of vitiligo and severe psoriasis. It has a role as an antineoplastic agent, a photosensitizing agent, a dermatologic drug, a cross-linking reagent and a plant metabolite. It is a member of psoralens and an aromatic ether. It is functionally related to a psoralen. — ChEBI

IUPAC name
9-methoxyfuro[3,2-g]chromen-7-one
Molecular formula
C12H8O4
Molecular weight
216.19 g/mol
Exact mass
216.04225873 Da
XLogP3
1.9
Topological polar surface area
48.7 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
4
Covalent units
1
Defined stereocentres
0

Also known as

methoxsalenXANTHOTOXIN8-MOPOxsoralen9-Methoxy-7H-furo[3,2-g]chromen-7-oneMeladinineOxypsoralenMeloxine
16 more reported names
PuvalenXanthotoxineAmmoidinMeladininMeladoxenAmmodinUvadex8-MethoxypsoraleneGeroxalenNew-MeladininZanthotoxinPuvametPsoralon-MOP9-MethoxypsoralenOxsoralen Ultra8-Methoxyfuranocoumarin
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 3902-71-4
CAS 3902-71-4PubChem CID 5585

Trimethylpsoralen

Trioxsalen is 7H-Furo[3,2-g]chromen-7-one in which positions 2, 5, and 9 are substituted by methyl groups. Like other psoralens, trioxsalen causes photosensitization of the skin. It is administered orally in conjunction with UV-A for phototherapy treatment of vitiligo. After photoactivation it creates interstrand cross-links in DNA, inhibiting DNA synthesis and cell division, and can lead to cell injury; recovery from the cell injury may be followed by increased melanisation of the epidermis. It has a role as a photosensitizing agent and a dermatologic drug. — ChEBI

IUPAC name
2,5,9-trimethylfuro[3,2-g]chromen-7-one
Molecular formula
C14H12O3
Molecular weight
228.24 g/mol
Exact mass
228.078644241 Da
XLogP3
3.0
Topological polar surface area
39.4 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
3
Covalent units
1
Defined stereocentres
0

Also known as

trioxsalenTrioxysalen4,5',8-TrimethylpsoralenTrioxisalenoTrioxysalene2',4,8-TrimethylpsoralenTrioxysalenumTmp (psoralen)
16 more reported names
NSC 710477H-Furo[3,2-g][1]benzopyran-7-one, 2,5,9-trimethyl-Y6UY8OV51T2,5,9-Trimethyl-7H-furo(3,2-g)(1)benzopyran-7-one7H-Furo(3,2-g)(1)benzopyran-7-one, 2,5,9-trimethyl-2,5,9-Trimethyl-7H-furo[3,2-g][1]benzopyran-7-oneCHEBI:283296-hydroxy-beta,2,7-trimethyl-5-benzofuranacrylic acid, delta-lactoneTrioxisalenum2,5,9-trimethylfuro(3,2-g)chromen-7-one4,7,9-trimethyl-2H-furo(3,2-g)chromen-2-one4,7,9-trimethyl-2H-furo[3,2-g]chromen-2-onetrioxisaleneRefChem:581762,5,9-Trimethyl-7H-furo(3,2-g)benzopyran-7-oneD05AD01
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External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 484-20-8
CAS 484-20-8PubChem CID 2355

Bergapten

5-methoxypsoralen is a 5-methoxyfurocoumarin that is psoralen substituted by a methoxy group at position 5. It has a role as a hepatoprotective agent and a plant metabolite. It is a member of psoralens, an organic heterotricyclic compound and a 5-methoxyfurocoumarin. It is functionally related to a psoralen. — ChEBI

IUPAC name
4-methoxyfuro[3,2-g]chromen-7-one
Molecular formula
C12H8O4
Molecular weight
216.19 g/mol
Exact mass
216.04225873 Da
XLogP3
2.3
Topological polar surface area
48.7 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
4
Covalent units
1
Defined stereocentres
0

Also known as

5-MethoxypsoralenbergapteneHeraclinMajudinBERGAPTAN5-MopPsoradermO-Methylbergaptol
16 more reported names
5-Methoxy psoralen5-Methoxy-6,7-furanocoumarin5-MethoxyfuranocoumarinGeralen4-Methoxy-7H-furo(3,2-g)(1)benzopyran-7-one7H-Furo[3,2-g][1]benzopyran-7-one, 4-methoxy-5 methoxypsoralen4-methoxy-7H-furo[3,2-g][1]benzopyran-7-oneNSC-954376-Hydroxy-4-methoxy-5-benzofuranacrylic acid, gamma-lactone4FVK84C92X7H-Furo(3,2-g)(1)benzopyran-7-one, 4-methoxy-CHEBI:182935-methoxy-2H-furo[3,2-g]chromen-2-one5 Methoxy Psoralen5-methoxy-2H-furo(3,2-g)chromen-2-one
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

Furocoumarines (e.g. trioxysalen (INN), 8-methoxypsoralen, 5-methoxypsoralen) except for normal content in natural essences used. In sun protection and in bronzing products, furocoumarines shall be below 1 mg/kg

Regulatory information

Regulation

(EC) 2009/1223

See every entry this act set

SCCS opinions

Identified ingredients

Key data

CAS
298-81-7 / 484-20-8 / 3902-71-4
EC
206-066-9 / 207-604-5 / 223-459-0
Annex
II
Entry number
358

Inventory links for Furocoumarines (e.g. trioxysalen (INN), 8-methoxypsoralen, 5-methoxypsoralen) except for normal content in natural essences used. In sun protection and in bronzing products, furocoumarines shall be below 1 mg/kg

Inventory Restriction reference
Ref 55375

CITRUS GRANDIS PEEL

CAS: 90045-43-5 / 8016-20-4
EC: 289-904-6 / -
Inventory Restriction reference
Ref 85118

CITRUS LIMON JUICE

CAS: 92346-89-9 / 84929-31-7
EC: 296-174-2 / 284-515-8
Inventory Restriction reference
Ref 85121

CITRUS LIMON LEAF OIL

CAS: 92346-89-9 / 84929-31-7
EC: 296-174-2 / 284-515-8
Inventory Restriction reference
Ref 85122

CITRUS LIMON PEEL

CAS: 92346-89-9 / 84929-31-7
EC: 296-174-2 / 284-515-8
Inventory Restriction reference
Ref 84775

CITRUS LIMON SEED OIL

CAS: 92346-89-9 / 84929-31-7 / 85085-28-5
EC: 296-174-2 / 284-515-8 / 285-359-3
Inventory Restriction reference
Ref 37563

RUTA GRAVEOLENS OIL

CAS: 8014-29-7 / 84929-47-5
EC: - / 284-531-5

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

Annex II 352
Nearby record in the same annex

Bithionol (INN)

CAS: 97-18-7
EC: 202-565-0

What Annex II means for Furocoumarines (e.g. trioxysalen (INN), 8-methoxypsoralen, 5-methoxypsoralen) except for normal content in natural essences used. In sun protection and in bronzing products, furocoumarines shall be below 1 mg/kg

Furocoumarines (e.g. trioxysalen (INN), 8-methoxypsoralen, 5-methoxypsoralen) except for normal content in natural essences used. In sun protection and in bronzing products, furocoumarines shall be below 1 mg/kg is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

This record is linked to 94 CosIng inventory ingredients for name and identifier cross-reference. The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).

Frequently asked questions

Yes. Furocoumarines (e.g. trioxysalen (INN), 8-methoxypsoralen, 5-methoxypsoralen) except for normal content in natural essences used. In sun protection and in bronzing products, furocoumarines shall be below 1 mg/kg is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 298-81-7 / 484-20-8 / 3902-71-4 is the unique numerical identifier assigned to Furocoumarines (e.g. trioxysalen (INN), 8-methoxypsoralen, 5-methoxypsoralen) except for normal content in natural essences used. In sun protection and in bronzing products, furocoumarines shall be below 1 mg/kg by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record Furocoumarines (e.g. trioxysalen (INN), 8-methoxypsoralen, 5-methoxypsoralen) except for normal content in natural essences used. In sun protection and in bronzing products, furocoumarines shall be below 1 mg/kg

This page summarizes one Annex II record for Furocoumarines (e.g. trioxysalen (INN), 8-methoxypsoralen, 5-methoxypsoralen) except for normal content in natural essences used. In sun protection and in bronzing products, furocoumarines shall be below 1 mg/kg from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for Furocoumarines (e.g. trioxysalen (INN), 8-methoxypsoralen, 5-methoxypsoralen) except for normal content in natural essences used. In sun protection and in bronzing products, furocoumarines shall be below 1 mg/kg, but confirm any final regulatory decision against the current official annex wording and source files.

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