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METHENAMINE

The current Australian Poisons Standard places this cosmetic or personal-care use in Schedule 5.

All Australia recordsOpen ingredient profileCompare all marketsOpen official source

Regulatory decision and full conditions

Status
Restricted
Legal role
Binding rule
Regulatory summary
The current Australian Poisons Standard places this cosmetic or personal-care use in Schedule 5.
Conditions and restrictions
METHENAMINE in cosmetic preparations, except in preparations containing 0.15% or less of methenamine.

Substance identity

Official source name
METHENAMINE
CAS
100-97-0
EC
202-905-8
Identity mapping
exact_name
Linked ingredient
METHENAMINE
Search this identity across the siteCAS 100-97-0EC 202-905-8

Linked CosIng identity data

Names and aliases

METHENAMINEmethenamine

CosIng description: 1,3,5,7-Tetraazatricyclo[3.3.1.1(3,7)]decane

EU inventory restriction note: V/30

Recorded cosmetic function: ANTIMICROBIAL, PRESERVATIVE

Function pages:ANTIMICROBIAL, PRESERVATIVE

View the complete ingredient profile

Cross-market snapshot for this identity

Exact linked records currently present in this site. An absent market means no imported exact match, not permission to use the substance.

7 market datasets

European Union

Positive-list entry with conditions

1 linked record · 1 with specific conditions

Open supporting record

Great Britain

Permitted list with conditions

1 linked record · 1 with specific conditions

Open supporting record
PubChem 2D chemical structure for CAS 100-97-0
CAS 100-97-0PubChem CID 4101

Verified chemistry for CAS 100-97-0

Hexamethylenetetramine

IUPAC name
1,3,5,7-tetrazatricyclo[3.3.1.13,7]decane
Molecular formula
C6H12N4
Molecular weight
140.19 g/mol
Exact mass
140.106196400 Da
Monoisotopic mass
140.106196400 Da
XLogP3
0.3
Topological polar surface area
13.0 Ų
Molecular complexity
84.0
Formal charge
0
Hydrogen-bond donors
0
Hydrogen-bond acceptors
4
Rotatable bonds
0
Heavy atoms
10
Covalent units
1

Names and synonyms reported to PubChem

methenamineHexamineUrotropineUrotropin1,3,5,7-TetraazaadamantaneUritoneHMTAHexamethylenamine
16 more reported names
FormamineHexamethylene tetramineMethenaminAmmoformCystaminCystogenAmmonioformaldehydeForminAceto HMTHexamethylenetetraamineAminoformaldehydePreparation AFAntihydralDuirexolHexaformMetenamina
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D pharmacophore features
8
3D rings
4
3D hydrophobes
0
3D acceptor features
0
3D donor features
0
3D anionic centres
0
3D cationic centres
4
3D conformers
1
Effective 3D rotors
1.2
Machine-readable structure identifiers
SMILES
C1N2CN3CN1CN(C2)C3
InChI
InChI=1S/C6H12N4/c1-7-2-9-4-8(1)5-10(3-7)6-9/h1-6H2
InChIKey
VKYKSIONXSXAKP-UHFFFAOYSA-N

Evidence from additional scientific databases

EMBL-EBI ChEBI
Exact identifier matchCHEBI:6824

hexamethylenetetramine

A polycyclic cage that is adamantane in which the carbon atoms at positions 1, 3, 5 and 7 are replaced by nitrogen atoms.

Formula
C6H12N4
Average mass
140.190 g/mol
Monoisotopic mass
140.10620 Da
Formal charge
0
  • polycyclic cage — is a (CHEBI:33640)
  • polyazaalkane — is a (CHEBI:39474)
  • tetramine — is a (CHEBI:39166)
  • antibacterial drug — has role (CHEBI:36047)
  • antibacterial agent — has role (CHEBI:33282)
  • antibacterial drug — has role (CHEBI:36047)
  • antibacterial agent — has role (CHEBI:33282)
  • polycyclic cage — is a (CHEBI:33640)
  • polyazaalkane — is a (CHEBI:39474)
  • tetramine — is a (CHEBI:39166)
Additional curated names
1,3,5,7-tetraazaadamantane1,3,5,7-tetraazatricyclo[3.3.1.1(3,7)]decaneAminoformE-239E239hexamethylenaminehexamethylene tetraminehexamethylenetetramineHexamethylentetraminhexamethylentetraminumhexaminehexaminumHMTHMTAINS-239INS NO.239methenamineNSC-26346NSC-403347
Cross-references from this source
  • CAS: 100-97-0 — ChemIDplus
  • CAS: 100-97-0 — NIST Chemistry WebBook
  • REGISTRY_NUMBER: 2018 — Reaxys
  • REGISTRY_NUMBER: 26964 — Gmelin
  • MANUAL_X_REF: 3344 — DrugCentral
  • MANUAL_X_REF: D00393 — KEGG DRUG
  • MANUAL_X_REF: HMDB0029598 — HMDB
  • MANUAL_X_REF: LSM-5440 — LINCS
  • MANUAL_X_REF: Methenamine — Wikipedia
  • MANUAL_X_REF: US2762799 — Patent
  • MANUAL_X_REF: US2762800 — Patent

Mapped by: Exact CAS cross-reference in the ChEBI compound record. Source updated: 2017-02-22. Retrieved: 2026-08-31. Open source record

NIH PubChem PUG-View
Exact identifier match4101

Attributed physical-property, hazard, environmental and use annotations.

  • First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.; SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.; INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) shou Source: CAMEO Chemicals
  • ERG2024, Guide 133 (Hexamethylenetetramine): General First Aid:; · Call 911 or emergency medical service.; · Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.; · Move victim to fresh air if it can be done safely.; · Administer oxygen if breathing is difficult.; · If victim is not breathing:; -- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.; -- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).; -- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.; · Remove and isolate contaminated clothing and shoes.; · For minor skin contact, avoid spreading material on unaffected skin.; · In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.; · For severe burns, immediate medical attention is required.; · Effects of exposure (inhalation, ingestion, Source: Emergency Response Guidebook (ERG)
  • Signal: Warning Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • GHS Hazard Statements: H228: Flammable solid [Danger Flammable solids]; H317: May cause an allergic skin reaction [Warning Sensitization, Skin] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Precautionary Statement Codes: P210, P240, P241, P261, P272, P280, P302+P352, P321, P333+P317, P362+P364, P370+P378, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Signal: Danger Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H228 (100%): Flammable solid [Danger Flammable solids]; H317 (100%): May cause an allergic skin reaction [Warning Sensitization, Skin] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P210, P240, P241, P261, P272, P280, P302+P352, P321, P333+P317, P362+P364, P370+P378, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 1051 reports by companies from 19 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]; H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]; H317 (100%): May cause an allergic skin reaction [Warning Sensitization, Skin]; H334 (100%): May cause allergy or asthma symptoms or breathing difficulties if inhaled [Danger Sensitization, respiratory]; H351 (100%): Suspected of causing cancer [Warning Carcinogenicity] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P203, P233, P260, P261, P264, P270, P271, P272, P280, P284, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P316, P318, P321, P330, P333+P317, P342+P316, P362+P364, P363, P403, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 39 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Signal: Danger Source: NITE-CMC
  • GHS Hazard Statements: H228: Flammable solid [Danger Flammable solids]; H317: May cause an allergic skin reaction [Warning Sensitization, Skin]; H361: Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]; H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure] Source: NITE-CMC
  • Cosmetic Ingredient Review Conclusion: On the basis of the animal and clinical data presented in this report, the CIR Expert Panel concludes that Methenamine is safe for cosmetic use at concentrations not to exceed 0.16% in formulation. It cannot be concluded that Methenamine is safe for use in cosmetic products intended to be aerosolized. Source: Cosmetic Ingredient Review (CIR)
  • Cosmetic Ingredient Review Finding(s): Safe for use in cosmetics, with qualifications Source: Cosmetic Ingredient Review (CIR)
  • Toxicity Summary: IDENTIFICATION AND USE: Methenamine is a white or colorless crystalline solid. It is an anti-infective agent. Methenamine hippurate tablets, USP are indicated for prophylactic or suppressive treatment of frequently recurring urinary tract infections when long-term therapy is considered necessary. Non-medical uses include the following: in adhesives, coatings, and sealing compounds; as cross-linking agent for hardening phenol-formaldehyde resin and vulcanizing rubber; as corrosion inhibitor for steel; as fuel tablets for camping stoves; as stabilizer for lubricating and insulating oils; in the chemical detection of metals; in the preservation of hides; as dye fixative; for the manufacture of explosive compounds; antimicrobial food additive. HUMAN EXPOSURE AND TOXICITY: GI distress frequently is caused by doses >500 mg four times a day, even with enteric coated tablets. Painful and frequent micturition, albuminuria, hematuria, and rashes may result from doses of 4 to 8 g/day given for longer than 3-4 weeks. Inhalation may cause asthma-like reactions in previously sensitized individuals. Vapors or solutions have produced skin irritation. Methenamine does not appear to be linked to con Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Bioconcentration: An estimated BCF of 3 was calculated in fish for methenamine(SRC), using a log Kow of -2.18(1) and a regression-derived equation(2). According to a classification scheme(2), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 10(SRC), determined from a structure estimation method(2), indicates that methenamine is expected to have very high mobility in soil(SRC). The pKa of methenamine is 4.89(3), indicating that this compound will exist partially in cation form in the environment and cations generally adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(4). Volatilization of methenamine from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 3.7X10-10 atm-cu m/mole(SRC), derived from its vapor pressure, 6.1X10-4 mm Hg(5), and water solubility, 3.02X10+5 mg/L(6). Methenamine is not expected to volatilize from dry soil surfaces based on its vapor pressure(SRC). Various biolodegradation screening studies have observed between 28-100% degradation of methenamine(7) suggesting that biodegradation is an important environmental fate process in soil(SRC). However, part (or most) of the degradation may be explained by hydrolysis to form formaldehyde and ammonia followed by biodegradation with the degradation rate increasing wi Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 10(SRC), determined from a structure estimation method(2), indicates that methenamine is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon an estimated Henry's Law constant of 3.7X10-10 atm-cu m/mole(SRC), derived from its vapor pressure, 6.1X10-4 mm Hg(4), and water solubility, 3.02X10+5 mg/L(5). According to a classification scheme(6), an estimated BCF of 3(SRC), from its log Kow of -2.18(7) and a regression-derived equation(2), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Various biolodegradation screening studies have observed between 28-100% degradation of methenamine(8) suggesting that biodegradation is an important environmental fate process in soil(SRC). However, part (or most) of the degradation may be explained by hydrolysis to form formaldehyde and ammonia followed by biodegradation with the degradation rate increasing with acidity(8). Aqueous hydrolysis half-lives of 13.8 hours and 1.6 hours have been measured at 37.5 °C and pH 5.8 and pH 2 respectively(9). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), methenamine, which has a vapor pressure of 6.1X10-4 mm Hg at 25 °C(2), will exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase methenamine is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 45 minutes(SRC), calculated from its rate constant of 5.1X10-10 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Particulate-phase methenamine may be removed from the air by wet and dry deposition(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Industry Uses: Chemical reaction regulator; Monomers; Processing aids not otherwise specified; Binder; Other; Energy Releasers (explosives, motive propellant); Polymerization promoter; Terminator/Blocker; Processing aids, specific to petroleum production; Intermediate; Hardener; Adhesion/cohesion promoter; Not Known or Reasonably Ascertainable; Catalyst Source: EPA Chemical Data Reporting (CDR)
  • Cosmetic Ingredient Review Link: CIR ingredient: Methenamine Source: Cosmetic Ingredient Review (CIR)
  • Sources/Uses: Used in adhesives, coatings, sealants, and leather preservatives; also used as an anticorrosion agent, antibiotic, dye fixative, chemical stabilizer, and curing agent for formaldehyde resins and rubber; [HSDB] Used as a drug (methenamine) taken by mouth to prevent recurrent urinary tract infections; [Medscape DrugInfo] Used as a hardener for epoxy resins of the bisphenol A type; Used in the tire, rubber, foundry, and phenol-formaldehyde resin industries; Sometimes used in topical drugs and cosmetics; [Kanerva, p. 1811] Used as a formaldehyde releaser for photographic film development. [Kanerva, p. 1054-5] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Industrial Processes with risk of exposure: Molding and Core Making [Category: Foundry]; Painting (Pigments, Binders, and Biocides) [Category: Paint]; Working with Glues and Adhesives [Category: Other]; Plastic Composites Manufacturing [Category: Industry]; Leather Tanning and Processing [Category: Industry]; Photographic Processing [Category: Other] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Uses: Anti-Infective Agents, Urinary Source: Hazardous Substances Data Bank (HSDB)
  • Uses: For methenamine (USEPA/OPP Pesticide Code: 045501) there are 0 labels match. /SRP: Not registered for current use in the U.S., but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses./ Source: Hazardous Substances Data Bank (HSDB)
  • Uses: HMTA is used in the rubber industry to prevent vulcanized rubber from blocking and as a accelerator, as a curing agent for thermosetting resins (particularly phenyl-formaldehyde and urea-formaldehyde resins; in foundry mold castings as part of binder resins, in the production of nitrilotriacetic acid; in the manufacture of adhesives and coatings; in firelogs and briquettes for camping; and in flame-retardent materials. Because of its unique ability to hydrolyze to formaldehyde and ammonia under acidic conditions, it is also used in pharmaceuticals, for intestinal infection, and as a preservative in the food industry. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: In adhesives, coatings, and sealing compounds; as cross-linking agent for hardening phenol-formaldehyde resin and vulcanizing rubber; as corrosion inhibitor for steel; as fuel tablets for camping stoves; as stabilizer for lubricating and insulating oils; in the chemical detection of metals; in the preservation of hides; as dye fixative; for the manufacture of explosive compounds; antimicrobial food additive; detection of metals. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: For more Uses (Complete) data for METHENAMINE (9 total), please visit the HSDB record page. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Use (kg; approx.) in Germany (2009): >500; Use (kg; exact) in Germany (2009): 670; Consumption (g per capita; approx.) in Germany (2009): 0.00611; Consumption (g per capita; exact) in Germany (2009): 0.00818; Calculated removal (%): 8.8 Source: NORMAN Suspect List Exchange

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
EMBL-EBI ChEBIExact match2026-08-31
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Official source and provenance

Registered source
Australia Poisons Standard (SUSMP)
Source reference
Therapeutic Goods (Poisons Standard—June 2026) Instrument 2026, Schedule 5
Source record ID
schedule-5:methenamine:11
Source version
Therapeutic Goods (Poisons Standard—June 2026) Instrument 2026
Source language
English
Translation status
Original is English
Effective date
2026-06-01
Source updated
2026-05-28
Snapshot checked
2026-08-31 15:26 UTC
Validation method
pdftotext -layout; 674 pages; exact cosmetic-relevant per-schedule counts {2: 4, 4: 12, 5: 15, 6: 62, 10: 32}
SHA-256
38478bdefd4ebaf571ac39001e2ce35026a7edafbaec995e75746ce69a650e11

Registered dataset notes

Dataset coverage
All current Poisons Standard entries whose source wording explicitly covers cosmetics or personal-care uses
Authority note
Binding Commonwealth scheduling instrument; state and territory implementation and AICIS duties still apply
Inspect the exact official sourceRegulator guidance

How this record fits the market dataset

125
current Australia records
93
records marked Restricted
125
records from this source version
41
market records with CAS identity

Status distribution

Prohibited: 32Restricted: 93

Condition text is present on 125 of 125 current records. An empty condition field is interpreted according to the record type above; it is never converted into an unrestricted-use claim.

Australia market context

Complete cosmetic-relevant Poisons Standard subset plus official workflow

Coverage version: Therapeutic Goods (Poisons Standard—June 2026) Instrument 2026

All 125 current Schedule 2, 4, 5, 6 and 10 entries whose legal wording explicitly covers cosmetics or personal-care uses, plus AICIS verification links.

Verification checklist

  1. Decide whether the product is a cosmetic or therapeutic good.
  2. Check the current Poisons Standard for every ingredient.
  3. Search AICIS Inventory terms and assessment certificates by exact identity.
  4. Determine introduction category, registration, reporting, records and labelling duties.

Official market sources

Verification workflow and record completeness

Before using this result in a compliance decision

  1. Confirm that “METHENAMINE” and every CAS/EC identifier refer to the material in your supplier specification.
  2. Decide whether the product is a cosmetic or therapeutic good.
  3. Check the current Poisons Standard for every ingredient.
  4. Search AICIS Inventory terms and assessment certificates by exact identity.
  5. Determine introduction category, registration, reporting, records and labelling duties.
  6. Document the source version and recheck the regulator before manufacture, notification or market placement.

Fields available in this record

  • Official substance nameAvailable
  • CASAvailable
  • ECAvailable
  • Separate condition textAvailable
  • Effective dateAvailable
  • Snapshot hash and methodAvailable

Questions this page answers

This substance is not unrestricted: cosmetic use is subject to the conditions in the cited official record. Check product type, body area, concentration, purity and warning requirements before deciding whether a formulation is compliant.

If this row does not reproduce conditions, open the cited official detail because omission does not mean unrestricted use. An AICIS Inventory match is not cosmetic approval; no Inventory match can indicate a new, exempted, reported or confidential introduction.

The record cites Therapeutic Goods (Poisons Standard—June 2026) Instrument 2026, Schedule 5, source version Therapeutic Goods (Poisons Standard—June 2026) Instrument 2026. Open the official source.

No. CAS helps resolve identity, but jurisdictions can classify the same substance differently and can apply different product scopes, limits, warnings and transition dates.

Stable citation

METHENAMINE. Therapeutic Goods (Poisons Standard—June 2026) Instrument 2026, Schedule 5. Australia. Source version Therapeutic Goods (Poisons Standard—June 2026) Instrument 2026. CosIng Checker regulatory record: https://cosingchecker.com/regulations/au/records/13109/

Cite the regulator as the legal authority. This page is a structured evidence index and verification aid, not a substitute for the official text or professional legal assessment.

Interpretation and limits for Australia

This substance is not unrestricted: cosmetic use is subject to the conditions in the cited official record.

Check product type, body area, concentration, purity and warning requirements before deciding whether a formulation is compliant.

How to interpret the legal role

The cited row forms part of a binding rule or legally incorporated list for this market.

Evidence on this page

  • Recorded outcome: Restricted
  • Legal role: Binding rule
  • Source version: Therapeutic Goods (Poisons Standard—June 2026) Instrument 2026
  • Effective date: 2026-06-01

What it does not prove

An AICIS Inventory match is not cosmetic approval; no Inventory match can indicate a new, exempted, reported or confidential introduction.

Further authoritative substance research

These sources can add identity, safety, exposure or hazard context. A link is not evidence that the database contains this exact substance, and none of these sources overrides the market decision above.

Cosmetic Ingredient Review safety assessments

Expert Panel conclusions, assessed ingredient groups, use conditions, dates and report documents

Independent expert review considered by FDA; not a government approval or binding market rule

Research this identity at the source

FDA Global Substance Registration System

UNII identifiers, preferred names, substance types, codes and public substance relationships

Identity registry only; UNII availability does not imply FDA review or approval

Research this identity at the source

ILO/WHO International Chemical Safety Cards

Hazards, symptoms, first aid, storage, incompatibilities and physical properties for covered chemicals

International occupational chemical-safety reference; not cosmetic-use approval

Research this identity at the source

Japan NITE-CHRIP

Chemical identity, Japanese and foreign legal lists, GHS hazards and exposure-related information

Chemical-management evidence; cosmetic status remains governed by the applicable MHLW standard and market rules

Research this identity at the source

NIOSH Pocket Guide to Chemical Hazards

REL, PEL, IDLH, properties, exposure routes, symptoms, target organs, first aid and measurement methods for covered workplace chemicals

US occupational-health guidance and limits; not a cosmetic ingredient decision

Research this identity at the source

OECD eChemPortal

Gateway to authority-owned physical-property, fate, ecotoxicity, toxicity, exposure and GHS records

Discovery gateway; each linked authority remains responsible for its data

Research this identity at the source

US EPA CompTox CTX APIs

API key required for import

DTXSID identity, experimental and predicted properties, toxicity, bioactivity, exposure and environmental data

Scientific and computational evidence; predictions must remain labelled and do not determine cosmetic legality

Research this identity at the source