Hydroxypropyl bis(N-hydroxyethyl-p- phenylenediamine) and its tetrahydrochloride Hydroxypropyl bis(N-hydroxyethyl-p- phenylenediamine) HCl CAS No 128729-30-6 / 128729-28-2
ASEAN Annex III lists this record among substances allowed only under restrictions and conditions. Member-state transition rules and deviations still require local verification.
Regulatory decision and full conditions
- Status
- Restricted
- Legal role
- Binding rule
- Regulatory summary
- ASEAN Annex III lists this record among substances allowed only under restrictions and conditions. Member-state transition rules and deviations still require local verification.
- Conditions and restrictions
- Hair dye substance in oxidative hair dye products Use for dyeing eyelashes and eyebrows is not permitted. · After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 0.4 % (as tetrahydrochloride) The direction for use “wear suitable gloves” must be included in label or leaflet text. · The mixing ratio must be printed on the label. Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary “black henna” tattoos may increase your risk of allergy. Do not colour your hair if: • you have a rash on your face or sensitive, irritated and damaged scalp, • you have ever experienced any reaction after colouring your hair, • you have experienced a reaction to a temporary “black henna” tattoo in the past Do not use to dye eyelashes or eyebrows
Substance identity
- Official source name
- Hydroxypropyl bis(N-hydroxyethyl-p- phenylenediamine) and its tetrahydrochloride Hydroxypropyl bis(N-hydroxyethyl-p- phenylenediamine) HCl CAS No 128729-30-6 / 128729-28-2
- CAS
- 128729-30-6; 128729-28-2
- EC
- 416-320-2
- Identity mapping
- cas_number
- Linked ingredient
- HYDROXYPROPYL BIS(N-HYDROXYETHYL-P-PHENYLENEDIAMINE) HCL
Linked CosIng identity data
Names and aliases
CosIng description: 1,4-Benzenediamine, N(4)-(2-hydroxyethyl)-N(1),N'(1)-[2-hydroxypropanediyl]-
EU inventory restriction note: III/239
Recorded cosmetic function: HAIR DYEING
Function pages:HAIR DYEING
View the complete ingredient profileCross-market snapshot for this identity
Exact linked records currently present in this site. An absent market means no imported exact match, not permission to use the substance.
European Union
1 linked record · 1 with specific conditions
Open supporting recordGreat Britain
1 linked record · 1 with specific conditions
Open supporting recordNew Zealand
2 linked records · 2 with specific conditions
Open supporting recordASEAN
Current record1 linked record · 1 with specific conditions
Open supporting recordSouth Korea
3 linked records · 3 with specific conditions
Open supporting recordIndia
1 linked record · 1 with specific conditions
Open supporting recordSaudi Arabia
1 linked record
Open supporting recordVerified chemistry for CAS 128729-28-2
Hydroxypropyl bis(N-hydroxyethyl-p-phenylenediamine) hydrochloride
- IUPAC name
- 1,3-bis[4-amino-N-(2-hydroxyethyl)anilino]propan-2-ol;tetrahydrochloride
- Molecular formula
- C19H32Cl4N4O3
- Molecular weight
- 506.3 g/mol
- Exact mass
- 506.119902 Da
- Monoisotopic mass
- 504.122852 Da
- Topological polar surface area
- 119.0 Ų
- Molecular complexity
- 338.0
- Formal charge
- 0
- Hydrogen-bond donors
- 9
- Hydrogen-bond acceptors
- 7
- Rotatable bonds
- 10
- Heavy atoms
- 30
- Covalent units
- 5
Names and synonyms reported to PubChem
9 more reported names
External database identifiers
- EPA DTXSID:DTXSID30155976
Advanced structure statistics
- Defined atom stereocentres
- 0
- Undefined atom stereocentres
- 0
- Defined bond stereocentres
- 0
- Undefined bond stereocentres
- 0
- 3D conformers
- 0
Machine-readable structure identifiers
- SMILES
C1=CC(=CC=C1N)N(CCO)CC(CN(CCO)C2=CC=C(C=C2)N)O.Cl.Cl.Cl.Cl- InChI
InChI=1S/C19H28N4O3.4ClH/c20-15-1-5-17(6-2-15)22(9-11-24)13-19(26)14-23(10-12-25)18-7-3-16(21)4-8-18;;;;/h1-8,19,24-26H,9-14,20-21H2;4*1H- InChIKey
GATCALZBQPZIFW-UHFFFAOYSA-N
Evidence from additional scientific databases
NIH PubChem PUG-View
Attributed physical-property, hazard, environmental and use annotations.
- Signal: Danger Source: European Chemicals Agency (ECHA)
- GHS Hazard Statements: H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]; H317 (100%): May cause an allergic skin reaction [Warning Sensitization, Skin]; H318 (100%): Causes serious eye damage [Danger Serious eye damage/eye irritation]; H400 (100%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410 (100%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
- Precautionary Statement Codes: P261, P264, P264+P265, P272, P273, P280, P302+P352, P305+P354+P338, P317, P321, P332+P317, P333+P317, P362+P364, P391, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
- ECHA C&L Notifications Summary: Aggregated GHS information provided per 2 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
- ECHA C&L Notifications Summary: The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory. Source: European Chemicals Agency (ECHA)
- Cosmetic Ingredient Review Finding(s): Safe in the present practices of use and concentration. Ingredient, concentration, and use information are available in documents discoverable at https://cir-reports.cir-safety.org Source: Cosmetic Ingredient Review (CIR)
- Cosmetic Ingredient Review Link: CIR ingredient: Hydroxypropyl Bis(N-Hydroxyethyl-p-Phenylenediamine) HCl Source: Cosmetic Ingredient Review (CIR)
Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record
Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.
Additional source coverage and match status
| Source | Result | Checked |
|---|---|---|
| NIH PubChem PUG-View | Exact match | 2026-08-31 |
A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.
Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Verified chemistry for CAS 128729-30-6
1,3-Bis((4-aminophenyl)-(2-hydroxyethyl)-amino)-propan-2-ol
- IUPAC name
- 1,3-bis[4-amino-N-(2-hydroxyethyl)anilino]propan-2-ol
- Molecular formula
- C19H28N4O3
- Molecular weight
- 360.5 g/mol
- Exact mass
- 360.21614077 Da
- Monoisotopic mass
- 360.21614077 Da
- XLogP3
- 0.5
- Topological polar surface area
- 119.0 Ų
- Molecular complexity
- 338.0
- Formal charge
- 0
- Hydrogen-bond donors
- 5
- Hydrogen-bond acceptors
- 7
- Rotatable bonds
- 10
- Heavy atoms
- 26
- Covalent units
- 1
Names and synonyms reported to PubChem
External database identifiers
- EPA DTXSID:DTXSID90879823
Advanced structure statistics
- Defined atom stereocentres
- 0
- Undefined atom stereocentres
- 0
- Defined bond stereocentres
- 0
- Undefined bond stereocentres
- 0
- 3D pharmacophore features
- 14
- 3D rings
- 2
- 3D hydrophobes
- 0
- 3D acceptor features
- 3
- 3D donor features
- 5
- 3D anionic centres
- 0
- 3D cationic centres
- 4
- 3D conformers
- 10
- Effective 3D rotors
- 10.0
Machine-readable structure identifiers
- SMILES
C1=CC(=CC=C1N)N(CCO)CC(CN(CCO)C2=CC=C(C=C2)N)O- InChI
InChI=1S/C19H28N4O3/c20-15-1-5-17(6-2-15)22(9-11-24)13-19(26)14-23(10-12-25)18-7-3-16(21)4-8-18/h1-8,19,24-26H,9-14,20-21H2- InChIKey
VIXBPSTZNCRCJE-UHFFFAOYSA-N
Evidence from additional scientific databases
NIH PubChem PUG-View
Attributed physical-property, hazard, environmental and use annotations.
Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record
Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.
Additional source coverage and match status
| Source | Result | Checked |
|---|---|---|
| NIH PubChem PUG-View | Exact match | 2026-08-31 |
A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.
Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Official source and provenance
- Registered source
- ASEAN Cosmetic Directive annexes
- Source reference
- ASEAN Annex III, reference 242
- Source record ID
III-242- Source version
- 2026-1
- Source language
- English
- Translation status
- Original is English
- Source updated
- 2026-06-22
- Snapshot checked
- 2026-08-30 04:44 UTC
- Validation method
- pdfplumber ruled-table extraction with per-annex reviewed counts
- SHA-256
ffad59f6c01a92c82042c54203ee14969425c2a82bd04c2f4012ff82513e69f1
Registered dataset notes
- Dataset coverage
- Banned, restricted and positive-list substances under the harmonised ASEAN framework
- Authority note
- Regional directive; member-state transitions and deviations still require local verification
How this record fits the market dataset
Status distribution
Condition text is present on 462 of 2224 current records. An empty condition field is interpreted according to the record type above; it is never converted into an unrestricted-use claim.
ASEAN market context
Complete regional annex dataset
Coverage version: ASEAN Cosmetic Directive annexes 2026-1, 22 June 2026
Annexes II, III, IV, VI and VII covering prohibited, restricted and positive-list substances.
Verification checklist
- Search all ACD annexes by name and identifiers.
- Apply product type, maximum level and warning conditions.
- Confirm the target member state's adoption and transition date.
- Complete the local notification and responsible-company requirements.
Official market sources
- ASEAN Cosmetic Directive annexesRegional directive; member-state transitions and deviations still require local verification
Verification workflow and record completeness
Before using this result in a compliance decision
- Confirm that “Hydroxypropyl bis(N-hydroxyethyl-p- phenylenediamine) and its tetrahydrochloride Hydroxypropyl bis(N-hydroxyethyl-p- phenylenediamine) HCl CAS No 128729-30-6 / 128729-28-2” and every CAS/EC identifier refer to the material in your supplier specification.
- Search all ACD annexes by name and identifiers.
- Apply product type, maximum level and warning conditions.
- Confirm the target member state's adoption and transition date.
- Complete the local notification and responsible-company requirements.
- Document the source version and recheck the regulator before manufacture, notification or market placement.
Fields available in this record
- Official substance nameAvailable
- CASAvailable
- ECAvailable
- Separate condition textAvailable
- Effective dateNot supplied
- Snapshot hash and methodAvailable
Questions this page answers
Stable citation
Hydroxypropyl bis(N-hydroxyethyl-p- phenylenediamine) and its tetrahydrochloride Hydroxypropyl bis(N-hydroxyethyl-p- phenylenediamine) HCl CAS No 128729-30-6 / 128729-28-2. ASEAN Annex III, reference 242. ASEAN. Source version 2026-1. CosIng Checker regulatory record: https://cosingchecker.com/regulations/asean/records/3998/
Cite the regulator as the legal authority. This page is a structured evidence index and verification aid, not a substitute for the official text or professional legal assessment.
Interpretation and limits for ASEAN
This substance is not unrestricted: cosmetic use is subject to the conditions in the cited official record.
Check product type, body area, concentration, purity and warning requirements before deciding whether a formulation is compliant.
How to interpret the legal role
The cited row forms part of a binding rule or legally incorporated list for this market.
Evidence on this page
- Recorded outcome: Restricted
- Legal role: Binding rule
- Source version: 2026-1
What it does not prove
Regional annex coverage does not replace member-state implementation dates, notifications or national deviations.
Further authoritative substance research
These sources can add identity, safety, exposure or hazard context. A link is not evidence that the database contains this exact substance, and none of these sources overrides the market decision above.
Cosmetic Ingredient Review safety assessments
Expert Panel conclusions, assessed ingredient groups, use conditions, dates and report documents
Independent expert review considered by FDA; not a government approval or binding market rule
Research this identity at the sourceFDA Global Substance Registration System
UNII identifiers, preferred names, substance types, codes and public substance relationships
Identity registry only; UNII availability does not imply FDA review or approval
Research this identity at the sourceILO/WHO International Chemical Safety Cards
Hazards, symptoms, first aid, storage, incompatibilities and physical properties for covered chemicals
International occupational chemical-safety reference; not cosmetic-use approval
Research this identity at the sourceJapan NITE-CHRIP
Chemical identity, Japanese and foreign legal lists, GHS hazards and exposure-related information
Chemical-management evidence; cosmetic status remains governed by the applicable MHLW standard and market rules
Research this identity at the sourceNIOSH Pocket Guide to Chemical Hazards
REL, PEL, IDLH, properties, exposure routes, symptoms, target organs, first aid and measurement methods for covered workplace chemicals
US occupational-health guidance and limits; not a cosmetic ingredient decision
Research this identity at the sourceOECD eChemPortal
Gateway to authority-owned physical-property, fate, ecotoxicity, toxicity, exposure and GHS records
Discovery gateway; each linked authority remains responsible for its data
Research this identity at the sourceUS EPA CompTox CTX APIs
API key required for importDTXSID identity, experimental and predicted properties, toxicity, bioactivity, exposure and environmental data
Scientific and computational evidence; predictions must remain labelled and do not determine cosmetic legality
Research this identity at the source