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Diethylene glycol monobutyl ether (DEGBE) Butoxydiglycol CAS No 112-34-5

ASEAN Annex III lists this record among substances allowed only under restrictions and conditions. Member-state transition rules and deviations still require local verification.

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Regulatory decision and full conditions

Status
Restricted
Legal role
Binding rule
Regulatory summary
ASEAN Annex III lists this record among substances allowed only under restrictions and conditions. Member-state transition rules and deviations still require local verification.
Conditions and restrictions
Solvent in hair dye products · 9% · No use in aerosol dispensers (sprays)

Substance identity

Official source name
Diethylene glycol monobutyl ether (DEGBE) Butoxydiglycol CAS No 112-34-5
CAS
112-34-5
EC
203-961-6
Identity mapping
cas_number
Linked ingredient
BUTOXYDIGLYCOL
Search this identity across the siteCAS 112-34-5EC 203-961-6

Linked CosIng identity data

Names and aliases

BUTOXYDIGLYCOL

CosIng description: 2-(2-Butoxyethoxy)ethanol; diethylene glycol monobutyl ether; DEGBE

EU inventory restriction note: III/187

Recorded cosmetic function: FRAGRANCE, SOLVENT, VISCOSITY CONTROLLING

Function pages:FRAGRANCE, SOLVENT, VISCOSITY CONTROLLING

View the complete ingredient profile

Cross-market snapshot for this identity

Exact linked records currently present in this site. An absent market means no imported exact match, not permission to use the substance.

7 market datasets
PubChem 2D chemical structure for CAS 112-34-5
CAS 112-34-5PubChem CID 8177

Verified chemistry for CAS 112-34-5

Diethylene Glycol Monobutyl Ether

IUPAC name
2-(2-butoxyethoxy)ethanol
Molecular formula
C8H18O3
Molecular weight
162.23 g/mol
Exact mass
162.125594432 Da
Monoisotopic mass
162.125594432 Da
XLogP3
0.6
Topological polar surface area
38.7 Ų
Molecular complexity
66.0
Formal charge
0
Hydrogen-bond donors
1
Hydrogen-bond acceptors
3
Rotatable bonds
8
Heavy atoms
11
Covalent units
1

Names and synonyms reported to PubChem

Diethylene glycol butyl etherButyl carbitolButoxydiglycolButyl diglycolButyl dioxitolButyl digolGlycol ether DBBUCB
16 more reported names
Dowanol DBButoxyethoxyethanolEthanol, 2-(2-butoxyethoxy)-Jeffersol dbEktasolve DBButoxydiethylene glycolDiethylene glycol mono-n-butyl etherDiglycol monobutyl etherO-Butyl diethylene glycolButoxy diethylene glycolDiethylene glycol n-butyl etherDiethylene gylcol monobutyl etherButyl Ethyl CellosolveMonobutyl diethylene glycol etherEthanol, 2,2'-oxybis-, monobutyl ether9TB90IYC0E
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D pharmacophore features
5
3D rings
0
3D hydrophobes
1
3D acceptor features
3
3D donor features
1
3D anionic centres
0
3D cationic centres
0
3D conformers
10
Effective 3D rotors
8.0
Machine-readable structure identifiers
SMILES
CCCCOCCOCCO
InChI
InChI=1S/C8H18O3/c1-2-3-5-10-7-8-11-6-4-9/h9H,2-8H2,1H3
InChIKey
OAYXUHPQHDHDDZ-UHFFFAOYSA-N

Evidence from additional scientific databases

NIH PubChem PUG-View
Exact identifier match8177

Attributed physical-property, hazard, environmental and use annotations.

  • First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.; SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.; INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) shou Source: CAMEO Chemicals
  • Signal: Warning Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • GHS Hazard Statements: H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Precautionary Statement Codes: P264+P265, P280, P305+P351+P338, and P337+P317 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Note: This chemical does not meet GHS hazard criteria for < 0.1% (2 of 4089) of reports. Source: European Chemicals Agency (ECHA)
  • Signal: Warning Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H319 (> 99.9%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P264+P265, P280, P305+P351+P338, and P337+P317 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 4089 reports by companies from 12 notifications to the ECHA C&L Inventory.; Reported as not meeting GHS hazard criteria per 2 of 4089 reports by companies.; There are 11 notifications provided by 4087 of 4089 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Signal: Danger Source: NITE-CMC
  • GHS Hazard Statements: H227: Combustible liquid [Warning Flammable liquids]; H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H336: May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects]; H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure] Source: NITE-CMC
  • Precautionary Statement Codes: P210, P260, P261, P264, P264+P265, P270, P271, P280, P304+P340, P305+P351+P338, P319, P337+P317, P370+P378, P403, P403+P233, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • Signal: Warning Source: NITE-CMC
  • NFPA Health Rating: 1 - Materials that, under emergency conditions, can cause significant irritation. Source: Hazardous Substances Data Bank (HSDB)
  • NFPA Fire Rating: 2 - Materials that must be moderately heated or exposed to relatively high ambient temperatures before ignition can occur. Materials would not under normal conditions form hazardous atmospheres with air, but under high ambient temperatures or under moderate heating could release vapor in sufficient quantities to produce hazardous atmospheres with air. Source: Hazardous Substances Data Bank (HSDB)
  • NFPA Instability Rating: 1 - Materials that in themselves are normally stable but that can become unstable at elevated temperatures and pressures. Source: Hazardous Substances Data Bank (HSDB)
  • Toxicity Summary: IDENTIFICATION AND USE: Diethylene glycol mono-n-butyl ether (DGBE) is a colorless liquid with a faint butyl odor. It is used as an inert ingredient that is not registered for current use as a pesticide in the U.S., but is used in pesticide products. It is also used as a coalescing agent in latex paints; solvent for stamp pad inks; dye solvent; solvent in high baked enamels; dispersant; diluent for hydraulic brake fluids; and a mutual solvent for soap, oil, and water in household cleaners. HUMAN EXPOSURE AND TOXICITY: The ethers of diethylene glycol are lower in toxicity than the ethers of ethylene glycol, but they have many similar characteristics. Exposure to some ether derivatives of ethylene and diethylene glycols can cause central nervous depression, no hypocalcemic tetany or metabolic acidosis, nausea, vomiting, & sometimes diarrhea, headache, later abdominal and lumbar pain, costovertebral angle tenderness, transient polyuria & then oliguria, progressing to anuria, acute renal failure, and pathological lesions may appear in brain, lung, liver, meninges & heart. ANIMAL STUDIES: Observations in animals suggest a possibility of pulmonary edema, intravascular hemolysis and bone Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Bioconcentration: An estimated BCF of 3 was calculated in fish for diethylene glycol mono-n-butyl ether(SRC), using a log Kow of 0.56(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 10(SRC), determined from a structure estimation method(2), indicates that diethylene glycol mono-n-butyl ether is expected to have very high mobility in soil(SRC). Volatilization of diethylene glycol mono-n-butyl ether from moist soil surfaces is not expected to be an important fate process(SRC) given a Henry's Law constant of 7.2X10-9 atm-cu m/mole(3). Diethylene glycol mono-n-butyl ether is not expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 0.0219 mm Hg at 25 °C(4). Biodegradation of ethylene glycol mono-n-butyl ether ranges from 2% using 5 day BOD(5) to 100% in 6 days using a modified Zahns-Wellens test(6), suggesting that biodegradation may be an important fate process in aerobic soil under certain conditions(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 10(SRC), determined from a structure estimation method(2), indicates that diethylene glycol mono-n-butyl ether is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon a Henry's Law constant of 7.2X10-9 atm-cu m/mole(4). Diethylene glycol mono-n-butyl ether is not expected to undergo hydrolysis in the environment due to the lack of functional groups that hydrolyze under environmental conditions(3). According to a classification scheme(5), an estimated BCF of 3(SRC), from its log Kow of 0.56(6) and a regression-derived equation(2), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Aqueous aerobic screening tests gave biodegradation rates ranging from 2% in 5 day BOD(7) to 100% in 6 days using a modified Zahns-Wellens test(8), suggesting that biodegradation may be an important environmental fate process in water under certain condtions(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), diethylene glycol mono-n-butyl ether, which has a vapor pressure of 0.0219 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase diethylene glycol mono-n-butyl ether is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 5.2 hours(SRC), calculated from its rate constant of 7.44X10-11 cu cm/molecule-sec at 23 °C(3). Alcohols and ethers do not contain chromophores that absorb at wavelengths >290 nm(4) and, therefore, diethylene glycol mono-n-butyl ether is not expected to be susceptible to direct photolysis by sunlight(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Consumer Uses: Cleaning agent; Hydraulic fluids; Corrosion inhibitor; Thickening agent; Not Known or Reasonably Ascertainable; Viscosity modifiers; Film former; Intermediate; Etching agent; Humectant; Softener and conditioner; Solvent; Lubricating agent; Other Source: EPA Chemical Data Reporting (CDR)
  • Industry Uses: Plating agent; Processing aids not otherwise specified; Monomers; Lubricating agent; Solvent; Defoamer; Surface modifier; Softener and conditioner; Humectant; Laboratory chemicals; Drier; Etching agent; Chelating agent; Intermediate; Processing aids, specific to petroleum production; Film former; Anti-stain agent; Emulsifier; Viscosity modifiers; Waterproofing agent; Corrosion inhibitor; Not Known or Reasonably Ascertainable; Cleaning agent Source: EPA Chemical Data Reporting (CDR)
  • Sources/Uses: Used as a solvent and diluent for polymers, resins, coatings, inks, cleaners, and metalworking fluids; [HSDB] Used as a solvent (nitrocellulose, oils, dyes, gums, soaps, and polymers) and coalescing agent in latex paints; In paints containing 1.5% w/w, painters exposed to 4-5 mg/m3; [ACGIH] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Industrial Processes with risk of exposure: Metal Machining [Category: Heat or Machine]; Semiconductor Manufacturing [Category: Industry]; Painting (Solvents) [Category: Paint]; Plastic Composites Manufacturing [Category: Industry]; Textiles (Printing, Dyeing, or Finishing) [Category: Industry]; Silk-Screen Printing [Category: Other] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Uses: For diethylene glycol monobutyl ether (USEPA/OPP Pesticide Code: 011502) there are 0 labels match. /SRP: Not registered for current use in the U.S., but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses./ Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Inert ingredient in pesticide products. Diethylene glycol monobutyl ether is found on List 2: potentially toxic other ingredients/high priority for testing inerts. ... List 2 inert ingredients are structurally similar to chemicals known to be toxic; some have data suggesting a concern. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: CHEM INT FOR DIETHYLENE GLYCOL MONOBUTYL ETHER ACETATE; COALESCING AGENT IN LATEX PAINTS; SOLVENT FOR STAMP PAD INKS; DYE SOLVENT; SOLVENT IN HIGH BAKED ENAMELS; DISPERSANT FOR VINYL CHLORIDE RESINS IN ORGANOSOLS; DILUENT FOR HYDRAULIC BRAKE FLUIDS; MUTUAL SOLVENT FOR SOAP, OIL, WATER IN HOUSEHOLD CLEANERS Source: Hazardous Substances Data Bank (HSDB)
  • Uses: In textile industry as wetting-out soln Source: Hazardous Substances Data Bank (HSDB)
  • Uses: For more Uses (Complete) data for DIETHYLENE GLYCOL MONO-N-BUTYL ETHER (10 total), please visit the HSDB record page. Source: Hazardous Substances Data Bank (HSDB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Official source and provenance

Registered source
ASEAN Cosmetic Directive annexes
Source reference
ASEAN Annex III, reference 187
Source record ID
III-187
Source version
2026-1
Source language
English
Translation status
Original is English
Source updated
2026-06-22
Snapshot checked
2026-08-30 04:44 UTC
Validation method
pdfplumber ruled-table extraction with per-annex reviewed counts
SHA-256
ffad59f6c01a92c82042c54203ee14969425c2a82bd04c2f4012ff82513e69f1

Registered dataset notes

Dataset coverage
Banned, restricted and positive-list substances under the harmonised ASEAN framework
Authority note
Regional directive; member-state transitions and deviations still require local verification
Inspect the exact official sourceRegulator guidance

How this record fits the market dataset

2224
current ASEAN records
249
records marked Restricted
2224
records from this source version
1930
market records with CAS identity

Status distribution

Permitted list with conditions: 247Prohibited: 1728Restricted: 249

Condition text is present on 462 of 2224 current records. An empty condition field is interpreted according to the record type above; it is never converted into an unrestricted-use claim.

ASEAN market context

Complete regional annex dataset

Coverage version: ASEAN Cosmetic Directive annexes 2026-1, 22 June 2026

Annexes II, III, IV, VI and VII covering prohibited, restricted and positive-list substances.

Verification checklist

  1. Search all ACD annexes by name and identifiers.
  2. Apply product type, maximum level and warning conditions.
  3. Confirm the target member state's adoption and transition date.
  4. Complete the local notification and responsible-company requirements.

Official market sources

Verification workflow and record completeness

Before using this result in a compliance decision

  1. Confirm that “Diethylene glycol monobutyl ether (DEGBE) Butoxydiglycol CAS No 112-34-5” and every CAS/EC identifier refer to the material in your supplier specification.
  2. Search all ACD annexes by name and identifiers.
  3. Apply product type, maximum level and warning conditions.
  4. Confirm the target member state's adoption and transition date.
  5. Complete the local notification and responsible-company requirements.
  6. Document the source version and recheck the regulator before manufacture, notification or market placement.

Fields available in this record

  • Official substance nameAvailable
  • CASAvailable
  • ECAvailable
  • Separate condition textAvailable
  • Effective dateNot supplied
  • Snapshot hash and methodAvailable

Questions this page answers

This substance is not unrestricted: cosmetic use is subject to the conditions in the cited official record. Check product type, body area, concentration, purity and warning requirements before deciding whether a formulation is compliant.

If this row does not reproduce conditions, open the cited official detail because omission does not mean unrestricted use. Regional annex coverage does not replace member-state implementation dates, notifications or national deviations.

The record cites ASEAN Annex III, reference 187, source version 2026-1. Open the official source.

No. CAS helps resolve identity, but jurisdictions can classify the same substance differently and can apply different product scopes, limits, warnings and transition dates.

Stable citation

Diethylene glycol monobutyl ether (DEGBE) Butoxydiglycol CAS No 112-34-5. ASEAN Annex III, reference 187. ASEAN. Source version 2026-1. CosIng Checker regulatory record: https://cosingchecker.com/regulations/asean/records/3951/

Cite the regulator as the legal authority. This page is a structured evidence index and verification aid, not a substitute for the official text or professional legal assessment.

Interpretation and limits for ASEAN

This substance is not unrestricted: cosmetic use is subject to the conditions in the cited official record.

Check product type, body area, concentration, purity and warning requirements before deciding whether a formulation is compliant.

How to interpret the legal role

The cited row forms part of a binding rule or legally incorporated list for this market.

Evidence on this page

  • Recorded outcome: Restricted
  • Legal role: Binding rule
  • Source version: 2026-1

What it does not prove

Regional annex coverage does not replace member-state implementation dates, notifications or national deviations.

Further authoritative substance research

These sources can add identity, safety, exposure or hazard context. A link is not evidence that the database contains this exact substance, and none of these sources overrides the market decision above.

Cosmetic Ingredient Review safety assessments

Expert Panel conclusions, assessed ingredient groups, use conditions, dates and report documents

Independent expert review considered by FDA; not a government approval or binding market rule

Research this identity at the source

FDA Global Substance Registration System

UNII identifiers, preferred names, substance types, codes and public substance relationships

Identity registry only; UNII availability does not imply FDA review or approval

Research this identity at the source

ILO/WHO International Chemical Safety Cards

Hazards, symptoms, first aid, storage, incompatibilities and physical properties for covered chemicals

International occupational chemical-safety reference; not cosmetic-use approval

Research this identity at the source

Japan NITE-CHRIP

Chemical identity, Japanese and foreign legal lists, GHS hazards and exposure-related information

Chemical-management evidence; cosmetic status remains governed by the applicable MHLW standard and market rules

Research this identity at the source

NIOSH Pocket Guide to Chemical Hazards

REL, PEL, IDLH, properties, exposure routes, symptoms, target organs, first aid and measurement methods for covered workplace chemicals

US occupational-health guidance and limits; not a cosmetic ingredient decision

Research this identity at the source

OECD eChemPortal

Gateway to authority-owned physical-property, fate, ecotoxicity, toxicity, exposure and GHS records

Discovery gateway; each linked authority remains responsible for its data

Research this identity at the source

US EPA CompTox CTX APIs

API key required for import

DTXSID identity, experimental and predicted properties, toxicity, bioactivity, exposure and environmental data

Scientific and computational evidence; predictions must remain labelled and do not determine cosmetic legality

Research this identity at the source