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1,3-benzenediol Resorcinol CAS No. 108-46-3

ASEAN Annex III lists this record among substances allowed only under restrictions and conditions. Member-state transition rules and deviations still require local verification.

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Regulatory decision and full conditions

Status
Restricted
Legal role
Binding rule
Regulatory summary
ASEAN Annex III lists this record among substances allowed only under restrictions and conditions. Member-state transition rules and deviations still require local verification.
Conditions and restrictions
(a) Hair dye substance in oxidative hair dye products Use for dyeing eyelashes and eyebrows is not permitted. (b) Hair Lotions and Shampoos · (b) 0.5% · For (a): After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 1.25 % The direction for use “wear suitable gloves” must be included in label or leaflet text. · (a) To be printed on the label: The mixing ratio. “Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary ‘black henna’ tattoos may increase your risk of allergy.

Substance identity

Official source name
1,3-benzenediol Resorcinol CAS No. 108-46-3
CAS
108-46-3
EC
203-585-2
Identity mapping
cas_number
Linked ingredient
RESORCINOL
Search this identity across the siteCAS 108-46-3EC 203-585-2

Linked CosIng identity data

Names and aliases

RESORCINOL

CosIng description: Resorcinol (CI 76505)

EU inventory restriction note: III/22

Recorded cosmetic function: ANTIOXIDANT, DENATURANT, HAIR DYEING, PERFUMING

Function pages:ANTIOXIDANT, DENATURANT, HAIR DYEING, PERFUMING

View the complete ingredient profile

Cross-market snapshot for this identity

Exact linked records currently present in this site. An absent market means no imported exact match, not permission to use the substance.

9 market datasets
PubChem 2D chemical structure for CAS 108-46-3
CAS 108-46-3PubChem CID 5054

Verified chemistry for CAS 108-46-3

Resorcinol

Resorcinol is a benzenediol that is benzene dihydroxylated at positions 1 and 3. It has a role as a sensitiser and an erythropoietin inhibitor. It is a phenolic donor, a benzenediol and a member of resorcinols. — ChEBI

IUPAC name
benzene-1,3-diol
Molecular formula
C6H6O2
Molecular weight
110.11 g/mol
Exact mass
110.036779430 Da
Monoisotopic mass
110.036779430 Da
XLogP3
0.8
Topological polar surface area
40.5 Ų
Molecular complexity
64.0
Formal charge
0
Hydrogen-bond donors
2
Hydrogen-bond acceptors
2
Rotatable bonds
0
Heavy atoms
8
Covalent units
1

Names and synonyms reported to PubChem

1,3-Benzenediol1,3-DihydroxybenzeneResorcinm-Hydroxyphenolm-Hydroquinonem-Dihydroxybenzene3-HydroxyphenolResorcine
16 more reported names
m-Benzenediolm-DioxybenzenePelagol RSDihydroxybenzolPelagol Grey RSResorzinDeveloper ODeveloper RDeveloper RSFouramine RSFourrine EWResorcinolumFourrine 79Nako TGGDurafur developer GC.I. Oxidation Base 31
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D pharmacophore features
3
3D rings
1
3D hydrophobes
0
3D acceptor features
0
3D donor features
2
3D anionic centres
0
3D cationic centres
0
3D conformers
1
Effective 3D rotors
0.0
Machine-readable structure identifiers
SMILES
C1=CC(=CC(=C1)O)O
InChI
InChI=1S/C6H6O2/c7-5-2-1-3-6(8)4-5/h1-4,7-8H
InChIKey
GHMLBKRAJCXXBS-UHFFFAOYSA-N

Evidence from additional scientific databases

NIH PubChem PUG-View
Exact identifier match5054

Attributed physical-property, hazard, environmental and use annotations.

  • First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.; SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.; INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) shou Source: CAMEO Chemicals
  • ERG2024, Guide 153 (Resorcinol): General First Aid:; · Call 911 or emergency medical service.; · Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.; · Move victim to fresh air if it can be done safely.; · Administer oxygen if breathing is difficult.; · If victim is not breathing:; -- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.; -- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).; -- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.; · Remove and isolate contaminated clothing and shoes.; · For minor skin contact, avoid spreading material on unaffected skin.; · In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.; · For severe burns, immediate medical attention is required.; · Effects of exposure (inhalation, ingestion, Source: Emergency Response Guidebook (ERG)
  • First Aid: (General first aid procedures); Eye: Irrigate immediately - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.; Skin: Water wash immediately - If this chemical contacts the skin, immediately wash the contaminated skin with water. If this chemical penetrates the clothing, immediately remove the clothing and wash the skin with water. If symptoms occur after washing, get medical attention immediately.; Breathing: Respiratory support; Swallow: Medical attention immediately - If this chemical has been swallowed, get medical attention immediately. Source: The National Institute for Occupational Safety and Health (NIOSH)
  • Signal: Danger Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • GHS Hazard Statements: H302: Harmful if swallowed [Warning Acute toxicity, oral]; H315: Causes skin irritation [Warning Skin corrosion/irritation]; H317: May cause an allergic skin reaction [Warning Sensitization, Skin]; H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]; H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Precautionary Statement Codes: P260, P261, P264, P264+P265, P270, P272, P273, P280, P301+P317, P302+P352, P305+P351+P338, P308+P316, P321, P330, P332+P317, P333+P317, P337+P317, P362+P364, P391, P405, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Signal: Danger Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H302 (> 99.9%): Harmful if swallowed [Warning Acute toxicity, oral]; H315 (> 99.9%): Causes skin irritation [Warning Skin corrosion/irritation]; H317 (15.2%): May cause an allergic skin reaction [Warning Sensitization, Skin]; H319 (90.6%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H370 (15.1%): Causes damage to organs [Danger Specific target organ toxicity, single exposure]; H371 (11.2%): May cause damage to organs [Warning Specific target organ toxicity, single exposure]; H400 (99.9%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P260, P261, P264, P264+P265, P270, P272, P273, P280, P301+P317, P302+P352, P305+P351+P338, P308+P316, P321, P330, P332+P317, P333+P317, P337+P317, P362+P364, P391, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 2727 reports by companies from 51 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Signal: Warning Source: NITE-CMC
  • GHS Hazard Statements: H317: May cause an allergic skin reaction [Warning Sensitization, Skin]; H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard] Source: NITE-CMC
  • Precautionary Statement Codes: P261, P264+P265, P272, P273, P280, P302+P352, P305+P351+P338, P321, P333+P317, P337+P317, P362+P364, P391, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • Signal: Danger Source: NITE-CMC
  • GHS Hazard Statements: H302: Harmful if swallowed [Warning Acute toxicity, oral]; H315: Causes skin irritation [Warning Skin corrosion/irritation]; H317: May cause an allergic skin reaction [Warning Sensitization, Skin]; H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]; H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure] Source: NITE-CMC
  • NFPA Health Rating: 3 - Materials that, under emergency conditions, can cause serious or permanent injury. Source: Hazardous Substances Data Bank (HSDB)
  • NFPA Fire Rating: 1 - Materials that must be preheated before ignition can occur. Materials require considerable preheating, under all ambient temperature conditions, before ignition and combustion can occur. Source: Hazardous Substances Data Bank (HSDB)
  • NFPA Instability Rating: 0 - Materials that in themselves are normally stable, even under fire conditions. Source: Hazardous Substances Data Bank (HSDB)
  • Cosmetic Ingredient Review Finding(s): Safe in the present practices of use and concentration. Ingredient, concentration, and use information are available in documents discoverable at https://cir-reports.cir-safety.org Source: Cosmetic Ingredient Review (CIR)
  • Toxicity Summary: IDENTIFICATION AND USE: Resorcinol is a white crystalline compound with a faint odor and bitter-sweet taste. It exists in at least two crystalline modifications. Crystalline resorcinol turns pale red in the presence of light and air and is hygroscopic. It is miscible in water. It is used in tanning, photography; manufacture of resins, resin adhesives, hexylresorcinol, p-aminosalicylic acid, explosives, dyes, tires, rubber products; in cosmetics; dyeing and printing textiles; and as a reagent for zinc. It is not registered for current pesticide use in the U.S., but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses. Resorcinol is also a medication, used as an antifungal, antibacterial, mildly keratolytic and local irritant agent. It is a pharmaceutical agent used topically in dermatological treatments such as acne and related skin conditions. It could also be used in combination with the other acne treatment agents such as sulphur. HUMAN EXPOSURE AND TOXICITY: An application of 3-25% solution of resorcinol to skin may cause redness, itching, dermatitis, edema or corrosion of affected area. Potenti Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Bioconcentration: An estimated BCF of 3 was calculated in fish for resorcinol(SRC), using a log Kow of 0.80(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), a Koc value of 10.36(2) indicates that resorcinol is expected to have very high mobility in soil(SRC). The pKa1 of resorcinol is 9.30(3), indicating that this compound will exist partially in the anion form in the environment and anions generally do not adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(4). Volatilization of resorcinol from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 9.9X10-11 atm-cu m/mole(SRC), based upon its vapor pressure, 4.89X10-4 mm Hg(5), and water solubility, 7.17X10+5 mg/L(6). Resorcinol is not expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(5). Utilizing the Japanese MITI test, 100% of the Theoretical BOD was reached in 2 weeks(7) indicating that biodegradation is an important environmental fate process in soil(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), a Koc value of 10.36(2) indicates that resorcinol is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon an estimated Henry's Law constant of 9.9X10-11 atm-cu m/mole(SRC), derived from its vapor pressure, 4.89X10-4 mm Hg(4), and water solubility, 7.17X10+5 mg/L(5). As a class, phenols react relatively rapidly in sunlit natural water via reaction with photochemically produced hydroxyl radicals and peroxy radicals(6). According to a classification scheme(7), an estimated BCF of 3(SRC), from its log Kow of 0.80(8) and a regression-derived equation(9), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Utilizing the Japanese MITI test, 100% of the Theoretical BOD was reached in 2 weeks(10) indicating that biodegradation is an important environmental fate process in water(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), resorcinol, which has a vapor pressure of 4.89X10-4 mm Hg at 25 °C(2), will exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase resorcinol is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 1 hour(SRC), calculated from its rate constant of 2.0X10-10 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). The vapor-phase reaction of resorcinol with nitrate radicals may be an important atmospheric removal process in urban areas at night(4). Particulate-phase resorcinol may be removed from the air by wet and dry deposition(SRC). As a class, phenols react relatively rapidly in sunlit natural water via reaction with photochemically produced hydroxyl radicals and peroxy radicals(5). Therefore, resorcinol may be susceptible to direct photolysis by sunlight(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Industry Uses: Not Known or Reasonably Ascertainable; Dye; Adhesion/cohesion promoter; Intermediate; Other; Binder; Polymerization promoter; Monomers Source: EPA Chemical Data Reporting (CDR)
  • Cosmetic Ingredient Review Link: CIR ingredient: Resorcinol Source: Cosmetic Ingredient Review (CIR)
  • Sources/Uses: Used in tanning, photography, tire building, and in the manufacturing of resorcinol-formaldehyde resins; also used in dyes, cosmetics, pharmaceuticals, skin creams, laminates, and adhesives; [ACGIH] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Industrial Processes with risk of exposure: Working with Glues and Adhesives [Category: Other]; Plastic Composites Manufacturing [Category: Industry]; Leather Tanning and Processing [Category: Industry]; Photographic Processing [Category: Other]; Dressing Hair [Category: Other] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Uses: For resorcinol (USEPA/OPP Pesticide Code: 071401) there are 0 labels match. /SRP: Not registered for current use in the U.S., but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses./ Source: Hazardous Substances Data Bank (HSDB)
  • Uses: In tanning, photography; manuf of resins, resin adhesives, hexylresorcinol, p-aminosalicylic acid, explosives, dyes, tires, rubber products; in cosmetics; dyeing and printing textiles; as a reagent for zinc. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Used primarily in the rubber industry for tires & reinforced rubber products (conveyer belts, driving belts) & in high-quality wood adhesives ... It is also used in the preparation of dyes & pharmaceuticals, as a cross-linking agent for neoprene & a rubber tackifier, & in cosmetics. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Chemical intermediate for production of m-aminophenol, production of light stabilizers for plastics, production of sunscreen preparations for the skin, production of dyes (fluorescein, eosin), manufacture of special pharmaceuticals (e.g. acne preparations) Source: Hazardous Substances Data Bank (HSDB)
  • Uses: For more Uses (Complete) data for RESORCINOL (10 total), please visit the HSDB record page. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: 1,3-Benzenediol is found in alcoholic beverages. Source: Toxin and Toxin Target Database (T3DB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Official source and provenance

Registered source
ASEAN Cosmetic Directive annexes
Source reference
ASEAN Annex III, reference 22
Source record ID
III-22
Source version
2026-1
Source language
English
Translation status
Original is English
Source updated
2026-06-22
Snapshot checked
2026-08-30 04:44 UTC
Validation method
pdfplumber ruled-table extraction with per-annex reviewed counts
SHA-256
ffad59f6c01a92c82042c54203ee14969425c2a82bd04c2f4012ff82513e69f1

Registered dataset notes

Dataset coverage
Banned, restricted and positive-list substances under the harmonised ASEAN framework
Authority note
Regional directive; member-state transitions and deviations still require local verification
Inspect the exact official sourceRegulator guidance

How this record fits the market dataset

2224
current ASEAN records
249
records marked Restricted
2224
records from this source version
1930
market records with CAS identity

Status distribution

Permitted list with conditions: 247Prohibited: 1728Restricted: 249

Condition text is present on 462 of 2224 current records. An empty condition field is interpreted according to the record type above; it is never converted into an unrestricted-use claim.

ASEAN market context

Complete regional annex dataset

Coverage version: ASEAN Cosmetic Directive annexes 2026-1, 22 June 2026

Annexes II, III, IV, VI and VII covering prohibited, restricted and positive-list substances.

Verification checklist

  1. Search all ACD annexes by name and identifiers.
  2. Apply product type, maximum level and warning conditions.
  3. Confirm the target member state's adoption and transition date.
  4. Complete the local notification and responsible-company requirements.

Official market sources

Verification workflow and record completeness

Before using this result in a compliance decision

  1. Confirm that “1,3-benzenediol Resorcinol CAS No. 108-46-3” and every CAS/EC identifier refer to the material in your supplier specification.
  2. Search all ACD annexes by name and identifiers.
  3. Apply product type, maximum level and warning conditions.
  4. Confirm the target member state's adoption and transition date.
  5. Complete the local notification and responsible-company requirements.
  6. Document the source version and recheck the regulator before manufacture, notification or market placement.

Fields available in this record

  • Official substance nameAvailable
  • CASAvailable
  • ECAvailable
  • Separate condition textAvailable
  • Effective dateNot supplied
  • Snapshot hash and methodAvailable

Questions this page answers

This substance is not unrestricted: cosmetic use is subject to the conditions in the cited official record. Check product type, body area, concentration, purity and warning requirements before deciding whether a formulation is compliant.

If this row does not reproduce conditions, open the cited official detail because omission does not mean unrestricted use. Regional annex coverage does not replace member-state implementation dates, notifications or national deviations.

The record cites ASEAN Annex III, reference 22, source version 2026-1. Open the official source.

No. CAS helps resolve identity, but jurisdictions can classify the same substance differently and can apply different product scopes, limits, warnings and transition dates.

Stable citation

1,3-benzenediol Resorcinol CAS No. 108-46-3. ASEAN Annex III, reference 22. ASEAN. Source version 2026-1. CosIng Checker regulatory record: https://cosingchecker.com/regulations/asean/records/3892/

Cite the regulator as the legal authority. This page is a structured evidence index and verification aid, not a substitute for the official text or professional legal assessment.

Interpretation and limits for ASEAN

This substance is not unrestricted: cosmetic use is subject to the conditions in the cited official record.

Check product type, body area, concentration, purity and warning requirements before deciding whether a formulation is compliant.

How to interpret the legal role

The cited row forms part of a binding rule or legally incorporated list for this market.

Evidence on this page

  • Recorded outcome: Restricted
  • Legal role: Binding rule
  • Source version: 2026-1

What it does not prove

Regional annex coverage does not replace member-state implementation dates, notifications or national deviations.

Further authoritative substance research

These sources can add identity, safety, exposure or hazard context. A link is not evidence that the database contains this exact substance, and none of these sources overrides the market decision above.

Cosmetic Ingredient Review safety assessments

Expert Panel conclusions, assessed ingredient groups, use conditions, dates and report documents

Independent expert review considered by FDA; not a government approval or binding market rule

Research this identity at the source

FDA Global Substance Registration System

UNII identifiers, preferred names, substance types, codes and public substance relationships

Identity registry only; UNII availability does not imply FDA review or approval

Research this identity at the source

ILO/WHO International Chemical Safety Cards

Hazards, symptoms, first aid, storage, incompatibilities and physical properties for covered chemicals

International occupational chemical-safety reference; not cosmetic-use approval

Research this identity at the source

Japan NITE-CHRIP

Chemical identity, Japanese and foreign legal lists, GHS hazards and exposure-related information

Chemical-management evidence; cosmetic status remains governed by the applicable MHLW standard and market rules

Research this identity at the source

NIOSH Pocket Guide to Chemical Hazards

REL, PEL, IDLH, properties, exposure routes, symptoms, target organs, first aid and measurement methods for covered workplace chemicals

US occupational-health guidance and limits; not a cosmetic ingredient decision

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OECD eChemPortal

Gateway to authority-owned physical-property, fate, ecotoxicity, toxicity, exposure and GHS records

Discovery gateway; each linked authority remains responsible for its data

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US EPA CompTox CTX APIs

API key required for import

DTXSID identity, experimental and predicted properties, toxicity, bioactivity, exposure and environmental data

Scientific and computational evidence; predictions must remain labelled and do not determine cosmetic legality

Research this identity at the source