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ProhibitedBinding ruleASEANOriginal is EnglishOfficial-source import checked

Metaldehyde (ISO); 2,4,6,8-tetramethyl- 1,3,5,7-

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

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Regulatory decision and full conditions

Status
Prohibited
Legal role
Binding rule
Regulatory summary
ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.
Conditions and restrictions
A prohibition entry may contain no separate condition text because the regulatory outcome is the prohibition itself. Open the cited source and apply the market-wide requirements below.

Substance identity

Official source name
Metaldehyde (ISO); 2,4,6,8-tetramethyl- 1,3,5,7-
CAS
108-62-3
EC
Not supplied in this source row
Identity mapping
standalone:official_asean_record
Search this identity across the siteCAS 108-62-3

Cross-market snapshot for this identity

Exact linked records currently present in this site. An absent market means no imported exact match, not permission to use the substance.

5 market datasets
PubChem 2D chemical structure for CAS 108-62-3
CAS 108-62-3PubChem CID 61021

Verified chemistry for CAS 108-62-3

Metaldehyde

IUPAC name
2,4,6,8-tetramethyl-1,3,5,7-tetraoxocane
Molecular formula
C8H16O4
Molecular weight
176.21 g/mol
Exact mass
176.10485899 Da
Monoisotopic mass
176.10485899 Da
XLogP3
1.1
Topological polar surface area
36.9 Ų
Molecular complexity
91.0
Formal charge
0
Hydrogen-bond donors
0
Hydrogen-bond acceptors
4
Rotatable bonds
0
Heavy atoms
12
Covalent units
1

Names and synonyms reported to PubChem

MetacetaldehydeSlug-ToxCekumetaAcetaldehyde, tetramerAriotoxHalizanMetason1,3,5,7-Tetroxocane, 2,4,6,8-tetramethyl-
16 more reported names
MetaldehydCorry's Slug DeathMetaldeideAcetaldehyde Tetramer2,4,6,8-Tetramethyl-1,3,5,7-tetraoxacyclooctane2,4,6,8-Tetramethyl-1,3,5,7-tetroxocaneSlugfestr-2,c-4,c-6,c-8-Tetramethyl-1,3,5,7-tetroxocane4CI033VJYGCHEBI:81931AntimilaceSchneckokornLimovetNamekilLimaxSlugit
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D pharmacophore features
4
3D rings
0
3D hydrophobes
0
3D acceptor features
4
3D donor features
0
3D anionic centres
0
3D cationic centres
0
3D conformers
3
Effective 3D rotors
1.6
Machine-readable structure identifiers
SMILES
CC1OC(OC(OC(O1)C)C)C
InChI
InChI=1S/C8H16O4/c1-5-9-6(2)11-8(4)12-7(3)10-5/h5-8H,1-4H3
InChIKey
GKKDCARASOJPNG-UHFFFAOYSA-N

Evidence from additional scientific databases

NIH PubChem PUG-View
Exact identifier match61021

Attributed physical-property, hazard, environmental and use annotations.

  • Physical Description: Metaldehyde is a white-colored crystalline solid. It is insoluble in water. It is highly flammable and when ignited will give off irritating fumes. It may be toxic by ingestion and is very irritating to skin and eyes. It is used to make other chemicals. Source: CAMEO Chemicals
  • Physical Description: Solid; [IUCLID] Formulated as granules, pellets, mini-pellets, meal, paste, and liquid; [Reference #1] Colorless or white solid; [Reference #2] White odorless powder; [Alfa Aesar MSDS] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • First Aid: Excerpt from ERG Guide 133 [Flammable Solids]:; Refer to the "General First Aid" section. Specific First Aid: Removal of solidified molten material from skin requires medical assistance. (ERG, 2024) Source: CAMEO Chemicals
  • ERG2024, Guide 133 (Metaldehyde): General First Aid:; · Call 911 or emergency medical service.; · Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.; · Move victim to fresh air if it can be done safely.; · Administer oxygen if breathing is difficult.; · If victim is not breathing:; -- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.; -- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).; -- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.; · Remove and isolate contaminated clothing and shoes.; · For minor skin contact, avoid spreading material on unaffected skin.; · In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.; · For severe burns, immediate medical attention is required.; · Effects of exposure (inhalation, ingestion, Source: Emergency Response Guidebook (ERG)
  • Signal: Danger Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • GHS Hazard Statements: H228: Flammable solid [Danger Flammable solids]; H301: Toxic if swallowed [Danger Acute toxicity, oral]; H361f: Suspected of damaging fertility [Warning Reproductive toxicity]; H412: Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Precautionary Statement Codes: P203, P210, P240, P241, P264, P270, P273, P280, P301+P316, P318, P321, P330, P370+P378, P405, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Signal: Danger Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H228 (100%): Flammable solid [Danger Flammable solids]; H301 (77.2%): Toxic if swallowed [Danger Acute toxicity, oral]; H312 (17.2%): Harmful in contact with skin [Warning Acute toxicity, dermal]; H361 (11.9%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]; H361f (44%): Suspected of damaging fertility [Warning Reproductive toxicity]; H412 (68.2%): Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P203, P210, P240, P241, P264, P270, P273, P280, P301+P316, P302+P352, P317, P318, P321, P330, P362+P364, P370+P378, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 302 reports by companies from 13 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: Not Classified Source: NITE-CMC
  • Signal: Danger Source: NITE-CMC
  • GHS Hazard Statements: H228: Flammable solid [Danger Flammable solids]; H301: Toxic if swallowed [Danger Acute toxicity, oral]; H320: Causes eye irritation [Warning Serious eye damage/eye irritation]; H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]; H373: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure] Source: NITE-CMC
  • Precautionary Statement Codes: P210, P240, P241, P260, P264, P264+P265, P270, P280, P301+P316, P305+P351+P338, P308+P316, P319, P321, P330, P337+P317, P370+P378, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • Signal: Danger Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
  • Health Effects: Metaldehyde intoxicatin leads to central nervous system depression, and liver and kidney injury. Death from respiratory failure can occur within a few hours of exposure. (L1787) Source: Toxin and Toxin Target Database (T3DB)
  • NFPA Health Rating: 3 - Materials that, under emergency conditions, can cause serious or permanent injury. Source: Hazardous Substances Data Bank (HSDB)
  • NFPA Fire Rating: 3 - Liquids and solids that can be ignited under almost all ambient temperature conditions. Materials produce hazardous atmospheres with air under almost all ambient temperatures or, though unaffected by ambient temperatures, are readily ignited under almost all conditions. Source: Hazardous Substances Data Bank (HSDB)
  • NFPA Instability Rating: 1 - Materials that in themselves are normally stable but that can become unstable at elevated temperatures and pressures. Source: Hazardous Substances Data Bank (HSDB)
  • Toxicity Summary: The toxicologically active substance in metaldehyde intoxication is mainly the degradation product acetaldehyde; other toxic products are probably also formed. Acetaldehyde acts as a releasing factor for 5-hydroxytryptamine (5-HT) and noradrenaline (NA). It also competitively inhibits biogenic amine oxidation which, in turn, decreases 5-hydroxyindoleacetic acid (5-HIAA), a metabolite of 5-HT by competitively inhibiting 5-HT-oxidation. Acetaldehyde also increases monoamine oxidase activity and decreases central serotonin levels. (L1782) Source: Toxin and Toxin Target Database (T3DB)
  • Environmental Bioconcentration: An estimated BCF of 3.2 was calculated for metaldehyde(SRC), using a log Kow of 0.12(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), a measured Koc value of 240(2) indicates that metaldehyde is expected to have moderate mobility in soil(SRC). Volatilization of metaldehyde from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry's Law constant of 5.2X10-5 atm-cu m/mole(SRC), derived from its vapor pressure, 5.0X10-2 mm Hg(2), and water solubility, 2.22X10+2 mg/L(2). Metaldehyde is not expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(2). The results of a laboratory volatility study suggest that volatilization losses from soil surfaces will be minor(3). In a field study, 6% metaldehyde pellets were broadcast at the rate of 4 kg product/ha in a rice paddy ecosystem(4). Paddy soil samples collected 3 to 14 days after application had metaldehyde residue concentrations ranging from 0.053 to 0.127 mg/kg, reaching a peak at 0.127 mg/kg 14 days after application(4). Metaldehyde residue was below the minimum detection limit of 0.016 mg/kg 22 days after application(4). A reported half-life of approximately 2 months for metaldehyde in soil(3) suggests that biodegradation is not an important environ Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), a measured Koc value of 240(2) indicates that metaldehyde is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon an estimated Henry's Law constant of 5.2X10-5 atm-cu m/mole(SRC), derived from its vapor pressure, 5.0X10-2 mm Hg(2), and water solubility, 2.22X10+2 mg/L(2). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 26 hours and 12 days, respectively(SRC). In a field study, 6% metaldehyde pellets were broadcast at the rate of 4 kg product/ha in a rice paddy ecosystem(4). Paddy water samples collected 1 to 3 days after application had metaldehyde residue concentrations of 1.58 to 1.47 mg/L(4). Residues could be detected only up to 9 days after application, with its degradation pattern following pseudo first-order kinetics showing a half-life of 0.27 days(4). According to a classification scheme(5), an estimated BCF of 3.2(SRC), from its log Kow(2) and a regression-derived equation(6), suggests the potential for bioconcentration in aquatic organisms is low. Utilizing the Japanese MITI te Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), metaldehyde, which has a vapor pressure of 5.0X10-2 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase metaldehyde is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 13 hours(SRC), calculated from its rate constant of 2.9X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Metaldehyde does not contain chromophores that absorb at wavelengths >290 nm(4) and therefore is not expected to be susceptible to direct photolysis by sunlight(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Sources/Uses: Used for control of snails in seed crops, turf, ornamentals, berries, citrus, vegetables, and other crops; [Reference #1] Used for synthesis in the chemical industry, as odor agent, and as pesticide; [IUCLID] Used as molluscicide, solid fuel for small heaters (alcohol replacement), and fire starter; [Reference #2] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Industrial Processes with risk of exposure: Farming (Pesticides) [Category: Industry] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Uses: For metaldehyde (USEPA/OPP Pesticide Code: 053001) ACTIVE products with label matches. /SRP: Registered for use in the U.S. but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses./ Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Metaldehyde is a molluscicide used to control snails and slugs on a wide variety of sites, including turf, ornamentals, berries, citrus, and vegetables. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: In compressed form as a fuel instead of alcohol; molluscicide. /Polymer/ Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Metaldehyde is used as a pesticide against slugs, snails, and other gastropods, it is also used in tablets as a solid fuel for small heaters, and as fire-starter. (L1782) Source: Toxin and Toxin Target Database (T3DB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Official source and provenance

Registered source
ASEAN Cosmetic Directive annexes
Source reference
ASEAN Annex II, reference 1646
Source record ID
II-1646
Source version
2026-1
Source language
English
Translation status
Original is English
Source updated
2026-06-22
Snapshot checked
2026-08-30 04:44 UTC
Validation method
pdfplumber ruled-table extraction with per-annex reviewed counts
SHA-256
ffad59f6c01a92c82042c54203ee14969425c2a82bd04c2f4012ff82513e69f1

Registered dataset notes

Dataset coverage
Banned, restricted and positive-list substances under the harmonised ASEAN framework
Authority note
Regional directive; member-state transitions and deviations still require local verification
Inspect the exact official sourceRegulator guidance

How this record fits the market dataset

2224
current ASEAN records
1728
records marked Prohibited
2224
records from this source version
1930
market records with CAS identity

Status distribution

Permitted list with conditions: 247Prohibited: 1728Restricted: 249

Condition text is present on 462 of 2224 current records. An empty condition field is interpreted according to the record type above; it is never converted into an unrestricted-use claim.

ASEAN market context

Complete regional annex dataset

Coverage version: ASEAN Cosmetic Directive annexes 2026-1, 22 June 2026

Annexes II, III, IV, VI and VII covering prohibited, restricted and positive-list substances.

Verification checklist

  1. Search all ACD annexes by name and identifiers.
  2. Apply product type, maximum level and warning conditions.
  3. Confirm the target member state's adoption and transition date.
  4. Complete the local notification and responsible-company requirements.

Official market sources

Verification workflow and record completeness

Before using this result in a compliance decision

  1. Confirm that “Metaldehyde (ISO); 2,4,6,8-tetramethyl- 1,3,5,7-” and every CAS/EC identifier refer to the material in your supplier specification.
  2. Search all ACD annexes by name and identifiers.
  3. Apply product type, maximum level and warning conditions.
  4. Confirm the target member state's adoption and transition date.
  5. Complete the local notification and responsible-company requirements.
  6. Document the source version and recheck the regulator before manufacture, notification or market placement.

Fields available in this record

  • Official substance nameAvailable
  • CASAvailable
  • ECNot supplied
  • Separate condition textNot present in source row
  • Effective dateNot supplied
  • Snapshot hash and methodAvailable

Questions this page answers

This official record identifies the substance as prohibited for cosmetic use in the stated market scope. Do not rely on a formulation containing this identity until the cited source, effective date and exact substance match have been verified.

A prohibition entry may contain no separate condition text because the regulatory outcome is the prohibition itself. Regional annex coverage does not replace member-state implementation dates, notifications or national deviations.

The record cites ASEAN Annex II, reference 1646, source version 2026-1. Open the official source.

No. CAS helps resolve identity, but jurisdictions can classify the same substance differently and can apply different product scopes, limits, warnings and transition dates.

Stable citation

Metaldehyde (ISO); 2,4,6,8-tetramethyl- 1,3,5,7-. ASEAN Annex II, reference 1646. ASEAN. Source version 2026-1. CosIng Checker regulatory record: https://cosingchecker.com/regulations/asean/records/3781/

Cite the regulator as the legal authority. This page is a structured evidence index and verification aid, not a substitute for the official text or professional legal assessment.

Interpretation and limits for ASEAN

This official record identifies the substance as prohibited for cosmetic use in the stated market scope.

Do not rely on a formulation containing this identity until the cited source, effective date and exact substance match have been verified.

How to interpret the legal role

The cited row forms part of a binding rule or legally incorporated list for this market.

Evidence on this page

  • Recorded outcome: Prohibited
  • Legal role: Binding rule
  • Source version: 2026-1

What it does not prove

Regional annex coverage does not replace member-state implementation dates, notifications or national deviations.

Further authoritative substance research

These sources can add identity, safety, exposure or hazard context. A link is not evidence that the database contains this exact substance, and none of these sources overrides the market decision above.

Cosmetic Ingredient Review safety assessments

Expert Panel conclusions, assessed ingredient groups, use conditions, dates and report documents

Independent expert review considered by FDA; not a government approval or binding market rule

Research this identity at the source

FDA Global Substance Registration System

UNII identifiers, preferred names, substance types, codes and public substance relationships

Identity registry only; UNII availability does not imply FDA review or approval

Research this identity at the source

ILO/WHO International Chemical Safety Cards

Hazards, symptoms, first aid, storage, incompatibilities and physical properties for covered chemicals

International occupational chemical-safety reference; not cosmetic-use approval

Research this identity at the source

Japan NITE-CHRIP

Chemical identity, Japanese and foreign legal lists, GHS hazards and exposure-related information

Chemical-management evidence; cosmetic status remains governed by the applicable MHLW standard and market rules

Research this identity at the source

NIOSH Pocket Guide to Chemical Hazards

REL, PEL, IDLH, properties, exposure routes, symptoms, target organs, first aid and measurement methods for covered workplace chemicals

US occupational-health guidance and limits; not a cosmetic ingredient decision

Research this identity at the source

OECD eChemPortal

Gateway to authority-owned physical-property, fate, ecotoxicity, toxicity, exposure and GHS records

Discovery gateway; each linked authority remains responsible for its data

Research this identity at the source

US EPA CompTox CTX APIs

API key required for import

DTXSID identity, experimental and predicted properties, toxicity, bioactivity, exposure and environmental data

Scientific and computational evidence; predictions must remain labelled and do not determine cosmetic legality

Research this identity at the source