Ethanaminium, N-(4-((4-diethylamino)phenyl)(2,4-
ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.
Regulatory decision and full conditions
- Status
- Prohibited
- Legal role
- Binding rule
- Regulatory summary
- ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.
- Conditions and restrictions
- A prohibition entry may contain no separate condition text because the regulatory outcome is the prohibition itself. Open the cited source and apply the market-wide requirements below.
Substance identity
- Official source name
- Ethanaminium, N-(4-((4-diethylamino)phenyl)(2,4-
- CAS
- 129-17-9
- EC
- Not supplied in this source row
- Identity mapping
- standalone:official_asean_record
Cross-market snapshot for this identity
Exact linked records currently present in this site. An absent market means no imported exact match, not permission to use the substance.
European Union
2 linked records · 1 with specific conditions
Open supporting recordGreat Britain
1 linked record
Open supporting recordNew Zealand
2 linked records · 1 with specific conditions
Open supporting recordASEAN
Current record1 linked record
Open supporting recordBrazil
1 linked record · 1 with specific conditions
Open supporting recordIndia
1 linked record · 1 with specific conditions
Open supporting recordSaudi Arabia
1 linked record
Open supporting recordVerified chemistry for CAS 129-17-9
Sulfan Blue
Patent blue is an organic molecular entity. — ChEBI
- IUPAC name
- sodium 4-[[4-(diethylamino)phenyl]-(4-diethylazaniumylidenecyclohexa-2,5-dien-1-ylidene)methyl]benzene-1,3-disulfonate
- Molecular formula
- C27H31N2NaO6S2
- Molecular weight
- 566.7 g/mol
- Exact mass
- 566.15212334 Da
- Monoisotopic mass
- 566.15212334 Da
- Topological polar surface area
- 137.0 Ų
- Molecular complexity
- 1040.0
- Formal charge
- 0
- Hydrogen-bond donors
- 0
- Hydrogen-bond acceptors
- 7
- Rotatable bonds
- 7
- Heavy atoms
- 38
- Covalent units
- 2
Names and synonyms reported to PubChem
16 more reported names
External database identifiers
- ChEBI:CHEBI:34906
- ChEMBL:CHEMBL1731183
- EPA DTXSID:DTXSID3026065
Advanced structure statistics
- Defined atom stereocentres
- 0
- Undefined atom stereocentres
- 0
- Defined bond stereocentres
- 0
- Undefined bond stereocentres
- 0
- 3D conformers
- 0
Machine-readable structure identifiers
- SMILES
CCN(CC)C1=CC=C(C=C1)C(=C2C=CC(=[N+](CC)CC)C=C2)C3=C(C=C(C=C3)S(=O)(=O)[O-])S(=O)(=O)[O-].[Na+]- InChI
InChI=1S/C27H32N2O6S2.Na/c1-5-28(6-2)22-13-9-20(10-14-22)27(21-11-15-23(16-12-21)29(7-3)8-4)25-18-17-24(36(30,31)32)19-26(25)37(33,34)35;/h9-19H,5-8H2,1-4H3,(H-,30,31,32,33,34,35);/q;+1/p-1- InChIKey
SJEYSFABYSGQBG-UHFFFAOYSA-M
Evidence from additional scientific databases
NIH PubChem PUG-View
Attributed physical-property, hazard, environmental and use annotations.
- Color/Form: VIOLET POWDER Source: Hazardous Substances Data Bank (HSDB)
- Color/Form: Dark bluish-green powder Source: Hazardous Substances Data Bank (HSDB)
- Physical Description: Sulfan blue is a dark greenish-black powder. (NTP, 1992) Source: CAMEO Chemicals
- Physical Description: Liquid; Wet Solid Source: EPA Chemical Data Reporting (CDR)
- Physical Description: Violet or dark bluish-green solid; [HSDB] Violet powder; [MSDSonline] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Solubility: Soluble (>=10 mg/ml at 70 °F) (NTP, 1992) Source: CAMEO Chemicals
- Solubility: ONE G DISSOLVES IN 20 ML WATER @ 20 °C; PARTLY SOL IN ALCOHOL Source: Hazardous Substances Data Bank (HSDB)
- Solubility: 30 mg/ml in water; 30 mg/ml in 2-methoxyethanol; 7 mg/ml in ethanol Source: Hazardous Substances Data Bank (HSDB)
- IARC Carcinogenic Agent: Blue VRS Source: International Agency for Research on Cancer (IARC)
- IARC Carcinogenic Classes: Group 3: Not classifiable as to its carcinogenicity to humans Source: International Agency for Research on Cancer (IARC)
- IARC Monographs: Volume 16: (1978) Some Aromatic Amines and Related Nitro Compounds – Hair Dyes, Colouring Agents and Miscellaneous Industrial Chemicals; Volume Sup 7: Overall Evaluations of Carcinogenicity: An Updating of IARC Monographs Volumes 1 to 42, 1987; 440 pages; ISBN 92-832-1411-0 (out of print) Source: International Agency for Research on Cancer (IARC)
- Publication Year: 1987 Source: International Agency for Research on Cancer (IARC)
- Evaluation Year: 1987 Source: International Agency for Research on Cancer (IARC)
- First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.; SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.; INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Ap Source: CAMEO Chemicals
- Note: This chemical does not meet GHS hazard criteria for 91.8% (2068 of 2253) of all reports. Source: European Chemicals Agency (ECHA)
- GHS Hazard Statements: Not Classified; Reported as not meeting GHS hazard criteria by 2068 of 2253 companies (only 8.2% companies provided GHS information). For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
- ECHA C&L Notifications Summary: Aggregated GHS information provided per 2253 reports by companies from 7 notifications to the ECHA C&L Inventory.; Reported as not meeting GHS hazard criteria per 2068 of 2253 reports by companies.; There are 6 notifications provided by 185 of 2253 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
- Environmental Bioconcentration: An estimated BCF value of 2 was calculated for C.I. Acid Blue 1(SRC), using a measured water solubility of 30,000 mg/l(1) and a recommended regression-derived equation(2). According to a classification scheme(3), this BCF value suggests that bioconcentration in aquatic organisms is low(SRC). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: TERRESTRIAL FATE: Based on a recommended classification scheme(1), an estimated Koc value of 15(SRC), determined from a measured water solubility(2) and a recommended regression-derived equation(3), indicates that C.I. Acid Blue 1 will have very high mobility in soil(SRC). Due to the ionic nature of C.I. Acid Blue 1, the retention of the dye by ion-exchange processes(4,SRC), particularly on clay surfaces, and adsorption at mineral surfaces such as geothite(5,SRC), may slow down or prevent leaching(SRC). As C.I. Acid Blue 1 is an ionic compound, volatilization of this compound will not be important from moist soil surfaces(4,SRC). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: AQUATIC FATE: Based on a recommended classification scheme(1), an estimated Koc value of 15(SRC), determined from a measured water solubility(2) and a recommended regression-derived equation(1), indicates that C.I. Acid Blue 1 should not adsorb to suspended solids and sediment in water(SRC). However, due to the ionic nature of C.I. Acid Blue 1, the retention of the dye by ion-exchange processes(3,SRC), particularly on clay surfaces, and adsorption at mineral surfaces such as geothite(4,SRC), may lead to increased adsorption on some surfaces(SRC). As C.I. Acid Blue 1 is an ionic compound, volatilization from water surfaces is not expected(3,SRC). According to a classification scheme(5), an estimated BCF value of 2(1,SRC), from a measured water solubility(2), suggests that bioconcentration in aquatic organisms is low(SRC). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: ATMOSPHERIC FATE: The ionic state of C.I. Acid Blue 1 makes this compound essentially non-volatile(1,SRC); therefore, this compound should exist in the particulate phase in the ambient atmosphere. Particulate-phase C.I. Acid Blue 1 may be physically removed from the air, mainly by wet deposition(SRC). Source: Hazardous Substances Data Bank (HSDB)
- Consumer Uses: Not Known or Reasonably Ascertainable Source: EPA Chemical Data Reporting (CDR)
- Sources/Uses: Used as dye (medicinal products, wool, silk, leather, jute, paper, phenol-formaldehyde resins, milled soaps, inks, methylated spirit wash, casein, and lymphography) and biological stain; [HSDB] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Restricted Notes: Formerly used as a food dye (not currently permitted for use in food in the US, Japan, or EU, but is reportedly still used in some countries); Accepted for use in cosmetics not in contact with mucous membranes; [HSDB] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Industrial Processes with risk of exposure: Pulp and Paper Processing [Category: Industry]; Leather Tanning and Processing [Category: Industry]; Textiles (Printing, Dyeing, or Finishing) [Category: Industry] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Uses: COLORING MEDICINAL PRODUCTS Source: Hazardous Substances Data Bank (HSDB)
- Uses: USED TO DYE WOOL, SILK, LEATHER, JUTE; TO STAIN PAPER, TO COLOR PHENOL-FORMALDEHYDE RESINS, MILLED SOAPS; TO COLOR INKS & METHYLATED SPIRIT WASH, MASS COLORATION OF CASEIN; AS A BIOLOGICAL STAIN; HEAVY METAL SALTS OF THE FREE ACID ARE USED AS PIGMENTS; ALUMINUM SALTS USED TO COLOR PHARMACEUTICALS Source: Hazardous Substances Data Bank (HSDB)
- Uses: FOOD DYE (REPORTED NON-U.S. USE) Source: Hazardous Substances Data Bank (HSDB)
- Uses: Used to dye wool directly and silk from either a sulfuric acid or acetic acid bath. It dyes fully chromed leather a bright blue, prints wool and silk directly. Source: Hazardous Substances Data Bank (HSDB)
Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record
Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.
Additional source coverage and match status
| Source | Result | Checked |
|---|---|---|
| NIH PubChem PUG-View | Exact match | 2026-08-31 |
A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.
Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Official source and provenance
- Registered source
- ASEAN Cosmetic Directive annexes
- Source reference
- ASEAN Annex II, reference 1355
- Source record ID
II-1355- Source version
- 2026-1
- Source language
- English
- Translation status
- Original is English
- Source updated
- 2026-06-22
- Snapshot checked
- 2026-08-30 04:44 UTC
- Validation method
- pdfplumber ruled-table extraction with per-annex reviewed counts
- SHA-256
ffad59f6c01a92c82042c54203ee14969425c2a82bd04c2f4012ff82513e69f1
Registered dataset notes
- Dataset coverage
- Banned, restricted and positive-list substances under the harmonised ASEAN framework
- Authority note
- Regional directive; member-state transitions and deviations still require local verification
How this record fits the market dataset
Status distribution
Condition text is present on 462 of 2224 current records. An empty condition field is interpreted according to the record type above; it is never converted into an unrestricted-use claim.
ASEAN market context
Complete regional annex dataset
Coverage version: ASEAN Cosmetic Directive annexes 2026-1, 22 June 2026
Annexes II, III, IV, VI and VII covering prohibited, restricted and positive-list substances.
Verification checklist
- Search all ACD annexes by name and identifiers.
- Apply product type, maximum level and warning conditions.
- Confirm the target member state's adoption and transition date.
- Complete the local notification and responsible-company requirements.
Official market sources
- ASEAN Cosmetic Directive annexesRegional directive; member-state transitions and deviations still require local verification
Verification workflow and record completeness
Before using this result in a compliance decision
- Confirm that “Ethanaminium, N-(4-((4-diethylamino)phenyl)(2,4-” and every CAS/EC identifier refer to the material in your supplier specification.
- Search all ACD annexes by name and identifiers.
- Apply product type, maximum level and warning conditions.
- Confirm the target member state's adoption and transition date.
- Complete the local notification and responsible-company requirements.
- Document the source version and recheck the regulator before manufacture, notification or market placement.
Fields available in this record
- Official substance nameAvailable
- CASAvailable
- ECNot supplied
- Separate condition textNot present in source row
- Effective dateNot supplied
- Snapshot hash and methodAvailable
Questions this page answers
Stable citation
Ethanaminium, N-(4-((4-diethylamino)phenyl)(2,4-. ASEAN Annex II, reference 1355. ASEAN. Source version 2026-1. CosIng Checker regulatory record: https://cosingchecker.com/regulations/asean/records/3496/
Cite the regulator as the legal authority. This page is a structured evidence index and verification aid, not a substitute for the official text or professional legal assessment.
Interpretation and limits for ASEAN
This official record identifies the substance as prohibited for cosmetic use in the stated market scope.
Do not rely on a formulation containing this identity until the cited source, effective date and exact substance match have been verified.
How to interpret the legal role
The cited row forms part of a binding rule or legally incorporated list for this market.
Evidence on this page
- Recorded outcome: Prohibited
- Legal role: Binding rule
- Source version: 2026-1
What it does not prove
Regional annex coverage does not replace member-state implementation dates, notifications or national deviations.
Further authoritative substance research
These sources can add identity, safety, exposure or hazard context. A link is not evidence that the database contains this exact substance, and none of these sources overrides the market decision above.
Cosmetic Ingredient Review safety assessments
Expert Panel conclusions, assessed ingredient groups, use conditions, dates and report documents
Independent expert review considered by FDA; not a government approval or binding market rule
Research this identity at the sourceFDA Global Substance Registration System
UNII identifiers, preferred names, substance types, codes and public substance relationships
Identity registry only; UNII availability does not imply FDA review or approval
Research this identity at the sourceILO/WHO International Chemical Safety Cards
Hazards, symptoms, first aid, storage, incompatibilities and physical properties for covered chemicals
International occupational chemical-safety reference; not cosmetic-use approval
Research this identity at the sourceJapan NITE-CHRIP
Chemical identity, Japanese and foreign legal lists, GHS hazards and exposure-related information
Chemical-management evidence; cosmetic status remains governed by the applicable MHLW standard and market rules
Research this identity at the sourceNIOSH Pocket Guide to Chemical Hazards
REL, PEL, IDLH, properties, exposure routes, symptoms, target organs, first aid and measurement methods for covered workplace chemicals
US occupational-health guidance and limits; not a cosmetic ingredient decision
Research this identity at the sourceOECD eChemPortal
Gateway to authority-owned physical-property, fate, ecotoxicity, toxicity, exposure and GHS records
Discovery gateway; each linked authority remains responsible for its data
Research this identity at the sourceUS EPA CompTox CTX APIs
API key required for importDTXSID identity, experimental and predicted properties, toxicity, bioactivity, exposure and environmental data
Scientific and computational evidence; predictions must remain labelled and do not determine cosmetic legality
Research this identity at the source