Resorcinol diglycidyl ether
ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.
Regulatory decision and full conditions
- Status
- Prohibited
- Legal role
- Binding rule
- Regulatory summary
- ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.
- Conditions and restrictions
- A prohibition entry may contain no separate condition text because the regulatory outcome is the prohibition itself. Open the cited source and apply the market-wide requirements below.
Substance identity
- Official source name
- Resorcinol diglycidyl ether
- CAS
- 101-90-6
- EC
- Not supplied in this source row
- Identity mapping
- standalone:official_asean_record
Cross-market snapshot for this identity
Exact linked records currently present in this site. An absent market means no imported exact match, not permission to use the substance.
European Union
1 linked record
Open supporting recordGreat Britain
1 linked record
Open supporting recordNew Zealand
1 linked record
Open supporting recordASEAN
Current record1 linked record
Open supporting recordChina
1 linked record · 1 with specific conditions
Open supporting recordSouth Korea
1 linked record
Open supporting recordBrazil
1 linked record · 1 with specific conditions
Open supporting recordIndia
1 linked record · 1 with specific conditions
Open supporting recordSaudi Arabia
1 linked record
Open supporting recordVerified chemistry for CAS 101-90-6
Resorcinol diglycidyl ether
- IUPAC name
- 2-[[3-(oxiran-2-ylmethoxy)phenoxy]methyl]oxirane
- Molecular formula
- C12H14O4
- Molecular weight
- 222.24 g/mol
- Exact mass
- 222.08920892 Da
- Monoisotopic mass
- 222.08920892 Da
- XLogP3
- 1.2
- Topological polar surface area
- 43.5 Ų
- Molecular complexity
- 211.0
- Formal charge
- 0
- Hydrogen-bond donors
- 0
- Hydrogen-bond acceptors
- 4
- Rotatable bonds
- 6
- Heavy atoms
- 16
- Covalent units
- 1
Names and synonyms reported to PubChem
16 more reported names
External database identifiers
- ChEBI:CHEBI:82318
- ChEMBL:CHEMBL1338613
- EPA DTXSID:DTXSID2020470
- PubMed:22029968
- PubMed:12748690
- PubMed:3768853
- PubMed:2276701
Advanced structure statistics
- Defined atom stereocentres
- 0
- Undefined atom stereocentres
- 2
- Defined bond stereocentres
- 0
- Undefined bond stereocentres
- 0
- 3D pharmacophore features
- 5
- 3D rings
- 1
- 3D hydrophobes
- 0
- 3D acceptor features
- 4
- 3D donor features
- 0
- 3D anionic centres
- 0
- 3D cationic centres
- 0
- 3D conformers
- 10
- Effective 3D rotors
- 7.2
Machine-readable structure identifiers
- SMILES
C1C(O1)COC2=CC(=CC=C2)OCC3CO3- InChI
InChI=1S/C12H14O4/c1-2-9(13-5-11-7-15-11)4-10(3-1)14-6-12-8-16-12/h1-4,11-12H,5-8H2- InChIKey
WPYCRFCQABTEKC-UHFFFAOYSA-N
Evidence from additional scientific databases
EMBL-EBI ChEBI
Diglycidyl resorcinol ether
- Formula
- C12H14O4
- Average mass
- 222.240 g/mol
- Monoisotopic mass
- 222.08921 Da
- Formal charge
- 0
- aromatic ether — is a (CHEBI:35618)
- aromatic ether — is a (CHEBI:35618)
Cross-references from this source
- CAS: 101-90-6 — KEGG COMPOUND
- MANUAL_X_REF: C19228 — KEGG COMPOUND
Mapped by: Exact CAS cross-reference in the ChEBI compound record. Retrieved: 2026-08-31. Open source record
NIH PubChem PUG-View
Attributed physical-property, hazard, environmental and use annotations.
- Boiling Point: 342 °F at 0.8 mmHg (NTP, 1992) Source: CAMEO Chemicals
- Boiling Point: 172 °C @ 0.8 MM HG Source: Hazardous Substances Data Bank (HSDB)
- Boiling Point: at 0.0001kPa: 172 °C Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Color/Form: STRAW-YELLOW LIQUID Source: Hazardous Substances Data Bank (HSDB)
- Density: 1.21 at 77 °F (NTP, 1992) - Denser than water; will sink Source: CAMEO Chemicals
- Density: SP GR: 1.21 @ 25 °C Source: Hazardous Substances Data Bank (HSDB)
- Density: Relative density (water = 1): 1.21 Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Flash Point: 350 °F (NTP, 1992) Source: CAMEO Chemicals
- Flash Point: 113 °C Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Flash Point: 350 °F (OPEN CUP) Source: Hazardous Substances Data Bank (HSDB)
- Flash Point: 113 °C c.c. Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Melting Point: 98 to 115 °F (NTP, 1992) Source: CAMEO Chemicals
- Melting Point: 32 TO 33 °C Source: Hazardous Substances Data Bank (HSDB)
- Melting Point: 32-33 °C Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Odor: SLIGHT PHENOLIC ODOR Source: Hazardous Substances Data Bank (HSDB)
- Physical Description: Diglycidyl resorcinol ether appears as clear yellow or straw-yellow viscous liquid. Boiling point 172 °C; density 1.21 g / cm3. Possible carcinogen. Source: CAMEO Chemicals
- Physical Description: Liquid Source: EPA Chemical Data Reporting (CDR)
- Physical Description: Yellow paste or liquid; [ICSC] Light yellow liquid; [MSDSonline] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Physical Description: YELLOW PASTE OR LIQUID WITH CHARACTERISTIC ODOUR. Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Refractive Index: INDEX OF REFRACTION: 1.541 @ 25 °C/D Source: Hazardous Substances Data Bank (HSDB)
- Solubility: less than 0.1 mg/mL at 64 °F (NTP, 1992) Source: CAMEO Chemicals
- Solubility: Miscible with most org resins Source: Hazardous Substances Data Bank (HSDB)
- Vapor Pressure: 40.7 mmHg at 77 °F ; 54.6 mmHg at 108 °F (NTP, 1992) Source: CAMEO Chemicals
- Vapor Pressure: 40.7 [mmHg] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Vapor Pressure: VAPOR PRESSURE LOW Source: Hazardous Substances Data Bank (HSDB)
- Viscosity: 500 CENTIPOISES (25 °C) Source: Hazardous Substances Data Bank (HSDB)
- IARC Carcinogenic Agent: Diglycidyl resorcinol ether Source: International Agency for Research on Cancer (IARC)
- IARC Carcinogenic Classes: Group 2B: Possibly carcinogenic to humans Source: International Agency for Research on Cancer (IARC)
- IARC Monographs: Volume 36: (1985) Allyl Compounds, Aldehydes, Epoxides and Peroxides; Volume Sup 7: Overall Evaluations of Carcinogenicity: An Updating of IARC Monographs Volumes 1 to 42, 1987; 440 pages; ISBN 92-832-1411-0 (out of print); Volume 71: (1999) Re-evaluation of Some Organic Chemicals, Hydrazine and Hydrogen Peroxide (Part 1, Part 2, Part 3) Source: International Agency for Research on Cancer (IARC)
- Publication Year: 1999 Source: International Agency for Research on Cancer (IARC)
- Evaluation Year: 1998 Source: International Agency for Research on Cancer (IARC)
- Substance: Diglycidyl resorcinol ether (DGRE) Source: NTP Technical Reports
- NTP Technical Report: TR-257: Toxicology and Carcinogenesis Studies of Diglycidyl Resorcinol Ether (Technical Grade) (CASRN 101-90-6) In F344/N Rats and B6C3F1 Mice (Gavage Studies) (1986 ) Source: NTP Technical Reports
- Peer Review Date: 02/28/83 Source: NTP Technical Reports
- Conclusion for Male Rat: Clear Evidence Source: NTP Technical Reports
- Conclusion for Female Rat: Clear Evidence Source: NTP Technical Reports
- Conclusion for Male Mice: Clear Evidence Source: NTP Technical Reports
- Conclusion for Female Mice: Clear Evidence Source: NTP Technical Reports
- Exposure Routes: The substance can be absorbed into the body through the skin and by ingestion. Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.; SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas.; INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknow Source: CAMEO Chemicals
- Signal: Danger Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
- GHS Hazard Statements: H302: Harmful if swallowed [Warning Acute toxicity, oral]; H311: Toxic in contact with skin [Danger Acute toxicity, dermal]; H315: Causes skin irritation [Warning Skin corrosion/irritation]; H317: May cause an allergic skin reaction [Warning Sensitization, Skin]; H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H341: Suspected of causing genetic defects [Warning Germ cell mutagenicity]; H350: May cause cancer [Danger Carcinogenicity]; H412: Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
- Precautionary Statement Codes: P203, P261, P262, P264, P264+P265, P270, P272, P273, P280, P301+P317, P302+P352, P305+P351+P338, P316, P318, P321, P330, P332+P317, P333+P317, P337+P317, P361+P364, P362+P364, P405, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
- Signal: Danger Source: European Chemicals Agency (ECHA)
- GHS Hazard Statements: H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]; H311 (26.8%): Toxic in contact with skin [Danger Acute toxicity, dermal]; H312 (73.2%): Harmful in contact with skin [Warning Acute toxicity, dermal]; H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]; H317 (100%): May cause an allergic skin reaction [Warning Sensitization, Skin]; H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H341 (100%): Suspected of causing genetic defects [Warning Germ cell mutagenicity]; H350 (26.8%): May cause cancer [Danger Carcinogenicity]; H351 (73.2%): Suspected of causing cancer [Warning Carcinogenicity]; H372 (22.6%): Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]; H373 (22.6%): May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]; H412 (94.6%): Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
- Precautionary Statement Codes: P203, P260, P261, P262, P264, P264+P265, P270, P272, P273, P280, P301+P317, P302+P352, P305+P351+P338, P316, P317, P318, P319, P321, P330, P332+P317, P333+P317, P337+P317, P361+P364, P362+P364, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
- ECHA C&L Notifications Summary: Aggregated GHS information provided per 504 reports by companies from 9 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
- Signal: Danger Source: NITE-CMC
- GHS Hazard Statements: H350: May cause cancer [Danger Carcinogenicity] Source: NITE-CMC
- Precautionary Statement Codes: P203, P280, P318, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
- Signal: Warning Source: NITE-CMC
- GHS Hazard Statements: H315: Causes skin irritation [Warning Skin corrosion/irritation]; H317: May cause an allergic skin reaction [Warning Sensitization, Skin]; H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]; H341: Suspected of causing genetic defects [Warning Germ cell mutagenicity]; H351: Suspected of causing cancer [Warning Carcinogenicity] Source: NITE-CMC
- Consumer Uses: Viscosity modifiers; Dispersing agent Source: EPA Chemical Data Reporting (CDR)
- Industry Uses: Viscosity modifiers; Intermediate; Dispersing agent Source: EPA Chemical Data Reporting (CDR)
- Sources/Uses: Used in epoxy resins and as a curing agent for polysulfide rubber; [HSDB] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Industrial Processes with risk of exposure: Plastic Composites Manufacturing [Category: Industry] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Uses: Epoxy resins Source: Hazardous Substances Data Bank (HSDB)
- Uses: CURING AGENT FOR POLYSULFIDE RUBBER Source: Hazardous Substances Data Bank (HSDB)
- Uses: ... AS LIQUID EPOXY RESIN & AS REACTIVE DILUENT IN PRODN OF OTHER EPOXY RESINS. Source: Hazardous Substances Data Bank (HSDB)
Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record
Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.
Additional source coverage and match status
| Source | Result | Checked |
|---|---|---|
| EMBL-EBI ChEBI | Exact match | 2026-08-31 |
| NIH PubChem PUG-View | Exact match | 2026-08-31 |
A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.
Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Official source and provenance
- Registered source
- ASEAN Cosmetic Directive annexes
- Source reference
- ASEAN Annex II, reference 992
- Source record ID
II-992- Source version
- 2026-1
- Source language
- English
- Translation status
- Original is English
- Source updated
- 2026-06-22
- Snapshot checked
- 2026-08-30 04:44 UTC
- Validation method
- pdfplumber ruled-table extraction with per-annex reviewed counts
- SHA-256
ffad59f6c01a92c82042c54203ee14969425c2a82bd04c2f4012ff82513e69f1
Registered dataset notes
- Dataset coverage
- Banned, restricted and positive-list substances under the harmonised ASEAN framework
- Authority note
- Regional directive; member-state transitions and deviations still require local verification
How this record fits the market dataset
Status distribution
Condition text is present on 462 of 2224 current records. An empty condition field is interpreted according to the record type above; it is never converted into an unrestricted-use claim.
ASEAN market context
Complete regional annex dataset
Coverage version: ASEAN Cosmetic Directive annexes 2026-1, 22 June 2026
Annexes II, III, IV, VI and VII covering prohibited, restricted and positive-list substances.
Verification checklist
- Search all ACD annexes by name and identifiers.
- Apply product type, maximum level and warning conditions.
- Confirm the target member state's adoption and transition date.
- Complete the local notification and responsible-company requirements.
Official market sources
- ASEAN Cosmetic Directive annexesRegional directive; member-state transitions and deviations still require local verification
Verification workflow and record completeness
Before using this result in a compliance decision
- Confirm that “Resorcinol diglycidyl ether” and every CAS/EC identifier refer to the material in your supplier specification.
- Search all ACD annexes by name and identifiers.
- Apply product type, maximum level and warning conditions.
- Confirm the target member state's adoption and transition date.
- Complete the local notification and responsible-company requirements.
- Document the source version and recheck the regulator before manufacture, notification or market placement.
Fields available in this record
- Official substance nameAvailable
- CASAvailable
- ECNot supplied
- Separate condition textNot present in source row
- Effective dateNot supplied
- Snapshot hash and methodAvailable
Questions this page answers
Stable citation
Resorcinol diglycidyl ether. ASEAN Annex II, reference 992. ASEAN. Source version 2026-1. CosIng Checker regulatory record: https://cosingchecker.com/regulations/asean/records/3133/
Cite the regulator as the legal authority. This page is a structured evidence index and verification aid, not a substitute for the official text or professional legal assessment.
Interpretation and limits for ASEAN
This official record identifies the substance as prohibited for cosmetic use in the stated market scope.
Do not rely on a formulation containing this identity until the cited source, effective date and exact substance match have been verified.
How to interpret the legal role
The cited row forms part of a binding rule or legally incorporated list for this market.
Evidence on this page
- Recorded outcome: Prohibited
- Legal role: Binding rule
- Source version: 2026-1
What it does not prove
Regional annex coverage does not replace member-state implementation dates, notifications or national deviations.
Further authoritative substance research
These sources can add identity, safety, exposure or hazard context. A link is not evidence that the database contains this exact substance, and none of these sources overrides the market decision above.
Cosmetic Ingredient Review safety assessments
Expert Panel conclusions, assessed ingredient groups, use conditions, dates and report documents
Independent expert review considered by FDA; not a government approval or binding market rule
Research this identity at the sourceFDA Global Substance Registration System
UNII identifiers, preferred names, substance types, codes and public substance relationships
Identity registry only; UNII availability does not imply FDA review or approval
Research this identity at the sourceILO/WHO International Chemical Safety Cards
Hazards, symptoms, first aid, storage, incompatibilities and physical properties for covered chemicals
International occupational chemical-safety reference; not cosmetic-use approval
Research this identity at the sourceJapan NITE-CHRIP
Chemical identity, Japanese and foreign legal lists, GHS hazards and exposure-related information
Chemical-management evidence; cosmetic status remains governed by the applicable MHLW standard and market rules
Research this identity at the sourceNIOSH Pocket Guide to Chemical Hazards
REL, PEL, IDLH, properties, exposure routes, symptoms, target organs, first aid and measurement methods for covered workplace chemicals
US occupational-health guidance and limits; not a cosmetic ingredient decision
Research this identity at the sourceOECD eChemPortal
Gateway to authority-owned physical-property, fate, ecotoxicity, toxicity, exposure and GHS records
Discovery gateway; each linked authority remains responsible for its data
Research this identity at the sourceUS EPA CompTox CTX APIs
API key required for importDTXSID identity, experimental and predicted properties, toxicity, bioactivity, exposure and environmental data
Scientific and computational evidence; predictions must remain labelled and do not determine cosmetic legality
Research this identity at the source