Is NAPHTHAZARIN safe to use in EU cosmetics?

NAPHTHAZARIN is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Always verify against the current official CosIng database before formulating.

What other records share CAS 475-38-7?

CAS 475-38-7 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

How do I check if my formula contains NAPHTHAZARIN?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef cosing-live-997702023-05-23

NAPHTHAZARIN

Naphthazarin is the organic compound that conforms to the formula

NAPHTHAZARIN is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 475-38-7

CAS 475-38-7PubChem CID 10141

Naphthazarin

Naphthazarin is a naphthoquinone that is 1,4-naphthoquinone in which the hydrogens at positions 5 and 8 are replaced by hydroxy groups. It has a role as a geroprotector, an acaricide, an antibacterial agent, an antineoplastic agent, an apoptosis inducer and a plant metabolite. — ChEBI

IUPAC name: 5,8-dihydroxynaphthalene-1,4-dione

Molecular formula: C10H6O4
Molecular weight: 190.15 g/mol
Exact mass: 190.02660867 Da
XLogP3: 1.8
Topological polar surface area: 74.6 Å²
Hydrogen-bond donors: 2
Hydrogen-bond acceptors: 4
Covalent units: 1
Defined stereocentres: 0

Also known as

5,8-Dihydroxy-1,4-naphthoquinoneNaphthazarineNaphthazarone5,8-Dihydroxynaphthoquinone5,8-Dihydroxy-1,4-naphthalenedione5,8-Dihydroxy-1,4-naphthosemiquinoneS9IX5I5C0K1,4-NAPHTHOQUINONE, 5,8-DIHYDROXY-

16 more reported names

1,4-Naphthalenedione, 5,8-dihydroxy-CHEBI:28849NSC-26647NSC-3445555,8-dioxy-1,4-naphthoquinoneRefChem:831987207-495-4NAPHTHAZALIN5,8-Dihydroxy-[1,4]naphthoquinoneHY-N7526AS-76136CS-0132365doi:10.14272/RQNVIKXOOKXAJQ-UHFFFAOYSA-N.1DihydroxynaphthoquinoneNAPTHAZARIN NPHZ5,4-naphthosemiquinone

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:28849
ChEMBL:CHEMBL274056
EPA DTXSID:DTXSID00197161
PubMed:31301289
PubMed:26558468
PubMed:22908577
PubMed:22513651
PubMed:21873994
PubMed:21765926
PubMed:19220002
PubMed:18924186
PubMed:16526275
PubMed:16359837
PubMed:15871734
PubMed:15649814

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Official European Commission record

CosIng substance ID: 99770
Entry status: Active
Published in the Official Journal: Yes
Recorded by the Commission: 2023-05-23

Open this entry in the official CosIng database

Fields as published by the European Commission. The link opens the entry itself, not a search for it.

Inventory details for NAPHTHAZARIN

INCI name

NAPHTHAZARIN

Description

Naphthazarin is the organic compound that conforms to the formula

Record provenance

Inventory reference: cosing-live-99770
Imported identity: NAPHTHAZARIN
Source update: 2023-05-23

European Commission CosIng source notes

Annex records for NAPHTHAZARIN

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Key data

CAS

475-38-7

207-495-4

Restriction

—

Function

COLORANT: Exclusively or mainly intended to colour the cosmetic product, the body as a whole or certain parts thereof, by absorption or reflection of visible light. All authorised colorants are substances in the positive list of Annex IV to the Cosmetics Regulation 1223/2009.
HAIR CONDITIONING: Enhancing the appearance and feel of hair. Leaving the hair easy to comb, supple, soft and shiny and/or imparting volume, lightness, gloss, texture, etc.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#17224 · NAPHTHAZARIN

Ingredients with overlapping formulation functions

MAGNESIUM CARBONATEABSORBENT, BINDING, BULKING, COLORANT, OPACIFYING

MAGNESIUM STEARATEANTICAKING, BULKING, COLORANT, MOISTURISING

MICAANTICAKING, BULKING, COLORANT, OPACIFYING

MONASCUS FERMENT FILTRATE EXTRACT POWDERCOLORANT

NASTURTIUM OFFICINALE LEAF POWDERABRASIVE; COLORANT; EXFOLIATING

NATURAL RED 26COLORANT

NEOSAXITOXINANTIOXIDANT, ANTIPERSPIRANT, ASTRINGENT, COLORANT, SKIN PROTECTING

NICOTIANA BENTHAMIANA R-JELLYFISH POLYPEPTIDE-1COLORANT

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How NAPHTHAZARIN appears in the CosIng inventory

The CosIng inventory lists NAPHTHAZARIN as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

NAPHTHAZARIN is also tagged with 2 cosmetic functions in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

NAPHTHAZARIN is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, NAPHTHAZARIN carries the following function designation(s):

CAS 475-38-7 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for NAPHTHAZARIN

This page reproduces the CosIng inventory entry for NAPHTHAZARIN from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research NAPHTHAZARIN and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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Tools & next steps

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