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InventoryRef cosing-live-996342023-05-23

SHIKALKIN

Shikalkin is the racemic mixture of shikonin and alkannin that conforms generally to the formula:

SHIKALKIN is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

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MarketEvidence statusRecordsSource language
European UnionSource mapped
Inventory entry; no linked annex rule
0English and EU languages
Great BritainSource mapped
Official source mapped; ingredient rule not imported
0English
CanadaSource mapped
Official source mapped; ingredient rule not imported
0English and French
New ZealandSource mapped
Official source mapped; ingredient rule not imported
0English
ASEANSource mapped
Official source mapped; ingredient rule not imported
0English and national languages
ChinaSource mapped
Official source mapped; ingredient rule not imported
0Chinese with selected English material
JapanSource mapped
Official source mapped; ingredient rule not imported
0Japanese; official English translation available
South KoreaSource mapped
Official source mapped; ingredient rule not imported
0Korean with some English names
United StatesSource mapped
Official source mapped; ingredient rule not imported
0English
AustraliaSource mapped
Official source mapped; ingredient rule not imported
0English
BrazilSource mapped
Official source mapped; ingredient rule not imported
0Portuguese with INCI crosswalks
IndiaSource mapped
Official source mapped; ingredient rule not imported
0English and Hindi
Saudi ArabiaSource mapped
Official source mapped; ingredient rule not imported
0Arabic and English

Chemical identity and properties

PubChem 2D chemical structure for CAS 517-88-4
CAS 517-88-4PubChem CID 72521

Alkannin

IUPAC name
5,8-dihydroxy-2-[(1S)-1-hydroxy-4-methylpent-3-enyl]naphthalene-1,4-dione
Molecular formula
C16H16O5
Molecular weight
288.29 g/mol
Exact mass
288.09977361 Da
XLogP3
3.0
Topological polar surface area
94.8 Ų
Hydrogen-bond donors
3
Hydrogen-bond acceptors
5
Covalent units
1
Defined stereocentres
1

Also known as

AnchusinAlkanna RedAnchusa acid075CRZ9995NSC-945245,8-dihydroxy-2-[(1S)-1-hydroxy-4-methyl-pent-3-enyl]naphthalene-1,4-dione5,8-dihydroxy-2-((1S)-1-hydroxy-4-methyl-pent-3-enyl)naphthalene-1,4-dione5,8-dihydroxy-2-((1S)-1-hydroxy-4-methylpent-3-enyl)naphthalene-1,4-dione
16 more reported names
RefChem:554083208-245-7(-)-AlkanninAlkannin (VAN)Anchusin (VAN)Alkanna red (VAN)Anchusa acid (VAN)(S)-5,8-Dihydroxy-2-(1-hydroxy-4-methylpent-3-en-1-yl)naphthalene-1,4-dioneCHEBI:2578(S)-5,8-Dihydroxy-2-(1-hydroxy-4-methylpent-3-enyl)-1,4-naphthoquinoneE1035,8-dihydroxy-2-[(1S)-1-hydroxy-4-methylpent-3-en-1-yl]-1,4-dihydronaphthalene-1,4-dioneC.I. Natural Red 20 (VAN)Cerven prirodni 20Cerven prirodni 20 [Czech]UNII-075CRZ9995
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 517-89-5
CAS 517-89-5PubChem CID 479503

Shikonin

Shikonin is a hydroxy-1,4-naphthoquinone. — ChEBI

IUPAC name
5,8-dihydroxy-2-[(1R)-1-hydroxy-4-methylpent-3-enyl]naphthalene-1,4-dione
Molecular formula
C16H16O5
Molecular weight
288.29 g/mol
Exact mass
288.09977361 Da
XLogP3
3.0
Topological polar surface area
94.8 Ų
Hydrogen-bond donors
3
Hydrogen-bond acceptors
5
Covalent units
1
Defined stereocentres
1

Also known as

Isoarnebin 4ShikonineTokyo Violet(R)-(+)-Shikonin(+)-ShikoninNSC 252844CCRIS 64923IK6592UBW
16 more reported names
(+)-5,8-Dihydroxy-2-(1-hydroxy-4-methyl-3-pentenyl)-1,4-naphthoquinoneC.I. 755351,4-Naphthalenedione, 5,8-dihydroxy-2-(1-hydroxy-4-methyl-3-pentenyl)-, (R)-1,4-NAPHTHOQUINONE, 5,8-DIHYDROXY-2-(1-HYDROXY-4-METHYL-3-PENTENYL)-, (+)-NSC-2528441,4-naphthalenedione, 5,8-dihydroxy-2-((1r)-1-hydroxy-4-methyl-3-pentenyl)-1,4-Naphthalenedione, 5,8-dihydroxy-2-[(1R)-1-hydroxy-4-methyl-3-pentenyl]-5,8-dihydroxy-2-((1R)-1-hydroxy-4-methyl-3-penten-1-yl)-1,4-naphthalenedione5,8-DIHYDROXY-2-((1R)-1-HYDROXY-4-METHYLPENT-3-ENYL)NAPHTHALENE-1,4-DIONE5,8-Dihydroxy-2-[(1R)-1-hydroxy-4-methyl-3-penten-1-yl]-1,4-naphthalenedioneshikonin, (+)-RefChem:487985,8-dihydroxy-2-(1-hydroxy-4-methyl-3-pentenyl)-1,4-naphthalenedione610-730-71,4-naphthalenedione, 5,8-dihydroxy-2-((1R)-1-hydroxy-4-methyl-3-penten-1-yl)-2-((1R)-1-hydroxy-4-methyl-3-pentenyl)-5,8-dihydroxy-1,4-naphthoquinone
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Official European Commission record

CosIng substance ID
99634
Entry status
Active
Published in the Official Journal
Yes
Recorded by the Commission
2023-05-23
Open this entry in the official CosIng database

Fields as published by the European Commission. The link opens the entry itself, not a search for it.

Inventory details for SHIKALKIN

INCI name

SHIKALKIN

Description

Shikalkin is the racemic mixture of shikonin and alkannin that conforms generally to the formula:

Record provenance

Inventory reference
cosing-live-99634
Imported identity
SHIKALKIN
Source update
2023-05-23
European Commission CosIng source notes
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Key data

CAS
117746-18-6/517-88-4/517-89-5
EC
-/-/610-730-7
Restriction
—
Function
COLORANT; SKIN CONDITIONING - MISCELLANEOUS

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#25753 · SHIKALKIN

Additional official and scientific sources

11 external databases to check this identity in

Use identifiers from this page to verify chemical identity, hazard context and market-surveillance evidence in the sources below.

ECHA CHEM / Information on chemicals

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PubChem PUG REST

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Lookup identity: 117746-18-6/517-88-4/517-89-5

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EU Safety Gate cosmetic product alerts

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ECHA CHEM

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Cosmetic Ingredient Review safety assessments

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FDA Global Substance Registration System

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ILO/WHO International Chemical Safety Cards

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OECD eChemPortal

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How SHIKALKIN appears in the CosIng inventory

The CosIng inventory lists SHIKALKIN as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

SHIKALKIN is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

SHIKALKIN is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, SHIKALKIN carries the following function designation(s):

CAS 117746-18-6/517-88-4/517-89-5 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.
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Source note for SHIKALKIN

This page reproduces the CosIng inventory entry for SHIKALKIN from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research SHIKALKIN and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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