InventoryRef cosing-live-1052152024-08-26

NONOXYNOL-6

Nonoxynol-6 is the ethoxylated alkyl phenol that conforms generally to the formula, where n has an average value of 6.

NONOXYNOL-6 is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

Regulatory evidence by market

This matrix separates verified ingredient rules from sources that are mapped but not yet imported. No imported rule does not mean the ingredient is permitted.

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MarketEvidence statusRecordsSource language
European UnionSource mapped
Inventory entry; no linked annex rule
0English and EU languages
Great BritainSource mapped
Official source mapped; ingredient rule not imported
0English
CanadaSource mapped
Official source mapped; ingredient rule not imported
0English and French
New ZealandSource mapped
Official source mapped; ingredient rule not imported
0English
ASEANSource mapped
Official source mapped; ingredient rule not imported
0English and national languages
ChinaSource mapped
Official source mapped; ingredient rule not imported
0Chinese with selected English material
JapanSource mapped
Official source mapped; ingredient rule not imported
0Japanese; official English translation available
South KoreaSource mapped
Official source mapped; ingredient rule not imported
0Korean with some English names
United StatesSource mapped
Official source mapped; ingredient rule not imported
0English
AustraliaSource mapped
Official source mapped; ingredient rule not imported
0English
BrazilSource mapped
Official source mapped; ingredient rule not imported
0Portuguese with INCI crosswalks
IndiaSource mapped
Official source mapped; ingredient rule not imported
0English and Hindi
Saudi ArabiaSource mapped
Official source mapped; ingredient rule not imported
0Arabic and English

Chemical identity and properties

PubChem 2D chemical structure for CAS 27177-01-1
CAS 27177-01-1PubChem CID 168665

3,6,9,12,15-Pentaoxaheptadecan-1-ol, 17-(nonylphenoxy)-

IUPAC name
2-[2-[2-[2-[2-[2-(2-nonylphenoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol
Molecular formula
C27H48O7
Molecular weight
484.7 g/mol
Exact mass
484.34000387 Da
XLogP3
5.1
Topological polar surface area
75.6 Ų
Hydrogen-bond donors
1
Hydrogen-bond acceptors
7
Covalent units
1
Defined stereocentres
0

Also known as

hexaethylene glycol nonylphenyl etherRefChem:487159Nonylphenoxydiglycol17-(2-nonylphenoxy)-3,6,9,12,15-pentaoxaheptadecan-1-olTWIMUEGVLWNOMO-UHFFFAOYSA-N4-Nonylphenol hexaethoxylate, mixture of nonylisomers
External database identifiers

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 37205-87-1
CAS 37205-87-1PubChem CID 92035818

Nonoxynol-1

IUPAC name
1-ethoxy-4-(7-methyloctyl)benzene
Molecular formula
C17H28O
Molecular weight
248.4 g/mol
Exact mass
248.214015512 Da
XLogP3
6.6
Topological polar surface area
9.2 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
1
Covalent units
1
Defined stereocentres
0

Also known as

Marlophen NP 6Marlophen NP 8Marlophen NP 10Marlophen NP 12Neonol AF 9Neonol AF 10Neonol AF9 10ANeonol AF9 12A
16 more reported names
Neonol AF 9-5Neonol AF 9-9Neonol AF 9-10Neonol AF 9-22Neonol AF 9-25Neonol AF 9-60MAF 12Nonoxynol5Nonoxynol6Nonoxynol10Nonoxynol11Nonoxynol12Nonoxynol20Nonoxynol23Nonoxynol35Nonoxynol40

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 9016-45-9
CAS 9016-45-9PubChem CID 24773

4-Nonylphenol diethoxylate

IUPAC name
2-[2-(4-nonylphenoxy)ethoxy]ethanol
Molecular formula
C19H32O3
Molecular weight
308.5 g/mol
Exact mass
308.23514488 Da
XLogP3
5.6
Topological polar surface area
38.7 Ų
Hydrogen-bond donors
1
Hydrogen-bond acceptors
3
Covalent units
1
Defined stereocentres
0

Also known as

Nonoxynol-2U4A966MO25RefChem:1071320243-816-44-Nonyl Phenol Diethoxylate2-(2-(4-Nonylphenoxy)ethoxy)ethanol2-[2-(4-nonylphenoxy)ethoxy]ethan-1-olEthanol, 2-(2-(4-nonylphenoxy)ethoxy)-
16 more reported names
Polyoxyethylene (12) nonylphenyl etherEthanol, 2-[2-(4-nonylphenoxy)ethoxy]-DSSTox_CID_16588DSSTox_RID_79288DSSTox_GSID_36588Adekatol NPNonylphenol Ethoxylate(Tergitol NP-40)EON 2CAS-26027-38-3Igepal CO-210NonoxinolumUNII-U4A966MO25NPEOxEINECS 243-816-4NP-40 SubstituteNPEO2
External database identifiers

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for NONOXYNOL-6

INCI name

NONOXYNOL-6

Description

Nonoxynol-6 is the ethoxylated alkyl phenol that conforms generally to the formula, where n has an average value of 6.

Record provenance

Inventory reference
cosing-live-105215
Imported identity
NONOXYNOL-6
Source update
2024-08-26
European Commission CosIng source notes

Key data

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

An exact glossary-name match supports label identity; it does not by itself mean that an ingredient is permitted, safe for every use, or free from annex restrictions. Check the regulatory evidence above.

Ingredients with overlapping formulation functions

Additional official and scientific sources

Use identifiers from this page to verify chemical identity, hazard context and market-surveillance evidence. These sources add context; they do not replace the applicable cosmetics law.

ECHA CHEM / Information on chemicals

Use as CAS/EC enrichment for REACH/CLP hazard and regulatory status. Treat as targeted enrichment, not simple bulk import.

Open source site

PubChem PUG REST

Use name/CAS lookup to add CID, molecular formula, molecular weight, InChIKey and canonical SMILES.

Lookup identity: 68412-54-4/ 9016-45-9 (generic)/ 26027-38-3 (generic)/ 37205-87-1 (generic)/ 27177-01-1

Open identifier lookup

EU Safety Gate cosmetic product alerts

Published cosmetic product alerts, notifying country, risk, product identifiers and corrective measures

Open source site

ECHA CHEM

EU substance information, REACH context and CLP classification where available.

Open source site

US EPA CompTox

EPA chemistry, exposure and toxicity dashboard search by CAS or name.

Open source site

Cosmetic Ingredient Review safety assessments

Expert Panel conclusions, assessed ingredient groups, use conditions, dates and report documents

Open source site

FDA Global Substance Registration System

UNII identifiers, preferred names, substance types, codes and public substance relationships

Open source site

ILO/WHO International Chemical Safety Cards

Hazards, symptoms, first aid, storage, incompatibilities and physical properties for covered chemicals

Open source site

Japan NITE-CHRIP

Chemical identity, Japanese and foreign legal lists, GHS hazards and exposure-related information

Open source site

NIOSH Pocket Guide to Chemical Hazards

REL, PEL, IDLH, properties, exposure routes, symptoms, target organs, first aid and measurement methods for covered workplace chemicals

Open source site

OECD eChemPortal

Gateway to authority-owned physical-property, fate, ecotoxicity, toxicity, exposure and GHS records

Open source site

How NONOXYNOL-6 appears in the CosIng inventory

The CosIng inventory lists NONOXYNOL-6 as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

NONOXYNOL-6 is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

NONOXYNOL-6 is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, NONOXYNOL-6 carries the following function designation(s):

CAS 68412-54-4/ 9016-45-9 (generic)/ 26027-38-3 (generic)/ 37205-87-1 (generic)/ 27177-01-1 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

Use the INCI Checker to screen a full ingredient list across selected markets, or compare this substance across all supported market datasets.

Source note for NONOXYNOL-6

This page reproduces the CosIng inventory entry for NONOXYNOL-6 from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research NONOXYNOL-6 and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

Tools & next steps

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