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InventoryRef 9292004/03/2019

NONOXYNOL-9

Nonoxynol-9 is the ethoxylated alkyl phenol that conforms generally to the formula: (structure) where n has an average value of 9.

NONOXYNOL-9 is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

Chemical identity and properties

PubChem 2D chemical structure for CAS 14409-72-4
CAS 14409-72-4CAS 26571-11-9PubChem CID 72385

Nonaethylene Glycol Nonylphenyl Ether

Tergitol NP-9 is a tergitol polymer consisting of nonylbenzene with a nine-membered poly(ethylene glycol) moiety attached at position 4. It has a role as a nonionic surfactant and a contraceptive drug. ChEBI

IUPAC name
2-[2-[2-[2-[2-[2-[2-[2-[2-(4-nonylphenoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol
Molecular formula
C33H60O10
Molecular weight
616.8 g/mol
Exact mass
616.41864811 Da
XLogP3
4.6
Topological polar surface area
103.0 Ų
Hydrogen-bond donors
1
Hydrogen-bond acceptors
10
Covalent units
1
Defined stereocentres
0

Also known as

Nonoxynol-9ToDayDelfenTergitol NP9Nonylphenol octa(oxyethylene) ethanolNONOXINOL 9Nonoxinolum 9Norfox np-9
16 more reported names
Nonoxynol-9.5NSC-758941CHEBI:537753,6,9,12,15,18,21,24-Octaoxahexacosan-1-ol, 26-(nonylphenoxy)-1-(4-nonylphenyl)-1,4,7,10,13,16,19,22,25-nonaoxaheptacosan-27-olVcf ContraceptiveConceptrol OptionsGynol II Extra StrengthRefChem:927882Today Vaginal Contraceptive48Q180SH9TVcf Contraceptive Pre-filled Applicators247-816-5Nonoxynol 9Tergitol NP-9PEG-9 Nonyl phenyl ether
External database identifiers

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 37205-87-1
CAS 37205-87-1PubChem CID 92035818

Nonoxynol-1

The CIR Expert Panel concluded that the following 27 Nonoxynols listed below are safe in the present practices of use and concentration in cosmetics as described in this safety assessment, when formulated to be non-irritating..Nonoxynol-1... Cosmetic Ingredient Review (CIR)

IUPAC name
1-ethoxy-4-(7-methyloctyl)benzene
Molecular formula
C17H28O
Molecular weight
248.4 g/mol
Exact mass
248.214015512 Da
XLogP3
6.6
Topological polar surface area
9.2 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
1
Covalent units
1
Defined stereocentres
0

Also known as

Marlophen NP 6Marlophen NP 8Marlophen NP 10Marlophen NP 12Neonol AF 9Neonol AF 10Neonol AF9 10ANeonol AF9 12A
16 more reported names
Neonol AF 9-5Neonol AF 9-9Neonol AF 9-10Neonol AF 9-22Neonol AF 9-25Neonol AF 9-60MAF 12Nonoxynol5Nonoxynol6Nonoxynol10Nonoxynol11Nonoxynol12Nonoxynol20Nonoxynol23Nonoxynol35Nonoxynol40

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 9016-45-9
CAS 9016-45-9PubChem CID 24773

4-Nonylphenol diethoxylate

The CIR Expert Panel concluded that the following 27 Nonoxynols listed below are safe in the present practices of use and concentration in cosmetics as described in this safety assessment, when formulated to be non-irritating..Nonoxynol-2... Cosmetic Ingredient Review (CIR)

IUPAC name
2-[2-(4-nonylphenoxy)ethoxy]ethanol
Molecular formula
C19H32O3
Molecular weight
308.5 g/mol
Exact mass
308.23514488 Da
XLogP3
5.6
Topological polar surface area
38.7 Ų
Hydrogen-bond donors
1
Hydrogen-bond acceptors
3
Covalent units
1
Defined stereocentres
0

Also known as

Nonoxynol-2U4A966MO25RefChem:1071320243-816-44-Nonyl Phenol Diethoxylate2-(2-(4-Nonylphenoxy)ethoxy)ethanol2-[2-(4-nonylphenoxy)ethoxy]ethan-1-olEthanol, 2-(2-(4-nonylphenoxy)ethoxy)-
16 more reported names
Polyoxyethylene (12) nonylphenyl etherEthanol, 2-[2-(4-nonylphenoxy)ethoxy]-DSSTox_CID_16588DSSTox_RID_79288DSSTox_GSID_36588Adekatol NPNonylphenol Ethoxylate(Tergitol NP-40)EON 2CAS-26027-38-3Igepal CO-210NonoxinolumUNII-U4A966MO25NPEOxEINECS 243-816-4NP-40 SubstituteNPEO2
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for NONOXYNOL-9

INCI name

NONOXYNOL-9

Description

Nonoxynol-9 is the ethoxylated alkyl phenol that conforms generally to the formula: (structure) where n has an average value of 9.

Record provenance

Inventory reference
92920
Imported identity
NONOXYNOL-9
Source update
04/03/2019
European Commission CosIng source notes

Key data

CAS
14409-72-4; 26027-38-3(generic); 26571-11-9; 37205-87-1(generic); 68412-54-4; 9016-45-9(generic)
EC
Restriction
Function
SURFACTANT - CLEANSING
Wetting body surfaces, emulsifying or solubilizing oils, and suspending soil (generally, such ingredients contribute to the foaming and lathering properties of cleansing products).
SURFACTANT - EMULSIFYING
Helping suspensions or dispersions of liquids in a second liquid by reducing the surface tension of the substances to be emulsified.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

Ingredients with overlapping formulation functions

Additional official and scientific sources

11 external databases to check this identity in

How NONOXYNOL-9 appears in the CosIng inventory

The CosIng inventory lists NONOXYNOL-9 as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

NONOXYNOL-9 is also tagged with 2 cosmetic functions in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

NONOXYNOL-9 is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, NONOXYNOL-9 carries the following function designation(s):

CAS 14409-72-4; 26027-38-3(generic); 26571-11-9; 37205-87-1(generic); 68412-54-4; 9016-45-9(generic) may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

Use the INCI Checker to screen a full ingredient list across selected markets, or compare this substance across all supported market datasets.

Source note for NONOXYNOL-9

This page reproduces the CosIng inventory entry for NONOXYNOL-9 from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research NONOXYNOL-9 and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

Tools & next steps

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