Is LIDOCAINE HCL safe to use in EU cosmetics?

LIDOCAINE HCL is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Always verify against the current official CosIng database before formulating.

What does the restriction note for LIDOCAINE HCL mean?

The restriction field for LIDOCAINE HCL reads: II/399. This is the restriction note from the CosIng inventory. For authoritative conditions and limits, always refer to the linked annex entries.

What other records share CAS 6108-05-0?

CAS 6108-05-0 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

How do I check if my formula contains LIDOCAINE HCL?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef cosing-live-1051742024-08-26

LIDOCAINE HCL

Lidocaine HCl is the organic compound that conforms to the formula

LIDOCAINE HCL is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet. Inventory note: II/399.

INCI Checker Compare all markets Search similar

Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

Markets and their official sources Search every market for this name

Chemical identity and properties

PubChem 2D chemical structure for CAS 6108-05-0

CAS 6108-05-0PubChem CID 16219577

Lidocaine hydrochloride monohydrate

IUPAC name: 2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide;hydrate;hydrochloride

Molecular formula: C14H25ClN2O2
Molecular weight: 288.81 g/mol
Exact mass: 288.1604557 Da
Topological polar surface area: 33.3 Å²
Hydrogen-bond donors: 3
Hydrogen-bond acceptors: 3
Covalent units: 3
Defined stereocentres: 0

Also known as

DolicaineZingo TMLidocaine HCl hydrateAcetamide, 2-(diethylamino)-N-(2,6-dimethylphenyl)-, monohydrochloride, monohydrateLidocaine hydrochloride [USP:BAN:JAN]Diethylaminoacet-2,6-xylidide hydrochloride monohydrateLIDOCAINE HYDROCHLORIDE MONOHYDRATE [WHO-DD]2',6'-ACETOXYLIDIDE, 2-(DIETHYLAMINO)-, HYDROCHLORIDE, HYDRATE

16 more reported names

Lidocaine hydrochloride (USP:BAN:JAN)2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide monohydrochloride monohydrateN-(2,6-dimethylphenyl)-N(2),N(2)-diethylglycinamide hydrochloride--water (1/1)RefChem:7991052-(Diethylamino)-N-(2,6-dimethylphenyl)acetamide hydrochloride hydrateLidocaine (hydrochloride hydrate)DalcaineLidocaine (hydrochloride)2-(Diethylamino)-2',6'-acetoxylidide monohydrochloride monohydrateC14H25ClN2O2Lidocaine Hydrochloride Monohydrate; Lidocaine hydrochloride monohydrate; CCI 1873ALidocaine (TN)Zingo (TN)Lidocaine hydrochloride RSLidocaine hydrochloride CRSHY-B0185B

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEMBL:CHEMBL1200409
EPA DTXSID:DTXSID80209953

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Official European Commission record

CosIng substance ID: 105174
Entry status: Active
Published in the Official Journal: Yes
Recorded by the Commission: 2024-08-26

Open this entry in the official CosIng database

Fields as published by the European Commission. The link opens the entry itself, not a search for it.

Inventory details for LIDOCAINE HCL

INCI name

LIDOCAINE HCL

Description

Lidocaine HCl is the organic compound that conforms to the formula

Record provenance

Inventory reference: cosing-live-105174
Imported identity: LIDOCAINE HCL
Source update: 2024-08-26

European Commission CosIng source notes

Annex records for LIDOCAINE HCL

Browse

Browse EU annexes

Explore Annex II–VI to see which substances are prohibited, restricted or permitted under specific conditions.

Search annex entries

Search the annex database for entries matching LIDOCAINE HCL or related substances.

Key data

CAS

6108-05-0

—

Restriction

II/399

Function

NOT REPORTED: No function currently reported.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#15313 · LIDOCAINE HCl

Ingredients with overlapping formulation functions

LACTOBACILLUS/LAC/CALCIUM/PHOSPHORUS/MAGNESIUM/ZINC FERMENTNOT REPORTED

LACTOBACILLUS/MILK/CALCIUM/PHOSPHORUS/MAGNESIUM/ZINC FERMENTNOT REPORTED

LACTOCOCCUS/MILK FERMENT LYSATENOT REPORTED

LIDOCAINENOT REPORTED

LITHIUM CHLORIDENOT REPORTED

MACLURA COCHINCHINENSIS LEAF PRENYLFLAVONOIDSNOT REPORTED

MELAMINENOT REPORTED

MERCAPTOPHENYLBORONIC ACIDNOT REPORTED

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How LIDOCAINE HCL appears in the CosIng inventory

The CosIng inventory lists LIDOCAINE HCL as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

LIDOCAINE HCL is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

LIDOCAINE HCL is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

The restriction field for LIDOCAINE HCL reads: "II/399". This is the restriction note recorded in the CosIng inventory for this ingredient. For authoritative conditions and limits, always refer to the linked annex entries above.

According to the EU CosIng inventory, LIDOCAINE HCL carries the following function designation(s):

NOT REPORTED

CAS 6108-05-0 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

View CAS records

Use the INCI Checker to screen a full ingredient list across selected markets, or compare this substance across all supported market datasets.

Open INCI Checker

Source note for LIDOCAINE HCL

This page reproduces the CosIng inventory entry for LIDOCAINE HCL from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research LIDOCAINE HCL and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

View sources View updates

Tools & next steps

Check your formula

Scan a full INCI list to detect LIDOCAINE HCL and any linked EU annex restrictions or allergen flags.

INCI Checker

Search similar ingredients

Find other inventory ingredients and annex entries related to LIDOCAINE HCL, its identifiers or nearby name variants.