What does the restriction note for LIDOCAINE mean?

The restriction field for LIDOCAINE reads: II/399. This is the restriction note from the CosIng inventory. For authoritative conditions and limits, always refer to the linked annex entries.

What other records share CAS 137-58-6?

CAS 137-58-6 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

How do I check if my formula contains LIDOCAINE?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 8379415/10/2010

LIDOCAINE

Acetamide, 2-(diethylamino)-N-(2,6-dimethylphenyl)-

LIDOCAINE is linked to 1 EU annex record on this page. Inventory note: II/399.

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Regulatory evidence by market

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Market	Evidence status	Records	Source language
European Union	Evidence linked Prohibited entry found Open this evidence	1	English and EU languages
Great Britain	Evidence linked Prohibited Open this evidence	1	English
Canada	Evidence linked Prohibited Open this evidence	1	English and French
New Zealand	Evidence linked Prohibited Open this evidence	1	English
ASEAN	Evidence linked Prohibited Open this evidence	1	English and national languages
China	Evidence linked Prohibited Open this evidence	1	Chinese with selected English material
Japan	Source mapped Official source mapped; ingredient rule not imported	0	Japanese; official English translation available
South Korea	Evidence linked Prohibited Open this evidence	1	Korean with some English names
United States	Source mapped Official source mapped; ingredient rule not imported	0	English
Australia	Source mapped Official source mapped; ingredient rule not imported	0	English
Brazil	Evidence linked Prohibited Open this evidence	1	Portuguese with INCI crosswalks
India	Evidence linked Prohibited Open this evidence	1	English and Hindi
Saudi Arabia	Evidence linked Prohibited Open this evidence	1	Arabic and English

Chemical identity and properties

PubChem 2D chemical structure for CAS 137-58-6

CAS 137-58-6PubChem CID 3676

Lidocaine

Lidocaine is the monocarboxylic acid amide resulting from the formal condensation of N,N-diethylglycine with 2,6-dimethylaniline. It has a role as a xenobiotic, a local anaesthetic, an anti-arrhythmia drug, an environmental contaminant and a drug allergen. It is a member of benzenes, a monocarboxylic acid amide and a tertiary amino compound. It is functionally related to a glycinamide. — ChEBI

IUPAC name: 2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide

Molecular formula: C14H22N2O
Molecular weight: 234.34 g/mol
Exact mass: 234.173213330 Da
XLogP3: 2.3
Topological polar surface area: 32.3 Å²
Hydrogen-bond donors: 1
Hydrogen-bond acceptors: 2
Covalent units: 1
Defined stereocentres: 0

Also known as

XylocaineDuncaineLidodermXylestesinEsracaineGravocainIsicainaLeostesin

16 more reported names

MaricaineSolcainCappicaineSolarcaineIsicaineRucainaXycaineL-CaineAlphacaineXylotoxLida-MantleDentipatch2-(Diethylamino)-2',6'-acetoxylidideLidocainumCuivasilJetocaine

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:6456
ChEMBL:CHEMBL79
EPA DTXSID:DTXSID1045166
PubMed:28408390
PubMed:23087463
PubMed:23076919
PubMed:23066296
PubMed:23029843
PubMed:23029828
PubMed:22970216
PubMed:22949999
PubMed:22945778
PubMed:22942593
PubMed:22924356
PubMed:22919231

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for LIDOCAINE

INCI name

LIDOCAINE

INN name

Lidocaine [USAN:INN:JAN]

Description

Acetamide, 2-(diethylamino)-N-(2,6-dimethylphenyl)-

Record provenance

Inventory reference: 83794
Imported identity: LIDOCAINE
Source update: 15/10/2010

European Commission CosIng source notes

Annex records for LIDOCAINE

Annex II Restriction reference

Entry 399

Lidocaine (INN)

CAS: 137-58-6

EC: 205-302-8

Key data

CAS

137-58-6

205-302-8

Restriction

II/399

Function

NOT REPORTED: No function currently reported.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#15312 · LIDOCAINE

Ingredients with overlapping formulation functions

LACTOBACILLUS/GLYCERIN/HYDROLYZED CASEIN/LACTOSE/CATHARANTHUS ROSEUS SEED/YEAST…NOT REPORTED

LACTOBACILLUS/LAC/CALCIUM/PHOSPHORUS/MAGNESIUM/ZINC FERMENTNOT REPORTED

LACTOBACILLUS/MILK/CALCIUM/PHOSPHORUS/MAGNESIUM/ZINC FERMENTNOT REPORTED

LACTOCOCCUS/MILK FERMENT LYSATENOT REPORTED

LIDOCAINE HCLNOT REPORTED

LITHIUM CHLORIDENOT REPORTED

MACLURA COCHINCHINENSIS LEAF PRENYLFLAVONOIDSNOT REPORTED

MELAMINENOT REPORTED

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How LIDOCAINE appears in the CosIng inventory

The CosIng inventory lists LIDOCAINE as a cosmetic ingredient and this page links it to 1 annex record. The inventory entry captures names and identifiers, while the annex record shows where the substance is prohibited, restricted or positively listed in EU cosmetics law.

LIDOCAINE is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

LIDOCAINE appears in the EU CosIng inventory and has linked annex records. Check the annex records above for applicable restrictions, concentration limits and conditions of use. Annex II listing means prohibited; Annex III means restricted; Annexes IV, V and VI mean permitted under specified conditions.

The restriction field for LIDOCAINE reads: "II/399". This is the restriction note recorded in the CosIng inventory for this ingredient. For authoritative conditions and limits, always refer to the linked annex entries above.

According to the EU CosIng inventory, LIDOCAINE carries the following function designation(s):

NOT REPORTED

CAS 137-58-6 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for LIDOCAINE

This page combines the CosIng inventory entry for LIDOCAINE with 1 linked Annex II–VI record from the local dataset built from public European Commission cosmetic ingredient materials.

Use this inventory page to research LIDOCAINE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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Tools & next steps

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