Is PENTASILOXANE safe to use in EU cosmetics?

PENTASILOXANE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Always verify against the current official CosIng database before formulating.

What other records share CAS 141-63-9?

CAS 141-63-9 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

How do I check if my formula contains PENTASILOXANE?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef cosing-live-1021272024-03-25

PENTASILOXANE

Pentasiloxane is the linear siloxane that conforms to the formula.

PENTASILOXANE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 141-63-9

CAS 141-63-9PubChem CID 8853

Dodecamethylpentasiloxane

Dodecamethylpentasiloxane is an organosiloxane that is pentasiloxane in which all the hydrogens have been replaced by methyl groups. Metabolite observed in cancer metabolism. It has a role as a human metabolite. — ChEBI

IUPAC name: bis[[dimethyl(trimethylsilyloxy)silyl]oxy]-dimethylsilane

Molecular formula: C12H36O4Si5
Molecular weight: 384.84 g/mol
Exact mass: 384.14599230 Da
Topological polar surface area: 36.9 Å²
Hydrogen-bond donors: 0
Hydrogen-bond acceptors: 4
Covalent units: 1
Defined stereocentres: 0

Also known as

1,1,1,3,3,5,5,7,7,9,9,9-DodecamethylpentasiloxanePentasiloxane, dodecamethyl-0QDQ2VQ5YJBRN 1792965UNII-0QDQ2VQ5YJEINECS 205-492-2HSDB 8419Pentasiloxane, 1,1,1,3,3,5,5,7,7,9,9,9-dodecamethyl-

16 more reported names

CHEBI:84272EC 205-492-2PENTASILOXANE, DODECAMETHYL4-04-00-04124 (Beilstein Handbook Reference)DODECAMETHYLPENTASILOXANE [MI]Silicone liquidRefChem:1353991,1,1,3,3,5,5,7,7,9,9,9DodecamethylpentasiloxanePentasiloxane, 1,1,1,3,3,5,5,7,7,9,9,9dodecamethyl205-492-2FBZANXDWQAVSTQ-UHFFFAOYSA-NSimethicone Impurity 8dodecamethyl pentasiloxaneDodecamethylpentasiloxane, 97%bis[[dimethyl(trimethylsilyloxy)silyl]oxy]-dimethyl-silanePentasiloxane,1,1,1,3,3,5,5,7,7,9,9,9-dodecamethyl-

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:84272
EPA DTXSID:DTXSID1044803
PubMed:22575024
PubMed:21455817

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Official European Commission record

CosIng substance ID: 102127
Published in the Official Journal: Yes
Recorded by the Commission: 2024-03-25

Open this entry in the official CosIng database

Fields as published by the European Commission. The link opens the entry itself, not a search for it.

Inventory details for PENTASILOXANE

INCI name

PENTASILOXANE

Description

Pentasiloxane is the linear siloxane that conforms to the formula.

Record provenance

Inventory reference: cosing-live-102127
Imported identity: PENTASILOXANE
Source update: 2024-03-25

European Commission CosIng source notes

Annex records for PENTASILOXANE

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Key data

CAS

141-63-9

205-492-2

Restriction

—

Function

ANTIFOAMING: Suppressing foam during manufacturing or reducing the tendency of finished products to generate foam.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#20425 · PENTASILOXANE

Ingredients with overlapping formulation functions

PEG/PPG-12/16 DIMETHICONEANTIFOAMING, SKIN CONDITIONING, SURFACTANT - EMULSIFYING

PEG/PPG-12/18 DIMETHICONEANTIFOAMING, SKIN CONDITIONING, SURFACTANT - EMULSIFYING

PEG/PPG-16/8 DIMETHICONEANTIFOAMING, SKIN CONDITIONING, SURFACTANT - EMULSIFYING

PEG/PPG-8/26 DIMETHICONEANTIFOAMING, PLASTICISER, SKIN CONDITIONING, SURFACTANT - CLEANSING

PERFLUOROBUTYLETHYL STEARYL DIMETHICONEANTIFOAMING; SKIN CONDITIONING - EMOLLIENT; HAIR CONDITIONING; DISPERSING NON-SURFACTANT; SLIP MODI…

PETROLEUM DISTILLATESANTIFOAMING, SOLVENT

PHENETHYL DISILOXANEANTIFOAMING, SKIN CONDITIONING

PHENYL DIMETHICONEANTIFOAMING, SKIN CONDITIONING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How PENTASILOXANE appears in the CosIng inventory

The CosIng inventory lists PENTASILOXANE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

PENTASILOXANE is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

PENTASILOXANE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, PENTASILOXANE carries the following function designation(s):

ANTIFOAMING

CAS 141-63-9 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for PENTASILOXANE

This page reproduces the CosIng inventory entry for PENTASILOXANE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research PENTASILOXANE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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Tools & next steps

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