Is AMBROXIDE safe to use in EU cosmetics?

AMBROXIDE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Always verify against the current official CosIng database before formulating.

What other records share CAS 6790-58-5?

CAS 6790-58-5 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

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Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef cosing-live-1018682024-06-26

AMBROXIDE

Ambroxide is the heterocyclic compound that conforms to the formula:

AMBROXIDE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 6790-58-5

CAS 6790-58-5PubChem CID 10857465

(-)-Ambroxide

Ambroxan is a diterpenoid derived from sclareol that is responsible for the odour of ambergris (a solid, waxy, flammable substance produced in the digestive system of sperm whales). It is a diterpenoid and an organic heterotricyclic compound. — ChEBI

IUPAC name: (3aR,5aS,9aS,9bR)-3a,6,6,9a-tetramethyl-2,4,5,5a,7,8,9,9b-octahydro-1H-benzo[e][1]benzofuran

Molecular formula: C16H28O
Molecular weight: 236.39 g/mol
Exact mass: 236.214015512 Da
XLogP3: 4.7
Topological polar surface area: 9.2 Å²
Hydrogen-bond donors: 0
Hydrogen-bond acceptors: 1
Covalent units: 1
Defined stereocentres: 4

Also known as

AmbroxideAmbroxan(-)-ambroxK60YJF1E9AAmbroxide, (-)-(3aR,5aS,9aS,9bR)-3a,6,6,9a-tetramethyldodecahydronaphtho[2,1-b]furanTD34B3O8M9AMBERMOX

16 more reported names

AMBROFIXORCANOXCHEBI:78307AMBROXIDE [MI]EINECS 229-861-2(-)-NORLABDANE OXIDEEC 229-861-2Naphtho(2,1-b)furan, dodecahydro-3a,6,6,9a-tetramethyl-, (3aR,5aS,9aS,9bR)-Dodecahydro-3a,6,6,9a-tetramethylnaphtho(2,1-b)furan, (3aR-(3aalpha,5abeta,9aalpha,9bbeta))-Naphtho(2,1-b)furan, dodecahydro-3a,6,6,9a-tetramethyl-, (3aR,5aS,9aS,9bR)-rel-Naphtho(2,1-b)furan, dodecahydro-3a,6,6,9a-tetramethyl-, (3aR-(3aalpha,5abeta,9aalpha,9bbeta))-A-575915Naphtho(2,1-b)furan, dodecahydro-3a,6,6,9a-tetramethyl-, (3aalpha,5abeta,9aalpha,9bbeta)-Naphtho[2,1-b]furan, dodecahydro-3a,6,6,9a-tetramethyl-, (3aR,5aS,9aS,9bR)-NAPHTHO(2,1-B)FURAN, DODECAHYDRO-3A,6,6,9A-TETRAMETHYL-, (3A.ALPHA.,5A.BETA.,9A.ALPHA.,9B.BETA.)-NAPHTHO(2,1-B)FURAN, DODECAHYDRO-3A,6,6,9A-TETRAMETHYL-, (3AR-(3A.ALPHA.,5A.BETA.,9A.ALPHA.,9B.BETA.))-

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:78307
ChEMBL:CHEMBL496447
EPA DTXSID:DTXSID0047113

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Official European Commission record

CosIng substance ID: 101868
Published in the Official Journal: Yes
Recorded by the Commission: 2024-06-26

Open this entry in the official CosIng database

Fields as published by the European Commission. The link opens the entry itself, not a search for it.

Inventory details for AMBROXIDE

INCI name

AMBROXIDE

Description

Ambroxide is the heterocyclic compound that conforms to the formula:

Record provenance

Inventory reference: cosing-live-101868
Imported identity: AMBROXIDE
Source update: 2024-06-26

European Commission CosIng source notes

Annex records for AMBROXIDE

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Key data

CAS

6790-58-5

—

Restriction

—

Function

FRAGRANCE: Imparting an odour or taste. Creating a perceivable pleasant smell and/or masking a bad smell.
PERFUMING: Used for perfume and aromatic raw materials.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#1665 · AMBROXIDE

Ingredients with overlapping formulation functions

ALPINIA URAIENSIS LEAF OILFLAVOURING, FRAGRANCE, PERFUMING

ALPINIA URAIENSIS LEAF WATERFRAGRANCE, HUMECTANT

ALPINIA ZERUMBET LEAF OILFRAGRANCE

ALPINIA ZERUMBET LEAF WATER EXTRACTSKIN CONDITIONING - EMOLLIENT; FRAGRANCE; PERFUMING

AMELANCHIER ALNIFOLIA FLOWER EXTRACTFRAGRANCE

AMIDINOPROLINEFRAGRANCE, HUMECTANT, PERFUMING, SKIN CONDITIONING

AMMONIABUFFERING, FRAGRANCE

AMMONIUM CHLORIDEBUFFERING, FRAGRANCE, VISCOSITY CONTROLLING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How AMBROXIDE appears in the CosIng inventory

The CosIng inventory lists AMBROXIDE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

AMBROXIDE is also tagged with 2 cosmetic functions in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

AMBROXIDE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, AMBROXIDE carries the following function designation(s):

CAS 6790-58-5 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for AMBROXIDE

This page reproduces the CosIng inventory entry for AMBROXIDE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research AMBROXIDE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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Tools & next steps

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