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CAS 3943-89-3 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

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InventoryRef cosing-live-1016332024-06-28

ETHYL 3,4-DIHYDROXYBENZOATE

Ethyl 3,4-Dihydroxybenzoate is the ethyl ester of 3,4-Dihydroxybenzoic Acid that conforms to the formula

ETHYL 3,4-DIHYDROXYBENZOATE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 3943-89-3

CAS 3943-89-3PubChem CID 77547

Ethyl 3,4-Dihydroxybenzoate

Ethyl 3,4-dihydroxybenzoate is an ethyl ester resulting from the formal condensation of the carboxy group of 3,4-dihydroxybenzoic acid with ethanol. It is the anti-oxidative component of peanut seed testa. It has a role as an EC 1.14.11.2 (procollagen-proline dioxygenase) inhibitor, an antioxidant, an antibacterial agent, an apoptosis inducer and a plant metabolite. It is an ethyl ester and a member of catechols. It is functionally related to a 3,4-dihydroxybenzoic acid. — ChEBI

IUPAC name: ethyl 3,4-dihydroxybenzoate

Molecular formula: C9H10O4
Molecular weight: 182.17 g/mol
Exact mass: 182.05790880 Da
XLogP3: 1.8
Topological polar surface area: 66.8 Å²
Hydrogen-bond donors: 2
Hydrogen-bond acceptors: 4
Covalent units: 1
Defined stereocentres: 0

Also known as

Ethyl protocatechuateProtocatechuic acid ethyl ester3,4-Dihydroxybenzoic Acid Ethyl EsterEthyl-3,4-dihydroxybenzoate4YGJ96WTBGNSC-86130CHEBI:132364RefChem:138647

16 more reported names

223-529-0Benzoic acid, 3,4-dihydroxy-, ethyl esterErlotinib Impurity 553,4-Dihydroxy-benzoic acid ethyl esterEDHBUNII-4YGJ96WTBG3,4-Dihydroxybenzoic Acid Ethyl Ester; Protocatechuic Acid Ethyl Ester; Ethyl Protocatechuate; NSC 619681; NSC 86130;EINECS 223-529-0NSC 86130EC 223-529-03,4-DHBEEOPethyl 3,4-dihydroxy benzoateEthyl-3,4-dihydroxy-benzoateProtocatechuic acid, ethyl esterHMS6018C11Tox21_113836

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External database identifiers

ChEBI:CHEBI:132364
ChEMBL:CHEMBL486216
EPA DTXSID:DTXSID2057732
PubMed:24338020
PubMed:22823210
PubMed:22584042
PubMed:22312019
PubMed:21517900
PubMed:21467157
PubMed:21335549
PubMed:20663295
PubMed:20526373
PubMed:20510668
PubMed:20153315
PubMed:20107860

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Official European Commission record

CosIng substance ID: 101633
Published in the Official Journal: Yes
Recorded by the Commission: 2024-06-28

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Fields as published by the European Commission. The link opens the entry itself, not a search for it.

Inventory details for ETHYL 3,4-DIHYDROXYBENZOATE

INCI name

ETHYL 3,4-DIHYDROXYBENZOATE

Description

Ethyl 3,4-Dihydroxybenzoate is the ethyl ester of 3,4-Dihydroxybenzoic Acid that conforms to the formula

Record provenance

Inventory reference: cosing-live-101633
Imported identity: ETHYL 3,4-DIHYDROXYBENZOATE
Source update: 2024-06-28

European Commission CosIng source notes

Annex records for ETHYL 3,4-DIHYDROXYBENZOATE

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Key data

CAS

3943-89-3

223-529-0

Restriction

—

Function

ANTIMICROBIAL: Preventing and/or slowing down microbial growth.
ANTIOXIDANT: Inhibiting reactions promoted by oxygen, thus avoiding oxidation and rancidity.
SKIN CONDITIONING - MISCELLANEOUS: Enhancing the appearance of dry and/or damaged skin by reducing flaking and restoring suppleness.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#10016 · ETHYL 3,4-DIHYDROXYBENZOATE

Ingredients with overlapping formulation functions

EPIGALLOCATECHIN GALLATE SAFFLOWERATEANTIMICROBIAL

EPIMEDIUM KOREANUM EXTRACTANTIMICROBIAL

EREMOCHLOA OPHIUROIDES EXTRACTANTIMICROBIAL, ANTIOXIDANT

ERIOPHORUM SCHEUCHZERI CALLUS EXTRACTANTIMICROBIAL, ANTIOXIDANT, HAIR CONDITIONING, HUMECTANT, SKIN PROTECTING

ETHYL AMINOLEVULINATE HCLANTI-SEBUM, ANTIMICROBIAL, ANTIOXIDANT, SKIN CONDITIONING

ETHYL SORBOSIDEANTIMICROBIAL; HUMECTANT

ETHYL TRAVOPROSTAMIDEANTIMICROBIAL, ANTIOXIDANT, HAIR CONDITIONING, SKIN CONDITIONING

ETHYLHEXYLBICYCLOHEPTENE DICARBOXIMIDEANTIMICROBIAL

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How ETHYL 3,4-DIHYDROXYBENZOATE appears in the CosIng inventory

The CosIng inventory lists ETHYL 3,4-DIHYDROXYBENZOATE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

ETHYL 3,4-DIHYDROXYBENZOATE is also tagged with 3 cosmetic functions in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

ETHYL 3,4-DIHYDROXYBENZOATE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, ETHYL 3,4-DIHYDROXYBENZOATE carries the following function designation(s):

CAS 3943-89-3 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for ETHYL 3,4-DIHYDROXYBENZOATE

This page reproduces the CosIng inventory entry for ETHYL 3,4-DIHYDROXYBENZOATE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research ETHYL 3,4-DIHYDROXYBENZOATE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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