ETHYLHEXYLBICYCLOHEPTENE DICARBOXIMIDE
4,7-Methano-1H-isoindole-1,3(2H)-dione, 2-(2-ethylhexyl)-3a,4,7,7a-tetrahydro
ETHYLHEXYLBICYCLOHEPTENE DICARBOXIMIDE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.
Regulatory evidence by market
No rule for this ingredient has been imported for any of the 13 markets tracked here.
That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.
Chemical identity and properties
Mgk 264
N-Octyl bicycloheptene dicarboximide (MGK 264) is an ingredient in some common pesticides. It has no intrinsic pesticidal activity itself, but rather is a synergist enhancing the potency of pyrethroid ingredients. It is used in a variety of household and veterinary products — Toxin and Toxin Target Database (T3DB)
- IUPAC name
- (1R,2S,6R,7S)-4-(2-ethylhexyl)-4-azatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione
- Molecular formula
- C17H25NO2
- Molecular weight
- 275.4 g/mol
- Exact mass
- 275.188529040 Da
- XLogP3
- 3.4
- Topological polar surface area
- 37.4 Ų
- Hydrogen-bond donors
- 0
- Hydrogen-bond acceptors
- 2
- Covalent units
- 1
- Defined stereocentres
- 4
Also known as
16 more reported names
External database identifiers
- PubMed:33049310
Evidence from additional scientific databases
NIH PubChem PUG-View
Attributed physical-property, hazard, environmental and use annotations.
- Boiling Point: 157 °C Source: Hazardous Substances Data Bank (HSDB)
- Color/Form: Dark, oily liquid Source: Hazardous Substances Data Bank (HSDB)
- Color/Form: Very light, yellow colored liquid Source: Hazardous Substances Data Bank (HSDB)
- Density: 1.04 g/cu cm Source: Hazardous Substances Data Bank (HSDB)
- Flash Point: 177 °C (351 °F) - closed cup Source: Hazardous Substances Data Bank (HSDB)
- LogP: log Kow = 3.61 (cis-isomer); 3.80 (trans-siomer) /3.70 average/ Source: Hazardous Substances Data Bank (HSDB)
- Melting Point: <-20 °C Source: Hazardous Substances Data Bank (HSDB)
- Physical Description: Light yellow liquid; [HSDB] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Solubility: Practically insoluble in water Source: Hazardous Substances Data Bank (HSDB)
- Solubility: Miscible with most organic solvents including petroleum oils and fluorinated hydrocarbons, also DDT and HCH Source: Hazardous Substances Data Bank (HSDB)
- Solubility: Miscible in: acetone, methanol, isopropanol, petroleum ether, Concoco LPA (petroleum distillate), ethyl acetate, toluene, chloroform, acetonitrile, Cyclo Solv 53 (aromatic petroleum distillate) and Isopar M (petroleum distillate) Source: Hazardous Substances Data Bank (HSDB)
- Vapor Pressure: 0.000018 [mmHg] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Vapor Pressure: 1.80X10-5 mm Hg at 25 °C Source: Hazardous Substances Data Bank (HSDB)
- pH: pH = 6.9; typical range of 6.8 to 7.2 Source: Hazardous Substances Data Bank (HSDB)
- Carcinogen Classification: No indication of carcinogenicity to humans (not listed by IARC). Source: Toxin and Toxin Target Database (T3DB)
- Note: This chemical does not meet GHS hazard criteria for 2.5% (2 of 80) of reports. Source: European Chemicals Agency (ECHA)
- Signal: Danger Source: European Chemicals Agency (ECHA)
- GHS Hazard Statements: H311 (50%): Toxic in contact with skin [Danger Acute toxicity, dermal]; H317 (43.8%): May cause an allergic skin reaction [Warning Sensitization, Skin]; H332 (46.2%): Harmful if inhaled [Warning Acute toxicity, inhalation]; H411 (46.2%): Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
- Precautionary Statement Codes: P261, P262, P264, P270, P271, P272, P273, P280, P302+P352, P304+P340, P316, P317, P321, P333+P317, P361+P364, P362+P364, P391, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
- ECHA C&L Notifications Summary: Aggregated GHS information provided per 80 reports by companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Reported as not meeting GHS hazard criteria per 2 of 80 reports by companies.; There are 5 notifications provided by 78 of 80 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
- Signal: Danger Source: Hazardous Substances Data Bank (HSDB)
- GHS Hazard Statements: H311: Toxic in contact with skin [Danger Acute toxicity, dermal]; H401: Toxic to aquatic life [Hazardous to the aquatic environment, acute hazard]; H411: Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: Hazardous Substances Data Bank (HSDB)
- Precautionary Statement Codes: P262, P264, P270, P273, P280, P302+P352, P316, P321, P361+P364, P391, P405, and P501 (click each P-code to see the statement) Source: Hazardous Substances Data Bank (HSDB)
- Toxicity Summary: IDENTIFICATION AND USE: MGK 264 is a very light, yellow colored liquid. It is used as a synergist for pyrethroids in aerosol sprays for household and veterinary use. HUMAN STUDIES: In vitro, MGK 264 treatment did not result in statistically significant and reproducible alterations in testosterone or estradiol production. MGK 264 was negative for estrogen receptor transcriptional activation in the test system. MGK 264 inhibited aromatase activity. ANIMAL STUDIES: MGK 264 caused acute eye irritation in rabbits. A 90-day rat inhalation toxicity study demonstrated that at the lowest dose tested, there were indications of metaplasia/hyperplasia and changes in the larynx. At higher doses, histopathology of the larynx revealed additional changes and more intense changes in the epithelium and throat. The liver is the target organ of MGK 264. Liver effects were noted in the adults in a rat chronic/oncogenicity study, a mouse chronic/oncogenicity study, a rat multi-generation reproduction study, and subchronic and chronic dog studies. The dog appeared to be the most sensitive species for liver alterations but these alterations were limited to slight to moderate brown pigment and circulating Source: Hazardous Substances Data Bank (HSDB)
- Environmental Bioconcentration: An estimated BCF of 130 was calculated in fish for MGK 264(SRC), using a log Kow of 3.7(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is high, provided the compound is not metabolized by the organism. Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), Koc values of 636 and 3106(2) indicate that MGK 264 is expected to have low to slight mobility in soil(SRC). Volatilization of MGK 264 from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 2.8X10-7 atm-cu m/mole(SRC), using a fragment constant estimation method(3). MGK 264 is not expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 1.8X10-5 mm Hg at 25 °C(4). Biodegradation of MGK 264 is expected to be slow based on an aerobic biodegradation half-life of 341 days in soil(2). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), Koc values of 636 and 3106(2) indicate that MGK 264 is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon an estimated Henry's Law constant of 2.8X10-7 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). According to a classification scheme(5), an estimated BCF of 130(SRC), from its log Kow of 3.7(6) and a regression-derived equation(4), suggests the potential for bioconcentration in aquatic organisms is high. MGK 264 did not undergo hydrolysis after 30 days under environmental conditions (pH 5 to 9)(6). Based on an aerobic biodegradation half-life of 341 days in soil, MGK 264 is not expected to biodegrade in water(2). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), MGK 264, which has a vapor pressure of 1.8X10-5 mm Hg at 25 °C(2), will exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase MGK 264 is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 3.9 hours(SRC), calculated from its rate constant of 9.9X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). The rate constant for the vapor-phase reaction of MGK 264 with ozone has been estimated as 2.0X10-16 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). This corresponds to an atmospheric half-life of about 1.4 hours at an atmospheric concentration of 7X10+11 ozone molecules per cu cm(4). Particulate-phase MGK 264 may be removed from the air by wet and dry deposition(SRC). MGK 264 does not absorb at wavelengths >275 nm(5) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC). Source: Hazardous Substances Data Bank (HSDB)
- Sources/Uses: Used as synergist for pyrethrins, allethrin, pyethroids, and rotenone; Commonly used with piperonyl butoxide in household and industrial aerosols; [HSDB] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Industrial Processes with risk of exposure: Farming (Pesticides) [Category: Industry] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Uses: For MGK 264 (USEPA/OPP Pesticide Code: 057001) ACTIVE products with label matches. /SRP: Registered for use in the U.S. but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses./ Source: Hazardous Substances Data Bank (HSDB)
- Uses: MGK-264 is a pesticide active ingredient that is classified as a synergist. Source: Hazardous Substances Data Bank (HSDB)
- Uses: MKG-264 is used with insecticides to target many types of pests, including various types of ants, worms, beetles, mites, flies, gnats, spiders, weevils, caterpillars, grubs, moths, ticks, lice, wasps, aphids, midges, and others. Source: Hazardous Substances Data Bank (HSDB)
- Uses: Synergist for pyrethroids in aerosol sprays for household and veterinary use. Source: Hazardous Substances Data Bank (HSDB)
- Uses: It is used in a variety of household and veterinary products. Source: Toxin and Toxin Target Database (T3DB)
Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record
Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.
Additional source coverage and match status
| Source | Result | Checked |
|---|---|---|
| NIH PubChem PUG-View | Exact match | 2026-08-31 |
A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.
Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Inventory details for ETHYLHEXYLBICYCLOHEPTENE DICARBOXIMIDE
INCI name
ETHYLHEXYLBICYCLOHEPTENE DICARBOXIMIDE
Description
4,7-Methano-1H-isoindole-1,3(2H)-dione, 2-(2-ethylhexyl)-3a,4,7,7a-tetrahydro
Record provenance
- Inventory reference
- 56021
- Imported identity
- ETHYLHEXYLBICYCLOHEPTENE DICARBOXIMIDE
- Source update
- 15/10/2010
Annex records for ETHYLHEXYLBICYCLOHEPTENE DICARBOXIMIDE
Key data
Official EU ingredient-name evidence
The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.
Related inventory evidence
Ingredients with overlapping formulation functions
Additional official and scientific sources
11 external databases to check this identity in
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How ETHYLHEXYLBICYCLOHEPTENE DICARBOXIMIDE appears in the CosIng inventory
The CosIng inventory lists ETHYLHEXYLBICYCLOHEPTENE DICARBOXIMIDE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.
ETHYLHEXYLBICYCLOHEPTENE DICARBOXIMIDE is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.
Frequently asked questions
Source note for ETHYLHEXYLBICYCLOHEPTENE DICARBOXIMIDE
This page reproduces the CosIng inventory entry for ETHYLHEXYLBICYCLOHEPTENE DICARBOXIMIDE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.
Use this inventory page to research ETHYLHEXYLBICYCLOHEPTENE DICARBOXIMIDE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.
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