InventoryRef cosing-live-1011042024-07-04

3-METHYL-3-HYDROXYBUTYRIC ACID

3-Methyl-3-Hydroxybutyric Acid is the organic compound that conforms to the formula

3-METHYL-3-HYDROXYBUTYRIC ACID is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

Regulatory evidence by market

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MarketEvidence statusRecordsSource language
European UnionSource mapped
Inventory entry; no linked annex rule
0English and EU languages
Great BritainSource mapped
Official source mapped; ingredient rule not imported
0English
CanadaSource mapped
Official source mapped; ingredient rule not imported
0English and French
New ZealandSource mapped
Official source mapped; ingredient rule not imported
0English
ASEANSource mapped
Official source mapped; ingredient rule not imported
0English and national languages
ChinaSource mapped
Official source mapped; ingredient rule not imported
0Chinese with selected English material
JapanSource mapped
Official source mapped; ingredient rule not imported
0Japanese; official English translation available
South KoreaSource mapped
Official source mapped; ingredient rule not imported
0Korean with some English names
United StatesSource mapped
Official source mapped; ingredient rule not imported
0English
AustraliaSource mapped
Official source mapped; ingredient rule not imported
0English
BrazilSource mapped
Official source mapped; ingredient rule not imported
0Portuguese with INCI crosswalks
IndiaSource mapped
Official source mapped; ingredient rule not imported
0English and Hindi
Saudi ArabiaSource mapped
Official source mapped; ingredient rule not imported
0Arabic and English

Chemical identity and properties

PubChem 2D chemical structure for CAS 625-08-1
CAS 625-08-1PubChem CID 69362

3-Hydroxyisovaleric acid

3-hydroxyisovaleric acid is a 3-hydroxy monocarboxylic acid that is isovaleric acid substituted at position 3 by a hydroxy group. Used as indicator of biotin deficiency. It has a role as a human metabolite. It is functionally related to an isovaleric acid and a butyric acid. It is a conjugate acid of a 3-hydroxyisovalerate. ChEBI

IUPAC name
3-hydroxy-3-methylbutanoic acid
Molecular formula
C5H10O3
Molecular weight
118.13 g/mol
Exact mass
118.062994177 Da
XLogP3
-0.3
Topological polar surface area
57.5 Ų
Hydrogen-bond donors
2
Hydrogen-bond acceptors
3
Covalent units
1
Defined stereocentres
0

Also known as

beta-Hydroxyisovaleric acid3-Hydroxy-3-methylbutyric acid3-OH-isovaleric acid3-hydroxy-3-methyl-butanoic acid3-hydroxy-isovaleric acidHmb-d6beta-Hydroxy-methylbutyratebeta-hydroxy-beta-methylbutyric acid
16 more reported names
3F752311CDCHEBI:37084RefChem:911412beta hydroxy beta methylbutyratebeta-hydroxy beta-methylbutyrate626-699-8B-hydroxyisovaleric acidButanoic acid, 3-hydroxy-3-methyl-Juven3-hydroxy-3-methyl-Butyric acidButyric acid, 3-hydroxy-3-methyl-.beta.-Hydroxyisovaleric acidbeta-Hydroxyisovaleric Acid-d83-hydroxy-3-methyl butyric acidBeta-(Hydroxyisovaleric Acid)B-hydroxy-b-methylbutyric acid
External database identifiers

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for 3-METHYL-3-HYDROXYBUTYRIC ACID

INCI name

3-METHYL-3-HYDROXYBUTYRIC ACID

Description

3-Methyl-3-Hydroxybutyric Acid is the organic compound that conforms to the formula

Record provenance

Inventory reference
cosing-live-101104
Imported identity
3-METHYL-3-HYDROXYBUTYRIC ACID
Source update
2024-07-04
European Commission CosIng source notes

Key data

EC
Restriction
Function

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

An exact glossary-name match supports label identity; it does not by itself mean that an ingredient is permitted, safe for every use, or free from annex restrictions. Check the regulatory evidence above.

Ingredients with overlapping formulation functions

Additional official and scientific sources

Use identifiers from this page to verify chemical identity, hazard context and market-surveillance evidence. These sources add context; they do not replace the applicable cosmetics law.

ECHA CHEM / Information on chemicals

Use as CAS/EC enrichment for REACH/CLP hazard and regulatory status. Treat as targeted enrichment, not simple bulk import.

Open source site

PubChem PUG REST

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Lookup identity: 625-08-1

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EU Safety Gate cosmetic product alerts

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How 3-METHYL-3-HYDROXYBUTYRIC ACID appears in the CosIng inventory

The CosIng inventory lists 3-METHYL-3-HYDROXYBUTYRIC ACID as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

3-METHYL-3-HYDROXYBUTYRIC ACID is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

3-METHYL-3-HYDROXYBUTYRIC ACID is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, 3-METHYL-3-HYDROXYBUTYRIC ACID carries the following function designation(s):

CAS 625-08-1 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

Use the INCI Checker to screen a full ingredient list across selected markets, or compare this substance across all supported market datasets.

Source note for 3-METHYL-3-HYDROXYBUTYRIC ACID

This page reproduces the CosIng inventory entry for 3-METHYL-3-HYDROXYBUTYRIC ACID from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research 3-METHYL-3-HYDROXYBUTYRIC ACID and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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