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CAS 483-14-7 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

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InventoryRef cosing-live-1008772023-12-07

TETRAHYDROPALMATINE

Tetrahydropalmatine is the organic compound that conforms to the formula:

TETRAHYDROPALMATINE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 483-14-7

CAS 483-14-7PubChem CID 72301

(-)-Tetrahydropalmatine

Tetrahydropalmatine is a berberine alkaloid obtained by formal addition of two molecules of hydrogen to the pyridine ring of palmatine. It has a role as a non-narcotic analgesic, an adrenergic agent and a dopaminergic antagonist. It is an an (S)-7,8,13,14-tetrahydroprotoberberine, a berberine alkaloid and an organic heterotetracyclic compound. It is functionally related to a palmatine. — ChEBI

IUPAC name: (13aS)-2,3,9,10-tetramethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline

Molecular formula: C21H25NO4
Molecular weight: 355.4 g/mol
Exact mass: 355.17835828 Da
XLogP3: 3.2
Topological polar surface area: 40.2 Å²
Hydrogen-bond donors: 0
Hydrogen-bond acceptors: 5
Covalent units: 1
Defined stereocentres: 1

Also known as

tetrahydropalmatineGindarineHyndarineCaseanine(-)-Corydalis B(-)-rotundineTetrahydropalmatine, l-Tetrahydropalmatine, (-)-

16 more reported names

3X69CO5I79CHEBI:165635,8,13,13a-Tetrahydro-2,3,9,10-tetramethoxy-6H-dibenzo(a,g)quinolizinetetrahydropalmitine(13aS)-2,3,9,10-tetramethoxy-5,8,13,13a-tetrahydro-6H-isoquino[3,2-a]isoquinoline(13aS)-2,3,9,10-tetramethoxy-5,8,13,13a-tetrahydro-6H-isoquino(3,2-a)isoquinoline(13aS)-2,3,9,10-tetramethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino(2,1-b)isoquinolineTetrahydropalmatine l-RefChem:897187l-Tetrahydropalmatine(S)-Tetrahydropalmatinelevo-tetrahydropalmatine(S)-2,3,9,10-Tetramethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[3,2-a]isoquinoline(S)-(-)-tetrahydropalmatine2,3,9,10-tetramethoxy-13aalpha-berbine(-)-Corydalis

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:16563
ChEMBL:CHEMBL487182
EPA DTXSID:DTXSID701020650
PubMed:23019888
PubMed:22991695
PubMed:22908564
PubMed:22883103
PubMed:22792812
PubMed:22761149
PubMed:22737858
PubMed:22622821
PubMed:22552199
PubMed:22550539
PubMed:22517372
PubMed:22512784

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Official European Commission record

CosIng substance ID: 100877
Published in the Official Journal: Yes
Recorded by the Commission: 2023-12-07

Open this entry in the official CosIng database

Fields as published by the European Commission. The link opens the entry itself, not a search for it.

Inventory details for TETRAHYDROPALMATINE

INCI name

TETRAHYDROPALMATINE

Description

Tetrahydropalmatine is the organic compound that conforms to the formula:

Record provenance

Inventory reference: cosing-live-100877
Imported identity: TETRAHYDROPALMATINE
Source update: 2023-12-07

European Commission CosIng source notes

Annex records for TETRAHYDROPALMATINE

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Key data

CAS

483-14-7

—

Restriction

—

Function

HAIR CONDITIONING: Enhancing the appearance and feel of hair. Leaving the hair easy to comb, supple, soft and shiny and/or imparting volume, lightness, gloss, texture, etc.
SKIN CONDITIONING - MISCELLANEOUS: Enhancing the appearance of dry and/or damaged skin by reducing flaking and restoring suppleness.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#28571 · TETRAHYDROPALMATINE

Ingredients with overlapping formulation functions

TEPLINOVIVINT HCLSKIN PROTECTING; SKIN CONDITIONING - MISCELLANEOUS

TERMINALIA FERDINANDIANA SEED EXTRACTSKIN CONDITIONING - MISCELLANEOUS

TETRACARBOXYMETHYL TETRAPEPTIDE-91 N6-TRIPEPTIDE-91SKIN PROTECTING; SKIN CONDITIONING - MISCELLANEOUS

TETRADECYL AMINOBUTYROYLVALYLAMINOBUTYRIC UREA ACETATESKIN CONDITIONING - MISCELLANEOUS

TETRAPEPTIDE-100SKIN CONDITIONING - MISCELLANEOUS

TETRAPEPTIDE-105 BIS-CYCLOHEXYLPROPYL HISTIDINAMIDESKIN CONDITIONING - MISCELLANEOUS

TETRAPEPTIDE-109 AMIDESKIN CONDITIONING - MISCELLANEOUS

TETRAPEPTIDE-110SKIN CONDITIONING - MISCELLANEOUS

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How TETRAHYDROPALMATINE appears in the CosIng inventory

The CosIng inventory lists TETRAHYDROPALMATINE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

TETRAHYDROPALMATINE is also tagged with 2 cosmetic functions in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

TETRAHYDROPALMATINE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, TETRAHYDROPALMATINE carries the following function designation(s):

CAS 483-14-7 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for TETRAHYDROPALMATINE

This page reproduces the CosIng inventory entry for TETRAHYDROPALMATINE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research TETRAHYDROPALMATINE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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