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Official EU label nameGlossary entry 28571

TETRAHYDROPALMATINE

This record confirms an official common ingredient name for EU cosmetic product labelling. It does not by itself confirm that the substance is permitted, unrestricted or safe.

Global evidence snapshot

The resolved identity has matching regulatory evidence in 0 of 13 indexed market datasets: 0 country records and 0 EU Annex records. Every result and evidence gap is listed below.

0 markets with evidence
Markets checked
13
Markets with evidence
0
Evidence gaps
13
Resolved identifiers
1

Resolved substance identity

CAS:483-14-7
Ingredient index records:
TETRAHYDROPALMATINE
Cosmetic functions: HAIR CONDITIONING; SKIN CONDITIONING - MISCELLANEOUS

Tetrahydropalmatine is the organic compound that conforms to the formula:

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1 matched or reported name
TETRAHYDROPALMATINE

Regulatory evidence across markets

None of the 13 markets tracked here holds an imported rule under the name TETRAHYDROPALMATINE.

That is a statement about this inventory, not about the law: no imported rule is not evidence that a substance is permitted. A rule may exist under a different name, under a CAS or EC number this glossary entry does not carry, or in a dataset not yet imported.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 483-14-7
CAS 483-14-7PubChem CID 72301

(-)-Tetrahydropalmatine

Tetrahydropalmatine is a berberine alkaloid obtained by formal addition of two molecules of hydrogen to the pyridine ring of palmatine. It has a role as a non-narcotic analgesic, an adrenergic agent and a dopaminergic antagonist. It is an an (S)-7,8,13,14-tetrahydroprotoberberine, a berberine alkaloid and an organic heterotetracyclic compound. It is functionally related to a palmatine. — ChEBI

IUPAC name
(13aS)-2,3,9,10-tetramethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline
Molecular formula
C21H25NO4
Molecular weight
355.4 g/mol
Exact mass
355.17835828 Da
XLogP3
3.2
Topological polar surface area
40.2 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
5
Covalent units
1
Defined stereocentres
1

Also known as

tetrahydropalmatineGindarineHyndarineCaseanine(-)-Corydalis B(-)-rotundineTetrahydropalmatine, l-Tetrahydropalmatine, (-)-
16 more reported names
3X69CO5I79CHEBI:165635,8,13,13a-Tetrahydro-2,3,9,10-tetramethoxy-6H-dibenzo(a,g)quinolizinetetrahydropalmitine(13aS)-2,3,9,10-tetramethoxy-5,8,13,13a-tetrahydro-6H-isoquino[3,2-a]isoquinoline(13aS)-2,3,9,10-tetramethoxy-5,8,13,13a-tetrahydro-6H-isoquino(3,2-a)isoquinoline(13aS)-2,3,9,10-tetramethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino(2,1-b)isoquinolineTetrahydropalmatine l-RefChem:897187l-Tetrahydropalmatine(S)-Tetrahydropalmatinelevo-tetrahydropalmatine(S)-2,3,9,10-Tetramethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[3,2-a]isoquinoline(S)-(-)-tetrahydropalmatine2,3,9,10-tetramethoxy-13aalpha-berbine(-)-Corydalis
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Additional authoritative substance research

Each link searches that source for this identity. A link is a research route, not a claim that the source holds an exact record. What each source is, and its legal weight

Cosmetic Ingredient Review safety assessmentsFDA Global Substance Registration SystemILO/WHO International Chemical Safety CardsJapan NITE-CHRIPNIOSH Pocket Guide to Chemical HazardsOECD eChemPortalUS EPA CompTox CTX APIs

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Official source and scope

Imported from Commission Implementing Decision (EU) 2025/1175 (dataset version EU 2025/1175). The glossary supplies common ingredient names for the ingredient list required by Article 19(1)(g); it is not an approval or safety list.

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