Is DALOSIRVAT safe to use in EU cosmetics?

DALOSIRVAT is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Always verify against the current official CosIng database before formulating.

How do I check if my formula contains DALOSIRVAT?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef cosing-live-1002172023-05-23

DALOSIRVAT

Dalosirvat is the organic compound that conforms to the formula

DALOSIRVAT is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 1360540-81-3

CAS 1360540-81-3PubChem CID 56837361

Dalosirvat

Dalosirvat is under investigation in clinical trial NCT03742518 (A Study Evaluating the Efficacy and Safety of SM04554 Topical Solution in Male Subjects With Androgenetic Alopecia). — DrugBank

IUPAC name: 1-(2,3-dihydro-1,4-benzodioxin-6-yl)-4-phenylbutane-1,4-dione

Molecular formula: C18H16O4
Molecular weight: 296.3 g/mol
Exact mass: 296.10485899 Da
XLogP3: 1.8
Topological polar surface area: 52.6 Å²
Hydrogen-bond donors: 0
Hydrogen-bond acceptors: 4
Covalent units: 1
Defined stereocentres: 0

Also known as

Dalosirvat [INN]Dalosirvat [USAN]SM-04554QX6T87A52IUNII-QX6T87A52Icompound 1 [WO2012024404A1]1-(2,3-Dihydro-1,4-benzodioxin-6-yl)-4-phenyl-butane-1,4-dione1,4-Butanedione, 1-(2,3-dihydro-1,4-benzodioxin-6-yl)-4-phenyl-

16 more reported names

1-(2,3-Dihydro-benzo(1,4)dioxin-6-yl)-4-phenyl-butane-1,4-dionecompound 1 (WO2012024404A1)RefChem:130821Wnt pathway activator 11-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-4-phenylbutane-1,4-dioneDalosirvat [USAN:INN]AOCDRSSVFUCURK-UHFFFAOYSA-NUS10314832, Compound 1GLXC-20808GLXC-26868EX-A3071WHO 11422AC-31958MS-24243DB-179802HY-135516

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEMBL:CHEMBL4650339

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Official European Commission record

CosIng substance ID: 100217
Entry status: Active
Published in the Official Journal: Yes
Recorded by the Commission: 2023-05-23

Open this entry in the official CosIng database

Fields as published by the European Commission. The link opens the entry itself, not a search for it.

Inventory details for DALOSIRVAT

INCI name

DALOSIRVAT

Description

Dalosirvat is the organic compound that conforms to the formula

Record provenance

Inventory reference: cosing-live-100217
Imported identity: DALOSIRVAT
Source update: 2023-05-23

European Commission CosIng source notes

Annex records for DALOSIRVAT

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Key data

CAS

1360540-81-3

—

Restriction

—

Function

NOT REPORTED: No function currently reported.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#8020 · DALOSIRVAT

Ingredients with overlapping formulation functions

CUPRIC SULFIDENOT REPORTED

CYCLO PEG-6NOT REPORTED

CYCLOHEXANE DIMETHANOLNOT REPORTED

CYCLOHEXYLDIMETHANOLNOT REPORTED

DATURA STRAMONIUM POWDERNOT REPORTED

DECAPEPTIDE-47NOT REPORTED

DECYL POLYSTYRENE OXIDE/PEG-23 COPOLYMER PHOSPHATENOT REPORTED

DELTA-VALEROLACTONENOT REPORTED

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How DALOSIRVAT appears in the CosIng inventory

The CosIng inventory lists DALOSIRVAT as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

DALOSIRVAT is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

DALOSIRVAT is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, DALOSIRVAT carries the following function designation(s):

NOT REPORTED

CAS 1360540-81-3 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for DALOSIRVAT

This page reproduces the CosIng inventory entry for DALOSIRVAT from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research DALOSIRVAT and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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Tools & next steps

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