Is ZERUMBONE safe to use in EU cosmetics?

ZERUMBONE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Always verify against the current official CosIng database before formulating.

What other records share CAS 471-05-6?

CAS 471-05-6 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

How do I check if my formula contains ZERUMBONE?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 9838419/05/2020

ZERUMBONE

Zerumbone is the organic compound that conforms to the formula:

ZERUMBONE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 471-05-6

CAS 471-05-6PubChem CID 5470187

Zerumbone

Zerumbone is a sesquiterpenoid and cyclic ketone that is (1E,4E,8E)-alpha-humulene which is substituted by an oxo group at the carbon atom attached to two double bonds. It is obtained by steam distillation from a type of edible ginger, Zingiber zerumbet Smith, grown particularly in southeast Asia. It has a role as a glioma-associated oncogene inhibitor, an anti-inflammatory agent and a plant metabolite. It is a sesquiterpenoid and a cyclic ketone. It derives from a hydride of an alpha-humulene. — ChEBI

IUPAC name: (2E,6E,10E)-2,6,9,9-tetramethylcycloundeca-2,6,10-trien-1-one

Molecular formula: C15H22O
Molecular weight: 218.33 g/mol
Exact mass: 218.167065321 Da
XLogP3: 3.9
Topological polar surface area: 17.1 Å²
Hydrogen-bond donors: 0
Hydrogen-bond acceptors: 1
Covalent units: 1
Defined stereocentres: 0

Also known as

(E,E,E)-2,6,9,9-Tetramethyl-2,6,10-cycloundecatrien-1-oneCHEBI:63892RefChem:195923687-304-22,6,10-Cycloundecatrien-1-one, 2,6,9,9-tetramethyl-, (E,E,E)-2E,6E,9E-humulatrien-8-one(2E,6E,10E)-2,6,9,9-Tetramethylcycloundeca-2,6,10-trienoneerumbone

16 more reported names

Zerumbone (Standard)2,6,9,9-tetramethylcycloundeca-2,6,10-trien-1-oneZerumbone, >=98% (HPLC)HY-N7015RGIHNTRQPEMKFKO-SKTNYSRSSA-NGLXC-19155SRCZ-00151HY-N7015(2E,6E,10E)-2,6,9,9-Tetramethyl-2,6,10-cycloundecatrien-1-oneHB4130CCG-208558EBC-476059NSC-698299MS-23207CS-0003365T5712

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:63892
ChEMBL:CHEMBL245412
EPA DTXSID:DTXSID601318583

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for ZERUMBONE

INCI name

ZERUMBONE

Description

Zerumbone is the organic compound that conforms to the formula:

Record provenance

Inventory reference: 98384
Imported identity: ZERUMBONE
Source update: 19/05/2020

European Commission CosIng source notes

Annex records for ZERUMBONE

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Key data

CAS

471-05-6

687-304-2

Restriction

—

Function

SKIN CONDITIONING: Maintaining the skin in good condition.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#30278 · ZERUMBONE

Ingredients with overlapping formulation functions

ZEA MAYS STIGMA EXTRACTHUMECTANT, SKIN CONDITIONING

ZEATINSKIN CONDITIONING

ZEDERONESKIN CONDITIONING

ZEINFILM FORMING, HAIR CONDITIONING, SKIN CONDITIONING

ZINC ACETYLMETHIONATESKIN CONDITIONING

ZINC ADENOSINE TRIPHOSPHATEANTIOXIDANT, SKIN CONDITIONING

ZINC ADENOSINE TRIPHOSPHATE HYDROXIDEHAIR CONDITIONING, SKIN CONDITIONING, SKIN PROTECTING, UV ABSORBER

ZINC ASCORBATE HYDROXIDEHAIR CONDITIONING, SKIN CONDITIONING, SKIN PROTECTING, UV ABSORBER

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How ZERUMBONE appears in the CosIng inventory

The CosIng inventory lists ZERUMBONE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

ZERUMBONE is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

ZERUMBONE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, ZERUMBONE carries the following function designation(s):

SKIN CONDITIONING

CAS 471-05-6 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for ZERUMBONE

This page reproduces the CosIng inventory entry for ZERUMBONE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research ZERUMBONE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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