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CAS 1185-53-1 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

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InventoryRef 9807619/05/2020

TROMETHAMINE HCL

Tromethamine HCl is the amine salt that conforms to the formula:

TROMETHAMINE HCL is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 1185-53-1

CAS 1185-53-1PubChem CID 93573

Tromethamine hydrochloride

IUPAC name: 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydrochloride

Molecular formula: C4H12ClNO3
Molecular weight: 157.59 g/mol
Exact mass: 157.0505709 Da
Topological polar surface area: 86.7 Å²
Hydrogen-bond donors: 5
Hydrogen-bond acceptors: 4
Covalent units: 2
Defined stereocentres: 0

Also known as

Tris hydrochlorideTris(hydroxymethyl)aminomethane hydrochloride2-Amino-2-(hydroxymethyl)propane-1,3-diol hydrochlorideTRIS HClTris-HClTrometamol hydrochlorideTrizma hydrochlorideTromethamine HCl

16 more reported names

1,3-Propanediol, 2-amino-2-(hydroxymethyl)-, hydrochlorideTris chlorideTris hydrochloride bufferUNII-383V75M34EEINECS 214-684-5383V75M34E2-Amino-2-hydroxymethyl-1,3-propanediol hydrochlorideTROMETAMOL HYDROCHLORIDE [WHO-DD]1,3-Propanediol, 2-amino-2-(hydroxymethyl)-, hydrochloride (1:1)RefChem:1922472Amino2hydroxymethyl1,3propanediol hydrochloride2Amino2(hydroxymethyl)propane1,3diol hydrochloride1,3Propanediol, 2amino2(hydroxymethyl), hydrochloride2-Amino-2-(hydroxymethyl)-1,3-propanediol HydrochlorideTrometamol (hydrochloride)C4H12ClNO3

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEMBL:CHEMBL3183206
EPA DTXSID:DTXSID4044373
PubMed:4493

Evidence from additional scientific databases

NIH PubChem PUG-View

Exact identifier match93573

Attributed physical-property, hazard, environmental and use annotations.

Physical Description: Dry Powder; Liquid; Other Solid; Dry Powder Source: EPA Chemical Data Reporting (CDR)
Physical Description: Hygroscopic solid; [Sigma-Aldrich MSDS] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases

Note: This chemical does not meet GHS hazard criteria for 57.2% (103 of 180) of all reports. Source: European Chemicals Agency (ECHA)
Signal: Warning Source: European Chemicals Agency (ECHA)
GHS Hazard Statements: H315 (42.2%): Causes skin irritation [Warning Skin corrosion/irritation]; H319 (42.2%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H335 (40.6%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation] Source: European Chemicals Agency (ECHA)
Precautionary Statement Codes: P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
ECHA C&L Notifications Summary: Aggregated GHS information provided per 180 reports by companies from 16 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Reported as not meeting GHS hazard criteria per 103 of 180 reports by companies.; There are 14 notifications provided by 77 of 180 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)

Consumer Uses: Stabilizing agent Source: EPA Chemical Data Reporting (CDR)

Industry Uses: Other; Stabilizing agent Source: EPA Chemical Data Reporting (CDR)

Sources/Uses: Used to make surface-active agents and pharmaceuticals, as an emulsifier (for cosmetic creams and lotions, mineral oil, and paraffin wax emulsions), as a biological buffer, and as an alkalizer; [ChemIDplus] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status

Source	Result	Checked
NIH PubChem PUG-View	Exact match	2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for TROMETHAMINE HCL

INCI name

TROMETHAMINE HCL

Description

Tromethamine HCl is the amine salt that conforms to the formula:

Record provenance

Inventory reference: 98076
Imported identity: TROMETHAMINE HCL
Source update: 19/05/2020

European Commission CosIng source notes

Annex records for TROMETHAMINE HCL

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Key data

CAS

1185-53-1

214-684-5

Restriction

—

Function

ANTIMICROBIAL: Preventing and/or slowing down microbial growth.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#29534 · TROMETHAMINE HCl

Ingredients with overlapping formulation functions

TRIPEPTIDE-51ANTIMICROBIAL, ANTIOXIDANT, ASTRINGENT, HUMECTANT, SKIN CONDITIONING, SKIN PROTECTING

TRIPEPTIDE-77 VALINAMIDEANTIMICROBIAL, ANTIOXIDANT, SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT

TRIS(N-HYDROXYPROPYL) HEXAHYDROTRIAZINEANTIMICROBIAL

TRIS-HYDROXYMETHYLNITROMETHANEANTIMICROBIAL

TROPAEOLUM MAJUS EXTRACTANTIMICROBIAL, SKIN CONDITIONING, TONIC

TULIPA GESNERIANA CALLUS CULTURE EXTRACTABSORBENT, ANTIMICROBIAL, ANTIOXIDANT, HUMECTANT

UNDECYLENAMIDE DEAANTI-SEBORRHEIC, ANTIMICROBIAL, ANTISTATIC, HAIR CONDITIONING, SURFACTANT - FOAM BOOSTING, VISCOSIT…

UNDECYLENAMIDE MEAANTIMICROBIAL, ANTISTATIC, HAIR CONDITIONING, SURFACTANT - CLEANSING, SURFACTANT - FOAM BOOSTING, V…

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How TROMETHAMINE HCL appears in the CosIng inventory

The CosIng inventory lists TROMETHAMINE HCL as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

TROMETHAMINE HCL is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

TROMETHAMINE HCL is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, TROMETHAMINE HCL carries the following function designation(s):

ANTIMICROBIAL

CAS 1185-53-1 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for TROMETHAMINE HCL

This page reproduces the CosIng inventory entry for TROMETHAMINE HCL from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research TROMETHAMINE HCL and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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