CAS 1185-53-1PubChem CID 93573
Tromethamine hydrochloride
- IUPAC name
- 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydrochloride
- Molecular formula
- C4H12ClNO3
- Molecular weight
- 157.59 g/mol
- Exact mass
- 157.0505709 Da
- Topological polar surface area
- 86.7 Ų
- Hydrogen-bond donors
- 5
- Hydrogen-bond acceptors
- 4
- Covalent units
- 2
- Defined stereocentres
- 0
Also known as
Tris hydrochlorideTris(hydroxymethyl)aminomethane hydrochloride2-Amino-2-(hydroxymethyl)propane-1,3-diol hydrochlorideTRIS HClTris-HClTrometamol hydrochlorideTrizma hydrochlorideTromethamine HCl
16 more reported names
1,3-Propanediol, 2-amino-2-(hydroxymethyl)-, hydrochlorideTris chlorideTris hydrochloride bufferUNII-383V75M34EEINECS 214-684-5383V75M34E2-Amino-2-hydroxymethyl-1,3-propanediol hydrochlorideTROMETAMOL HYDROCHLORIDE [WHO-DD]1,3-Propanediol, 2-amino-2-(hydroxymethyl)-, hydrochloride (1:1)RefChem:1922472Amino2hydroxymethyl1,3propanediol hydrochloride2Amino2(hydroxymethyl)propane1,3diol hydrochloride1,3Propanediol, 2amino2(hydroxymethyl), hydrochloride2-Amino-2-(hydroxymethyl)-1,3-propanediol HydrochlorideTrometamol (hydrochloride)C4H12ClNO3
External database identifiers
- ChEMBL:CHEMBL3183206
- EPA DTXSID:DTXSID4044373
- PubMed:4493
Evidence from additional scientific databases
NIH PubChem PUG-View
Exact identifier match93573
Attributed physical-property, hazard, environmental and use annotations.
- Physical Description: Dry Powder; Liquid; Other Solid; Dry Powder Source: EPA Chemical Data Reporting (CDR)
- Physical Description: Hygroscopic solid; [Sigma-Aldrich MSDS] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Note: This chemical does not meet GHS hazard criteria for 57.2% (103 of 180) of all reports. Source: European Chemicals Agency (ECHA)
- Signal: Warning Source: European Chemicals Agency (ECHA)
- GHS Hazard Statements: H315 (42.2%): Causes skin irritation [Warning Skin corrosion/irritation]; H319 (42.2%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H335 (40.6%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation] Source: European Chemicals Agency (ECHA)
- Precautionary Statement Codes: P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
- ECHA C&L Notifications Summary: Aggregated GHS information provided per 180 reports by companies from 16 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Reported as not meeting GHS hazard criteria per 103 of 180 reports by companies.; There are 14 notifications provided by 77 of 180 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
- Consumer Uses: Stabilizing agent Source: EPA Chemical Data Reporting (CDR)
- Industry Uses: Other; Stabilizing agent Source: EPA Chemical Data Reporting (CDR)
- Sources/Uses: Used to make surface-active agents and pharmaceuticals, as an emulsifier (for cosmetic creams and lotions, mineral oil, and paraffin wax emulsions), as a biological buffer, and as an alkalizer; [ChemIDplus] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record
Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.
Additional source coverage and match status
| Source | Result | Checked |
|---|---|---|
| NIH PubChem PUG-View | Exact match | 2026-08-31 |
A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.
Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.