TRIS-HYDROXYMETHYLNITROMETHANE
Nitromethylidynetrimethanol
TRIS-HYDROXYMETHYLNITROMETHANE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.
Regulatory evidence by market
No rule for this ingredient has been imported for any of the 13 markets tracked here.
That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.
Chemical identity and properties
Tris(hydroxymethyl)nitromethane
- IUPAC name
- 2-(hydroxymethyl)-2-nitropropane-1,3-diol
- Molecular formula
- C4H9NO5
- Molecular weight
- 151.12 g/mol
- Exact mass
- 151.04807239 Da
- XLogP3
- -2.2
- Topological polar surface area
- 107.0 Ų
- Hydrogen-bond donors
- 3
- Hydrogen-bond acceptors
- 5
- Covalent units
- 1
- Defined stereocentres
- 0
Also known as
16 more reported names
External database identifiers
- ChEMBL:CHEMBL1895497
- EPA DTXSID:DTXSID8027034
- PubMed:22188016
- PubMed:22016638
- PubMed:20670016
- PubMed:20573163
- PubMed:19797229
Evidence from additional scientific databases
NIH PubChem PUG-View
Attributed physical-property, hazard, environmental and use annotations.
- Color/Form: Crystals from ethyl acetate and benzene Source: Hazardous Substances Data Bank (HSDB)
- Color/Form: White solid Source: Hazardous Substances Data Bank (HSDB)
- Melting Point: 214 °C (pure) Source: Hazardous Substances Data Bank (HSDB)
- Melting Point: MP: 180 °C (usual lab product); 175-176 °C (technical grade) Source: Hazardous Substances Data Bank (HSDB)
- Odor: Odorless Source: Hazardous Substances Data Bank (HSDB)
- Physical Description: Liquid; Dry Powder Source: EPA Chemical Data Reporting (CDR)
- Physical Description: White solid; [Hawley] Light yellow crystals; [MSDSonline] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Solubility: Soluble in polar solvents such as methanol and isopropanol. Insoluble in non-polar solvents such as aliphatic and aromatic hydrocarbons. Source: Hazardous Substances Data Bank (HSDB)
- Solubility: Freely soluble in alcohols, sparingly soluble in benzene Source: Hazardous Substances Data Bank (HSDB)
- Solubility: In water, 2.20X10+6 mg/L at 20 °C Source: Hazardous Substances Data Bank (HSDB)
- Vapor Pressure: 0.00000154 [mmHg] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Signal: Warning Source: European Chemicals Agency (ECHA)
- GHS Hazard Statements: H302+H332 (58.6%): Harmful if swallowed or if inhaled [Warning Acute toxicity, oral; acute toxicity, inhalation]; H302 (86.4%): Harmful if swallowed [Warning Acute toxicity, oral]; H315 (37.7%): Causes skin irritation [Warning Skin corrosion/irritation]; H319 (37.7%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H332 (59.3%): Harmful if inhaled [Warning Acute toxicity, inhalation]; H335 (24.1%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]; H400 (58%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410 (58%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
- Precautionary Statement Codes: P261, P264, P264+P265, P270, P271, P273, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P391, P403+P233, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
- ECHA C&L Notifications Summary: Aggregated GHS information provided per 162 reports by companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
- Environmental Bioconcentration: An estimated BCF of 1.3 was calculated for 2-hydroxymethyl-2-nitro-1,3-propanediol(SRC), using an estimated log Kow of -1.66(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 10(SRC), determined from a structure estimation method(2), indicates that 2-hydroxymethyl-2-nitro-1,3-propanediol is expected to have very high mobility in soil(SRC). Volatilization of 2-hydroxymethyl-2-nitro-1,3-propanediol from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 4.8X10-12 atm-cu m/mole(SRC), using a fragment constant estimation method(3). 2-Hydroxymethyl-2-nitro-1,3-propanediol is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 3.2X10-7 mm Hg(SRC), determined from a fragment constant method(4). Biodegradation data were not available(SRC, 2006). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 10(SRC), determined from a structure estimation method(2), indicates that 2-hydroxymethyl-2-nitro-1,3-propanediol is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon an estimated Henry's Law constant of 4.8X10-12 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). According to a classification scheme(5), an estimated BCF of 1.3(SRC), from an estimated log Kow of -1.66(6) and a regression-derived equation(7), suggests the potential for bioconcentration in aquatic organisms is low(SRC). 2-Hydroxymethyl-2-nitro-1,3-propanediol has reported hydrolysis half-lives of stable, 3.4 days and 2.4 days at pH values 5, 7 and 9, respectively(8). 2-Hydroxymethyl-2-nitro-1,3-propanediol decomposes to formaldehyde under alkaline conditions and at temperatures above 49 °C(9). Biodegradation data were not available(SRC, 2006). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 2-hydroxymethyl-2-nitro-1,3-propanediol, which has an estimated vapor pressure of 3.2X10-7 mm Hg at 25 °C(SRC), determined from a fragment constant method(2), will exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase 2-hydroxymethyl-2-nitro-1,3-propanediol is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 33 days(SRC), calculated from its rate constant of 1.9X10-12 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Particulate-phase 2-hydroxymethyl-2-nitro-1,3-propanediol may be removed from the air by wet and dry deposition(SRC). 2-Hydroxymethyl-2-nitro-1,3-propanediol does not contain chromophores that absorb at wavelengths >290 nm and therefore is not expected to be susceptible to direct photolysis by sunlight(SRC). Source: Hazardous Substances Data Bank (HSDB)
- Consumer Uses: Other Source: EPA Chemical Data Reporting (CDR)
- Industry Uses: Polymerization promoter; Other Source: EPA Chemical Data Reporting (CDR)
- Sources/Uses: Used as a general disinfectant, bactericide (circulating industrial water systems, cutting oils, secondary oil field recovery waters, and paper mills), and preservative (latex paints, polishes, non-protein glues, sizings, and detergents); Also used as a disinfectant in livestock and poultry farms; [HSDB] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Industrial Processes with risk of exposure: Metal Machining [Category: Heat or Machine]; Petroleum Production and Refining [Category: Industry]; Pulp and Paper Processing [Category: Industry]; Textiles (Fiber & Fabric Manufacturing) [Category: Industry]; Painting (Pigments, Binders, and Biocides) [Category: Paint]; Working with Glues and Adhesives [Category: Other]; Using Disinfectants or Biocides [Category: Clean] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Uses: For 2-hydroxymethyl-2-nitro-1,3-propanediol (USEPA/OPP Pesticide Code: 083902) ACTIVE products with label matches. /SRP: Registered for use in the U.S. but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses./ Source: Hazardous Substances Data Bank (HSDB)
- Uses: Bactericide for inanimate objects. To inhibit bacterial growth in circulating industrial water systems, cutting oils, non-protein glues and sizings. Source: Hazardous Substances Data Bank (HSDB)
- Uses: Disinfectant (general); microbicide/microbiostat (slime-forming bacteria and fungi) ... industrial preservative/preservative (bacteriostat) Source: Hazardous Substances Data Bank (HSDB)
- Uses: Microbiocide and bacteriostat in disinfectants and industrial preservatives. Specifically ... used as an industrial preservative in metalworking fluids, secondary oil field recovery waters, paper mills, and commercial/industrial water cooling systems; as an in-can preservative in latex paints, polishes, and detergents; and as a disinfectant to control disease organisms in livestock and poultry areas on farms and equipment. Source: Hazardous Substances Data Bank (HSDB)
Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record
Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.
Additional source coverage and match status
| Source | Result | Checked |
|---|---|---|
| NIH PubChem PUG-View | Exact match | 2026-08-31 |
A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.
Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Inventory details for TRIS-HYDROXYMETHYLNITROMETHANE
INCI name
TRIS-HYDROXYMETHYLNITROMETHANE
Description
Nitromethylidynetrimethanol
Record provenance
- Inventory reference
- 87454
- Imported identity
- TRIS-HYDROXYMETHYLNITROMETHANE
- Source update
- 15/10/2010
Annex records for TRIS-HYDROXYMETHYLNITROMETHANE
Key data
Official EU ingredient-name evidence
The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.
Related inventory evidence
Ingredients with overlapping formulation functions
Additional official and scientific sources
11 external databases to check this identity in
Each link searches that source for this identity. What each source is, and its legal weight
How TRIS-HYDROXYMETHYLNITROMETHANE appears in the CosIng inventory
The CosIng inventory lists TRIS-HYDROXYMETHYLNITROMETHANE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.
TRIS-HYDROXYMETHYLNITROMETHANE is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.
Frequently asked questions
Source note for TRIS-HYDROXYMETHYLNITROMETHANE
This page reproduces the CosIng inventory entry for TRIS-HYDROXYMETHYLNITROMETHANE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.
Use this inventory page to research TRIS-HYDROXYMETHYLNITROMETHANE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.
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