Is GINSENOSIDE RD safe to use in EU cosmetics?

GINSENOSIDE RD is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Always verify against the current official CosIng database before formulating.

What other records share CAS 52705-93-8?

CAS 52705-93-8 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

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InventoryRef 9722321/10/2019

GINSENOSIDE RD

\b-D-Glucopyranoside, (3.b\b.,12.\b)-20-(\b-D-glucopyranosyloxy)-12-hydroxydammar-24-en-3-yl 2-O-\b- D-glucopyranosyl-

GINSENOSIDE RD is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 52705-93-8

CAS 52705-93-8PubChem CID 11679800

Ginsenoside Rd

Ginsenoside Rd is a ginsenoside found in Panax ginseng and Panax japonicus var. major that is (20S)-ginsenoside Rg3 in which the hydroxy group at position 20 has been converted to its beta-D-glucopyranoside. It has a role as an anti-inflammatory drug, an immunosuppressive agent, a neuroprotective agent, an apoptosis inducer, a vulnerary and a plant metabolite. It is a beta-D-glucoside, a tetracyclic triterpenoid and a ginsenoside. It is functionally related to a (20S)-ginsenoside Rg3. — ChEBI

IUPAC name: (2S,3R,4S,5S,6R)-2-[(2R,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-2-[[(3S,5R,8R,9R,10R,12R,13R,14R,17S)-12-hydroxy-4,4,8,10,14-pentamethyl-17-[(2S)-6-methyl-2-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyhept-5-en-2-yl]-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]oxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol

Molecular formula: C48H82O18
Molecular weight: 947.2 g/mol
Exact mass: 946.55011576 Da
XLogP3: 2.4
Topological polar surface area: 298.0 Å²
Hydrogen-bond donors: 12
Hydrogen-bond acceptors: 18
Covalent units: 1
Defined stereocentres: 25

Also known as

Gypenoside VIIIChikusetsusaponin fk7WB232T95AVCHEBI:679882-O-beta-D-Glucopyranosyl-(3beta,12beta)-20-(beta-D-glucopyranosyloxy)-12-hydroxydammara-24-en-3-yl-beta-D-glucopyranosidebeta-D-Glucopyranoside, (3beta,12beta)-20-(beta-D-glucopyranosyloxy)-12-hydroxydammar-24-en-3-yl 2-O-beta-D-glucopyranosyl-(3beta,12beta)-20-(beta-D-glucopyranosyloxy)-12-hydroxydammar-24-en-3-yl 2-O-beta-D-glucopyranosyl-beta-D-glucopyranosideRefChem:37442

16 more reported names

UNII-WB232T95AVGINSENOSIDE RD (CONSTITUENT OF AMERICAN GINSENG, ASIAN GINSENG, AND TIENCHI GINSENG)258-118-5ginsenoside-RdNSC-308876GS-RdG-Rd(20S)-ginsenoside Rd20(S)-ginsenoside RdGinsenoside Rd (Standard)(GS)-RdGypenoside VIII (Standard)HMS3885A14HY-N0043EINECS 258-118-5CCG-270588

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:67988
ChEMBL:CHEMBL473659
EPA DTXSID:DTXSID301031221
PubMed:30545933
PubMed:26111763
PubMed:25297453
PubMed:24781185
PubMed:24599032
PubMed:10571242
PubMed:9933756
PubMed:8988629

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for GINSENOSIDE RD

INCI name

GINSENOSIDE RD

Description

\b-D-Glucopyranoside, (3.b\b.,12.\b)-20-(\b-D-glucopyranosyloxy)-12-hydroxydammar-24-en-3-yl 2-O-\b- D-glucopyranosyl-

Record provenance

Inventory reference: 97223
Imported identity: GINSENOSIDE RD
Source update: 21/10/2019

European Commission CosIng source notes

Annex records for GINSENOSIDE RD

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Key data

CAS

52705-93-8

258-118-5

Restriction

—

Function

ANTIOXIDANT: Inhibiting reactions promoted by oxygen, thus avoiding oxidation and rancidity.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#10958 · GINSENOSIDE RD

Ingredients with overlapping formulation functions

GINKGO BIFLAVONESANTIOXIDANT, SKIN PROTECTING

GINKGO BILOBA MERISTEM CELLANTIMICROBIAL, ANTIOXIDANT, SKIN CONDITIONING

GINKGO BILOBA MERISTEM CELL CULTURE CONDITIONED MEDIAANTIMICROBIAL, ANTIOXIDANT, SKIN CONDITIONING

GINKGO LEAF TERPENOIDSANTIMICROBIAL, ANTIOXIDANT, HAIR CONDITIONING

GINSENOSIDE REANTIOXIDANT, HUMECTANT, SKIN CONDITIONING

GINSENOSIDE RG4ANTIOXIDANT

GINSENOSIDE RG6ANTIOXIDANT, SKIN CONDITIONING, SKIN PROTECTING

GINSENOSIDE RH4ANTI-SEBORRHEIC, ANTIOXIDANT, SKIN CONDITIONING, SKIN PROTECTING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How GINSENOSIDE RD appears in the CosIng inventory

The CosIng inventory lists GINSENOSIDE RD as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

GINSENOSIDE RD is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

GINSENOSIDE RD is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, GINSENOSIDE RD carries the following function designation(s):

ANTIOXIDANT

CAS 52705-93-8 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for GINSENOSIDE RD

This page reproduces the CosIng inventory entry for GINSENOSIDE RD from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research GINSENOSIDE RD and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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