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CAS 94-53-1 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

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InventoryRef 9597519/04/2018

PIPERONYLIC ACID

Methylenedioxybenzoic Acid

PIPERONYLIC ACID is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 94-53-1

CAS 94-53-1PubChem CID 7196

1,3-Benzodioxole-5-carboxylic acid

Piperonylic acid is a member of the class of benzodioxoles that is 1,3-benzodioxole substituted by a carboxy group at position 5. It is a natural product isolated from several plant species. It is a selective mechanism-based inactivator of the trans-cinnamate 4-hydroxylase enzyme and exhibits antifungal and skin wound healing properties. It has a role as an EC 1.14.14.91 ( trans-cinnamate 4-monooxygenase) inhibitor, an antifungal agent, a vulnerary and a plant metabolite. It is a monocarboxylic acid, an aromatic carboxylic acid and a member of benzodioxoles. It is a conjugate acid of a piperonylate. — ChEBI

IUPAC name: 1,3-benzodioxole-5-carboxylic acid

Molecular formula: C8H6O4
Molecular weight: 166.13 g/mol
Exact mass: 166.02660867 Da
XLogP3: 0.4
Topological polar surface area: 55.8 Å²
Hydrogen-bond donors: 1
Hydrogen-bond acceptors: 4
Covalent units: 1
Defined stereocentres: 0

Also known as

PIPERONYLIC ACIDHeliotropic acid2H-1,3-Benzodioxole-5-Carboxylic Acid3,4-(Methylenedioxy)benzoic acidProtocatechuic acid methylene ether5-Benzodioxolecarboxylic acid3,4-Dioxymethylenebenzoic acidQX3V1NO0KH

16 more reported names

NSC-10072CHEBI:107644RefChem:863626202-342-8Benzo[d][1,3]dioxole-5-carboxylic acid3,4-Methylenedioxybenzoic acidbenzo[1,3]dioxole-5-carboxylic acid3,4-Methylene dioxybenzoic acidBenzoic acid, 3,4-(methylenedioxy)-Spectrum3_001022KBioSS_001644Benzo[d][I,3]dioxole-5-carboxylic acidP04591,3-dioxaindane-5-carboxylic acidPIPERONYLIC ACID-2,2-D2NSC 10072

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:107644
ChEMBL:CHEMBL573781
EPA DTXSID:DTXSID6059104
PubMed:22734410
PubMed:21489652
PubMed:19342120
PubMed:18626717
PubMed:17229869
PubMed:16569001
PubMed:16310363
PubMed:15913846
PubMed:15007421
PubMed:14511910
PubMed:12376665
PubMed:11154339

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for PIPERONYLIC ACID

INCI name

PIPERONYLIC ACID

Description

Methylenedioxybenzoic Acid

Record provenance

Inventory reference: 95975
Imported identity: PIPERONYLIC ACID
Source update: 19/04/2018

European Commission CosIng source notes

Annex records for PIPERONYLIC ACID

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Key data

CAS

94-53-1

202-342-8

Restriction

—

Function

SKIN CONDITIONING: Maintaining the skin in good condition.
SKIN PROTECTING: Helping to avoid harmful effects to the skin from external factors.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#21242 · PIPERONYLIC ACID

Ingredients with overlapping formulation functions

PIPER MARGINATUM LEAF EXTRACTSKIN PROTECTING

PIPER NIGRUM CALLUS EXTRACTANTIOXIDANT, SKIN PROTECTING

PIPERONYL BUTOXIDESKIN PROTECTING

PIPERONYL GLUCOSIDESKIN PROTECTING

PIPERONYLOYL PROLINESKIN PROTECTING

PISTACIA LENTISCUS LEAF CERASKIN PROTECTING, VISCOSITY CONTROLLING

PISUM SATIVUM EXTRACTSKIN CONDITIONING, SKIN PROTECTING

PISUM SATIVUM PHYTOPLACENTA EXTRACTANTIMICROBIAL, ANTIOXIDANT, HUMECTANT, SKIN CONDITIONING, SKIN PROTECTING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How PIPERONYLIC ACID appears in the CosIng inventory

The CosIng inventory lists PIPERONYLIC ACID as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

PIPERONYLIC ACID is also tagged with 2 cosmetic functions in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

PIPERONYLIC ACID is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, PIPERONYLIC ACID carries the following function designation(s):

CAS 94-53-1 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for PIPERONYLIC ACID

This page reproduces the CosIng inventory entry for PIPERONYLIC ACID from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research PIPERONYLIC ACID and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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Tools & next steps

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