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CAS 51-03-6 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

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InventoryRef 5956815/10/2010

PIPERONYL BUTOXIDE

1,3-Benzodioxole, 5-[[2-(2-butoxyethoxy)ethoxy]methyl]-6-propyl-

PIPERONYL BUTOXIDE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 51-03-6

CAS 51-03-6PubChem CID 5794

Piperonyl Butoxide

Piperonyl butoxide is a pale yellow to light brown liquid with a mild odor and a faint bitter taste. (NTP, 1992) — CAMEO Chemicals

IUPAC name: 5-[2-(2-butoxyethoxy)ethoxymethyl]-6-propyl-1,3-benzodioxole

Molecular formula: C19H30O5
Molecular weight: 338.4 g/mol
Exact mass: 338.20932405 Da
XLogP3: 3.7
Topological polar surface area: 46.2 Å²
Hydrogen-bond donors: 0
Hydrogen-bond acceptors: 5
Covalent units: 1
Defined stereocentres: 0

Also known as

ButacideButocideButoxidePyrenone 606Butyl carbitol 6-propylpiperonyl etherButoxide (synergist)6-Propylpiperonyl butyl diethylene glycol etherButoxide, Piperonyl

16 more reported names

NCI-C02813FMC 5273NIA 5273Piperonyl butoxydeENT 14,2502-(2-Butoxyethoxy)ethyl 6-propylpiperonyl etherNSC-8401Piperonyl butoxide, technical1,3-Benzodioxole, 5-((2-(2-butoxyethoxy)ethoxy)methyl)-6-propyl-LWK91TU9AH3,4-Methylenedioxy-6-propylbenzyl n-butyl diethyleneglycol etherPiperonyl butoxide technical6-(Propylpiperonyl)-butyl carbityl etherButyl-carbityl (6-propylpiperonyl) ether1,3-Benzodioxole, 5-[[2-(2-butoxyethoxy)ethoxy]methyl]-6-propyl-alpha-(2-(2-n-Butoxyethoxy)-ethoxy)-4,5-methylenedioxy-2-propyltoluene

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:32687
ChEMBL:CHEMBL1201131
EPA DTXSID:DTXSID1021166
PubMed:39255949
PubMed:36941454
PubMed:32767777
PubMed:32320717
PubMed:31642701
PubMed:30763314
PubMed:30572783
PubMed:30203046
PubMed:29183579
PubMed:29064635
PubMed:28903497
PubMed:28899750

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for PIPERONYL BUTOXIDE

INCI name

PIPERONYL BUTOXIDE

Description

1,3-Benzodioxole, 5-[[2-(2-butoxyethoxy)ethoxy]methyl]-6-propyl-

Record provenance

Inventory reference: 59568
Imported identity: PIPERONYL BUTOXIDE
Source update: 15/10/2010

European Commission CosIng source notes

Annex records for PIPERONYL BUTOXIDE

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Key data

CAS

51-03-6

200-076-7

Restriction

—

Function

SKIN PROTECTING: Helping to avoid harmful effects to the skin from external factors.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#21240 · PIPERONYL BUTOXIDE

Ingredients with overlapping formulation functions

PIPER ANGUSTIFOLIUM EXTRACTSKIN PROTECTING

PIPER ANGUSTIFOLIUM LEAF EXTRACTANTIOXIDANT, ASTRINGENT, SKIN CONDITIONING, SKIN PROTECTING

PIPER MARGINATUM LEAF EXTRACTSKIN PROTECTING

PIPER NIGRUM CALLUS EXTRACTANTIOXIDANT, SKIN PROTECTING

PIPERONYL GLUCOSIDESKIN PROTECTING

PIPERONYLIC ACIDSKIN CONDITIONING, SKIN PROTECTING

PIPERONYLOYL PROLINESKIN PROTECTING

PISTACIA LENTISCUS LEAF CERASKIN PROTECTING, VISCOSITY CONTROLLING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How PIPERONYL BUTOXIDE appears in the CosIng inventory

The CosIng inventory lists PIPERONYL BUTOXIDE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

PIPERONYL BUTOXIDE is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

PIPERONYL BUTOXIDE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, PIPERONYL BUTOXIDE carries the following function designation(s):

SKIN PROTECTING

CAS 51-03-6 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for PIPERONYL BUTOXIDE

This page reproduces the CosIng inventory entry for PIPERONYL BUTOXIDE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research PIPERONYL BUTOXIDE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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