Is NARIRUTIN safe to use in EU cosmetics?

NARIRUTIN is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Always verify against the current official CosIng database before formulating.

What other records share CAS 14259-46-2?

CAS 14259-46-2 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

How do I check if my formula contains NARIRUTIN?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 9481020/02/2018

NARIRUTIN

4H-1-Benzopyran-4-one, 7-[[6-O-(6-deoxy-.alpha.-L-mannopyranosyl)-.beta.-D-glucopyranosyl]oxy]-2,3-dihydro-5-hydroxy-2-(4-hydroxyphenyl)-, (2S)-,Isonaringin

NARIRUTIN is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

INCI Checker Compare all markets Search similar

Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

Markets and their official sources Search every market for this name

Chemical identity and properties

PubChem 2D chemical structure for CAS 14259-46-2

CAS 14259-46-2PubChem CID 442431

Narirutin

Narirutin is a disaccharide derivative that is (S)-naringenin substituted by a 6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage. It has a role as an antioxidant, a metabolite and an anti-inflammatory agent. It is a member of 4'-hydroxyflavanones, a (2S)-flavan-4-one, a rutinoside, a dihydroxyflavanone and a disaccharide derivative. It is functionally related to a (S)-naringenin. — ChEBI

IUPAC name: (2S)-5-hydroxy-2-(4-hydroxyphenyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxy-2,3-dihydrochromen-4-one

Molecular formula: C27H32O14
Molecular weight: 580.5 g/mol
Exact mass: 580.17920569 Da
XLogP3: -1.1
Topological polar surface area: 225.0 Å²
Hydrogen-bond donors: 8
Hydrogen-bond acceptors: 14
Covalent units: 1
Defined stereocentres: 11

Also known as

IsonaringeninIsonaringinNaringenin 7-O-rutinoside06M5EAT0YCCHEBI:28705(2S)-5-hydroxy-2-(4-hydroxyphenyl)-4-oxo-3,4-dihydro-2H-chromen-7-yl 6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosideRefChem:43558238-138-0

16 more reported names

4H-1-Benzopyran-4-one, 7-((6-O-(6-deoxy-alpa-L-mannopyranosyl)-beta-D-glucopyranosyl)oxy)-2,3-dihydro-5-hydroxy-2-(4-hydroxyphenyl)-, (2S)-4H-1-BENZOPYRAN-4-ONE, 7-((6-O-(6-DEOXY-alpha-L-MANNOPYRANOSYL)-beta-D-GLUCOPYRANOSYL)OXY)-2,3-DIHYDRO-5-HYDROXY-2-(4-HYDROXYPHENYL)-, (2S)-Naringenin-7-O-rutinoside(2S)-NarirutinNaringenin 7-beta-rutinosideFEMA No. 2769EINECS 238-138-0UNII-06M5EAT0YC4H-1-Benzopyran-4-one,7-[[6-O-(6-deoxy-a-L-mannopyranosyl)-b-D-glucopyranosyl]oxy]-2,3-dihydro-5-hydroxy-2-(4-hydroxyphenyl)-, (2S)-Narirutin (Standard)Naringenin-7-rutinosideISONARINGIN [USP-RS]Narirutin, >=98% (HPLC)HY-N0804RHXTFHSYLYXVTHC-AJHDJQPGSA-NHY-N0804

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:28705
ChEMBL:CHEMBL446246
EPA DTXSID:DTXSID30931535
PubMed:22957912
PubMed:22953908
PubMed:22888512
PubMed:22813871
PubMed:22454671
PubMed:22254014
PubMed:22194772
PubMed:22125675
PubMed:21837249
PubMed:21802267
PubMed:21799684
PubMed:21779843

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for NARIRUTIN

INCI name

NARIRUTIN

Description

4H-1-Benzopyran-4-one, 7-[[6-O-(6-deoxy-.alpha.-L-mannopyranosyl)-.beta.-D-glucopyranosyl]oxy]-2,3-dihydro-5-hydroxy-2-(4-hydroxyphenyl)-, (2S)-,Isonaringin

Record provenance

Inventory reference: 94810
Imported identity: NARIRUTIN
Source update: 20/02/2018

European Commission CosIng source notes

Annex records for NARIRUTIN

Browse

Browse EU annexes

Explore Annex II–VI to see which substances are prohibited, restricted or permitted under specific conditions.

Search annex entries

Search the annex database for entries matching NARIRUTIN or related substances.

Key data

CAS

14259-46-2

238-138-0

Restriction

—

Function

ANTIOXIDANT: Inhibiting reactions promoted by oxygen, thus avoiding oxidation and rancidity.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#17257 · NARIRUTIN

Ingredients with overlapping formulation functions

NARCISSUS POETICUS CALLUS EXTRACTANTIOXIDANT, SKIN CONDITIONING, SKIN PROTECTING

NARCISSUS TAZETTA CALLUS EXTRACELLULAR VESICLESANTIMICROBIAL; ANTIOXIDANT

NARCISSUS TAZETTA CALLUS EXTRACTANTIMICROBIAL, ANTIOXIDANT, SKIN CONDITIONING

NARCISSUS TRIANDRUS EXTRACTANTIOXIDANT, SKIN CONDITIONING

NAUCLEA ORIENTALIS CALLUS EXTRACTANTIOXIDANT, SKIN CONDITIONING, SKIN PROTECTING

NELUMBO NUCIFERA CALLUSANTI-SEBUM, ANTIFOAMING, ANTIMICROBIAL, ANTIOXIDANT, ASTRINGENT, HAIR CONDITIONING, SKIN PROTECTING

NELUMBO NUCIFERA CALLUS CULTURE EXTRACTANTIMICROBIAL, ANTIOXIDANT, HUMECTANT

NELUMBO NUCIFERA FLOWER/LEAF/STEM JUICEANTIOXIDANT

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How NARIRUTIN appears in the CosIng inventory

The CosIng inventory lists NARIRUTIN as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

NARIRUTIN is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

NARIRUTIN is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, NARIRUTIN carries the following function designation(s):

ANTIOXIDANT

CAS 14259-46-2 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

View CAS records

Use the INCI Checker to screen a full ingredient list across selected markets, or compare this substance across all supported market datasets.

Open INCI Checker

Source note for NARIRUTIN

This page reproduces the CosIng inventory entry for NARIRUTIN from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research NARIRUTIN and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

View sources View updates

Tools & next steps

Check your formula

Scan a full INCI list to detect NARIRUTIN and any linked EU annex restrictions or allergen flags.

INCI Checker

Search similar ingredients

Find other inventory ingredients and annex entries related to NARIRUTIN, its identifiers or nearby name variants.