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CAS 38204-93-2 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

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InventoryRef 9452008/09/2016

BIS-HYDROXYBENZYL SULFIDE

Bis(4-hydroxybenzyl)sulfide,Phenol, 4,4'-[thiobis(methylene)]bis-

BIS-HYDROXYBENZYL SULFIDE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 38204-93-2

CAS 38204-93-2PubChem CID 23651847

Bis(4-Hydroxybenzyl)Sulfide

Bis-(4-hydroxybenzyl)sulfide is an organic sulfide that consists of two 4-hydroxybenzyl groups covalently bound to a central sulfur atom. It is isolated from Gastrodia elata and Pleuropterus ciliinervis and exhibits neoroprotective activity. It has a role as a metabolite, an EC 3.5.1.98 (histone deacetylase) inhibitor and a neuroprotective agent. It is an organic sulfide and a polyphenol. — ChEBI

IUPAC name: 4-[(4-hydroxyphenyl)methylsulfanylmethyl]phenol

Molecular formula: C14H14O2S
Molecular weight: 246.33 g/mol
Exact mass: 246.07145086 Da
XLogP3: 3.2
Topological polar surface area: 65.8 Å²
Hydrogen-bond donors: 2
Hydrogen-bond acceptors: 3
Covalent units: 1
Defined stereocentres: 0

Also known as

4-((4-hydroxyphenyl)methylsulfanylmethyl)phenolRefChem:917260bis-(4-hydroxybenzyl)sulfide4,4'-(sulfanediyldimethanediyl)diphenolBis(4-hydroxybenzyl) sulfidePhenol, 4,4'-[thiobis(methylene)]bis-4,4'-dihydroxybenzylsulfide4-hydroxyphenylmethyl sulfide

3 more reported names

4-hydroxyphenylmethyl sulphideCHEBI:65500OEISQDWSEZCYNH-UHFFFAOYSA-N

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:65500
ChEMBL:CHEMBL224380
PubMed:17851433
PubMed:17381154
PubMed:12774351

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for BIS-HYDROXYBENZYL SULFIDE

INCI name

BIS-HYDROXYBENZYL SULFIDE

Description

Bis(4-hydroxybenzyl)sulfide,Phenol, 4,4'-[thiobis(methylene)]bis-

Record provenance

Inventory reference: 94520
Imported identity: BIS-HYDROXYBENZYL SULFIDE
Source update: 08/09/2016

European Commission CosIng source notes

Annex records for BIS-HYDROXYBENZYL SULFIDE

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Key data

CAS

38204-93-2

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Restriction

—

Function

ANTIOXIDANT: Inhibiting reactions promoted by oxygen, thus avoiding oxidation and rancidity.
BLEACHING: Bleaching or lightening the shade of hair and/or skin.
CHELATING: Forming complexes with metal ions which could affect the stability and/or appearance of cosmetics.
HUMECTANT: Retaining and/or preserving the moisture in a product during use.
SKIN PROTECTING: Helping to avoid harmful effects to the skin from external factors.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#3679 · BIS-HYDROXYBENZYL SULFIDE

Ingredients with overlapping formulation functions

APHANOTHECE SACRUM POLYSACCHARIDESCHELATING; EMULSION STABILISING; FILM FORMING; HUMECTANT; SKIN PROTECTING; VISCOSITY CONTROLLING; D…

ASCORBYL CYCLO PEG-6CHELATING

BETA-ALANINE DIACETIC ACIDCHELATING

BILIRUBINANTIOXIDANT; CHELATING; REDUCING

BISMUTH CITRATEBUFFERING, CHELATING, HAIR DYEING

BRACHIARIA MUTICA EXTRACTANTIOXIDANT, CHELATING

CAFFEOYL HEXAPEPTIDE-50ANTIOXIDANT, CHELATING, SKIN PROTECTING, UV FILTER

CAFFEOYL PENTAPEPTIDE-27ANTIOXIDANT, CHELATING, SKIN PROTECTING, UV ABSORBER

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How BIS-HYDROXYBENZYL SULFIDE appears in the CosIng inventory

The CosIng inventory lists BIS-HYDROXYBENZYL SULFIDE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

BIS-HYDROXYBENZYL SULFIDE is also tagged with 5 cosmetic functions in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

BIS-HYDROXYBENZYL SULFIDE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, BIS-HYDROXYBENZYL SULFIDE carries the following function designation(s):

CAS 38204-93-2 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for BIS-HYDROXYBENZYL SULFIDE

This page reproduces the CosIng inventory entry for BIS-HYDROXYBENZYL SULFIDE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research BIS-HYDROXYBENZYL SULFIDE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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