Is PROPAFENONE safe to use in EU cosmetics?

PROPAFENONE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Always verify against the current official CosIng database before formulating.

What other records share CAS 54063-53-5?

CAS 54063-53-5 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

How do I check if my formula contains PROPAFENONE?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 8899425/07/2012

PROPAFENONE

1-{2-[2-hydroxy-3-(propylamino)propoxy]phenyl}-3-phenylpropan-1-one

PROPAFENONE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

INCI Checker Compare all markets Search similar

Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

Markets and their official sources Search every market for this name

Chemical identity and properties

PubChem 2D chemical structure for CAS 54063-53-5

CAS 54063-53-5PubChem CID 4932

Propafenone

Propafenone is an aromatic ketone that is 3-(propylamino)propane-1,2-diol in which the hydrogen of the primary hydroxy group is replaced by a 2-(3-phenylpropanoyl)phenyl group. It is a class 1C antiarrhythmic drug with local anesthetic effects, and is used as the hydrochloride salt in the management of supraventricular and ventricular arrhythmias. It has a role as an anti-arrhythmia drug. It is a secondary alcohol, a secondary amino compound and an aromatic ketone. It is a conjugate base of a propafenone(1+). — ChEBI

IUPAC name: 1-[2-[2-hydroxy-3-(propylamino)propoxy]phenyl]-3-phenylpropan-1-one

Molecular formula: C21H27NO3
Molecular weight: 341.4 g/mol
Exact mass: 341.19909372 Da
XLogP3: 3.3
Topological polar surface area: 58.6 Å²
Hydrogen-bond donors: 2
Hydrogen-bond acceptors: 4
Covalent units: 1
Defined stereocentres: 0

Also known as

PropafenonaPropafenonum1-(2-(2-hydroxy-3-(propylamino)propoxy)phenyl)-3-phenylpropan-1-onePropafenon HexalGNF-Pf-45941-(2-(2-Hydroxy-3-(propylamino)propoxy)phenyl)-3-phenyl-1-propanone68IQX3T69U1-{2-[2-hydroxy-3-(propylamino)propoxy]phenyl}-3-phenylpropan-1-one

16 more reported names

CHEBI:636191-Propanone, 1-(2-(2-hydroxy-3-(propylamino)propoxy)phenyl)-3-phenyl-2-(2'-hydroxy-3'-propylaminopropoxy)-omega-phenylpropiophenone1-Propanone, 1-[2-[2-hydroxy-3-(propylamino)propoxy]phenyl]-3-phenyl-NorfenonPintoformPropafenon MindenRefChem:55924SA79C01BC03258-955-6RythmolPropafenonum [INN-Latin]Propafenona [INN-Spanish]Propafenone (INN)CHEMBL631

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:63619
ChEMBL:CHEMBL631
EPA DTXSID:DTXSID9045184
PubMed:23096368
PubMed:23074627
PubMed:22839589
PubMed:22839523
PubMed:22749688
PubMed:22708838
PubMed:22701087
PubMed:22641972
PubMed:22639627
PubMed:22628063
PubMed:22592700
PubMed:22557846

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for PROPAFENONE

INCI name

PROPAFENONE

Description

1-{2-[2-hydroxy-3-(propylamino)propoxy]phenyl}-3-phenylpropan-1-one

Record provenance

Inventory reference: 88994
Imported identity: PROPAFENONE
Source update: 25/07/2012

European Commission CosIng source notes

Annex records for PROPAFENONE

Browse

Browse EU annexes

Explore Annex II–VI to see which substances are prohibited, restricted or permitted under specific conditions.

Search annex entries

Search the annex database for entries matching PROPAFENONE or related substances.

Key data

CAS

54063-53-5

—

Restriction

—

Function

—

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#23257 · PROPAFENONE

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How PROPAFENONE appears in the CosIng inventory

The CosIng inventory lists PROPAFENONE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

Regulatory conditions, if any, come from Annex II–VI records and should be checked before use in a formulation.

Frequently asked questions

PROPAFENONE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

CAS 54063-53-5 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

View CAS records

Use the INCI Checker to screen a full ingredient list across selected markets, or compare this substance across all supported market datasets.

Open INCI Checker

Source note for PROPAFENONE

This page reproduces the CosIng inventory entry for PROPAFENONE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research PROPAFENONE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

View sources View updates

Tools & next steps

Check your formula

Scan a full INCI list to detect PROPAFENONE and any linked EU annex restrictions or allergen flags.

INCI Checker

Search similar ingredients

Find other inventory ingredients and annex entries related to PROPAFENONE, its identifiers or nearby name variants.