Official EU label nameGlossary entry 1672

AMENTOFLAVONE

This record confirms an official common ingredient name for EU cosmetic product labelling. It does not by itself confirm that the substance is permitted, unrestricted or safe.

Global evidence snapshot

The resolved identity has matching regulatory evidence in 0 of 13 indexed market datasets: 0 country records and 0 EU Annex records. Every result and evidence gap is listed below.

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Resolved identifiers

Resolved substance identity

CAS:1617-53-4

Ingredient index records:

AMENTOFLAVONE

Cosmetic functions: ANTIOXIDANT, BLEACHING

Bis-Apigenin ; 4H-1-Benzopyran-4-one, 8-(5-(5,7-dihydroxy-4-oxo-4H-1-benzopyran-2- yl)-2-hydroxyphenyl)-5,7-dihydroxy-2-(4-hydroxyphenyl)- .

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1 matched or reported name

AMENTOFLAVONE

Regulatory evidence across markets

None of the 13 markets tracked here holds an imported rule under the name AMENTOFLAVONE.

That is a statement about this inventory, not about the law: no imported rule is not evidence that a substance is permitted. A rule may exist under a different name, under a CAS or EC number this glossary entry does not carry, or in a dataset not yet imported.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 1617-53-4

CAS 1617-53-4PubChem CID 5281600

Amentoflavone

Amentoflavone is a biflavonoid that is obtained by oxidative coupling of two molecules of apigenin resulting in a bond between positions C-3 of the hydroxyphenyl ring and C-8 of the chromene ring. A natural product found particularly in Ginkgo biloba and Hypericum perforatum. It has a role as an antiviral agent, an angiogenesis inhibitor, a P450 inhibitor, a cathepsin B inhibitor and a plant metabolite. It is a hydroxyflavone, a ring assembly and a biflavonoid. — ChEBI

IUPAC name: 8-[5-(5,7-dihydroxy-4-oxochromen-2-yl)-2-hydroxyphenyl]-5,7-dihydroxy-2-(4-hydroxyphenyl)chromen-4-one

Molecular formula: C30H18O10
Molecular weight: 538.5 g/mol
Exact mass: 538.08999677 Da
XLogP3: 5.0
Topological polar surface area: 174.0 Å²
Hydrogen-bond donors: 6
Hydrogen-bond acceptors: 10
Covalent units: 1
Defined stereocentres: 0

Also known as

Didemethyl-ginkgetin3',8''-BiapigeninTridemethylsciadopitysin9I1VC79L77NSC-295677CHEBI:26314H-1-Benzopyran-4-one, 8-[5-(5,7-dihydroxy-4-oxo-4H-1-benzopyran-2-yl)-2-hydroxyphenyl]-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-Benzopyran-4-one, 8-(5-(5,7-dihydroxy-4-oxo-4H-1-benzopyran-2-yl)-2-hydroxyphenyl)-5,7-dihydroxy-2-(4-hydroxyphenyl)-

16 more reported names

8-(5-(5,7-dihydroxy-4-oxo-4H-1-benzopyran-2-yl)-2-hydroxyphenyl)-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one8-[5-(5,7-Dihydroxy-4-oxo-4H-1-benzopyran-2-yl)-2-hydroxyphenyl]-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one8-(5-(5,7-dihydroxy-4-oxochromen-2-yl)-2-hydroxyphenyl)-5,7-dihydroxy-2-(4-hydroxyphenyl)chromen-4-oneRefChem:111894Amenthoflavone8-(5-(5,7-Dihydroxy-4-oxo-4H-chromen-2-yl)-2-hydroxyphenyl)-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one8-[5-(5,7-dihydroxy-4-oxo-chromen-2-yl)-2-hydroxy-phenyl]-5,7-dihydroxy-2-(4-hydroxyphenyl)chromen-4-oneI3',II8-BIAPIGENINBIDD:PXR0028GINKGETIN, DIDEMETHYL-med.21724, Compound 138CCG-2699508-[5-(5,7-dihydroxy-4-oxo-4H-chromen-2-yl)-2-hydroxyphenyl]-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-oneSR-01000721725-2SR-01000721725UNII-9I1VC79L77

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External database identifiers

ChEBI:CHEBI:2631
ChEMBL:CHEMBL63354
EPA DTXSID:DTXSID20167225
PubMed:41524907
PubMed:40915523
PubMed:38225072
PubMed:34599948
PubMed:32421801
PubMed:29470958
PubMed:28185818
PubMed:26456343
PubMed:22445328
PubMed:19775597
PubMed:17473463
PubMed:17003167

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Additional authoritative substance research

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Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal US EPA CompTox CTX APIs

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Official source and scope

Imported from Commission Implementing Decision (EU) 2025/1175 (dataset version EU 2025/1175). The glossary supplies common ingredient names for the ingredient list required by Article 19(1)(g); it is not an approval or safety list.

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