What does the restriction note for THIOUREA mean?

The restriction field for THIOUREA reads: II/321. This is the restriction note from the CosIng inventory. For authoritative conditions and limits, always refer to the linked annex entries.

What other records share CAS 62-56-6?

CAS 62-56-6 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

How do I check if my formula contains THIOUREA?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 8807918/11/2016

THIOUREA

THIOUREA is linked to 1 EU annex record on this page. Inventory note: II/321.

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Regulatory evidence by market

This matrix separates verified ingredient rules from sources that are mapped but not yet imported. No imported rule does not mean the ingredient is permitted.

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Market	Evidence status	Records	Source language
European Union	Evidence linked Prohibited entry found Open this evidence	1	English and EU languages
Great Britain	Evidence linked Prohibited Open this evidence	1	English
Canada	Evidence linked Prohibited Open this evidence	1	English and French
New Zealand	Evidence linked Prohibited Open this evidence	1	English
ASEAN	Evidence linked Prohibited Open this evidence	1	English and national languages
China	Evidence linked Prohibited Open this evidence	1	Chinese with selected English material
Japan	Source mapped Official source mapped; ingredient rule not imported	0	Japanese; official English translation available
South Korea	Evidence linked Prohibited Open this evidence	1	Korean with some English names
United States	Source mapped Official source mapped; ingredient rule not imported	0	English
Australia	Source mapped Official source mapped; ingredient rule not imported	0	English
Brazil	Evidence linked Prohibited Open this evidence	1	Portuguese with INCI crosswalks
India	Evidence linked Prohibited Open this evidence	1	English and Hindi
Saudi Arabia	Evidence linked Prohibited Open this evidence	1	Arabic and English

Chemical identity and properties

PubChem 2D chemical structure for CAS 62-56-6

CAS 62-56-6PubChem CID 2723790

Thiourea

Thiourea is the simplest member of the thiourea class, consisting of urea with the oxygen atom substituted by sulfur. It has a role as an antioxidant and a chromophore. It is a member of ureas, a member of thioureas and a one-carbon compound. It is functionally related to a urea and a carbonothioic O,O-acid. — ChEBI

IUPAC name: thiourea

Molecular formula: CH4N2S
Molecular weight: 76.12 g/mol
Exact mass: 76.00951931 Da
XLogP3: -0.8
Topological polar surface area: 84.1 Å²
Hydrogen-bond donors: 2
Hydrogen-bond acceptors: 1
Covalent units: 1
Defined stereocentres: 0

Also known as

ThiocarbamideIsothioureaSulfourea2-ThioureaPseudothioureaThiuroniumSulourea2-Thiopseudourea

16 more reported names

Thiocarbonic acid diamideUrea, thio-beta-ThiopseudoureaThiomocovinaUrea, 2-thio-Tsizp 34Pseudourea, 2-thio-ThiocarbamidThioharnstoffThiokarbamidUSAF EK-497carbonothioic diamideRCRA waste number U219CCRIS 588GYV9AM2QAGH2NC(S)NH2

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:36946
ChEMBL:CHEMBL260876
EPA DTXSID:DTXSID9021348
PubMed:38888127
PubMed:29803612
PubMed:28117934
PubMed:27427241
PubMed:26160521
PubMed:23125680
PubMed:23053959
PubMed:23043446
PubMed:23031495
PubMed:23026000
PubMed:23019480
PubMed:23019459

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for THIOUREA

INCI name

THIOUREA

Record provenance

Inventory reference: 88079
Imported identity: THIOUREA
Source update: 18/11/2016

European Commission CosIng source notes

Annex records for THIOUREA

Annex II Restriction reference

Entry 321

Thiourea and its derivatives, with the exception of the one listed in Annex III

CAS: 62-56-6

EC: 200-543-5

Key data

CAS

62-56-6

200-543-5

Restriction

II/321

Function

ANTIMICROBIAL: Preventing and/or slowing down microbial growth.
HUMECTANT: Retaining and/or preserving the moisture in a product during use.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#28771 · THIOUREA

Ingredients with overlapping formulation functions

TETRAMETHYLOLGLYCOLURILANTIMICROBIAL

THIABENDAZOLEANTIMICROBIAL

THIANTHOLANTIMICROBIAL, SKIN CONDITIONING

THIOCTAMIDOETHYL DIMETHYLAMINE MALEATEANTIMICROBIAL, ANTIOXIDANT, BLEACHING, SKIN CONDITIONING

THIRAMANTIMICROBIAL

THUJA ORIENTALIS EXTRACTANTIMICROBIAL, ASTRINGENT, HUMECTANT, SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT

THUJA ORIENTALIS LEAF OILANTIMICROBIAL; ANTIOXIDANT; SKIN PROTECTING

THUJA ORIENTALIS LEAF WATERANTIMICROBIAL; ANTIOXIDANT; SKIN PROTECTING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How THIOUREA appears in the CosIng inventory

The CosIng inventory lists THIOUREA as a cosmetic ingredient and this page links it to 1 annex record. The inventory entry captures names and identifiers, while the annex record shows where the substance is prohibited, restricted or positively listed in EU cosmetics law.

THIOUREA is also tagged with 2 cosmetic functions in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

THIOUREA appears in the EU CosIng inventory and has linked annex records. Check the annex records above for applicable restrictions, concentration limits and conditions of use. Annex II listing means prohibited; Annex III means restricted; Annexes IV, V and VI mean permitted under specified conditions.

The restriction field for THIOUREA reads: "II/321". This is the restriction note recorded in the CosIng inventory for this ingredient. For authoritative conditions and limits, always refer to the linked annex entries above.

According to the EU CosIng inventory, THIOUREA carries the following function designation(s):

CAS 62-56-6 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for THIOUREA

This page combines the CosIng inventory entry for THIOUREA with 1 linked Annex II–VI record from the local dataset built from public European Commission cosmetic ingredient materials.

Use this inventory page to research THIOUREA and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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Tools & next steps

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